| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BI-3406 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the BI-3406_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.24166 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.20479 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.197054 |
| TPM3 | tropomyosin 3 | 0.106024 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0778713 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0654512 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0620351 |
| RPL3 | ribosomal protein L3 | 0.0598357 |
| TXNRD1 | thioredoxin reductase 1 | 0.0528364 |
| GOLGB1 | golgin B1 | 0.0505713 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.048155 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0480783 |
| UBC | ubiquitin C | 0.0478103 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0472369 |
| RACK1 | receptor for activated C kinase 1 | 0.046311 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0451548 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0432185 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0431658 |
| STC1 | stanniocalcin 1 | 0.043043 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0425293 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0423725 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0421167 |
| PCBP2 | poly(rC) binding protein 2 | 0.0412964 |
| COPA | coatomer protein complex, subunit alpha | 0.0406301 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0401409 |
| RPS4X | ribosomal protein S4, X-linked | 0.0400553 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0397809 |
| YBX1 | Y box binding protein 1 | 0.0382442 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0380413 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0370356 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0358732 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.034465 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0337811 |
| RPL4 | ribosomal protein L4 | 0.0337165 |
| GOLGA4 | golgin A4 | 0.033384 |
| HOMER1 | homer scaffolding protein 1 | 0.0333342 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.032238 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0321037 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0316356 |
| INTS6 | integrator complex subunit 6 | 0.0301427 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0296068 |
| TPI1 | triosephosphate isomerase 1 | 0.0292495 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0287206 |
| HDLBP | high density lipoprotein binding protein | 0.0282964 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0281765 |
| NCKAP1 | NCK-associated protein 1 | 0.0276943 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0274644 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0272391 |
| PREPL | prolyl endopeptidase-like | 0.0270605 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0269654 |
| ADIPOR2 | adiponectin receptor 2 | 0.0269612 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.026921 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0266335 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0266225 |
| CRY1 | cryptochrome circadian clock 1 | 0.0266044 |
| CCT2 | chaperonin containing TCP1, subunit 2 (beta) | 0.0265645 |
| RPS2 | ribosomal protein S2 | 0.025502 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0254132 |
| RPS27 | ribosomal protein S27 | 0.0251542 |
| RPS17 | ribosomal protein S17 | 0.0250444 |
| ACTN1 | actinin, alpha 1 | 0.0248976 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0248765 |
| SRP54 | signal recognition particle 54kDa | 0.0247304 |
| UBAP2L | ubiquitin associated protein 2-like | 0.024504 |
| KMT5B | lysine methyltransferase 5B | 0.0242175 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0241851 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0239717 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0237541 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0235935 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0234755 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.023458 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0234569 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0234562 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0233664 |
| RAB10 | RAB10, member RAS oncogene family | 0.0231758 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0231688 |
| CALU | calumenin | 0.0231356 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0230879 |
| MLEC | malectin | 0.0230733 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0229232 |
| MYO6 | myosin VI | 0.0229146 |
| R3HDM2 | R3H domain containing 2 | 0.0228253 |
| MORF4L2 | mortality factor 4 like 2 | 0.0227001 |
| ADAR | adenosine deaminase, RNA-specific | 0.0225826 |
| STK4 | serine/threonine kinase 4 | 0.0225645 |
| SERINC3 | serine incorporator 3 | 0.0223679 |
| TMEM41B | transmembrane protein 41B | 0.0223636 |
| CLTC | clathrin, heavy chain (Hc) | 0.0222719 |
| IL6ST | interleukin 6 signal transducer | 0.0222074 |
| RAB1A | RAB1A, member RAS oncogene family | 0.022187 |
| KIF5B | kinesin family member 5B | 0.0219474 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0219151 |
| TAPBP | TAP binding protein (tapasin) | 0.0218614 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0218318 |
| BRD2 | bromodomain containing 2 | 0.0217439 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.021721 |
| CCT7 | chaperonin containing TCP1, subunit 7 (eta) | 0.0216784 |
| MKRN1 | makorin ring finger protein 1 | 0.0215665 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.021456 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0208739 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.156972 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.140672 |
| RAD51B | RAD51 paralog B | -0.0991623 |
| TMSB10 | thymosin beta 10 | -0.0899689 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.086135 |
| YBX3 | Y box binding protein 3 | -0.0848796 |
| PTMA | prothymosin, alpha | -0.0824158 |
| PRELID2 | PRELI domain containing 2 | -0.0803522 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0736218 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0734103 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0690386 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0682053 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0665439 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.064919 |
| ACTG1 | actin gamma 1 | -0.0622762 |
| ATXN1 | ataxin 1 | -0.0620125 |
| RPS21 | ribosomal protein S21 | -0.061716 |
| EXOC4 | exocyst complex component 4 | -0.0612013 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0557675 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0508547 |
| RPL35A | ribosomal protein L35a | -0.0495964 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.049477 |
| SBF2 | SET binding factor 2 | -0.0493516 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0464341 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0463599 |
| RYR3 | ryanodine receptor 3 | -0.0458964 |
| PTK2 | protein tyrosine kinase 2 | -0.0450758 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0450563 |
| SSH2 | slingshot protein phosphatase 2 | -0.0447405 |
| CD2AP | CD2-associated protein | -0.0446146 |
| HLA-B | major histocompatibility complex, class I, B | -0.0437398 |
| OSMR | oncostatin M receptor | -0.0433501 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0429721 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0419506 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0408612 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0406976 |
| EFNA5 | ephrin-A5 | -0.0406691 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0394278 |
| USP34 | ubiquitin specific peptidase 34 | -0.0390516 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0386988 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0386258 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0384958 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0377002 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0369752 |
| NLGN1 | neuroligin 1 | -0.0366583 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0364235 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0358981 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0357262 |
| CUX1 | cut-like homeobox 1 | -0.0356833 |
| PHF21A | PHD finger protein 21A | -0.0354344 |
| HMGA2 | high mobility group AT-hook 2 | -0.0347954 |
| PHIP | pleckstrin homology domain interacting protein | -0.034769 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0343873 |
| BBX | bobby sox homolog (Drosophila) | -0.0340997 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0332416 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0332288 |
| MT1X | metallothionein 1X | -0.0328847 |
| DENND5B | DENN/MADD domain containing 5B | -0.0322576 |
| CCDC91 | coiled-coil domain containing 91 | -0.0321655 |
| THOC2 | THO complex 2 | -0.0320888 |
| RSF1 | remodeling and spacing factor 1 | -0.03155 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0309846 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0309221 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0307291 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0307243 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0306182 |
| PDE10A | phosphodiesterase 10A | -0.0304081 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0291435 |
| DIAPH3 | diaphanous-related formin 3 | -0.0289104 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0287532 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0287244 |
| EHBP1 | EH domain binding protein 1 | -0.0284709 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0282976 |
| DIAPH2 | diaphanous-related formin 2 | -0.028243 |
| NABP1 | nucleic acid binding protein 1 | -0.0280343 |
| MAP4 | microtubule-associated protein 4 | -0.0280288 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.0275083 |
| ZNF638 | zinc finger protein 638 | -0.0274275 |
| BNC2 | basonuclin 2 | -0.0273112 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0272631 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0269779 |
| ANKRD36B | ankyrin repeat domain 36B | -0.0269308 |
| RBM39 | RNA binding motif protein 39 | -0.0266356 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0266262 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.026473 |
| SUMF1 | sulfatase modifying factor 1 | -0.0262553 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0262334 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0261996 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0255241 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0255014 |
| PHF20 | PHD finger protein 20 | -0.0253431 |
| SMYD3 | SET and MYND domain containing 3 | -0.0251115 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0250344 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0246548 |
| CNKSR3 | CNKSR family member 3 | -0.0244747 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0242024 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0241127 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0237542 |
| RBMX | RNA binding motif protein, X-linked | -0.0236962 |
| FMN1 | formin 1 | -0.0236505 |
