BI-3406_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-3406 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-3406_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0802231
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0787642
CD44 CD44 molecule (Indian blood group) 0.0453256
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0424844
EEF2 eukaryotic translation elongation factor 2 0.0351453
PTMA prothymosin, alpha 0.0325411
RACK1 receptor for activated C kinase 1 0.0305914
RPS12 ribosomal protein S12 0.0281323
TPI1 triosephosphate isomerase 1 0.0271888
ENO1 enolase 1, (alpha) 0.0266988
AKAP12 A kinase (PRKA) anchor protein 12 0.0263345
LDHA lactate dehydrogenase A 0.0259865
SRRM2 serine/arginine repetitive matrix 2 0.0257927
ANXA1 annexin A1 0.025756
CNKSR3 CNKSR family member 3 0.0251761
AHNAK AHNAK nucleoprotein 0.0250559
VIM vimentin 0.0244877
RPL23 ribosomal protein L23 0.0237712
SVIL supervillin 0.022765
TPM3 tropomyosin 3 0.0227305
BIRC3 baculoviral IAP repeat containing 3 0.0226449
HLA-A major histocompatibility complex, class I, A 0.0218415
POTEF POTE ankyrin domain family, member F 0.0217342
ANKRD28 ankyrin repeat domain 28 0.020084
MT2A metallothionein 2A 0.01989
FN1 fibronectin 1 0.0197542
RPS27A ribosomal protein S27a 0.019662
SH3KBP1 SH3-domain kinase binding protein 1 0.0196581
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0196399
IGFBP3 insulin-like growth factor binding protein 3 0.0196054
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0193655
LOC112694756 uncharaterized LOC112694756 0.0190252
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0188522
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0187235
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0185954
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0184492
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0184024
NFE2L1 nuclear factor, erythroid 2-like 1 0.0183888
EXT1 exostosin glycosyltransferase 1 0.0177673
RPS8 ribosomal protein S8 0.017533
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.0174294
B2M beta-2-microglobulin 0.0174241
RPL4 ribosomal protein L4 0.0173101
CCDC91 coiled-coil domain containing 91 0.0173008
SQSTM1 sequestosome 1 0.0172575
RPS6 ribosomal protein S6 0.0170091
ANKRD11 ankyrin repeat domain 11 0.0169061
MACF1 microtubule-actin crosslinking factor 1 0.0168809
AHR aryl hydrocarbon receptor 0.0167955
RPL34 ribosomal protein L34 0.0164287
FTL ferritin, light polypeptide 0.0163716
TPM4 tropomyosin 4 0.0162717
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.016256
RPLP1 ribosomal protein, large, P1 0.0160059
RPS14 ribosomal protein S14 0.0159588
ANGPTL4 angiopoietin-like 4 0.0159553
SET SET nuclear proto-oncogene 0.0153013
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0152507
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0152441
ZMYND8 zinc finger, MYND-type containing 8 0.0151106
MARCHF4 membrane associated ring-CH-type finger 4 0.0149142
YBX1 Y box binding protein 1 0.0148382
RPS23 ribosomal protein S23 0.0148289
SERINC3 serine incorporator 3 0.0147455
SRSF3 serine/arginine-rich splicing factor 3 0.0146913
PDIA3 protein disulfide isomerase family A, member 3 0.0146789
FXR1 fragile X mental retardation, autosomal homolog 1 0.0146556
PKM pyruvate kinase, muscle 0.0145944
RPL12 ribosomal protein L12 0.0145773
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.014448
PNISR PNN-interacting serine/arginine-rich protein 0.0144332
OPTN optineurin 0.0142798
BRD2 bromodomain containing 2 0.0142625
NKD1 naked cuticle homolog 1 (Drosophila) 0.0141003
CANX calnexin 0.0140949
GOLIM4 golgi integral membrane protein 4 0.0139192
RPS13 ribosomal protein S13 0.0137365
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0137207
CORO1C coronin, actin binding protein, 1C 0.0134496
SFPQ splicing factor proline/glutamine-rich 0.0133358
ZFP36L1 ZFP36 ring finger protein-like 1 0.0133348
UBC ubiquitin C 0.0133195
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0132394
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0131875
RPL11 ribosomal protein L11 0.0131771
TIMP1 TIMP metallopeptidase inhibitor 1 0.0131519
HPCAL1 hippocalcin-like 1 0.0130049
LIMA1 LIM domain and actin binding 1 0.0129013
CDK6 cyclin-dependent kinase 6 0.0128962
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0128255
CALR calreticulin 0.0128174
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0127762
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0127072
RPS4X ribosomal protein S4, X-linked 0.0126049
MAP1B microtubule-associated protein 1B 0.0125526
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0125142
FTH1 ferritin, heavy polypeptide 1 0.0124636
ALCAM activated leukocyte cell adhesion molecule 0.0123943
RPL37A ribosomal protein L37a 0.0123586
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0122769

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.0749961
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0654283
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0651468
TAS2R14 taste receptor, type 2, member 14 -0.058225
GLS2 glutaminase 2 (liver, mitochondrial) -0.0311986
SPAG9 sperm associated antigen 9 -0.0306231
RBM39 RNA binding motif protein 39 -0.0296662
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0276159
ITCH itchy E3 ubiquitin protein ligase -0.0258642
SNX14 sorting nexin 14 -0.0258617
ZNF292 zinc finger protein 292 -0.0244791
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0238139
MCTP1 multiple C2 domains, transmembrane 1 -0.0238118
FNDC3A fibronectin type III domain containing 3A -0.0237001
USP34 ubiquitin specific peptidase 34 -0.0235664
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0224885
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0224514
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0224475
YAP1 Yes-associated protein 1 -0.0218307
RIGI RNA sensor RIG-I -0.0215342
OSMR oncostatin M receptor -0.0207133
BHLHE40 basic helix-loop-helix family, member e40 -0.0202386
WNK1 WNK lysine deficient protein kinase 1 -0.019779
FLNB filamin B, beta -0.0195436
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.019149
NAV2 neuron navigator 2 -0.0190571
CAPRIN2 caprin family member 2 -0.0189528
NAMPT nicotinamide phosphoribosyltransferase -0.018781
DNER delta/notch-like EGF repeat containing -0.0185529
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0184689
PRELID2 PRELI domain containing 2 -0.0184102
RBM25 RNA binding motif protein 25 -0.0182948
TM4SF1 transmembrane 4 L six family member 1 -0.0178802
PBX3 pre-B-cell leukemia homeobox 3 -0.0178481
MBD5 methyl-CpG binding domain protein 5 -0.0178344
TRA2A transformer 2 alpha homolog (Drosophila) -0.0177267
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0174307
TBC1D5 TBC1 domain family, member 5 -0.0174078
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0173403
NCOR1 nuclear receptor corepressor 1 -0.0169098
PRKCA protein kinase C, alpha -0.0167316
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0166729
PICALM phosphatidylinositol binding clathrin assembly protein -0.0165165
FAM13B family with sequence similarity 13, member B -0.0164524
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0164154
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0164132
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0161379
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0160817
STK24 serine/threonine kinase 24 -0.0160507
SMC4 structural maintenance of chromosomes 4 -0.0158328
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0156886
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0155481
R3HDM1 R3H domain containing 1 -0.0155305
ATG7 autophagy related 7 -0.0154752
NCOA1 nuclear receptor coactivator 1 -0.0154709
SEPTIN7 septin 7 -0.0154518
PHF21A PHD finger protein 21A -0.0152212
IFRD1 interferon-related developmental regulator 1 -0.0151096
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0150603
SMYD3 SET and MYND domain containing 3 -0.0150164
PRKCE protein kinase C, epsilon -0.0150033
TPX2 TPX2, microtubule-associated -0.0148567
BIRC6 baculoviral IAP repeat containing 6 -0.0148407
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0148299
CDCP1 CUB domain containing protein 1 -0.0146009
NBAS neuroblastoma amplified sequence -0.014578
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0145628
FMN1 formin 1 -0.0144838
HOOK2 hook microtubule-tethering protein 2 -0.0144637
QKI QKI, KH domain containing, RNA binding -0.0144171
PHIP pleckstrin homology domain interacting protein -0.0143844
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0143748
ARHGAP26 Rho GTPase activating protein 26 -0.0142571
CKAP5 cytoskeleton associated protein 5 -0.01416
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0140563
HELZ helicase with zinc finger -0.0139705
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0139433
VEZT vezatin, adherens junctions transmembrane protein -0.0137491
DTNA dystrobrevin, alpha -0.0136268
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0136108
ZNF207 zinc finger protein 207 -0.0133915
AKAP10 A kinase (PRKA) anchor protein 10 -0.0133914
NCEH1 neutral cholesterol ester hydrolase 1 -0.0133885
RSBN1 round spermatid basic protein 1 -0.0133797
SGO2 shugoshin 2 -0.0133471
MEF2A myocyte enhancer factor 2A -0.0133409
IL1RAP interleukin 1 receptor accessory protein -0.0133199
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0133137
HDAC9 histone deacetylase 9 -0.0131969
AKAP13 A kinase (PRKA) anchor protein 13 -0.0130565
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0129919
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0129879
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0129789
SAMD4A sterile alpha motif domain containing 4A -0.0129569
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0129161
FUS FUS RNA binding protein -0.0129047
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.012877
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0127447
MARCHF6 membrane associated ring-CH-type finger 6 -0.01274
ANO6 anoctamin 6 -0.0127352