| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BI-78D3 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the BI-78D3_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.100424 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0972701 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0721286 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0604207 |
| AHNAK | AHNAK nucleoprotein | 0.0584693 |
| ATXN1 | ataxin 1 | 0.0557384 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0546633 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0529012 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0519749 |
| TPI1 | triosephosphate isomerase 1 | 0.0516964 |
| CANX | calnexin | 0.0508695 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0479831 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0473504 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0469057 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0455956 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0443564 |
| EXOC4 | exocyst complex component 4 | 0.0443055 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0441115 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0435551 |
| KRT18 | keratin 18, type I | 0.0428433 |
| TMSB10 | thymosin beta 10 | 0.0420956 |
| ENO1 | enolase 1, (alpha) | 0.0410782 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0410132 |
| NCOA7 | nuclear receptor coactivator 7 | 0.040742 |
| PHF20 | PHD finger protein 20 | 0.0400941 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0396007 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0390487 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0380884 |
| XPO1 | exportin 1 | 0.0380379 |
| JMJD1C | jumonji domain containing 1C | 0.0368952 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0360897 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0352507 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0350791 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0341036 |
| RAD51B | RAD51 paralog B | 0.033844 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0338242 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0336105 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0332735 |
| SBF2 | SET binding factor 2 | 0.0329674 |
| SSH2 | slingshot protein phosphatase 2 | 0.0319036 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0311849 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.03082 |
| RPL23 | ribosomal protein L23 | 0.0305903 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0305735 |
| CENPF | centromere protein F, 350/400kDa | 0.0304731 |
| TLK1 | tousled-like kinase 1 | 0.0304171 |
| GOLGA4 | golgin A4 | 0.030194 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0297743 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0293886 |
| PGK1 | phosphoglycerate kinase 1 | 0.0290476 |
| RPLP0 | ribosomal protein, large, P0 | 0.0290275 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.028655 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | 0.0280741 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0277732 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0277144 |
| TPX2 | TPX2, microtubule-associated | 0.0275185 |
| ETV6 | ets variant 6 | 0.0274727 |
| APP | amyloid beta (A4) precursor protein | 0.027131 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0267897 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0266276 |
| LDHA | lactate dehydrogenase A | 0.0265833 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0262705 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0262323 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0259155 |
| RPS4X | ribosomal protein S4, X-linked | 0.0258523 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0256113 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0250829 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0250174 |
| KRT8 | keratin 8, type II | 0.0246591 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0246149 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0245176 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0240933 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0240703 |
| IGF2 | insulin-like growth factor 2 | 0.0239328 |
| H1-3 | H1.3 linker histone, cluster member | 0.0238102 |
| NOP58 | NOP58 ribonucleoprotein | 0.0236754 |
| RPL32 | ribosomal protein L32 | 0.023665 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0234458 |
| ZNF292 | zinc finger protein 292 | 0.0234244 |
| GOLGB1 | golgin B1 | 0.0232439 |
| CPNE8 | copine VIII | 0.0231014 |
| HM13 | histocompatibility (minor) 13 | 0.0228761 |
| CUX1 | cut-like homeobox 1 | 0.0228003 |
| PCBP2 | poly(rC) binding protein 2 | 0.0226608 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0226466 |
| SMAD3 | SMAD family member 3 | 0.022321 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0223083 |
| DEK | DEK proto-oncogene | 0.0221633 |
| PHF21A | PHD finger protein 21A | 0.0221418 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0221283 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0220372 |
| ASPH | aspartate beta-hydroxylase | 0.0220099 |
| TCF12 | transcription factor 12 | 0.0220022 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0219422 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0213262 |
| SRBD1 | S1 RNA binding domain 1 | 0.0213177 |
| PREPL | prolyl endopeptidase-like | 0.0212059 |
| SIK3 | SIK family kinase 3 | 0.0211693 |
| MYOF | myoferlin | 0.0211532 |
| SMYD3 | SET and MYND domain containing 3 | 0.0210887 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.148561 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.113012 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.104116 |
| TXNRD1 | thioredoxin reductase 1 | -0.0846666 |
| EGR1 | early growth response 1 | -0.0789109 |
| POTEF | POTE ankyrin domain family, member F | -0.0630554 |
| ACTG1 | actin gamma 1 | -0.0515466 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0515353 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0450038 |
| RTN4 | reticulon 4 | -0.0438287 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0421109 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0418056 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0415529 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0410424 |
| FBXO11 | F-box protein 11 | -0.0405341 |
| OSMR | oncostatin M receptor | -0.039148 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0388232 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0386091 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0383016 |
| BRD2 | bromodomain containing 2 | -0.0374431 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0372975 |
| ATP11A | ATPase, class VI, type 11A | -0.0364195 |
| MCL1 | myeloid cell leukemia 1 | -0.0351722 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0343454 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.034177 |
| TMEM41B | transmembrane protein 41B | -0.0340066 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0335506 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.031833 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0315691 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0313888 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0312695 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0307084 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.030559 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0303499 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0302392 |
| STC1 | stanniocalcin 1 | -0.029911 |
| KMT2D | lysine (K)-specific methyltransferase 2D | -0.0296802 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0285601 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0284911 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0273899 |
| INTS6 | integrator complex subunit 6 | -0.0267659 |
| AEBP2 | AE binding protein 2 | -0.0263131 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0262705 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0261216 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0251634 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0251555 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0248469 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0244853 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.024067 |
| MYPN | myopalladin | -0.0240043 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0239725 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | -0.0239458 |
| SETX | senataxin | -0.0235562 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0233667 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.023173 |
| USP8 | ubiquitin specific peptidase 8 | -0.0228198 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0224687 |
| TAPBP | TAP binding protein (tapasin) | -0.0224117 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0223173 |
| ACTN1 | actinin, alpha 1 | -0.0222904 |
| VCL | vinculin | -0.0222375 |
| MEF2D | myocyte enhancer factor 2D | -0.02223 |
| PRRC2A | proline-rich coiled-coil 2A | -0.0221808 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0221131 |
| PHIP | pleckstrin homology domain interacting protein | -0.0220941 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0218782 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0218566 |
| TUBA1B | tubulin, alpha 1b | -0.0217335 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.021606 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.021416 |
| SET | SET nuclear proto-oncogene | -0.021282 |
| SP3 | Sp3 transcription factor | -0.0209819 |
| PKM | pyruvate kinase, muscle | -0.0208635 |
| OGA | O-GlcNAcase | -0.0208064 |
| SPAG9 | sperm associated antigen 9 | -0.0207268 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0206163 |
| YBX3 | Y box binding protein 3 | -0.020605 |
| RIGI | RNA sensor RIG-I | -0.0205486 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0203886 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0201433 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0201224 |
| PER1 | period circadian clock 1 | -0.019981 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0199747 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0198909 |
| MSN | moesin | -0.0197325 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0194539 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0193634 |
| VDAC1 | voltage-dependent anion channel 1 | -0.019323 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0193108 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0190229 |
| RRM2 | ribonucleotide reductase M2 | -0.018976 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0188919 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0188232 |
| KCMF1 | potassium channel modulatory factor 1 | -0.018776 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0185727 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0184807 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0184629 |
| CDK17 | cyclin-dependent kinase 17 | -0.0184607 |
| HLA-B | major histocompatibility complex, class I, B | -0.0184541 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0183323 |
