| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BI-78D3 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the BI-78D3_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.171155 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0856904 |
| NLGN1 | neuroligin 1 | 0.0826203 |
| HMGA2 | high mobility group AT-hook 2 | 0.078876 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0782578 |
| EHBP1 | EH domain binding protein 1 | 0.0748451 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0648022 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.06253 |
| PCDH7 | protocadherin 7 | 0.0607135 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0570838 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0549476 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0531526 |
| EGR1 | early growth response 1 | 0.0444243 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0440721 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0392743 |
| NHSL1 | NHS-like 1 | 0.0392077 |
| MMP12 | matrix metallopeptidase 12 | 0.0385924 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0373553 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.037344 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0370488 |
| YAP1 | Yes-associated protein 1 | 0.0370107 |
| RASAL2 | RAS protein activator like 2 | 0.0355018 |
| ADIPOR2 | adiponectin receptor 2 | 0.0345706 |
| JMJD1C | jumonji domain containing 1C | 0.03219 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0313712 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0309276 |
| ASPH | aspartate beta-hydroxylase | 0.0307782 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0305679 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0303174 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0299596 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0288079 |
| USP34 | ubiquitin specific peptidase 34 | 0.0284001 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0277513 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0276189 |
| EPHA5 | EPH receptor A5 | 0.0276028 |
| SIK3 | SIK family kinase 3 | 0.0273634 |
| NECTIN3 | nectin cell adhesion molecule 3 | 0.027299 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0265539 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0263733 |
| INTS6 | integrator complex subunit 6 | 0.0263396 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0261165 |
| NEBL | nebulette | 0.0260099 |
| VMP1 | vacuole membrane protein 1 | 0.0258964 |
| EGFR | epidermal growth factor receptor | 0.0251155 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0249759 |
| PCDH9 | protocadherin 9 | 0.024847 |
| TENM3 | teneurin transmembrane protein 3 | 0.0245806 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0243794 |
| RAB10 | RAB10, member RAS oncogene family | 0.0242468 |
| NABP1 | nucleic acid binding protein 1 | 0.0240868 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0240686 |
| SETX | senataxin | 0.0238454 |
| ZNF407 | zinc finger protein 407 | 0.0237005 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0236218 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0234634 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0234575 |
| CMIP | c-Maf inducing protein | 0.0230101 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0227977 |
| DST | dystonin | 0.0224452 |
| HDAC9 | histone deacetylase 9 | 0.022218 |
| NEGR1 | neuronal growth regulator 1 | 0.0214621 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0214503 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0212933 |
| SON | SON DNA binding protein | 0.0211504 |
| PRKCE | protein kinase C, epsilon | 0.0211346 |
| RACK1 | receptor for activated C kinase 1 | 0.0211196 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0209566 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0209158 |
| IPO7 | importin 7 | 0.0206479 |
| ZNF804A | zinc finger protein 804A | 0.0206076 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0205037 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | 0.0202207 |
| DTNA | dystrobrevin, alpha | 0.0202165 |
| PDGFC | platelet derived growth factor C | 0.0201865 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.020143 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | 0.0199579 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0199557 |
| FNIP1 | folliculin interacting protein 1 | 0.0199214 |
| RPLP0 | ribosomal protein, large, P0 | 0.0198866 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0198808 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.019847 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0195161 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0194588 |
| TTC27 | tetratricopeptide repeat domain 27 | 0.0194551 |
| UTRN | utrophin | 0.0193021 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0190716 |
| SLC38A1 | solute carrier family 38, member 1 | 0.019036 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0189748 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0189275 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0188592 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.018828 |
| TPI1 | triosephosphate isomerase 1 | 0.0186985 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0186004 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0184784 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0181719 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.017548 |
| CLTC | clathrin, heavy chain (Hc) | 0.0173618 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0172673 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0171483 |
| CREM | cAMP responsive element modulator | 0.0170335 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | -0.179544 |
| RPS27A | ribosomal protein S27a | -0.0617972 |
| VIM | vimentin | -0.0585522 |
| PTMA | prothymosin, alpha | -0.0510892 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0482169 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0476997 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.044551 |
| UBC | ubiquitin C | -0.0429826 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0418381 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0415773 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0398652 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0390009 |
| AHNAK | AHNAK nucleoprotein | -0.036911 |
| OGA | O-GlcNAcase | -0.0364266 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0326927 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0323947 |
| RRM2 | ribonucleotide reductase M2 | -0.0314691 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0313264 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.02898 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0285308 |
| H1-0 | H1.0 linker histone | -0.0280366 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0279467 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0270812 |
| ZNF217 | zinc finger protein 217 | -0.0265101 |
| YBX1 | Y box binding protein 1 | -0.0263616 |
| YBX3 | Y box binding protein 3 | -0.0262251 |
| TPR | translocated promoter region, nuclear basket protein | -0.0258054 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0257314 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0256559 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.025502 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0254173 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0249678 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0241163 |
| RPL38 | ribosomal protein L38 | -0.0240722 |
| MKI67 | marker of proliferation Ki-67 | -0.0239297 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0236961 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0236376 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0236302 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0234831 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0229313 |
| CPOX | coproporphyrinogen oxidase | -0.0228144 |
| HMGB1 | high mobility group box 1 | -0.0227496 |
| PRR11 | proline rich 11 | -0.0226991 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0211347 |
| OXR1 | oxidation resistance 1 | -0.0210881 |
| CENPF | centromere protein F, 350/400kDa | -0.0210363 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0206174 |
| RBM25 | RNA binding motif protein 25 | -0.0203976 |
| MED13L | mediator complex subunit 13-like | -0.0199947 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0198946 |
| HMGB2 | high mobility group box 2 | -0.0196936 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0196701 |
| FTL | ferritin, light polypeptide | -0.0194291 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0194068 |
| XPO1 | exportin 1 | -0.0192864 |
| CLPTM1L | CLPTM1-like | -0.0191841 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0191645 |
| CENPE | centromere protein E, 312kDa | -0.0191537 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0189886 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0189557 |
| QKI | QKI, KH domain containing, RNA binding | -0.0189103 |
| NEK7 | NIMA-related kinase 7 | -0.0188815 |
| CAVIN1 | caveolae associated protein 1 | -0.0188109 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0186537 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0184544 |
| DEK | DEK proto-oncogene | -0.0184444 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0179123 |
| RPS24 | ribosomal protein S24 | -0.0178179 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0173866 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0172104 |
| CDCA2 | cell division cycle associated 2 | -0.0170333 |
| KIF4A | kinesin family member 4A | -0.0169803 |
| TPX2 | TPX2, microtubule-associated | -0.016728 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0165464 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0165444 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0163724 |
| RPL19 | ribosomal protein L19 | -0.0163156 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0162035 |
| FUS | FUS RNA binding protein | -0.0161755 |
| VCL | vinculin | -0.0160777 |
| NEMF | nuclear export mediator factor | -0.0160084 |
| ECT2 | epithelial cell transforming 2 | -0.0160017 |
| GMPS | guanine monphosphate synthase | -0.0159632 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -0.0156842 |
| IL6ST | interleukin 6 signal transducer | -0.0156625 |
| KIF5B | kinesin family member 5B | -0.0155583 |
| ANKRD36 | ankyrin repeat domain 36 | -0.0153982 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0153224 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -0.0153193 |
| SRSF7 | serine/arginine-rich splicing factor 7 | -0.0152516 |
| CDC27 | cell division cycle 27 | -0.0152202 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0151719 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0151502 |
| STAG2 | stromal antigen 2 | -0.0150846 |
| MARS1 | methionyl-tRNA synthetase 1 | -0.0150825 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0150479 |
| TUBB6 | tubulin, beta 6 class V | -0.0149549 |
| SET | SET nuclear proto-oncogene | -0.0149075 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0145448 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | -0.0144237 |
