BI-3406_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-3406 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-3406_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0857269
FTL ferritin, light polypeptide 0.0573865
RPS12 ribosomal protein S12 0.0460074
RPS8 ribosomal protein S8 0.0453814
RPS19 ribosomal protein S19 0.0353171
RPL23 ribosomal protein L23 0.0351379
B2M beta-2-microglobulin 0.0346814
RPL37A ribosomal protein L37a 0.0343587
RACK1 receptor for activated C kinase 1 0.032592
TP63 tumor protein p63 0.0324206
RPL36 ribosomal protein L36 0.0316913
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0302651
RPL12 ribosomal protein L12 0.030093
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0299058
DST dystonin 0.0271312
RPS3 ribosomal protein S3 0.0264176
EEF2 eukaryotic translation elongation factor 2 0.0256278
ZSWIM6 zinc finger, SWIM-type containing 6 0.0256079
RPL31 ribosomal protein L31 0.0251684
KTN1 kinectin 1 (kinesin receptor) 0.0234073
RPS27 ribosomal protein S27 0.0230723
RPL3 ribosomal protein L3 0.023056
RPS6 ribosomal protein S6 0.021594
RPS17 ribosomal protein S17 0.0213113
IFI6 interferon, alpha-inducible protein 6 0.0211671
RPL11 ribosomal protein L11 0.0201521
HLA-A major histocompatibility complex, class I, A 0.0200739
BIRC3 baculoviral IAP repeat containing 3 0.0188125
RPL37 ribosomal protein L37 0.017985
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0174587
ZFP36L1 ZFP36 ring finger protein-like 1 0.0174555
SP100 SP100 nuclear antigen 0.0167843
HMGA1 high mobility group AT-hook 1 0.0162074
SOX9 SRY (sex determining region Y)-box 9 0.0161854
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0161813
RPL26 ribosomal protein L26 0.0161428
PARP14 poly (ADP-ribose) polymerase family, member 14 0.015943
ENO1 enolase 1, (alpha) 0.0158225
ENO2 enolase 2 (gamma, neuronal) 0.0156593
RPS29 ribosomal protein S29 0.0156407
RPS14 ribosomal protein S14 0.0152512
MT1E metallothionein 1E 0.0151116
RPS4X ribosomal protein S4, X-linked 0.0149643
RPL27 ribosomal protein L27 0.0144434
INTS6 integrator complex subunit 6 0.0142801
MB21D2 Mab-21 domain containing 2 0.0139959
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.013989
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0132808
EEF1G eukaryotic translation elongation factor 1 gamma 0.0131298
RPLP1 ribosomal protein, large, P1 0.0130433
NEK10 NIMA-related kinase 10 0.0130037
EGFR epidermal growth factor receptor 0.0128993
IFITM1 interferon induced transmembrane protein 1 0.0127969
ASPH aspartate beta-hydroxylase 0.0126904
TPI1 triosephosphate isomerase 1 0.0126407
RPL7 ribosomal protein L7 0.0126115
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0123779
HLA-B major histocompatibility complex, class I, B 0.012301
HMOX1 heme oxygenase 1 0.0122088
UBC ubiquitin C 0.0121774
RPL18 ribosomal protein L18 0.0120665
SQSTM1 sequestosome 1 0.0120082
RPS25 ribosomal protein S25 0.0120067
CFB complement factor B 0.0118219
RPL8 ribosomal protein L8 0.0117307
ZBTB38 zinc finger and BTB domain containing 38 0.0116933
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0116414
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.011478
CXCL5 chemokine (C-X-C motif) ligand 5 0.0113051
DDIT4 DNA-damage-inducible transcript 4 0.0112399
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0111744
RPL21 ribosomal protein L21 0.0111194
HDAC9 histone deacetylase 9 0.0109916
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0109876
RPL4 ribosomal protein L4 0.0106801
HLA-E major histocompatibility complex, class I, E 0.0104224
RPLP2 ribosomal protein, large, P2 0.0103724
ISG15 ISG15 ubiquitin-like modifier 0.0103488
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0102979
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.010169
RPL13A ribosomal protein L13a 0.0100124
SRRM2 serine/arginine repetitive matrix 2 0.00994613
RPL34 ribosomal protein L34 0.00990107
HSPA8 heat shock 70kDa protein 8 0.00984327
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.00982965
AREG amphiregulin 0.00978362
TRIM56 tripartite motif containing 56 0.00975587
RPS27A ribosomal protein S27a 0.00964948
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00959053
GATAD1 GATA zinc finger domain containing 1 0.00947436
VIM vimentin 0.00935787
PRELID2 PRELI domain containing 2 0.00927146
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0092331
HOMER1 homer scaffolding protein 1 0.00910449
CFLAR CASP8 and FADD-like apoptosis regulator 0.00894613
RPS23 ribosomal protein S23 0.008914
ZMIZ1 zinc finger, MIZ-type containing 1 0.008895
YBX1 Y box binding protein 1 0.00886513
RPL35 ribosomal protein L35 0.00883213
FN1 fibronectin 1 0.00881293

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0803976
DLG1 discs, large homolog 1 (Drosophila) -0.0583424
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0535004
TMSB4X thymosin beta 4, X-linked -0.051578
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0512344
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0476645
TXNRD1 thioredoxin reductase 1 -0.0468096
APP amyloid beta (A4) precursor protein -0.0425114
TM4SF1 transmembrane 4 L six family member 1 -0.0420028
RAI1 retinoic acid induced 1 -0.0403538
SLC38A2 solute carrier family 38, member 2 -0.0378708
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.035793
CENPF centromere protein F, 350/400kDa -0.0338175
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0334946
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0315465
CANX calnexin -0.0313979
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.031373
ZMYND8 zinc finger, MYND-type containing 8 -0.0311239
RTN4 reticulon 4 -0.0299605
CD44 CD44 molecule (Indian blood group) -0.0299183
EHBP1 EH domain binding protein 1 -0.0298497
ARHGAP5 Rho GTPase activating protein 5 -0.0295522
PTK2 protein tyrosine kinase 2 -0.0286691
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.028666
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0277327
BIRC6 baculoviral IAP repeat containing 6 -0.0277045
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0275946
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0270415
WSB1 WD repeat and SOCS box containing 1 -0.0260801
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0258164
KDM3A lysine (K)-specific demethylase 3A -0.0253434
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0252726
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0250643
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0246194
ZNF292 zinc finger protein 292 -0.0245306
SRPK2 SRSF protein kinase 2 -0.0243363
XPO1 exportin 1 -0.0239046
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0237397
USP34 ubiquitin specific peptidase 34 -0.0237369
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0235544
ANKRD11 ankyrin repeat domain 11 -0.0232137
OGA O-GlcNAcase -0.0231847
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0229519
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0226924
RIGI RNA sensor RIG-I -0.022539
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0225078
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0223558
YEATS2 YEATS domain containing 2 -0.0223225
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0218082
TRIO trio Rho guanine nucleotide exchange factor -0.0216148
RBM39 RNA binding motif protein 39 -0.0215957
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0214858
PIAS2 protein inhibitor of activated STAT, 2 -0.0213951
PUM2 pumilio RNA-binding family member 2 -0.0212868
SBF2 SET binding factor 2 -0.0212561
GSK3B glycogen synthase kinase 3 beta -0.0211324
FBXO11 F-box protein 11 -0.0210357
SPAG9 sperm associated antigen 9 -0.0209773
ACTG1 actin gamma 1 -0.0209212
TMEM41B transmembrane protein 41B -0.0208472
TOP1 topoisomerase (DNA) I -0.0208131
BRWD1 bromodomain and WD repeat domain containing 1 -0.0204356
WDR26 WD repeat domain 26 -0.0203403
JMJD1C jumonji domain containing 1C -0.0203348
AFF4 AF4/FMR2 family, member 4 -0.0201179
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0200437
GARS1 glycyl-tRNA synthetase 1 -0.0199988
ATP13A3 ATPase type 13A3 -0.0197543
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0196666
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0196104
AHNAK AHNAK nucleoprotein -0.0196056
MACF1 microtubule-actin crosslinking factor 1 -0.0194673
TRIP12 thyroid hormone receptor interactor 12 -0.0194656
FNIP1 folliculin interacting protein 1 -0.0193226
CFDP1 craniofacial development protein 1 -0.0192772
NCOR1 nuclear receptor corepressor 1 -0.019276
ZNF207 zinc finger protein 207 -0.019008
CEP170 centrosomal protein 170kDa -0.0189186
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.018673
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0184877
TAOK1 TAO kinase 1 -0.018029
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0178968
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0178395
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0177032
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0176369
NAMPT nicotinamide phosphoribosyltransferase -0.0172884
SENP6 SUMO1/sentrin specific peptidase 6 -0.0171686
ZFAND3 zinc finger, AN1-type domain 3 -0.0170857
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0170825
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0169843
TMEM123 transmembrane protein 123 -0.0169225
RBM25 RNA binding motif protein 25 -0.0169146
MARCHF6 membrane associated ring-CH-type finger 6 -0.0169146
PGK1 phosphoglycerate kinase 1 -0.0168787
FMNL2 formin-like 2 -0.0168562
TAS2R14 taste receptor, type 2, member 14 -0.016766
WDR45B WD repeat domain 45B -0.0167599
FAF1 Fas (TNFRSF6) associated factor 1 -0.0165414
TRA2A transformer 2 alpha homolog (Drosophila) -0.0165279
NF1 neurofibromin 1 -0.016527