BI-78D3_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-78D3 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-78D3_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.164778
PDE4D phosphodiesterase 4D, cAMP-specific 0.116688
CD44 CD44 molecule (Indian blood group) 0.116228
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.100554
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0959651
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0923964
SLC35F3 solute carrier family 35, member F3 0.0900924
PDLIM5 PDZ and LIM domain 5 0.0889218
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0880999
EXT1 exostosin glycosyltransferase 1 0.0710199
ZSWIM6 zinc finger, SWIM-type containing 6 0.0709056
JMJD1C jumonji domain containing 1C 0.0700449
EFNA5 ephrin-A5 0.0697966
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0681618
MSN moesin 0.0677534
RASAL2 RAS protein activator like 2 0.0667896
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0643432
CDK6 cyclin-dependent kinase 6 0.0592435
MTSS1 metastasis suppressor 1 0.0590465
DPYD dihydropyrimidine dehydrogenase 0.0589775
HMGA2 high mobility group AT-hook 2 0.0586333
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0579384
DOK5 docking protein 5 0.0578743
MT2A metallothionein 2A 0.0573411
MBNL1 muscleblind-like splicing regulator 1 0.0572274
RAI14 retinoic acid induced 14 0.0561606
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0547291
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0541621
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0538859
B2M beta-2-microglobulin 0.0532589
LAMC2 laminin, gamma 2 0.0532006
EXOC4 exocyst complex component 4 0.0504665
RAD51B RAD51 paralog B 0.049737
MBNL2 muscleblind-like splicing regulator 2 0.0496028
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0491087
ALCAM activated leukocyte cell adhesion molecule 0.0490186
EGFR epidermal growth factor receptor 0.0488881
FOXO1 forkhead box O1 0.0481981
RNF217 ring finger protein 217 0.0461983
SIK3 SIK family kinase 3 0.0460124
MACF1 microtubule-actin crosslinking factor 1 0.0452674
PSD3 pleckstrin and Sec7 domain containing 3 0.0448112
DOCK5 dedicator of cytokinesis 5 0.0445352
HDAC9 histone deacetylase 9 0.0443522
OSMR oncostatin M receptor 0.044091
ESYT2 extended synaptotagmin-like protein 2 0.0437219
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0436563
SVIL supervillin 0.0435583
APLP2 amyloid beta (A4) precursor-like protein 2 0.0431299
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0419274
ANO1 anoctamin 1, calcium activated chloride channel 0.0414054
SETX senataxin 0.0413225
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0411691
GRB10 growth factor receptor-bound protein 10 0.0401463
MCL1 myeloid cell leukemia 1 0.0399236
TXNRD1 thioredoxin reductase 1 0.0398876
FAM107B family with sequence similarity 107, member B 0.0397612
NAV2 neuron navigator 2 0.0396557
FTH1 ferritin, heavy polypeptide 1 0.0396491
TJP1 tight junction protein 1 0.0396224
MECOM MDS1 and EVI1 complex locus 0.0396134
SLC38A2 solute carrier family 38, member 2 0.0392302
DIAPH1 diaphanous-related formin 1 0.0388426
ATXN1 ataxin 1 0.0388361
RIGI RNA sensor RIG-I 0.0385664
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0376221
ARHGAP21 Rho GTPase activating protein 21 0.0374643
TXNIP thioredoxin interacting protein 0.0374427
DST dystonin 0.0371254
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0369114
UTRN utrophin 0.035461
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0353038
PLS3 plastin 3 0.0352346
HLA-E major histocompatibility complex, class I, E 0.0351798
CYSTM1 cysteine-rich transmembrane module containing 1 0.0346392
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0337702
NRIP1 nuclear receptor interacting protein 1 0.0334359
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0334299
AMOTL1 angiomotin like 1 0.0333234
ANKRD28 ankyrin repeat domain 28 0.0331554
PICALM phosphatidylinositol binding clathrin assembly protein 0.0327484
SGMS2 sphingomyelin synthase 2 0.0325376
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0324504
ZC3H12C zinc finger CCCH-type containing 12C 0.0321475
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0317272
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0317177
TNS3 tensin 3 0.0314584
WARS1 tryptophanyl-tRNA synthetase 1 0.0314546
TPM3 tropomyosin 3 0.0312034
KLF5 Kruppel-like factor 5 (intestinal) 0.0305363
CUX1 cut-like homeobox 1 0.0297765
MYADM myeloid-associated differentiation marker 0.0297404
PCDH1 protocadherin 1 0.0296037
CNTNAP3 contactin associated protein-like 3 0.029448
RPL37A ribosomal protein L37a 0.0294176
THSD4 thrombospondin, type I, domain containing 4 0.0290909
PCBP2 poly(rC) binding protein 2 0.0290358
RIN2 Ras and Rab interactor 2 0.0288314
EGR1 early growth response 1 0.0287742
MYO1E myosin IE 0.0286734

decreased expression

Symbol Name Standardized Value
MEF2A myocyte enhancer factor 2A -0.116711
H1-0 H1.0 linker histone -0.101994
TPT1 tumor protein, translationally-controlled 1 -0.089038
PTMA prothymosin, alpha -0.0881185
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0793933
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0704622
KRT17 keratin 17, type I -0.0701228
OGA O-GlcNAcase -0.0673404
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0669196
STC1 stanniocalcin 1 -0.0659309
AHNAK AHNAK nucleoprotein -0.0659125
KDM3A lysine (K)-specific demethylase 3A -0.0635808
NAMPT nicotinamide phosphoribosyltransferase -0.0631209
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0621194
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0610668
ANLN anillin, actin binding protein -0.0599349
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0597764
NDRG1 N-myc downstream regulated 1 -0.0541959
GOLGA4 golgin A4 -0.0537897
NPEPPS aminopeptidase puromycin sensitive -0.0475719
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0472049
CUL4B cullin 4B -0.0453242
EMP1 epithelial membrane protein 1 -0.0452978
PGK1 phosphoglycerate kinase 1 -0.0446186
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0443082
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0435351
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0425044
WSB1 WD repeat and SOCS box containing 1 -0.0424594
RBM39 RNA binding motif protein 39 -0.0419277
KDM5B lysine (K)-specific demethylase 5B -0.0418332
RAB6A RAB6A, member RAS oncogene family -0.0408543
MT1X metallothionein 1X -0.0408416
CLU clusterin -0.0400825
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0399391
MORF4L2 mortality factor 4 like 2 -0.0376167
VDAC1 voltage-dependent anion channel 1 -0.037382
RLF rearranged L-myc fusion -0.0368484
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0365478
PNISR PNN-interacting serine/arginine-rich protein -0.0359308
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0355568
CAVIN1 caveolae associated protein 1 -0.0354719
MARCHF6 membrane associated ring-CH-type finger 6 -0.0350289
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0349114
COG5 component of oligomeric golgi complex 5 -0.0347474
ANKRD10 ankyrin repeat domain 10 -0.033627
USP3 ubiquitin specific peptidase 3 -0.0334108
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0330107
YBX1 Y box binding protein 1 -0.0327874
SUCO SUN domain containing ossification factor -0.0325636
RPS21 ribosomal protein S21 -0.032538
S100A10 S100 calcium binding protein A10 -0.0324046
ZNF292 zinc finger protein 292 -0.0320311
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0319665
BRWD3 bromodomain and WD repeat domain containing 3 -0.0319122
MXI1 MAX interactor 1, dimerization protein -0.031866
SKIC3 SKI3 subunit of superkiller complex -0.0317362
HELZ helicase with zinc finger -0.0316376
NUP58 nucleoporin 58 -0.0314432
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.031319
CDC73 cell division cycle 73 -0.0310716
LMAN1 lectin, mannose-binding, 1 -0.0309292
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0304802
SPAG9 sperm associated antigen 9 -0.0304657
SLC45A4 solute carrier family 45, member 4 -0.0302886
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0300057
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0295108
CANX calnexin -0.0292774
YBX3 Y box binding protein 3 -0.0290993
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0288615
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0287347
SETD5 SET domain containing 5 -0.0278667
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.027801
TMSB4X thymosin beta 4, X-linked -0.0277619
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0277421
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0276707
FAM13A family with sequence similarity 13, member A -0.0275383
ITCH itchy E3 ubiquitin protein ligase -0.0273459
DENND4C DENN/MADD domain containing 4C -0.0267813
RRBP1 ribosome binding protein 1 -0.0264282
LMNA lamin A/C -0.0261964
BZW2 basic leucine zipper and W2 domains 2 -0.0261402
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0261222
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0261048
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0260583
SQLE squalene epoxidase -0.0258046
RNF145 ring finger protein 145 -0.0257373
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0254803
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0252636
MYOF myoferlin -0.0251771
HOOK2 hook microtubule-tethering protein 2 -0.0251387
KMT2E lysine (K)-specific methyltransferase 2E -0.0251029
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0245577
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0243191
KCMF1 potassium channel modulatory factor 1 -0.0241513
INSIG2 insulin induced gene 2 -0.0236086
RAB1A RAB1A, member RAS oncogene family -0.0233424
UBE2I ubiquitin-conjugating enzyme E2I -0.0232089
GNAS GNAS complex locus -0.0230573
IFRD1 interferon-related developmental regulator 1 -0.0226882
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0226363