BI-3406_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-3406 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-3406_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0871639
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0827609
B2M beta-2-microglobulin 0.0753671
CD44 CD44 molecule (Indian blood group) 0.0704887
TGM2 transglutaminase 2 0.0641859
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0574166
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0558703
APLP2 amyloid beta (A4) precursor-like protein 2 0.0489712
YBX1 Y box binding protein 1 0.0476738
EEF2 eukaryotic translation elongation factor 2 0.0465723
SMAD3 SMAD family member 3 0.0448778
RPS8 ribosomal protein S8 0.0447403
IFITM3 interferon induced transmembrane protein 3 0.0444972
RPS12 ribosomal protein S12 0.0441338
RACK1 receptor for activated C kinase 1 0.0440549
RPL23 ribosomal protein L23 0.0402669
IFITM1 interferon induced transmembrane protein 1 0.0388315
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0382142
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0369204
RPL37 ribosomal protein L37 0.0364333
ARRDC3 arrestin domain containing 3 0.0359651
RPS6 ribosomal protein S6 0.03584
MBNL1 muscleblind-like splicing regulator 1 0.0353649
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0345151
RPL3 ribosomal protein L3 0.0334653
FTH1 ferritin, heavy polypeptide 1 0.0331418
PLEC plectin 0.0319017
MKI67 marker of proliferation Ki-67 0.0313578
RPS19 ribosomal protein S19 0.0304179
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0303816
IFI6 interferon, alpha-inducible protein 6 0.0303335
LOC112694756 uncharaterized LOC112694756 0.0303219
RPS4X ribosomal protein S4, X-linked 0.0303092
NDRG1 N-myc downstream regulated 1 0.0299925
FLNA filamin A, alpha 0.0295183
KLF5 Kruppel-like factor 5 (intestinal) 0.028824
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.028661
RPLP2 ribosomal protein, large, P2 0.0281622
HSPA8 heat shock 70kDa protein 8 0.0277125
PCDH1 protocadherin 1 0.0274146
MSN moesin 0.0271089
CENPF centromere protein F, 350/400kDa 0.0269567
RPL21 ribosomal protein L21 0.0267679
IFI27 interferon, alpha-inducible protein 27 0.0266455
TPM3 tropomyosin 3 0.0263963
RPL36 ribosomal protein L36 0.0263959
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0263429
SRRM2 serine/arginine repetitive matrix 2 0.0261826
PKM pyruvate kinase, muscle 0.0260576
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0257555
RPS14 ribosomal protein S14 0.025658
RPL7 ribosomal protein L7 0.0255424
RPS3 ribosomal protein S3 0.0253287
CSNK1A1 casein kinase 1, alpha 1 0.0252457
SLK STE20-like kinase 0.0249764
JAG1 jagged 1 0.0249287
SIK3 SIK family kinase 3 0.0248937
MYH9 myosin, heavy chain 9, non-muscle 0.0242701
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0242431
RPLP1 ribosomal protein, large, P1 0.0242349
RPS13 ribosomal protein S13 0.0241902
RPL11 ribosomal protein L11 0.0237891
KIAA1217 KIAA1217 0.0232981
RPS2 ribosomal protein S2 0.0232743
RPL31 ribosomal protein L31 0.023193
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0230144
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0228746
POTEF POTE ankyrin domain family, member F 0.0223084
IFI44L interferon-induced protein 44-like 0.0221935
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.022108
EEF1G eukaryotic translation elongation factor 1 gamma 0.022064
ANXA1 annexin A1 0.0219636
RPL12 ribosomal protein L12 0.0219314
DSTN destrin (actin depolymerizing factor) 0.0218171
SEPTIN9 septin 9 0.0217838
RPS27 ribosomal protein S27 0.0216633
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0215021
MT1E metallothionein 1E 0.02132
KTN1 kinectin 1 (kinesin receptor) 0.0212331
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0210967
FTL ferritin, light polypeptide 0.0208865
LAMA5 laminin, alpha 5 0.0207844
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0207833
RPL37A ribosomal protein L37a 0.0207083
DIAPH1 diaphanous-related formin 1 0.0205586
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0205019
SH3PXD2A SH3 and PX domains 2A 0.0204138
ANO6 anoctamin 6 0.0202707
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0200651
UBC ubiquitin C 0.0199502
RPL5 ribosomal protein L5 0.0196837
LDHA lactate dehydrogenase A 0.0195698
MYOF myoferlin 0.019457
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0194183
NCOR2 nuclear receptor corepressor 2 0.0188847
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0185774
ANKH ANKH inorganic pyrophosphate transport regulator 0.0181911
RPL30 ribosomal protein L30 0.0181154
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0180141
ECE1 endothelin converting enzyme 1 0.0179966

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.255715
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.250069
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.179454
FLNB filamin B, beta -0.147711
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.130184
DPYD dihydropyrimidine dehydrogenase -0.123001
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.119363
ABI3BP ABI family, member 3 (NESH) binding protein -0.07862
SULF1 sulfatase 1 -0.0782882
AHNAK AHNAK nucleoprotein -0.0688032
ALCAM activated leukocyte cell adhesion molecule -0.0671166
SLC35F3 solute carrier family 35, member F3 -0.066842
MECOM MDS1 and EVI1 complex locus -0.0624497
TRIO trio Rho guanine nucleotide exchange factor -0.061082
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0588289
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0566984
ZEB1 zinc finger E-box binding homeobox 1 -0.0561165
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0525269
PDLIM5 PDZ and LIM domain 5 -0.0522747
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0486058
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0458283
PALLD palladin, cytoskeletal associated protein -0.0452375
RBM39 RNA binding motif protein 39 -0.0444187
CANX calnexin -0.0434101
ANO1 anoctamin 1, calcium activated chloride channel -0.0433854
NAMPT nicotinamide phosphoribosyltransferase -0.0418673
IGF2 insulin-like growth factor 2 -0.0400862
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0400153
RABGAP1L RAB GTPase activating protein 1-like -0.0398842
ZMYND8 zinc finger, MYND-type containing 8 -0.0391241
PSD3 pleckstrin and Sec7 domain containing 3 -0.0390645
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0389068
ITGA6 integrin, alpha 6 -0.0387099
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0387
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.038601
GRB10 growth factor receptor-bound protein 10 -0.0377694
TMSB4X thymosin beta 4, X-linked -0.036428
GARS1 glycyl-tRNA synthetase 1 -0.0362574
DLG1 discs, large homolog 1 (Drosophila) -0.0357378
EXOC6B exocyst complex component 6B -0.0352413
DGKH diacylglycerol kinase, eta -0.0351572
UTRN utrophin -0.0349272
BLCAP bladder cancer associated protein -0.0346264
ITCH itchy E3 ubiquitin protein ligase -0.0344338
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0343815
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0332492
RAI14 retinoic acid induced 14 -0.0328253
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0326643
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0324969
ITSN1 intersectin 1 (SH3 domain protein) -0.032387
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0321578
EMP1 epithelial membrane protein 1 -0.0320645
LMO7 LIM domain 7 -0.0317058
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0306266
CALU calumenin -0.0304203
FNDC3A fibronectin type III domain containing 3A -0.0302659
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0300043
NCOA3 nuclear receptor coactivator 3 -0.0299834
IARS1 isoleucyl-tRNA synthetase 1 -0.0296198
NRIP1 nuclear receptor interacting protein 1 -0.0286704
C4BPB complement component 4 binding protein, beta -0.0276121
AGMO alkylglycerol monooxygenase -0.0272783
FOXO1 forkhead box O1 -0.0270692
SEC31A SEC31 homolog A (S. cerevisiae) -0.0269393
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0269237
OXR1 oxidation resistance 1 -0.0268971
HM13 histocompatibility (minor) 13 -0.0267465
FSTL1 follistatin-like 1 -0.0265777
GLG1 golgi glycoprotein 1 -0.0265716
EXOC4 exocyst complex component 4 -0.0264241
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0262128
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0261655
CAVIN1 caveolae associated protein 1 -0.0261264
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0258587
TBC1D22A TBC1 domain family, member 22A -0.0256412
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.025608
HDLBP high density lipoprotein binding protein -0.0254723
CDK13 cyclin-dependent kinase 13 -0.0252644
EGFR epidermal growth factor receptor -0.0245516
PTMA prothymosin, alpha -0.0244414
NEK7 NIMA-related kinase 7 -0.0243057
DOCK5 dedicator of cytokinesis 5 -0.0240251
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0239037
PRSS23 protease, serine, 23 -0.0237084
CDK6 cyclin-dependent kinase 6 -0.0234786
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0233565
COPB1 coatomer protein complex, subunit beta 1 -0.0233459
SPAG9 sperm associated antigen 9 -0.0232671
KDM3A lysine (K)-specific demethylase 3A -0.0230546
LMAN1 lectin, mannose-binding, 1 -0.0228308
THBD thrombomodulin -0.0228161
DSG2 desmoglein 2 -0.0227924
SULF2 sulfatase 2 -0.0226777
NBEAL1 neurobeachin-like 1 -0.0225593
KLF12 Kruppel-like factor 12 -0.0225572
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0222731
PODXL podocalyxin-like -0.0222312
TNS3 tensin 3 -0.0221434
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0221391
COL4A5 collagen, type IV, alpha 5 -0.0219576