BI-3406_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-3406 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-3406_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0703453
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0489073
SMAD3 SMAD family member 3 0.0378054
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0374672
TOP1 topoisomerase (DNA) I 0.0362876
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0342198
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.033402
RACK1 receptor for activated C kinase 1 0.0319095
SVIL supervillin 0.0299731
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0297499
EEF2 eukaryotic translation elongation factor 2 0.0281716
TMEM156 transmembrane protein 156 0.0268783
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0265182
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0261264
TPR translocated promoter region, nuclear basket protein 0.0258724
SEPTIN9 septin 9 0.0253246
NAMPT nicotinamide phosphoribosyltransferase 0.0252919
PCBP2 poly(rC) binding protein 2 0.0245795
FLNA filamin A, alpha 0.0237756
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0233893
CXCL8 chemokine (C-X-C motif) ligand 8 0.0231807
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0228608
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0228567
RPL23 ribosomal protein L23 0.0224117
SON SON DNA binding protein 0.0220744
EREG epiregulin 0.0220496
PRRC2C proline-rich coiled-coil 2C 0.0217885
RBM39 RNA binding motif protein 39 0.0215573
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0215289
LOC112694756 uncharaterized LOC112694756 0.0213668
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0204576
EMP1 epithelial membrane protein 1 0.0196548
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0195512
MCL1 myeloid cell leukemia 1 0.0192192
RNF145 ring finger protein 145 0.0189281
PELO pelota homolog (Drosophila) 0.0183588
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0180294
MATR3 matrin 3 0.0178928
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0178456
ZSWIM6 zinc finger, SWIM-type containing 6 0.0177834
AKAP12 A kinase (PRKA) anchor protein 12 0.0177698
MYH9 myosin, heavy chain 9, non-muscle 0.0173637
SMYD3 SET and MYND domain containing 3 0.0173205
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0169755
FHL2 four and a half LIM domains 2 0.0169713
APLP2 amyloid beta (A4) precursor-like protein 2 0.0169431
PLEC plectin 0.0168213
BICD1 bicaudal D homolog 1 (Drosophila) 0.0164032
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0163976
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0161908
AHR aryl hydrocarbon receptor 0.0161084
SHB Src homology 2 domain containing adaptor protein B 0.0160399
RO60 Ro60, Y RNA binding protein 0.0158564
TPM3 tropomyosin 3 0.0158471
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0157295
MYO10 myosin X 0.0156635
NFE2L1 nuclear factor, erythroid 2-like 1 0.015496
NPAS2 neuronal PAS domain protein 2 0.0153172
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0153083
CD44 CD44 molecule (Indian blood group) 0.0152403
SPRED2 sprouty-related, EVH1 domain containing 2 0.0152017
FXR1 fragile X mental retardation, autosomal homolog 1 0.0151532
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0151281
RPS19 ribosomal protein S19 0.015042
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0149783
SOX9 SRY (sex determining region Y)-box 9 0.0149488
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0149259
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0147941
HSPA8 heat shock 70kDa protein 8 0.0147015
RPL3 ribosomal protein L3 0.0146935
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0146931
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0146104
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0145697
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0145325
SDC2 syndecan 2 0.0144336
YBX1 Y box binding protein 1 0.0143017
MARCHF6 membrane associated ring-CH-type finger 6 0.0142904
MLPH melanophilin 0.0142808
MACF1 microtubule-actin crosslinking factor 1 0.0141459
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0140956
RICTOR RPTOR independent companion of MTOR, complex 2 0.0139062
ADAR adenosine deaminase, RNA-specific 0.013882
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0138605
BASP1 brain abundant, membrane attached signal protein 1 0.0137265
NRP1 neuropilin 1 0.0136471
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0135321
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0134035
PUM2 pumilio RNA-binding family member 2 0.0133844
RPL7 ribosomal protein L7 0.0133553
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0132463
WASL Wiskott-Aldrich syndrome-like 0.0132242
SLTM SAFB-like, transcription modulator 0.0131883
PDLIM5 PDZ and LIM domain 5 0.0131744
AHNAK AHNAK nucleoprotein 0.0131725
NXN nucleoredoxin 0.013143
CSDE1 cold shock domain containing E1, RNA-binding 0.01295
CUL3 cullin 3 0.0129448
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0127955
RPL11 ribosomal protein L11 0.0127693
PCM1 pericentriolar material 1 0.0127452

decreased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.122903
FN1 fibronectin 1 -0.11259
TRIO trio Rho guanine nucleotide exchange factor -0.0902558
NRG1 neuregulin 1 -0.0741466
MRPS6 mitochondrial ribosomal protein S6 -0.0676925
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0665615
P4HB prolyl 4-hydroxylase, beta polypeptide -0.064114
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0619836
SQSTM1 sequestosome 1 -0.0591155
NDRG1 N-myc downstream regulated 1 -0.0471149
TMEM165 transmembrane protein 165 -0.0448688
CANX calnexin -0.0445485
PLIN2 perilipin 2 -0.0436351
CADM1 cell adhesion molecule 1 -0.0422093
S100A6 S100 calcium binding protein A6 -0.041272
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0393279
GPC6 glypican 6 -0.0380792
FNDC3B fibronectin type III domain containing 3B -0.0376345
TNS3 tensin 3 -0.0372036
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.03642
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0363773
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0362828
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0356048
CD109 CD109 molecule -0.0351246
GLIS3 GLIS family zinc finger 3 -0.0347928
DST dystonin -0.033311
ANKRD28 ankyrin repeat domain 28 -0.0331804
LIMCH1 LIM and calponin homology domains 1 -0.0317015
ACTG1 actin gamma 1 -0.0305266
PALLD palladin, cytoskeletal associated protein -0.0297443
RAI14 retinoic acid induced 14 -0.028984
TMSB10 thymosin beta 10 -0.0288801
TMSB4X thymosin beta 4, X-linked -0.0273605
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.027298
SAMD4A sterile alpha motif domain containing 4A -0.0272445
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0263862
STC2 stanniocalcin 2 -0.0258357
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0249344
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0246291
ENO2 enolase 2 (gamma, neuronal) -0.0239881
IFI27 interferon, alpha-inducible protein 27 -0.0234538
TAS2R14 taste receptor, type 2, member 14 -0.0234062
VIM vimentin -0.0233846
SOD2 superoxide dismutase 2, mitochondrial -0.0229669
GNAS GNAS complex locus -0.0225949
INTS6 integrator complex subunit 6 -0.0224999
SLC38A2 solute carrier family 38, member 2 -0.021013
RUNX2 runt-related transcription factor 2 -0.020904
FTH1 ferritin, heavy polypeptide 1 -0.0205791
FRY furry homolog (Drosophila) -0.0200223
MAP1B microtubule-associated protein 1B -0.0199535
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0197291
DLG1 discs, large homolog 1 (Drosophila) -0.0190418
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0190319
IGFBP3 insulin-like growth factor binding protein 3 -0.0186679
PCBP3 poly(rC) binding protein 3 -0.018629
TENT5A terminal nucleotidyltransferase 5A -0.0184827
AOPEP aminopeptidase O (putative) -0.018141
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0180487
RTN4 reticulon 4 -0.0179143
MAP4 microtubule-associated protein 4 -0.0178663
SYT1 synaptotagmin I -0.0175985
MAML2 mastermind-like 2 (Drosophila) -0.0174689
PTMA prothymosin, alpha -0.0173716
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0173462
RANBP17 RAN binding protein 17 -0.0171185
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0171162
PTGR1 prostaglandin reductase 1 -0.0170518
CFB complement factor B -0.0170167
PTPRD protein tyrosine phosphatase, receptor type, D -0.0166874
LRRC23 leucine rich repeat containing 23 -0.0166362
TBC1D22A TBC1 domain family, member 22A -0.0165533
HLA-B major histocompatibility complex, class I, B -0.0165367
THBS1 thrombospondin 1 -0.0164562
ARHGAP24 Rho GTPase activating protein 24 -0.0164393
FBN1 fibrillin 1 -0.0162973
ZBTB20 zinc finger and BTB domain containing 20 -0.0160257
AEBP2 AE binding protein 2 -0.0156767
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0155927
MYO1E myosin IE -0.0154973
GLUL glutamate-ammonia ligase -0.0154679
ETV6 ets variant 6 -0.0153684
ITGA1 integrin, alpha 1 -0.0152541
PDIA3 protein disulfide isomerase family A, member 3 -0.0151553
RPL35A ribosomal protein L35a -0.0150423
MBNL2 muscleblind-like splicing regulator 2 -0.0149958
DNAH5 dynein, axonemal, heavy chain 5 -0.0149863
SSBP2 single-stranded DNA binding protein 2 -0.0149267
PRKCA protein kinase C, alpha -0.0149255
MYOF myoferlin -0.0147011
HILPDA hypoxia inducible lipid droplet-associated -0.0144816
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0144637
SEC31A SEC31 homolog A (S. cerevisiae) -0.0144444
MICU1 mitochondrial calcium uptake 1 -0.0144422
NOVA1 neuro-oncological ventral antigen 1 -0.0143313
TGFA transforming growth factor, alpha -0.0142581
SOS1 son of sevenless homolog 1 (Drosophila) -0.0142416
MUSK muscle, skeletal, receptor tyrosine kinase -0.0141029
S100A9 S100 calcium binding protein A9 -0.0140113
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0139183