BID Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description BH3 interacting domain death agonist|This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 637)
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Genes

304 genes differentially expressed following the BID gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPACA5 sperm acrosome associated 5 3.18601
SH2D7 SH2 domain containing 7 3.18601
HORMAD1 HORMA domain containing 1 3.18601
TM4SF1 transmembrane 4 L six family member 1 3.18601
MUC6 mucin 6, oligomeric mucus/gel-forming 3.18601
DNASE1L3 deoxyribonuclease I-like 3 3.18601
TRIM15 tripartite motif containing 15 3.18601
SCGB3A1 secretoglobin, family 3A, member 1 3.18601
ADGRE3 adhesion G protein-coupled receptor E3 3.18601
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.18601
SCGN secretagogin, EF-hand calcium binding protein 3.18601
USP26 ubiquitin specific peptidase 26 3.18601
OR5P3 olfactory receptor, family 5, subfamily P, member 3 3.18601
FABP9 fatty acid binding protein 9, testis 3.18601
SYCP2 synaptonemal complex protein 2 3.18601
TBX21 T-box 21 3.18601
OASL 2'-5'-oligoadenylate synthetase-like 3.18601
CCDC17 coiled-coil domain containing 17 3.18601
EPB42 erythrocyte membrane protein band 4.2 3.18601
PDE7B phosphodiesterase 7B 3.18601
CSNK2A3 casein kinase 2, alpha 3 polypeptide 3.18601
ETV2 ets variant 2 3.18601
KLLN killin, p53-regulated DNA replication inhibitor 3.18601
ASGR2 asialoglycoprotein receptor 2 3.18601
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.18601
PRDM12 PR domain containing 12 3.18601
VSX1 visual system homeobox 1 3.18601
HBD hemoglobin, delta 3.18601
LCN12 lipocalin 12 3.18601
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.18601
TCAF2 TRPM8 channel-associated factor 2 3.18601
MYOM3 myomesin 3 3.18601
ASPA aspartoacylase 3.18601
RSPO1 R-spondin 1 3.18601
UCN2 urocortin 2 3.18601
ASB12 ankyrin repeat and SOCS box containing 12 3.18601
PAX6 paired box 6 3.18601
TEX101 testis expressed 101 3.18601
TRIM60 tripartite motif containing 60 3.18601
SPRR2D small proline-rich protein 2D 3.18601
SPRR2F small proline-rich protein 2F 3.18601
RHCG Rh family, C glycoprotein 3.18601
SCEL sciellin 3.18601
GBP4 guanylate binding protein 4 3.18601
H3-5 H3.5 histone 3.18601
ANGPTL8 angiopoietin like 8 3.18601
PMIS2 PMIS2 transmembrane protein 3.18601
TOMT transmembrane O-methyltransferase 3.18601
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 3.18601
SPACA9 sperm acrosome associated 9 3.18601
H2BW1 H2B.W histone 1 3.18601
GARIN6 golgi associated RAB2 interactor family member 6 3.18601
DNAAF6 dynein axonemal assembly factor 6 3.18601
SMIM35 small integral membrane protein 35 3.18601
NOTCH2NLB notch 2 N-terminal like B 3.18601
FAM240C family with sequence similarity 240 member C 3.18601
PDF peptide deformylase (mitochondrial) 3.18601
PLCZ1 phospholipase C, zeta 1 3.18601
NXPE1 neurexophilin and PC-esterase domain family, member 1 3.18601
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 3.18601
DAO D-amino-acid oxidase 3.18601
MAG myelin associated glycoprotein 3.18601
ANXA13 annexin A13 3.18601
LDHAL6B lactate dehydrogenase A-like 6B 3.18601
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.18601
MSX2 msh homeobox 2 3.18601
SCRT1 scratch family zinc finger 1 3.18601
C1ORF162 chromosome 1 open reading frame 162 3.18601
C1QL2 complement component 1, q subcomponent-like 2 3.18601
INSRR insulin receptor-related receptor 3.18601
LGSN lengsin, lens protein with glutamine synthetase domain 3.18601
CNTN6 contactin 6 3.18601
CCDC42 coiled-coil domain containing 42 3.18601
GATA2 GATA binding protein 2 3.18601
MAGIX MAGI family member, X-linked 3.18601
SPMIP10 sperm microtubule inner protein 10 3.18601
LOC105378220 macrophage receptor MARCO-like 3.18601
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 3.18601
CRYBB2 crystallin, beta B2 3.18601
TESPA1 thymocyte expressed, positive selection associated 1 3.18601
EDN3 endothelin 3 3.18601
RGS11 regulator of G-protein signaling 11 3.18601
KRT3 keratin 3, type II 3.18601
FBXO39 F-box protein 39 3.18601
HGFAC HGF activator 3.18601
EPYC epiphycan 3.18601
COL6A5 collagen, type VI, alpha 5 3.18601
OR3A1 olfactory receptor, family 3, subfamily A, member 1 3.18601
GPR50 G protein-coupled receptor 50 3.18601
CALML6 calmodulin-like 6 3.18601
TBC1D28 TBC1 domain family, member 28 3.18601
C9ORF50 chromosome 9 open reading frame 50 3.18601
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 3.18601
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 3.18601
TUBAL3 tubulin, alpha-like 3 3.18601
LCN8 lipocalin 8 3.18601
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 3.18601
PLA2G2C phospholipase A2, group IIC 3.18601
CAPSL calcyphosine-like 3.18601
CD28 CD28 molecule 3.18601
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.18601
UTS2R urotensin 2 receptor 3.18601
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 3.18601
PLA1A phospholipase A1 member A 3.18601
CHI3L2 chitinase 3-like 2 3.18601
COMP cartilage oligomeric matrix protein 3.18601
ISL1 ISL LIM homeobox 1 3.18601
CCL17 chemokine (C-C motif) ligand 17 3.18601
ITGA8 integrin, alpha 8 3.18601
CBX8 chromobox homolog 8 3.18601
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 3.18601
TREH trehalase (brush-border membrane glycoprotein) 3.18601
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3.18601
MKRN3 makorin ring finger protein 3 3.18601
ARGFX arginine-fifty homeobox 3.18601
PTPN7 protein tyrosine phosphatase, non-receptor type 7 3.18601
CCNO cyclin O 3.18601
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.18601
BANF2 barrier to autointegration factor 2 3.18601
CLEC2A C-type lectin domain family 2, member A 3.18601
FGF6 fibroblast growth factor 6 3.18601
ASCL1 achaete-scute family bHLH transcription factor 1 3.18601
MAGEC3 melanoma antigen family C3 3.18601
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.18601
METTL21C methyltransferase like 21C 3.18601
GHRH growth hormone releasing hormone 3.18601
CCDC83 coiled-coil domain containing 83 3.18601
XCR1 chemokine (C motif) receptor 1 3.18601
OR4E2 olfactory receptor, family 4, subfamily E, member 2 3.18601
ZC2HC1B zinc finger, C2HC-type containing 1B 3.18601
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.18601
RXRG retinoid X receptor, gamma 3.18601
ST18 suppression of tumorigenicity 18, zinc finger 3.18601
PSD2 pleckstrin and Sec7 domain containing 2 3.18601
TMPRSS12 transmembrane (C-terminal) protease, serine 12 3.18601
ACP6 acid phosphatase 6, lysophosphatidic 3.11883
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 3.11252
ZC3H7B zinc finger CCCH-type containing 7B 3.08356
TXNDC16 thioredoxin domain containing 16 2.89123
TMEM117 transmembrane protein 117 2.8816
MAP2K6 mitogen-activated protein kinase kinase 6 2.83061
CCDC175 coiled-coil domain containing 175 2.79029
LSMEM1 leucine-rich single-pass membrane protein 1 2.74226
YIPF2 Yip1 domain family, member 2 2.67912
LCOR ligand dependent nuclear receptor corepressor 2.6456
ZCCHC14 zinc finger, CCHC domain containing 14 2.63838
CAPS2 calcyphosine 2 2.56949
SESN1 sestrin 1 2.54271
CABLES1 Cdk5 and Abl enzyme substrate 1 2.53094
FBN1 fibrillin 1 2.50757
RIC3 RIC3 acetylcholine receptor chaperone 2.46192
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 2.45945
TOP1 topoisomerase (DNA) I 2.44417
KDM5A lysine (K)-specific demethylase 5A 2.41489
FBXL17 F-box and leucine-rich repeat protein 17 2.33639
MGAT4C MGAT4 family, member C 2.33639
CXCL6 chemokine (C-X-C motif) ligand 6 2.31972
SYNGR1 synaptogyrin 1 2.31972
KRTCAP2 keratinocyte associated protein 2 2.3099
ARL5C ADP-ribosylation factor-like 5C 2.30194
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 2.30043
PON3 paraoxonase 3 2.29701
LOC114841035 uncharacterized LOC114841035 2.29701
EBF3 early B-cell factor 3 2.29701
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.29701
TAS2R31 taste receptor, type 2, member 31 2.29701
SPDYA speedy/RINGO cell cycle regulator family member A 2.2911
GPR12 G protein-coupled receptor 12 2.29026
FBXO8 F-box protein 8 2.25282
ATXN1 ataxin 1 2.24387
DPCD deleted in primary ciliary dyskinesia homolog (mouse) 2.23935
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.22096
TMEM108 transmembrane protein 108 2.20691
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 2.17425
CEP70 centrosomal protein 70kDa 2.16726
TXNRD1 thioredoxin reductase 1 2.14099
HPCAL1 hippocalcin-like 1 2.12526
TMEM18 transmembrane protein 18 2.09506
NAGA N-acetylgalactosaminidase, alpha- 2.09429
CALCB calcitonin-related polypeptide beta 2.09418
GRM1 glutamate receptor, metabotropic 1 2.0929
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 2.08982
ARSA arylsulfatase A 2.0888
LCLAT1 lysocardiolipin acyltransferase 1 2.07926
SIAE sialic acid acetylesterase 2.07221
ZBTB48 zinc finger and BTB domain containing 48 2.072
LONP1 lon peptidase 1, mitochondrial 2.06168
CA5B carbonic anhydrase VB, mitochondrial 2.06168
ITM2A integral membrane protein 2A 2.04729
ZNF202 zinc finger protein 202 2.00005

decreased expression

Symbol Name Standardized Value
KRTDAP keratinocyte differentiation-associated protein -3.18601
LRRC19 leucine rich repeat containing 19 -3.18601
WBP2NL WBP2 N-terminal like -3.18601
EXOSC9 exosome component 9 -3.18601
PKD1L1 polycystic kidney disease 1 like 1 -3.18601
CHCT1 CHD1 helical C-terminal domain containing 1 -3.18601
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 -3.18601
TRIM73 tripartite motif containing 73 -3.08356
VWC2L von Willebrand factor C domain containing protein 2-like -3.08356
GALR3 galanin receptor 3 -3.08356
ANGPTL3 angiopoietin-like 3 -3.08356
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 -3.08356
PRRT1B proline rich transmembrane protein 1B -3.08356
AOC3 amine oxidase, copper containing 3 -3.08356
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -3.08356
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 -3.08356
PLSCR2 phospholipid scramblase 2 -3.08356
GNRHR gonadotropin-releasing hormone receptor -3.08356
TRIM47 tripartite motif containing 47 -3.08356
TEX46 testis expressed 46 -3.08356
CFAP100 cilia and flagella associated protein 100 -3.08356
TBC1D3L TBC1 domain family, member 3L -3.08356
ENKUR enkurin, TRPC channel interacting protein -3.08356
GDF6 growth differentiation factor 6 -3.08356
CCR9 chemokine (C-C motif) receptor 9 -3.08356
CBLN3 cerebellin 3 precursor -3.08356
FAM153A family with sequence similarity 153, member A -3.08356
BTC betacellulin -3.08356
UNC13C unc-13 homolog C (C. elegans) -3.08356
OR10A2 olfactory receptor, family 10, subfamily A, member 2 -3.08356
BHLHE40 basic helix-loop-helix family, member e40 -3.08356
EDN1 endothelin 1 -3.08356
ITGB7 integrin, beta 7 -3.08356
DLX3 distal-less homeobox 3 -3.08356
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -3.08356
ZCCHC12 zinc finger, CCHC domain containing 12 -3.08356
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -3.08356
LTB lymphotoxin beta (TNF superfamily, member 3) -3.08356
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 -3.08356
CFP complement factor properdin -3.08356
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -3.02057
TEX10 testis expressed 10 -2.88772
CRYBG3 beta-gamma crystallin domain containing 3 -2.793
GPX7 glutathione peroxidase 7 -2.78989
WDR12 WD repeat domain 12 -2.78442
TCEAL3 transcription elongation factor A (SII)-like 3 -2.66988
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.61988
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.52308
PRMT1 protein arginine methyltransferase 1 -2.46567
PCID2 PCI domain containing 2 -2.45945
CYB561D1 cytochrome b561 family, member D1 -2.44613
DENND2D DENN/MADD domain containing 2D -2.44613
POLL polymerase (DNA directed), lambda -2.43837
HDAC3 histone deacetylase 3 -2.43837
OSER1 oxidative stress responsive serine-rich 1 -2.42568
CLGN calmegin -2.4163
FBLN7 fibulin 7 -2.4163
PPCS phosphopantothenoylcysteine synthetase -2.41613
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -2.41489
GARIN2 golgi associated RAB2 interactor family member 2 -2.41064
TMEM65 transmembrane protein 65 -2.39147
CRYAB crystallin, alpha B -2.35851
OGFR opioid growth factor receptor -2.33942
C21ORF58 chromosome 21 open reading frame 58 -2.33509
TMEM50A transmembrane protein 50A -2.30624
HSPB8 heat shock 22kDa protein 8 -2.30595
MPLKIP M-phase specific PLK1 interacting protein -2.30043
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.2911
DPPA2 developmental pluripotency associated 2 -2.2911
RANBP6 RAN binding protein 6 -2.2911
GFY golgi-associated, olfactory signaling regulator -2.2911
PPP2R5D protein phosphatase 2, regulatory subunit B', delta -2.28541
PGS1 phosphatidylglycerophosphate synthase 1 -2.25282
TMEM92 transmembrane protein 92 -2.24502
CASS4 Cas scaffolding protein family member 4 -2.24387
CREBBP CREB binding protein -2.24387
MYO1H myosin IH -2.24387
ADCY4 adenylate cyclase 4 -2.24387
IRF2BP2 interferon regulatory factor 2 binding protein 2 -2.22871
C5ORF58 chromosome 5 open reading frame 58 -2.22356
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.22356
TEK TEK tyrosine kinase, endothelial -2.18223
FXR1 fragile X mental retardation, autosomal homolog 1 -2.18223
TMC7 transmembrane channel-like 7 -2.16726
EXT2 exostosin glycosyltransferase 2 -2.12526
CHMP1B charged multivesicular body protein 1B -2.12526
BTN2A2 butyrophilin, subfamily 2, member A2 -2.12519
AAMP angio-associated, migratory cell protein -2.09557
UGDH UDP-glucose 6-dehydrogenase -2.09286
ADRA2C adrenoceptor alpha 2C -2.09264
FBXO10 F-box protein 10 -2.08122
YBX3 Y box binding protein 3 -2.08122
RFX4 regulatory factor X, 4 (influences HLA class II expression) -2.07221
SERF1A small EDRK-rich factor 1A (telomeric) -2.072
PLXNB1 plexin B1 -2.07012
NECAP2 NECAP endocytosis associated 2 -2.06897
JPT1 Jupiter microtubule associated homolog 1 -2.04978
SRP72 signal recognition particle 72kDa -2.04742
ZNF518B zinc finger protein 518B -2.0459
PIGN phosphatidylinositol glycan anchor biosynthesis, class N -2.03968
SYT14 synaptotagmin XIV -2.03423
PDLIM7 PDZ and LIM domain 7 (enigma) -2.03152
STAT2 signal transducer and activator of transcription 2, 113kDa -2.01998
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -2.00539
NPC2 Niemann-Pick disease, type C2 -2.00539
BAX BCL2-associated X protein -2.00539
RER1 retention in endoplasmic reticulum sorting receptor 1 -2.00539
SCFD1 sec1 family domain containing 1 -2.00345
OSTN osteocrin -2.00005
USP18 ubiquitin specific peptidase 18 -2.00005
TLR2 toll-like receptor 2 -2.00005
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.00005
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.00005
CHD5 chromodomain helicase DNA binding protein 5 -2.00005