BIRC6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description baculoviral IAP repeat containing 6|This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 57448)
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Genes

340 genes differentially expressed following the BIRC6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CPED1 cadherin-like and PC-esterase domain containing 1 4.69657
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 4.69657
ZNF491 zinc finger protein 491 4.69657
ADGRE3 adhesion G protein-coupled receptor E3 4.69657
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 4.69657
PRICKLE4 prickle homolog 4 (Drosophila) 4.69657
PLXDC1 plexin domain containing 1 4.69657
HES4 hes family bHLH transcription factor 4 4.69657
TBX15 T-box 15 4.69657
OR10A2 olfactory receptor, family 10, subfamily A, member 2 4.69657
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 4.69657
FGF21 fibroblast growth factor 21 4.69657
LRRD1 leucine-rich repeats and death domain containing 1 4.69657
LBHD1 LBH domain containing 1 4.69657
FAM3D family with sequence similarity 3, member D 4.69657
TSSK4 testis-specific serine kinase 4 4.69657
GPR75 G protein-coupled receptor 75 4.69657
FAM90A26 family with sequence similarity 90, member A26, pseudogene 4.69657
UPK3B uroplakin 3B 4.69657
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 4.69657
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 4.69657
RASL10A RAS-like, family 10, member A 4.69657
FETUB fetuin B 4.69657
NFAM1 NFAT activating protein with ITAM motif 1 4.69657
SPHK1 sphingosine kinase 1 4.69657
GYS2 glycogen synthase 2 (liver) 4.69657
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 4.69657
DNAAF3 dynein, axonemal, assembly factor 3 4.69657
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 4.69657
TMEM132C transmembrane protein 132C 4.69657
IL23A interleukin 23, alpha subunit p19 4.69657
PRSS21 protease, serine, 21 (testisin) 4.69657
FXYD2 FXYD domain containing ion transport regulator 2 4.69657
LRRC61 leucine rich repeat containing 61 4.69657
FOXJ1 forkhead box J1 4.69657
COPZ2 coatomer protein complex, subunit zeta 2 4.69657
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 4.69657
ARSF arylsulfatase F 4.69657
C11ORF87 chromosome 11 open reading frame 87 4.69657
GCKR glucokinase (hexokinase 4) regulator 4.69657
THRSP thyroid hormone responsive 4.69657
ZNF792 zinc finger protein 792 4.69657
C1ORF146 chromosome 1 open reading frame 146 4.69657
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 4.69657
CD68 CD68 molecule 4.69657
EYA4 EYA transcriptional coactivator and phosphatase 4 4.69657
PCDHA2 protocadherin alpha 2 4.69657
FAM237A family with sequence similarity 237 member A 4.69657
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 4.69657
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 4.69657
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 4.69657
TMPRSS4 transmembrane protease, serine 4 4.69657
GRAP GRB2-related adaptor protein 4.69657
ZNF441 zinc finger protein 441 4.69657
OR52E4 olfactory receptor, family 52, subfamily E, member 4 4.69657
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 4.69657
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 4.69657
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.69657
MCHR1 melanin-concentrating hormone receptor 1 4.69657
UNC93A unc-93 homolog A (C. elegans) 4.69657
LOC124904542 uncharacterized LOC124904542 4.69657
MINDY4B MINDY family member 4B 4.69657
NFILZ NFIL3 like basic leucine zipper 4.69657
ODAPH odontogenesis associated phosphoprotein 4.69657
GARIN1A golgi associated RAB2 interactor 1A 4.69657
CBLIF cobalamin binding intrinsic factor 4.69657
GRAMD2A GRAM domain containing 2A 4.69657
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 4.69657
ERVW-1 endogenous retrovirus group W, member 1 4.69657
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 4.69657
GATA1 GATA binding protein 1 (globin transcription factor 1) 4.69657
GOLGA6L4 golgin A6 family-like 4 4.69657
C3ORF80 chromosome 3 open reading frame 80 4.69657
IL31RA interleukin 31 receptor A 4.69657
CCR6 chemokine (C-C motif) receptor 6 4.69657
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 4.69657
EDAR ectodysplasin A receptor 4.69657
BIK BCL2-interacting killer (apoptosis-inducing) 4.69657
PCDHB10 protocadherin beta 10 4.69657
GGT6 gamma-glutamyltransferase 6 4.69657
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 4.69657
PTP4A1 protein tyrosine phosphatase type IVA, member 1 4.69657
PDE1B phosphodiesterase 1B, calmodulin-dependent 4.69657
NDP Norrie disease (pseudoglioma) 4.69657
SYT15 synaptotagmin XV 4.69657
CNTN3 contactin 3 (plasmacytoma associated) 4.69657
DYNAP dynactin associated protein 4.69657
PXDC1 PX domain containing 1 4.69657
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 4.69657
FMR1NB fragile X mental retardation 1 neighbor 4.69657
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 4.69657
C6ORF118 chromosome 6 open reading frame 118 4.69657
PCDHB14 protocadherin beta 14 4.69657
CSPG4 chondroitin sulfate proteoglycan 4 4.69657
BTNL9 butyrophilin-like 9 4.69657
C11ORF96 chromosome 11 open reading frame 96 4.69657
TMEM204 transmembrane protein 204 4.69657
F2RL2 coagulation factor II (thrombin) receptor-like 2 4.69657
NUPR1 nuclear protein, transcriptional regulator, 1 4.69657
IL11 interleukin 11 4.69657
COL17A1 collagen, type XVII, alpha 1 4.69657
PCDH12 protocadherin 12 4.69657
DYDC1 DPY30 domain containing 1 4.69657
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 4.69657
BOLL boule-like RNA-binding protein 4.69657
HSPB2 heat shock 27kDa protein 2 4.69657
FCN3 ficolin (collagen/fibrinogen domain containing) 3 4.69657
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 4.69657
TBPL2 TATA box binding protein like 2 4.69657
FBXO39 F-box protein 39 4.69657
PCDHGB4 protocadherin gamma subfamily B, 4 4.69657
FNDC9 fibronectin type III domain containing 9 4.69657
ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 4.69657
CEL carboxyl ester lipase 4.69657
CFAP61 cilia and flagella associated protein 61 4.69657
MYLK2 myosin light chain kinase 2 4.69657
ORM2 orosomucoid 2 4.69657
SLC25A34 solute carrier family 25, member 34 4.69657
C1ORF105 chromosome 1 open reading frame 105 4.69657
ABLIM3 actin binding LIM protein family, member 3 4.69657
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 4.69657
ZPBP zona pellucida binding protein 4.69657
STRC stereocilin 4.69657
RIBC1 RIB43A domain with coiled-coils 1 4.69657
TMPPE transmembrane protein with metallophosphoesterase domain 4.69657
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 4.69657
NPIPB15 nuclear pore complex interacting protein family, member B15 4.69657
ZC3H12D zinc finger CCCH-type containing 12D 4.69657
TPPP3 tubulin polymerization-promoting protein family member 3 4.69657
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 4.69657
PDCD1LG2 programmed cell death 1 ligand 2 4.69657
CCDC177 coiled-coil domain containing 177 4.69657
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) 4.69657
GOLGA8H golgin A8 family, member H 4.69657
AMER2 APC membrane recruitment protein 2 4.69657
POU3F2 POU class 3 homeobox 2 4.69657
EPX eosinophil peroxidase 4.69657
TMEM88 transmembrane protein 88 4.69657
AZU1 azurocidin 1 4.69657
AHSG alpha-2-HS-glycoprotein 4.69657
ADAM20 ADAM metallopeptidase domain 20 4.69657
PPP1R3G protein phosphatase 1, regulatory subunit 3G 4.69657
CARNS1 carnosine synthase 1 4.69657
CIB3 calcium and integrin binding family member 3 4.69657
SYTL5 synaptotagmin-like 5 4.69657
DEFB134 defensin, beta 134 4.69657
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 4.69657
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 4.69657
FGF10 fibroblast growth factor 10 4.69657
NLRP6 NLR family, pyrin domain containing 6 4.69657
NPC1L1 NPC1-like 1 4.69657
TBC1D26 TBC1 domain family, member 26 4.69657
IFI16 interferon, gamma-inducible protein 16 4.69657
DCST1 DC-STAMP domain containing 1 4.69657
MAEL maelstrom spermatogenic transposon silencer 4.69657
HLA-F major histocompatibility complex, class I, F 4.60625
KCP kielin/chordin-like protein 4.27659
PLPPR4 phospholipid phosphatase related 4 3.78523
PNMA6A paraneoplastic Ma antigen family member 6A 3.78523
TAPBPL TAP binding protein-like 3.78523
GPX2 glutathione peroxidase 2 3.78523
ANO2 anoctamin 2, calcium activated chloride channel 3.49911
PXMP2 peroxisomal membrane protein 2, 22kDa 3.39169
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 3.38349
E2F3 E2F transcription factor 3 3.37231
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 3.34974
SIRAL2 SIR2 antiphage like 2 3.23942
CDON cell adhesion associated, oncogene regulated 3.23439
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.0909
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 3.08453
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.9682
TBC1D15 TBC1 domain family, member 15 2.87317
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.82088
LMNA lamin A/C 2.79039
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.78497
ZNF516 zinc finger protein 516 2.77471
REPS1 RALBP1 associated Eps domain containing 1 2.69938
H2AC25 H2A clustered histone 25 2.61256
PHKA2 phosphorylase kinase, alpha 2 (liver) 2.58205
LDHD lactate dehydrogenase D 2.57396
SGMS2 sphingomyelin synthase 2 2.57396
NFIB nuclear factor I/B 2.5504
FUBP1 far upstream element (FUSE) binding protein 1 2.53983
PDIA5 protein disulfide isomerase family A, member 5 2.52582
ZFP36 ZFP36 ring finger protein 2.51213
TP53INP2 tumor protein p53 inducible nuclear protein 2 2.51213
SNPH syntaphilin 2.49197
PLCZ1 phospholipase C, zeta 1 2.49197
PRR12 proline rich 12 2.49197
TMEM74B transmembrane protein 74B 2.49197
LOX lysyl oxidase 2.49197
OTP orthopedia homeobox 2.49197
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 2.41564
PARVG parvin, gamma 2.41465
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.39734
RABL2A RAB, member of RAS oncogene family-like 2A 2.38258
CALY calcyon neuron-specific vesicular protein 2.37169
HUS1 HUS1 checkpoint homolog (S. pombe) 2.36628
CDK6 cyclin-dependent kinase 6 2.33587
REST RE1-silencing transcription factor 2.33587
MIA3 melanoma inhibitory activity family, member 3 2.25791
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 2.25791
SPATA7 spermatogenesis associated 7 2.2399
GFM2 G elongation factor, mitochondrial 2 2.23552
AUP1 ancient ubiquitous protein 1 2.23181
PSIP1 PC4 and SFRS1 interacting protein 1 2.22661
ZC2HC1A zinc finger, C2HC-type containing 1A 2.22615
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 2.22251
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.22085
DDAH1 dimethylarginine dimethylaminohydrolase 1 2.2013
MRPL10 mitochondrial ribosomal protein L10 2.18285
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 2.17503
COL6A3 collagen, type VI, alpha 3 2.17136
DUSP4 dual specificity phosphatase 4 2.16547
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 2.15275
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 2.14151
FAM161A family with sequence similarity 161, member A 2.1272
PIERCE1 piercer of microtubule wall 1 2.1143
KREMEN1 kringle containing transmembrane protein 1 2.11334
SEC24C SEC24 family member C 2.07226
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.07226
MRPL24 mitochondrial ribosomal protein L24 2.06256
NLGN1 neuroligin 1 2.02606
GCLM glutamate-cysteine ligase, modifier subunit 2.00698
GPRC5B G protein-coupled receptor, class C, group 5, member B 2.00698
GAB2 GRB2-associated binding protein 2 2.00011

decreased expression

Symbol Name Standardized Value
TCL1A T-cell leukemia/lymphoma 1A -4.69657
H2BC12 H2B clustered histone 12 -4.69657
ALS2CL ALS2 C-terminal like -4.69657
ESR1 estrogen receptor 1 -4.69657
WDR24 WD repeat domain 24 -4.69657
JOSD2 Josephin domain containing 2 -4.32285
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -4.32285
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -4.32285
SOX30 SRY (sex determining region Y)-box 30 -4.32285
OPN1SW opsin 1 (cone pigments), short-wave-sensitive -4.32285
SCIN scinderin -4.32285
CORIN corin, serine peptidase -4.32285
STARD5 StAR-related lipid transfer (START) domain containing 5 -4.32285
C19ORF84 chromosome 19 open reading frame 84 -4.32285
RUMY2 RUMY family member 2 -4.32285
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 -4.32285
TLR3 toll-like receptor 3 -4.32285
MBLAC1 metallo-beta-lactamase domain containing 1 -4.32285
FABP6 fatty acid binding protein 6, ileal -4.32285
SYCP1 synaptonemal complex protein 1 -4.32285
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -4.32285
C2ORF80 chromosome 2 open reading frame 80 -4.32285
FTCD formimidoyltransferase cyclodeaminase -4.32285
CPB2 carboxypeptidase B2 (plasma) -4.32285
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -4.32285
HCRTR1 hypocretin (orexin) receptor 1 -4.32285
MEOX2 mesenchyme homeobox 2 -4.32285
HBEGF heparin-binding EGF-like growth factor -4.32285
FGF9 fibroblast growth factor 9 -4.32285
AURKC aurora kinase C -4.32285
IGFBP7 insulin-like growth factor binding protein 7 -4.32285
NLRC4 NLR family, CARD domain containing 4 -4.32285
SPATA18 spermatogenesis associated 18 -4.32285
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -4.32285
ATP10B ATPase, class V, type 10B -4.32285
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 -4.32285
PTPN20 protein tyrosine phosphatase, non-receptor type 20 -4.32285
LOC122526780 uncharacterized LOC122526780 -4.32285
MYOT myotilin -4.32285
C10ORF105 chromosome 10 open reading frame 105 -4.32285
ILDR2 immunoglobulin-like domain containing receptor 2 -4.32285
CEND1 cell cycle exit and neuronal differentiation 1 -4.32285
LRRC19 leucine rich repeat containing 19 -4.32285
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -4.32285
KRT222 keratin 222, type II -4.32285
RASL12 RAS-like, family 12 -4.10258
GPSM3 G-protein signaling modulator 3 -4.10258
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -3.69591
ADCY1 adenylate cyclase 1 (brain) -3.39795
CNPY4 canopy FGF signaling regulator 4 -3.16983
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 -3.05602
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -2.91885
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) -2.84513
RNASEH2A ribonuclease H2, subunit A -2.83055
SNAI3 snail family zinc finger 3 -2.82553
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -2.80239
CA13 carbonic anhydrase XIII -2.79768
KLHL14 kelch-like family member 14 -2.78497
ZMAT1 zinc finger, matrin-type 1 -2.77471
DCBLD1 discoidin, CUB and LCCL domain containing 1 -2.77471
LAMA3 laminin, alpha 3 -2.73171
ABHD4 abhydrolase domain containing 4 -2.73171
DZIP3 DAZ interacting zinc finger protein 3 -2.52693
CAB39 calcium binding protein 39 -2.42858
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -2.42444
KIF14 kinesin family member 14 -2.41465
TIMP3 TIMP metallopeptidase inhibitor 3 -2.4126
GTPBP10 GTP-binding protein 10 (putative) -2.39936
SYNGR3 synaptogyrin 3 -2.38361
CDC37L1 cell division cycle 37-like 1 -2.38176
AS3MT arsenite methyltransferase -2.35031
PRXL2B peroxiredoxin like 2B -2.33836
COPRS coordinator of PRMT5, differentiation stimulator -2.33587
RNF122 ring finger protein 122 -2.32887
RPUSD1 RNA pseudouridylate synthase domain containing 1 -2.32827
DGCR2 DiGeorge syndrome critical region gene 2 -2.3224
ZNF774 zinc finger protein 774 -2.30565
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -2.30565
CAV2 caveolin 2 -2.30565
C14ORF119 chromosome 14 open reading frame 119 -2.30565
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -2.29299
ACER2 alkaline ceramidase 2 -2.25828
FKBPL FK506 binding protein like -2.25791
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.25791
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein -2.25791
RPP14 ribonuclease P/MRP 14kDa subunit -2.25791
PDGFB platelet-derived growth factor beta polypeptide -2.25791
GPR155 G protein-coupled receptor 155 -2.25791
FAM86B1 family with sequence similarity 86, member B1 -2.23797
CLPSL2 colipase-like 2 -2.23797
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 -2.22807
SAMD10 sterile alpha motif domain containing 10 -2.20807
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -2.19626
DIPK2A divergent protein kinase domain 2A -2.19487
PDGFD platelet derived growth factor D -2.1934
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -2.19058
ARF1 ADP-ribosylation factor 1 -2.18285
TTYH2 tweety family member 2 -2.17312
TMC4 transmembrane channel-like 4 -2.17312
SUN2 Sad1 and UNC84 domain containing 2 -2.17312
THAP9 THAP domain containing 9 -2.16871
RGS19 regulator of G-protein signaling 19 -2.12047
SBF2 SET binding factor 2 -2.11729
METTL8 methyltransferase like 8 -2.11577
GALNT17 polypeptide N-acetylgalactosaminyltransferase 17 -2.11334
MKRN2 makorin ring finger protein 2 -2.09712
DNAAF10 dynein axonemal assembly factor 10 -2.07688
TACC2 transforming, acidic coiled-coil containing protein 2 -2.05913
DNPEP aspartyl aminopeptidase -2.04722
BEX4 brain expressed, X-linked 4 -2.0439
ZC3H14 zinc finger CCCH-type containing 14 -2.01205
TMEM230 transmembrane protein 230 -2.00737
SETD9 SET domain containing 9 -2.00698
KIF23 kinesin family member 23 -2.00371