BI-3406_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-3406 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-3406_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.253561
TGFBI transforming growth factor, beta-induced, 68kDa 0.121161
B2M beta-2-microglobulin 0.105232
VIM vimentin 0.105077
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.100136
FN1 fibronectin 1 0.0925917
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0859037
HLA-B major histocompatibility complex, class I, B 0.0805
EGFR epidermal growth factor receptor 0.0661063
POTEF POTE ankyrin domain family, member F 0.06512
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0636258
COL5A1 collagen, type V, alpha 1 0.0625605
CXCL8 chemokine (C-X-C motif) ligand 8 0.0585116
HLA-A major histocompatibility complex, class I, A 0.0574536
MYH9 myosin, heavy chain 9, non-muscle 0.056594
CDH13 cadherin 13 0.051583
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0495461
VCL vinculin 0.0482995
PRSS23 protease, serine, 23 0.046191
FTH1 ferritin, heavy polypeptide 1 0.0458393
TIMP3 TIMP metallopeptidase inhibitor 3 0.0456985
AKAP12 A kinase (PRKA) anchor protein 12 0.0447314
PDIA3 protein disulfide isomerase family A, member 3 0.0445302
STC1 stanniocalcin 1 0.0444962
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0440767
EEF2 eukaryotic translation elongation factor 2 0.0436487
FLNA filamin A, alpha 0.0436403
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0433692
COL6A1 collagen, type VI, alpha 1 0.0427781
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0427206
IL6 interleukin 6 0.0417207
PRELID2 PRELI domain containing 2 0.0406458
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0401637
TMSB10 thymosin beta 10 0.0383766
SBF2 SET binding factor 2 0.0383649
IGFBP7 insulin-like growth factor binding protein 7 0.0381427
RPS8 ribosomal protein S8 0.0378708
TNIP1 TNFAIP3 interacting protein 1 0.0377418
RPL11 ribosomal protein L11 0.0374157
TNS3 tensin 3 0.0371939
MAP4 microtubule-associated protein 4 0.0360466
PTMA prothymosin, alpha 0.0355709
LDHA lactate dehydrogenase A 0.0354273
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0352259
ZSWIM6 zinc finger, SWIM-type containing 6 0.0349701
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.033781
ITGAV integrin, alpha V 0.0332005
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0326356
KYNU kynureninase 0.0323516
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0323322
KMT2C lysine (K)-specific methyltransferase 2C 0.0316795
LOXL2 lysyl oxidase-like 2 0.0314595
SRRM2 serine/arginine repetitive matrix 2 0.0313755
RAI14 retinoic acid induced 14 0.0307081
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.030592
HLA-C major histocompatibility complex, class I, C 0.0304344
TOP2A topoisomerase (DNA) II alpha 170kDa 0.030425
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.02991
PDLIM5 PDZ and LIM domain 5 0.0298914
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0289194
EIF1 eukaryotic translation initiation factor 1 0.0284802
FAM107B family with sequence similarity 107, member B 0.0281575
RPS6 ribosomal protein S6 0.0281142
FBXL7 F-box and leucine-rich repeat protein 7 0.0280339
PLEC plectin 0.0278475
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0278266
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0277784
MYOF myoferlin 0.0277446
MACF1 microtubule-actin crosslinking factor 1 0.0275384
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0273089
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0269599
LOC112694756 uncharaterized LOC112694756 0.0269444
NAV1 neuron navigator 1 0.0265956
AUTS2 autism susceptibility candidate 2 0.026537
ZEB2 zinc finger E-box binding homeobox 2 0.0264599
RASAL2 RAS protein activator like 2 0.0262606
INHBA inhibin, beta A 0.0258603
PDIA6 protein disulfide isomerase family A, member 6 0.0253622
SEPTIN9 septin 9 0.0253608
RPL3 ribosomal protein L3 0.0251262
NABP1 nucleic acid binding protein 1 0.0246338
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0244884
S100A10 S100 calcium binding protein A10 0.0244857
LAMB1 laminin, beta 1 0.0244808
LAMB3 laminin, beta 3 0.0240555
L1CAM L1 cell adhesion molecule 0.024028
FNIP1 folliculin interacting protein 1 0.0240179
EHBP1 EH domain binding protein 1 0.0240171
CCDC88A coiled-coil domain containing 88A 0.023968
UBC ubiquitin C 0.0239679
RACK1 receptor for activated C kinase 1 0.0239294
ARHGAP24 Rho GTPase activating protein 24 0.0237444
FNDC3B fibronectin type III domain containing 3B 0.0236691
SCARB2 scavenger receptor class B, member 2 0.0233514
BSG basigin (Ok blood group) 0.0232551
SND1 staphylococcal nuclease and tudor domain containing 1 0.0230654
TPM3 tropomyosin 3 0.023048
RND3 Rho family GTPase 3 0.0230394
YBX1 Y box binding protein 1 0.0230356
TPM2 tropomyosin 2 (beta) 0.0229617

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0804741
COL1A1 collagen, type I, alpha 1 -0.0585023
FAM13A family with sequence similarity 13, member A -0.057829
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0574113
NAMPT nicotinamide phosphoribosyltransferase -0.044675
CADM1 cell adhesion molecule 1 -0.0423386
TBC1D23 TBC1 domain family, member 23 -0.0407759
KMT2E lysine (K)-specific methyltransferase 2E -0.03997
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0393494
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0387678
H3-3B H3.3 histone B -0.0359646
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0327528
ANKRD17 ankyrin repeat domain 17 -0.0327051
MEF2A myocyte enhancer factor 2A -0.0326029
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0317686
ADM adrenomedullin -0.031508
OGA O-GlcNAcase -0.031321
PIAS1 protein inhibitor of activated STAT, 1 -0.0312836
MBD5 methyl-CpG binding domain protein 5 -0.0311107
SEC23A Sec23 homolog A (S. cerevisiae) -0.0298797
ELL2 elongation factor, RNA polymerase II, 2 -0.0295778
WDR26 WD repeat domain 26 -0.0292901
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.029128
BIRC6 baculoviral IAP repeat containing 6 -0.0290505
DLG1 discs, large homolog 1 (Drosophila) -0.0287965
FLNB filamin B, beta -0.0286095
ARRDC3 arrestin domain containing 3 -0.0285042
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0278644
CD99 CD99 molecule -0.0278344
SDC4 syndecan 4 -0.027423
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0270655
MARCHF6 membrane associated ring-CH-type finger 6 -0.0267981
PDE10A phosphodiesterase 10A -0.0267668
BRWD3 bromodomain and WD repeat domain containing 3 -0.0266977
IKBIP IKBKB interacting protein -0.0266654
BHLHE40 basic helix-loop-helix family, member e40 -0.0265214
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0262215
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0255661
EP300 E1A binding protein p300 -0.0252834
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0251426
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0250467
CTTNBP2NL CTTNBP2 N-terminal like -0.0249585
EFNA5 ephrin-A5 -0.0247822
ZNF292 zinc finger protein 292 -0.0246155
POMP proteasome maturation protein -0.0245775
ESYT2 extended synaptotagmin-like protein 2 -0.0243427
UBE2O ubiquitin-conjugating enzyme E2O -0.0242261
NDRG1 N-myc downstream regulated 1 -0.0242175
ADNP activity-dependent neuroprotector homeobox -0.0229197
RSF1 remodeling and spacing factor 1 -0.0228089
TXNIP thioredoxin interacting protein -0.022796
ANO6 anoctamin 6 -0.0225144
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0223851
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0222
MT1X metallothionein 1X -0.0221873
PSD3 pleckstrin and Sec7 domain containing 3 -0.0220577
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0220465
ACVR1 activin A receptor, type I -0.0216581
COL1A2 collagen, type I, alpha 2 -0.0215378
TXNRD1 thioredoxin reductase 1 -0.0214107
CFDP1 craniofacial development protein 1 -0.021378
RLF rearranged L-myc fusion -0.0211536
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.020899
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0208846
ZMYM2 zinc finger, MYM-type 2 -0.0207613
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0206354
TENT5A terminal nucleotidyltransferase 5A -0.0205918
PPHLN1 periphilin 1 -0.020423
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0202012
KLF6 Kruppel-like factor 6 -0.0201443
YME1L1 YME1-like 1 ATPase -0.0199907
TM4SF1 transmembrane 4 L six family member 1 -0.0199798
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.019799
RSPRY1 ring finger and SPRY domain containing 1 -0.019731
HPCAL1 hippocalcin-like 1 -0.0196427
THOC2 THO complex 2 -0.0196053
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0195861
USP3 ubiquitin specific peptidase 3 -0.0195733
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -0.019486
CCL2 chemokine (C-C motif) ligand 2 -0.0194566
RAB27A RAB27A, member RAS oncogene family -0.0192031
NUP54 nucleoporin 54kDa -0.0191188
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0190864
HIPK2 homeodomain interacting protein kinase 2 -0.0190277
CD109 CD109 molecule -0.0189586
ZNF395 zinc finger protein 395 -0.0189058
UBE2B ubiquitin-conjugating enzyme E2B -0.0188416
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0188073
IFI16 interferon, gamma-inducible protein 16 -0.0187797
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.018751
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0186865
HOOK2 hook microtubule-tethering protein 2 -0.0186129
TNRC6A trinucleotide repeat containing 6A -0.0185807
THRAP3 thyroid hormone receptor associated protein 3 -0.018549
USP9X ubiquitin specific peptidase 9, X-linked -0.0184828
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0184516
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0184234
AKR1C1 aldo-keto reductase family 1, member C1 -0.0183846
NRBP1 nuclear receptor binding protein 1 -0.0183636
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0183381