BI-78D3_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-78D3 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-78D3_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.07133
DLG1 discs, large homolog 1 (Drosophila) 0.0588819
RPS12 ribosomal protein S12 0.0494617
RPL12 ribosomal protein L12 0.0450849
ZDHHC14 zinc finger, DHHC-type containing 14 0.0425461
MYOF myoferlin 0.0382132
ENO1 enolase 1, (alpha) 0.0372396
RPL37A ribosomal protein L37a 0.037191
SP100 SP100 nuclear antigen 0.0363125
RPS8 ribosomal protein S8 0.0355042
LDHA lactate dehydrogenase A 0.0347829
EFNA5 ephrin-A5 0.0341198
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0340165
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0334424
EPHA4 EPH receptor A4 0.0333158
HDAC9 histone deacetylase 9 0.033288
RPL23 ribosomal protein L23 0.0332398
TMSB10 thymosin beta 10 0.0331453
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0313314
B2M beta-2-microglobulin 0.0307053
RPL31 ribosomal protein L31 0.0306925
PARP14 poly (ADP-ribose) polymerase family, member 14 0.030172
INTS6 integrator complex subunit 6 0.0297113
CADM2 cell adhesion molecule 2 0.029172
ZSWIM6 zinc finger, SWIM-type containing 6 0.0260073
FTL ferritin, light polypeptide 0.0259205
JUN jun proto-oncogene 0.0257783
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0253462
RPL27 ribosomal protein L27 0.0250364
PLIN2 perilipin 2 0.0242885
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0241471
RPS20 ribosomal protein S20 0.0237637
RPS27 ribosomal protein S27 0.0225032
TSC22D1 TSC22 domain family, member 1 0.0223373
GLS2 glutaminase 2 (liver, mitochondrial) 0.0223106
RPLP0 ribosomal protein, large, P0 0.022006
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0217717
FTH1 ferritin, heavy polypeptide 1 0.0217172
RACK1 receptor for activated C kinase 1 0.0217112
RPL39 ribosomal protein L39 0.0215557
RPLP1 ribosomal protein, large, P1 0.0215447
RPL37 ribosomal protein L37 0.021432
TTC3 tetratricopeptide repeat domain 3 0.0211272
EEF1G eukaryotic translation elongation factor 1 gamma 0.0209944
EGFR epidermal growth factor receptor 0.0208666
RPL28 ribosomal protein L28 0.0206806
RPL36 ribosomal protein L36 0.0202993
HSPH1 heat shock 105kDa/110kDa protein 1 0.0202346
RPS17 ribosomal protein S17 0.0200587
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0197909
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.019593
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192345
CSMD3 CUB and Sushi multiple domains 3 0.0186551
FOS FBJ murine osteosarcoma viral oncogene homolog 0.018531
RPL35 ribosomal protein L35 0.0184256
RPS4X ribosomal protein S4, X-linked 0.0183215
LRRC23 leucine rich repeat containing 23 0.0180306
ENO2 enolase 2 (gamma, neuronal) 0.0178462
HOMER1 homer scaffolding protein 1 0.017327
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0172562
HM13 histocompatibility (minor) 13 0.0171863
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0168982
VIM vimentin 0.0166635
IFITM1 interferon induced transmembrane protein 1 0.0162867
PRKCE protein kinase C, epsilon 0.0162552
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0161309
RPL35A ribosomal protein L35a 0.0158366
SOD2 superoxide dismutase 2, mitochondrial 0.0158289
BIRC3 baculoviral IAP repeat containing 3 0.0157339
RPL26 ribosomal protein L26 0.0156854
TNS3 tensin 3 0.0155963
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0155567
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0151792
RPL30 ribosomal protein L30 0.0149682
GOLGB1 golgin B1 0.014857
ACAD11 acyl-CoA dehydrogenase family, member 11 0.0147806
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0146774
MBNL2 muscleblind-like splicing regulator 2 0.0146297
RPL27A ribosomal protein L27a 0.0145202
DGKH diacylglycerol kinase, eta 0.0143818
MRPL13 mitochondrial ribosomal protein L13 0.0141295
ANXA2 annexin A2 0.0140313
RPS25 ribosomal protein S25 0.0139766
MCTP1 multiple C2 domains, transmembrane 1 0.0137731
FHIT fragile histidine triad 0.0136773
FN1 fibronectin 1 0.0134754
UBAP2 ubiquitin associated protein 2 0.0133658
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0133052
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0131276
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0129692
DDIT4 DNA-damage-inducible transcript 4 0.0128823
CRY1 cryptochrome circadian clock 1 0.0128297
TIMP2 TIMP metallopeptidase inhibitor 2 0.012686
PCDH1 protocadherin 1 0.0125036
RPS27A ribosomal protein S27a 0.0125
RPS3 ribosomal protein S3 0.0123773
SEC24D SEC24 family member D 0.0123724
RPS5 ribosomal protein S5 0.0123709
FNDC3B fibronectin type III domain containing 3B 0.0121846
EGR1 early growth response 1 0.0121149

decreased expression

Symbol Name Standardized Value
TM4SF1 transmembrane 4 L six family member 1 -0.181541
ERRFI1 ERBB receptor feedback inhibitor 1 -0.167936
TXNRD1 thioredoxin reductase 1 -0.136792
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.100523
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.096066
PTMA prothymosin, alpha -0.0952229
CENPF centromere protein F, 350/400kDa -0.088835
RAI1 retinoic acid induced 1 -0.0847258
KMT2E lysine (K)-specific methyltransferase 2E -0.0806855
MT2A metallothionein 2A -0.0752756
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0735785
POTEF POTE ankyrin domain family, member F -0.0723271
MT1X metallothionein 1X -0.0716067
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0687708
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0681569
ARHGAP5 Rho GTPase activating protein 5 -0.067393
USP34 ubiquitin specific peptidase 34 -0.0662519
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0657583
MKI67 marker of proliferation Ki-67 -0.0657482
ZMYND8 zinc finger, MYND-type containing 8 -0.0636255
KTN1 kinectin 1 (kinesin receptor) -0.0630017
TMEM41B transmembrane protein 41B -0.0628386
BCAR3 breast cancer anti-estrogen resistance 3 -0.0621773
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0562842
SPAG9 sperm associated antigen 9 -0.0543152
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.052763
RAB27B RAB27B, member RAS oncogene family -0.0525304
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0523021
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0516617
RTN4 reticulon 4 -0.0514768
PRRC2C proline-rich coiled-coil 2C -0.0503298
FMNL2 formin-like 2 -0.0493448
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.049147
RBM39 RNA binding motif protein 39 -0.0484868
APP amyloid beta (A4) precursor protein -0.0472051
SRPK2 SRSF protein kinase 2 -0.0460577
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0458479
TRIP12 thyroid hormone receptor interactor 12 -0.0453026
NAMPT nicotinamide phosphoribosyltransferase -0.0448299
WWTR1 WW domain containing transcription regulator 1 -0.0445151
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0441225
ADAM17 ADAM metallopeptidase domain 17 -0.0439951
ZEB1 zinc finger E-box binding homeobox 1 -0.0437464
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0433687
RPS2 ribosomal protein S2 -0.0432364
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0431667
SRGN serglycin -0.0428364
FLNB filamin B, beta -0.0425185
DSCAM Down syndrome cell adhesion molecule -0.0424721
YBX3 Y box binding protein 3 -0.0423083
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0422406
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0420173
PNISR PNN-interacting serine/arginine-rich protein -0.04168
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0411942
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0411895
BIRC2 baculoviral IAP repeat containing 2 -0.0411318
SPRY4 sprouty homolog 4 (Drosophila) -0.0407238
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0407102
CAPRIN2 caprin family member 2 -0.0405892
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0403638
PUM2 pumilio RNA-binding family member 2 -0.0402264
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.040152
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0399467
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0396458
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0394674
CSNK1A1 casein kinase 1, alpha 1 -0.0394632
TP63 tumor protein p63 -0.0392361
EZR ezrin -0.0391139
ACTG1 actin gamma 1 -0.0390474
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0390405
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0389729
TMSB4X thymosin beta 4, X-linked -0.0381707
CDCP1 CUB domain containing protein 1 -0.0379666
ANLN anillin, actin binding protein -0.0378504
CKAP5 cytoskeleton associated protein 5 -0.0377303
CLTC clathrin, heavy chain (Hc) -0.0376373
RRM2 ribonucleotide reductase M2 -0.0375454
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0374941
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0373028
BMERB1 bMERB domain containing 1 -0.037163
HSPA8 heat shock 70kDa protein 8 -0.0371457
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0363601
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0362704
SMC4 structural maintenance of chromosomes 4 -0.0362168
MIS18BP1 MIS18 binding protein 1 -0.0361906
ANXA1 annexin A1 -0.0360476
RBM25 RNA binding motif protein 25 -0.0358939
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0358586
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0356394
EREG epiregulin -0.0353794
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0349176
GSK3B glycogen synthase kinase 3 beta -0.0344033
XPO1 exportin 1 -0.0343852
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0342438
ANKRD12 ankyrin repeat domain 12 -0.0340068
NUP58 nucleoporin 58 -0.0339728
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0337486
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0336753
DIAPH3 diaphanous-related formin 3 -0.0335003
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0333093