BI-78D3_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-78D3 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-78D3_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.127675
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0749643
GMDS GDP-mannose 4,6-dehydratase 0.0712149
ARHGAP26 Rho GTPase activating protein 26 0.0601413
SMAD3 SMAD family member 3 0.0576979
INTS6 integrator complex subunit 6 0.053097
BTBD9 BTB (POZ) domain containing 9 0.0498245
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0487818
PRKCA protein kinase C, alpha 0.0453576
EXT1 exostosin glycosyltransferase 1 0.0435151
LPP LIM domain containing preferred translocation partner in lipoma 0.0431596
AKAP13 A kinase (PRKA) anchor protein 13 0.0426567
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0394471
ZSWIM6 zinc finger, SWIM-type containing 6 0.0380679
EPSTI1 epithelial stromal interaction 1 (breast) 0.037329
FNDC3B fibronectin type III domain containing 3B 0.0372449
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0359704
ANXA2 annexin A2 0.035453
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0324508
CATSPERB catsper channel auxiliary subunit beta 0.0320097
MYO1E myosin IE 0.0319082
VMP1 vacuole membrane protein 1 0.0311896
MBNL2 muscleblind-like splicing regulator 2 0.0298467
ANKRD10 ankyrin repeat domain 10 0.029691
MACC1 metastasis associated in colon cancer 1 0.0290801
ERBIN erbb2 interacting protein 0.0286982
MSI2 musashi RNA-binding protein 2 0.0286874
ASPH aspartate beta-hydroxylase 0.0283877
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0276344
RUNX1 runt-related transcription factor 1 0.0275397
ZBTB20 zinc finger and BTB domain containing 20 0.0272016
RAD51B RAD51 paralog B 0.0270629
RABGAP1L RAB GTPase activating protein 1-like 0.0270438
ITGA6 integrin, alpha 6 0.0268031
TSHZ2 teashirt zinc finger homeobox 2 0.026745
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0265346
MCU mitochondrial calcium uniporter 0.0258604
GCLC glutamate-cysteine ligase, catalytic subunit 0.0258514
ATXN1 ataxin 1 0.025725
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0255904
VCL vinculin 0.0243408
STS steroid sulfatase (microsomal), isozyme S 0.0237269
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0229295
TM4SF19 transmembrane 4 L six family member 19 0.0214911
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0211369
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0210845
ATP11A ATPase, class VI, type 11A 0.0204426
FNIP2 folliculin interacting protein 2 0.0200343
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0198941
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0196273
SERINC5 serine incorporator 5 0.019621
PLSCR1 phospholipid scramblase 1 0.0195133
MAP7 microtubule-associated protein 7 0.0193353
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0193281
ETV6 ets variant 6 0.0191622
DST dystonin 0.0190063
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0189188
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0185324
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.018297
EFNB2 ephrin-B2 0.018026
CEMIP cell migration inducing protein, hyaluronan binding 0.017967
STAT1 signal transducer and activator of transcription 1, 91kDa 0.01786
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0175803
NF1 neurofibromin 1 0.0175399
SORBS1 sorbin and SH3 domain containing 1 0.0174044
MED13 mediator complex subunit 13 0.0168768
CEMIP2 cell migration inducing hyaluronidase 2 0.0168541
SPATA13 spermatogenesis associated 13 0.0168285
SEPTIN9 septin 9 0.0166927
MACF1 microtubule-actin crosslinking factor 1 0.0165842
SP100 SP100 nuclear antigen 0.0164213
SPAG9 sperm associated antigen 9 0.0160749
TRIM2 tripartite motif containing 2 0.0160377
SSH2 slingshot protein phosphatase 2 0.0160248
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0158621
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0157957
EREG epiregulin 0.0156161
ATP10B ATPase, class V, type 10B 0.0155207
PARD3 par-3 family cell polarity regulator 0.015518
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0154329
RBM47 RNA binding motif protein 47 0.0153572
AREG amphiregulin 0.0153426
RSAD2 radical S-adenosyl methionine domain containing 2 0.015242
PLSCR2 phospholipid scramblase 2 0.0151435
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0150556
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0148589
FNIP1 folliculin interacting protein 1 0.0148523
TRIO trio Rho guanine nucleotide exchange factor 0.0148179
HKDC1 hexokinase domain containing 1 0.0145473
UTRN utrophin 0.0144338
YAP1 Yes-associated protein 1 0.0143721
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0142768
DSPP dentin sialophosphoprotein 0.0142662
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0142273
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0141538
MEIS2 Meis homeobox 2 0.0138469
EZR ezrin 0.0138219
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0137597
KYNU kynureninase 0.0137172
EHBP1 EH domain binding protein 1 0.013607

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.109299
B2M beta-2-microglobulin -0.0734942
LCN2 lipocalin 2 -0.057154
FTL ferritin, light polypeptide -0.0460003
HLA-B major histocompatibility complex, class I, B -0.0427476
PTMA prothymosin, alpha -0.0402085
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0391153
RPL35A ribosomal protein L35a -0.0337268
LOC102724023 ES1 protein homolog, mitochondrial -0.0315602
IFI6 interferon, alpha-inducible protein 6 -0.030895
RPS6 ribosomal protein S6 -0.0299461
NDRG1 N-myc downstream regulated 1 -0.0274468
TMSB10 thymosin beta 10 -0.0269734
EIF1 eukaryotic translation initiation factor 1 -0.0239531
RPL34 ribosomal protein L34 -0.0230038
RPL23 ribosomal protein L23 -0.0220374
RPLP1 ribosomal protein, large, P1 -0.0213282
IFI27 interferon, alpha-inducible protein 27 -0.0204075
TXNIP thioredoxin interacting protein -0.0197699
RPL19 ribosomal protein L19 -0.0197471
RPL12 ribosomal protein L12 -0.0194742
MT2A metallothionein 2A -0.0192845
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0188508
UBC ubiquitin C -0.0174084
RPL37A ribosomal protein L37a -0.016914
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0167152
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0166321
RPS8 ribosomal protein S8 -0.0165307
GNAS GNAS complex locus -0.0162576
IFITM3 interferon induced transmembrane protein 3 -0.0161462
RPS19 ribosomal protein S19 -0.0159188
RPL26 ribosomal protein L26 -0.0155435
GCC2 GRIP and coiled-coil domain containing 2 -0.0153028
RPS3 ribosomal protein S3 -0.0152718
HLA-C major histocompatibility complex, class I, C -0.0150891
ZMYND8 zinc finger, MYND-type containing 8 -0.0148619
EGR1 early growth response 1 -0.0148563
MPHOSPH8 M-phase phosphoprotein 8 -0.0147379
RPLP0 ribosomal protein, large, P0 -0.0145989
RPL31 ribosomal protein L31 -0.0145464
PRRC2C proline-rich coiled-coil 2C -0.0139013
RPL9 ribosomal protein L9 -0.013737
CSTB cystatin B (stefin B) -0.0134691
LOC112694756 uncharaterized LOC112694756 -0.0132234
RPS4X ribosomal protein S4, X-linked -0.0130935
RPS25 ribosomal protein S25 -0.0130705
ACBD3 acyl-CoA binding domain containing 3 -0.0130529
PTPRF protein tyrosine phosphatase, receptor type, F -0.0127199
RPS12 ribosomal protein S12 -0.0126452
RRBP1 ribosome binding protein 1 -0.0126292
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.012476
RPL11 ribosomal protein L11 -0.0120374
VDAC1 voltage-dependent anion channel 1 -0.012032
TPI1 triosephosphate isomerase 1 -0.0119739
HLA-A major histocompatibility complex, class I, A -0.0119077
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0117284
RPLP2 ribosomal protein, large, P2 -0.0116842
RPL30 ribosomal protein L30 -0.0114489
S100A9 S100 calcium binding protein A9 -0.0114213
RPL37 ribosomal protein L37 -0.0113978
RPL18 ribosomal protein L18 -0.0113825
RPL28 ribosomal protein L28 -0.0113716
RPS23 ribosomal protein S23 -0.0112345
RPS11 ribosomal protein S11 -0.0111687
RPL7A ribosomal protein L7a -0.0111495
ACTG1 actin gamma 1 -0.0111468
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0111107
RPL32 ribosomal protein L32 -0.0109567
MUC20 mucin 20, cell surface associated -0.0108666
UBE2B ubiquitin-conjugating enzyme E2B -0.0107901
RACK1 receptor for activated C kinase 1 -0.0106863
SLC38A1 solute carrier family 38, member 1 -0.0105851
ISG15 ISG15 ubiquitin-like modifier -0.0105687
RNF149 ring finger protein 149 -0.010429
HMGB1 high mobility group box 1 -0.010405
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0103884
ATF4 activating transcription factor 4 -0.0103579
MT1X metallothionein 1X -0.010243
SRRM2 serine/arginine repetitive matrix 2 -0.00998137
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00988089
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00977911
S100A6 S100 calcium binding protein A6 -0.00974676
RPL36 ribosomal protein L36 -0.00971491
SON SON DNA binding protein -0.00962486
NPEPPS aminopeptidase puromycin sensitive -0.00961659
POMP proteasome maturation protein -0.00959311
ZC3H13 zinc finger CCCH-type containing 13 -0.00957391
RPS29 ribosomal protein S29 -0.00953726
RPL21 ribosomal protein L21 -0.00951576
ATP5F1E ATP synthase F1 subunit epsilon -0.00944628
LMNA lamin A/C -0.00942043
RPS27 ribosomal protein S27 -0.00939886
RPL8 ribosomal protein L8 -0.00939261
KDM3A lysine (K)-specific demethylase 3A -0.00936738
RPL35 ribosomal protein L35 -0.00935976
RHOBTB3 Rho-related BTB domain containing 3 -0.00927431
RPL36AL ribosomal protein L36a-like -0.00925098
NACA nascent polypeptide-associated complex alpha subunit -0.00921569
EPCAM epithelial cell adhesion molecule -0.00921226
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.00915839