| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BI-3406 perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the BI-3406_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS12 | ribosomal protein S12 | 0.0305713 |
| RPL3 | ribosomal protein L3 | 0.0299819 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0296852 |
| DSPP | dentin sialophosphoprotein | 0.0233358 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0227854 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0208108 |
| MUC13 | mucin 13, cell surface associated | 0.0201074 |
| B2M | beta-2-microglobulin | 0.0183108 |
| RPL23 | ribosomal protein L23 | 0.0180635 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0170995 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0166393 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0159729 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0157299 |
| DST | dystonin | 0.0156032 |
| TPM3 | tropomyosin 3 | 0.0150185 |
| RACK1 | receptor for activated C kinase 1 | 0.0149844 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0149091 |
| RPS8 | ribosomal protein S8 | 0.0141368 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0140944 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 0.0134953 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0133215 |
| RPS27 | ribosomal protein S27 | 0.0130091 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0128394 |
| RPS3 | ribosomal protein S3 | 0.0127647 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0123151 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.0120287 |
| TPI1 | triosephosphate isomerase 1 | 0.0113818 |
| RPS19 | ribosomal protein S19 | 0.0112553 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.01091 |
| FLNA | filamin A, alpha | 0.010855 |
| FOXP1 | forkhead box P1 | 0.0106578 |
| RPS26 | ribosomal protein S26 | 0.010318 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0102742 |
| CENPF | centromere protein F, 350/400kDa | 0.0102642 |
| RPL37A | ribosomal protein L37a | 0.0101826 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0100808 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0100752 |
| USP54 | ubiquitin specific peptidase 54 | 0.009876 |
| FN1 | fibronectin 1 | 0.00978962 |
| GOLGB1 | golgin B1 | 0.00950162 |
| SFPQ | splicing factor proline/glutamine-rich | 0.00940952 |
| RPL21 | ribosomal protein L21 | 0.00939311 |
| VIM | vimentin | 0.00911938 |
| FTL | ferritin, light polypeptide | 0.00910472 |
| VEGFA | vascular endothelial growth factor A | 0.00909941 |
| SDHA | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 0.00897743 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00890545 |
| GOLIM4 | golgi integral membrane protein 4 | 0.00882579 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00876998 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.00873731 |
| TMF1 | TATA element modulatory factor 1 | 0.00868034 |
| WWOX | WW domain containing oxidoreductase | 0.00848975 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.00829975 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0082875 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.00811308 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.00806151 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00799014 |
| SET | SET nuclear proto-oncogene | 0.00795542 |
| SHROOM3 | shroom family member 3 | 0.00789963 |
| JUN | jun proto-oncogene | 0.00780651 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.00770983 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.00770069 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.00769377 |
| SLK | STE20-like kinase | 0.00768272 |
| PCM1 | pericentriolar material 1 | 0.00765972 |
| RPL7 | ribosomal protein L7 | 0.00761688 |
| DUSP16 | dual specificity phosphatase 16 | 0.00760802 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00759831 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00759346 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | 0.0074389 |
| HYOU1 | hypoxia up-regulated 1 | 0.00743625 |
| XPC | xeroderma pigmentosum, complementation group C | 0.00740218 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | 0.00735515 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.00730168 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.00726899 |
| FOSL2 | FOS-like antigen 2 | 0.00709532 |
| YBX1 | Y box binding protein 1 | 0.00708285 |
| RPS17 | ribosomal protein S17 | 0.00707201 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.00704995 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.00704444 |
| PCBP2 | poly(rC) binding protein 2 | 0.00702715 |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 | 0.00699299 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.00692202 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00690413 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.00683813 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.00681559 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | 0.00678692 |
| COX6C | cytochrome c oxidase subunit VIc | 0.00676084 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.00669726 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0066538 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.00656937 |
| STK38L | serine/threonine kinase 38 like | 0.00648232 |
| MT2A | metallothionein 2A | 0.006458 |
| RPL36 | ribosomal protein L36 | 0.00643436 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0064294 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.00642919 |
| NUB1 | negative regulator of ubiquitin-like proteins 1 | 0.00642316 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.00642011 |
| THBS1 | thrombospondin 1 | 0.00639586 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.00634345 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.158178 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.107905 |
| ANXA2 | annexin A2 | -0.0863879 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0854405 |
| TMSB10 | thymosin beta 10 | -0.075288 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0735458 |
| NPSR1 | neuropeptide S receptor 1 | -0.0732614 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0732495 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0723713 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0656035 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0648124 |
| MYO1E | myosin IE | -0.0560146 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0512693 |
| FLNB | filamin B, beta | -0.0481338 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0477361 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0475947 |
| PIGR | polymeric immunoglobulin receptor | -0.0442025 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0397294 |
| FAT1 | FAT atypical cadherin 1 | -0.0378022 |
| LMO7 | LIM domain 7 | -0.0372196 |
| ASPH | aspartate beta-hydroxylase | -0.0366892 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0364269 |
| KRT18 | keratin 18, type I | -0.036145 |
| KRT8 | keratin 8, type II | -0.0344697 |
| CADPS | Ca++-dependent secretion activator | -0.0342536 |
| ONECUT3 | one cut homeobox 3 | -0.0341061 |
| H1-0 | H1.0 linker histone | -0.0326802 |
| S100A6 | S100 calcium binding protein A6 | -0.031833 |
| TXNIP | thioredoxin interacting protein | -0.0311869 |
| TNS4 | tensin 4 | -0.0310101 |
| PTMA | prothymosin, alpha | -0.0309602 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0308477 |
| ITGA6 | integrin, alpha 6 | -0.0307091 |
| NDRG1 | N-myc downstream regulated 1 | -0.0301089 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.029912 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0296451 |
| AHNAK | AHNAK nucleoprotein | -0.0294569 |
| VCL | vinculin | -0.0291837 |
| SMYD3 | SET and MYND domain containing 3 | -0.0290353 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.028829 |
| RPS24 | ribosomal protein S24 | -0.0286462 |
| PRELID2 | PRELI domain containing 2 | -0.0276862 |
| TPM4 | tropomyosin 4 | -0.0275255 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0273931 |
| ACTG1 | actin gamma 1 | -0.0273687 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0271095 |
| RPLP0 | ribosomal protein, large, P0 | -0.0263266 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0261025 |
| NFIA | nuclear factor I/A | -0.0259739 |
| USP53 | ubiquitin specific peptidase 53 | -0.0256363 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0254717 |
| FERMT1 | fermitin family member 1 | -0.0251008 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0250688 |
| CANX | calnexin | -0.0247957 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0247862 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0245328 |
| CCNY | cyclin Y | -0.024468 |
| LDHA | lactate dehydrogenase A | -0.0244277 |
| IER3 | immediate early response 3 | -0.0242898 |
| RAB10 | RAB10, member RAS oncogene family | -0.0242399 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0241048 |
| FHIT | fragile histidine triad | -0.0240819 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0239841 |
| FBXO11 | F-box protein 11 | -0.0239137 |
| SBF2 | SET binding factor 2 | -0.0238573 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0236033 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0234897 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.02295 |
| JMJD1C | jumonji domain containing 1C | -0.022759 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0226258 |
| SNX9 | sorting nexin 9 | -0.0225936 |
| PGK1 | phosphoglycerate kinase 1 | -0.0222932 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0222877 |
| GPHN | gephyrin | -0.0222618 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0221803 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0221775 |
| AGR2 | anterior gradient 2 | -0.0219956 |
| LAMA4 | laminin, alpha 4 | -0.0219249 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0219134 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0218895 |
| DENND1A | DENN/MADD domain containing 1A | -0.0218547 |
| PKP2 | plakophilin 2 | -0.0218505 |
| RREB1 | ras responsive element binding protein 1 | -0.0217361 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0216021 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | -0.0215755 |
| PRSS3 | protease, serine, 3 | -0.0215675 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0214243 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0211921 |
| MED13L | mediator complex subunit 13-like | -0.0211905 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0210264 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0209708 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0209513 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0209384 |
| S100A10 | S100 calcium binding protein A10 | -0.020937 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0208378 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0206063 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0205384 |
| RPL35A | ribosomal protein L35a | -0.0205269 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0204887 |
| SH3D19 | SH3 domain containing 19 | -0.0203449 |
