| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BI-78D3 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the BI-78D3_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.36118 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.241284 |
| EHBP1 | EH domain binding protein 1 | 0.0877676 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0722734 |
| ASPH | aspartate beta-hydroxylase | 0.066843 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0651088 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0644094 |
| VCL | vinculin | 0.0615429 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0568048 |
| SVIL | supervillin | 0.0557308 |
| DSPP | dentin sialophosphoprotein | 0.0555069 |
| GPC6 | glypican 6 | 0.0534026 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0515434 |
| FOXP1 | forkhead box P1 | 0.0483997 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0474676 |
| FAM107B | family with sequence similarity 107, member B | 0.0471555 |
| JMJD1C | jumonji domain containing 1C | 0.0445398 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0444855 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0438536 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0430494 |
| FRMD5 | FERM domain containing 5 | 0.0429535 |
| FN1 | fibronectin 1 | 0.0408075 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0407165 |
| ATXN1 | ataxin 1 | 0.038897 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0383908 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0379603 |
| DST | dystonin | 0.037324 |
| TMSB10 | thymosin beta 10 | 0.0368546 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0360748 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0358967 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0347062 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0345541 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0344403 |
| RASA2 | RAS p21 protein activator 2 | 0.033572 |
| KRT8 | keratin 8, type II | 0.033466 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0321327 |
| RAI14 | retinoic acid induced 14 | 0.031963 |
| MYO1E | myosin IE | 0.031953 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0313488 |
| FAT1 | FAT atypical cadherin 1 | 0.0310144 |
| CRY1 | cryptochrome circadian clock 1 | 0.0309722 |
| ITGAV | integrin, alpha V | 0.0286671 |
| RUNX1 | runt-related transcription factor 1 | 0.0284024 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0281482 |
| ENO1 | enolase 1, (alpha) | 0.0277899 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0275085 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0272613 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0267563 |
| CNKSR3 | CNKSR family member 3 | 0.0264745 |
| FLNB | filamin B, beta | 0.0264289 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0263838 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.025837 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0258364 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0255464 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0244893 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0244834 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0243087 |
| DSTN | destrin (actin depolymerizing factor) | 0.024083 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0229851 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0222102 |
| FHL2 | four and a half LIM domains 2 | 0.0221108 |
| CADM1 | cell adhesion molecule 1 | 0.0219963 |
| RPS17 | ribosomal protein S17 | 0.0215554 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0214873 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0212473 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0212302 |
| TCIM | transcriptional and immune response regulator | 0.0210548 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0207845 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0206201 |
| TXNRD1 | thioredoxin reductase 1 | 0.020372 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.020119 |
| LMO7 | LIM domain 7 | 0.0197937 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0197888 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0195789 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.019285 |
| GLIS3 | GLIS family zinc finger 3 | 0.0192211 |
| PALLD | palladin, cytoskeletal associated protein | 0.0190556 |
| TNS1 | tensin 1 | 0.0189264 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0189201 |
| STK17A | serine/threonine kinase 17a | 0.0188785 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0187851 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0187097 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0187049 |
| PLXDC2 | plexin domain containing 2 | 0.01856 |
| LDHA | lactate dehydrogenase A | 0.0182606 |
| TPM4 | tropomyosin 4 | 0.0179269 |
| SMAD3 | SMAD family member 3 | 0.0178246 |
| SMYD3 | SET and MYND domain containing 3 | 0.0177044 |
| SP100 | SP100 nuclear antigen | 0.0176779 |
| ENKUR | enkurin, TRPC channel interacting protein | 0.0175515 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0175264 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.017426 |
| ITGA1 | integrin, alpha 1 | 0.0174076 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0172918 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0171858 |
| TLE4 | transducin-like enhancer of split 4 | 0.0171291 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0170527 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0168742 |
| FERMT1 | fermitin family member 1 | 0.0167493 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.016683 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.413186 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.19889 |
| APOB | apolipoprotein B | -0.144934 |
| C3 | complement component 3 | -0.104527 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.102452 |
| MT2A | metallothionein 2A | -0.0696254 |
| FTL | ferritin, light polypeptide | -0.0570261 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0547017 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0523072 |
| APOA2 | apolipoprotein A-II | -0.0470326 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0459238 |
| GPC3 | glypican 3 | -0.0450998 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0420903 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0386168 |
| A2M | alpha-2-macroglobulin | -0.034764 |
| SDC4 | syndecan 4 | -0.0343727 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.031756 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0307489 |
| GOLGA4 | golgin A4 | -0.0302489 |
| CPE | carboxypeptidase E | -0.0293341 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0279665 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.027908 |
| RBM25 | RNA binding motif protein 25 | -0.0273415 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0263956 |
| INSIG2 | insulin induced gene 2 | -0.0263346 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0246637 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0241292 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0240707 |
| PDE8A | phosphodiesterase 8A | -0.0239607 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0235788 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0234896 |
| WDR45B | WD repeat domain 45B | -0.0234654 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0228797 |
| NDRG1 | N-myc downstream regulated 1 | -0.0223513 |
| MT1X | metallothionein 1X | -0.0222741 |
| RPLP0 | ribosomal protein, large, P0 | -0.0214981 |
| RPL35A | ribosomal protein L35a | -0.0213693 |
| HELZ | helicase with zinc finger | -0.0212407 |
| FAM162A | family with sequence similarity 162, member A | -0.0211644 |
| CFB | complement factor B | -0.0205599 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0203167 |
| ANGPTL8 | angiopoietin like 8 | -0.0199158 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0194874 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0194037 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0190632 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0189156 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0187058 |
| ZNF292 | zinc finger protein 292 | -0.0187024 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0185949 |
| APOE | apolipoprotein E | -0.0184933 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0184089 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | -0.0182652 |
| APOA1 | apolipoprotein A-I | -0.0180784 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0180326 |
| FGG | fibrinogen gamma chain | -0.017885 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0178826 |
| LRRC1 | leucine rich repeat containing 1 | -0.0178051 |
| OGA | O-GlcNAcase | -0.0177246 |
| PHIP | pleckstrin homology domain interacting protein | -0.0176749 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0176226 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0175154 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0173556 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0172449 |
| GNAS | GNAS complex locus | -0.0172339 |
| MED13L | mediator complex subunit 13-like | -0.017149 |
| CALR | calreticulin | -0.017125 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0170918 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0170904 |
| CCNL1 | cyclin L1 | -0.0167636 |
| GLG1 | golgi glycoprotein 1 | -0.0167275 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0164793 |
| FOXN3 | forkhead box N3 | -0.0164177 |
| RPLP2 | ribosomal protein, large, P2 | -0.0163405 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0161884 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.0161657 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | -0.0161308 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0160522 |
| HLF | hepatic leukemia factor | -0.0159952 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0159825 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.015967 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0159514 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0159508 |
| MYO1B | myosin IB | -0.0158376 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0158102 |
| H3-3B | H3.3 histone B | -0.0157009 |
| RPS5 | ribosomal protein S5 | -0.0154788 |
| NUP58 | nucleoporin 58 | -0.0153596 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0152484 |
| RPL27A | ribosomal protein L27a | -0.015195 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0149646 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0147616 |
| RDX | radixin | -0.014758 |
| BPIFB2 | BPI fold containing family B, member 2 | -0.0147217 |
| RPL32 | ribosomal protein L32 | -0.0147198 |
| GDF15 | growth differentiation factor 15 | -0.0147047 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0146861 |
| ADM | adrenomedullin | -0.0145428 |
| BRD4 | bromodomain containing 4 | -0.014464 |
| YY1 | YY1 transcription factor | -0.0144376 |
| YAP1 | Yes-associated protein 1 | -0.0144222 |
