BLNK Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description B-cell linker|This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012] (NCBI Entrez Gene Database, 29760)
External Link https://ncbi.nlm.nih.gov/gene/29760
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Genes

500 genes differentially expressed following the BLNK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
IFI27 interferon, alpha-inducible protein 27 0.0158152
CCND1 cyclin D1 0.0151502
FXYD3 FXYD domain containing ion transport regulator 3 0.0142287
TM4SF1 transmembrane 4 L six family member 1 0.0134185
KRT6A keratin 6A, type II 0.0132842
KRT5 keratin 5, type II 0.0131538
SFN stratifin 0.0129597
PI3 peptidase inhibitor 3, skin-derived 0.0128061
S100P S100 calcium binding protein P 0.0120717
SLPI secretory leukocyte peptidase inhibitor 0.0117478
SPRR1B small proline-rich protein 1B 0.0113079
KRT14 keratin 14, type I 0.0111779
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.0110902
SPARCL1 SPARC-like 1 (hevin) 0.0105446
HOPX HOP homeobox 0.0105194
S100A2 S100 calcium binding protein A2 0.00998235
AQP3 aquaporin 3 (Gill blood group) 0.00997633
TYRP1 tyrosinase-related protein 1 0.00996048
S100A7 S100 calcium binding protein A7 0.00989399
KRT17 keratin 17, type I 0.00989061
LAMP3 lysosomal-associated membrane protein 3 0.00986433
COPS7A COP9 signalosome subunit 7A 0.0098055
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.00943231
KLK10 kallikrein-related peptidase 10 0.00938477
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.00916995
PEG3 paternally expressed 3 0.00916502
ANXA3 annexin A3 0.00893805
S100A9 S100 calcium binding protein A9 0.00883917
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.0086715
FGFBP1 fibroblast growth factor binding protein 1 0.00865807
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.00862315
KRT1 keratin 1, type II 0.00861038
NFIB nuclear factor I/B 0.00859845
BCHE butyrylcholinesterase 0.00858985
NRN1 neuritin 1 0.00854041
KRT6B keratin 6B, type II 0.00849687
FABP7 fatty acid binding protein 7, brain 0.00845906
PDLIM2 PDZ and LIM domain 2 (mystique) 0.00845731
CD93 CD93 molecule 0.00840934
CD59 CD59 molecule, complement regulatory protein 0.008373
NSG1 neuron specific gene family member 1 0.00830468
KIFAP3 kinesin-associated protein 3 0.00827902
LAMC2 laminin, gamma 2 0.00827113
FABP5 fatty acid binding protein 5 (psoriasis-associated) 0.00826131
GPM6B glycoprotein M6B 0.0082135
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 0.00820399
SRPX sushi-repeat containing protein, X-linked 0.00820375
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.00807347
CLEC11A C-type lectin domain family 11, member A 0.00806848
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.00803076
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0079986
HBB hemoglobin, beta 0.00799663
AGR2 anterior gradient 2 0.00782623
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.00781571
TRIM29 tripartite motif containing 29 0.00760686
BHLHE41 basic helix-loop-helix family, member e41 0.00754357
ARID4A AT rich interactive domain 4A (RBP1-like) 0.00752484
DSG1 desmoglein 1 0.00751528
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 0.00751224
LYPD3 LY6/PLAUR domain containing 3 0.00745227
ZIC1 Zic family member 1 0.00743404
DLK1 delta-like 1 homolog (Drosophila) 0.00741781
F8 coagulation factor VIII, procoagulant component 0.00726093
MRPS16 mitochondrial ribosomal protein S16 0.007218
FGFR3 fibroblast growth factor receptor 3 0.00720412
PON2 paraoxonase 2 0.00717605
JCHAIN joining chain of multimeric IgA and IgM 0.00709407
TARP TCR gamma alternate reading frame protein 0.00707863
GNAS GNAS complex locus 0.00707598
ANXA6 annexin A6 0.0069764
FKBP11 FK506 binding protein 11, 19 kDa 0.00692563
MAGED1 melanoma antigen family D1 0.00690771
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 0.00687785
FOLR1 folate receptor 1 (adult) 0.00686265
LY6D lymphocyte antigen 6 complex, locus D 0.00685724
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 0.0068548
CCL15 chemokine (C-C motif) ligand 15 0.00685296
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.00685239
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.00683024
LAMA2 laminin, alpha 2 0.00683015
KLK5 kallikrein-related peptidase 5 0.00677806
EFNB2 ephrin-B2 0.00676253
APOLD1 apolipoprotein L domain containing 1 0.00673446
MLF1 myeloid leukemia factor 1 0.00670938
SPRR1A small proline-rich protein 1A 0.00667065
MSRB2 methionine sulfoxide reductase B2 0.00664422
CLCA2 chloride channel accessory 2 0.00663755
SOSTDC1 sclerostin domain containing 1 0.00661915
RPL36 ribosomal protein L36 0.00660589
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.00659839
TNNC1 troponin C type 1 (slow) 0.00659606
C7 complement component 7 0.00643738
VWF von Willebrand factor 0.00641442
MALL mal, T-cell differentiation protein-like 0.00641165
CDH5 cadherin 5, type 2 (vascular endothelium) 0.00640627
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.00639414
EGR3 early growth response 3 0.00639303
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.00637958
ATXN1 ataxin 1 0.00632514
CTSK cathepsin K 0.00631619
DSG3 desmoglein 3 0.00630997
CLTB clathrin, light chain B 0.00628847
TCTN1 tectonic family member 1 0.00622324
KRT16 keratin 16, type I 0.00620261
RNF144A ring finger protein 144A 0.0062003
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.00619614
KLF5 Kruppel-like factor 5 (intestinal) 0.00619452
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.00618253
ITM2A integral membrane protein 2A 0.00618176
TMEM45A transmembrane protein 45A 0.00617614
STOM stomatin 0.00616003
FXYD6 FXYD domain containing ion transport regulator 6 0.00615068
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.00613651
S100A14 S100 calcium binding protein A14 0.00612068
CLIC5 chloride intracellular channel 5 0.00605679
LDB2 LIM domain binding 2 0.0060534
LOR loricrin 0.00604793
TACSTD2 tumor-associated calcium signal transducer 2 0.00604287
CXCL6 chemokine (C-X-C motif) ligand 6 0.00604011
FGF13 fibroblast growth factor 13 0.00601875
POPDC3 popeye domain containing 3 0.00600797
QPRT quinolinate phosphoribosyltransferase 0.00600222
SMPX small muscle protein, X-linked 0.00600019
RAB38 RAB38, member RAS oncogene family 0.00598718
PMS2P3 postmeiotic segregation increased 2 pseudogene 3 0.00598098
SPRR2B small proline-rich protein 2B 0.00595438
PLK1 polo-like kinase 1 0.00593735
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 0.00593532
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.00592688
PALMD palmdelphin 0.00591477
PADI2 peptidyl arginine deiminase, type II 0.00590621
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.00589963
MGLL monoglyceride lipase 0.00588507
S100A8 S100 calcium binding protein A8 0.00584752
GREB1 growth regulation by estrogen in breast cancer 1 0.00584584
MMP1 matrix metallopeptidase 1 0.00584107
CYTL1 cytokine-like 1 0.00581759
RCAN1 regulator of calcineurin 1 0.00581481
SCEL sciellin 0.00579825
ADAT1 adenosine deaminase, tRNA-specific 1 0.00578643
PKP1 plakophilin 1 0.0057672
KLF10 Kruppel-like factor 10 0.00575364
IQCG IQ motif containing G 0.00570295
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00569764
JPT1 Jupiter microtubule associated homolog 1 0.00567375
SH3BGR SH3 domain binding glutamate-rich protein 0.0056637
MOXD1 monooxygenase, DBH-like 1 0.00565378
C1ORF115 chromosome 1 open reading frame 115 0.00561043
THYN1 thymocyte nuclear protein 1 0.0055913
EDNRB endothelin receptor type B 0.00558954
MARCKS myristoylated alanine-rich protein kinase C substrate 0.00556594
CXCL5 chemokine (C-X-C motif) ligand 5 0.00556387
CAV1 caveolin 1, caveolae protein, 22kDa 0.00555233
LTF lactotransferrin 0.00554836
PODXL podocalyxin-like 0.00554386
KLK8 kallikrein-related peptidase 8 0.00554031
CSTA cystatin A (stefin A) 0.0055027
TEAD4 TEA domain family member 4 0.00549579
IL13RA2 interleukin 13 receptor, alpha 2 0.00549395
SOX17 SRY (sex determining region Y)-box 17 0.00545734
AGTR1 angiotensin II receptor, type 1 0.0054558
PRKCQ protein kinase C, theta 0.00545374
AMACR alpha-methylacyl-CoA racemase 0.00544782
WWTR1 WW domain containing transcription regulator 1 0.00544774
RBKS ribokinase 0.00542626
GSTZ1 glutathione S-transferase zeta 1 0.00542363
SCGB2A2 secretoglobin, family 2A, member 2 0.0054233
ECI2 enoyl-CoA delta isomerase 2 0.00542118
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.00541345
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.0053966
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.00539565
GPR171 G protein-coupled receptor 171 0.00535567
GPM6A glycoprotein M6A 0.00535386
RPS26 ribosomal protein S26 0.00534134
GYG1 glycogenin 1 0.00533814
CHODL chondrolectin 0.00533379
RETREG3 reticulophagy regulator family member 3 0.00532803
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.00530719
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.00529005
CH25H cholesterol 25-hydroxylase 0.00526496
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.00526295
MXRA7 matrix-remodelling associated 7 0.00526244
RPS5 ribosomal protein S5 0.00525823
KLHL41 kelch-like family member 41 0.0052562
LAPTM4B lysosomal protein transmembrane 4 beta 0.00525141
MPZL2 myelin protein zero-like 2 0.00524249
CFLAR CASP8 and FADD-like apoptosis regulator 0.00522807
SCGB2A1 secretoglobin, family 2A, member 1 0.00522452
IFITM1 interferon induced transmembrane protein 1 0.00516259
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.00514783
CADPS2 Ca++-dependent secretion activator 2 0.00511085
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.00510911
SFTPD surfactant protein D 0.00510509
HHLA3 HERV-H LTR-associating 3 0.00509859
MEIS1 Meis homeobox 1 0.00509247
H1-10 H1.10 linker histone 0.0050744
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.00506599
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 0.00506311
DIO2 deiodinase, iodothyronine, type II 0.00504993
DUSP7 dual specificity phosphatase 7 0.00504629
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.00503159
BTN3A2 butyrophilin, subfamily 3, member A2 0.00499991
MMP7 matrix metallopeptidase 7 0.00499521
HIGD1A HIG1 hypoxia inducible domain family, member 1A 0.00499072
LGALSL lectin, galactoside-binding-like 0.00498363
ISLR immunoglobulin superfamily containing leucine-rich repeat 0.00497886
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 0.00497306
MSLN mesothelin 0.00495462
C8ORF4 chromosome 8 open reading frame 4 0.00493613
SYCP2 synaptonemal complex protein 2 0.00493542
BIRC3 baculoviral IAP repeat containing 3 0.00493146
KRT2 keratin 2, type II 0.00493032
NAP1L2 nucleosome assembly protein 1-like 2 0.00492557
GSTA4 glutathione S-transferase alpha 4 0.00492137
ERGIC3 ERGIC and golgi 3 0.00491346
PCDH17 protocadherin 17 0.00491134
DUSP22 dual specificity phosphatase 22 0.00490979
C1QA complement component 1, q subcomponent, A chain 0.00490283
PDE2A phosphodiesterase 2A, cGMP-stimulated 0.00489866
HECA headcase homolog (Drosophila) 0.00488975
HPF1 histone PARylation factor 1 0.00488139
EDNRA endothelin receptor type A 0.00487353
CD320 CD320 molecule 0.0048656
STK17A serine/threonine kinase 17a 0.00486285
AUTS2 autism susceptibility candidate 2 0.00486191
STAB1 stabilin 1 0.00485896
ZSCAN31 zinc finger and SCAN domain containing 31 0.0048583
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 0.0048503
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 0.00484738
CTSG cathepsin G 0.00484492
PRR5L proline rich 5 like 0.00484477
TSPAN8 tetraspanin 8 0.00484161
PRMT1 protein arginine methyltransferase 1 0.00483658
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0048352
PMS2P5 postmeiotic segregation increased 2 pseudogene 5 0.00483082
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.00482857
HSPA8 heat shock 70kDa protein 8 0.00481672
RAB22A RAB22A, member RAS oncogene family 0.00480328
REEP1 receptor accessory protein 1 0.00479704
VIM vimentin 0.00479206
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0047892
CSTB cystatin B (stefin B) 0.0047875
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.0047869
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.00478395
IVL involucrin 0.00478357
TEK TEK tyrosine kinase, endothelial 0.00477963
CXCL12 chemokine (C-X-C motif) ligand 12 0.00477923
SELL selectin L 0.00477688
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00476912
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.00475302

decreased expression

Symbol Name Standardized Value
SLC38A1 solute carrier family 38, member 1 -0.0147813
CHIC2 cysteine-rich hydrophobic domain 2 -0.0123484
BMP4 bone morphogenetic protein 4 -0.0121083
PTK2 protein tyrosine kinase 2 -0.0121009
CNPY3 canopy FGF signaling regulator 3 -0.0118614
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0110005
S100A4 S100 calcium binding protein A4 -0.0106398
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.0104908
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0102468
KRT19 keratin 19, type I -0.010044
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00931625
ADM adrenomedullin -0.00908526
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00907592
PCP4 Purkinje cell protein 4 -0.00889891
CA12 carbonic anhydrase XII -0.00882728
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) -0.00868185
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.00861799
LYZ lysozyme -0.00846316
PLAAT3 phospholipase A and acyltransferase 3 -0.00820063
BTF3P11 basic transcription factor 3 pseudogene 11 -0.00779922
SDC4 syndecan 4 -0.00778644
ANPEP alanyl (membrane) aminopeptidase -0.00755034
FTH1 ferritin, heavy polypeptide 1 -0.00740058
TMEM176B transmembrane protein 176B -0.00737082
ALOX5 arachidonate 5-lipoxygenase -0.00734768
G0S2 G0/G1 switch 2 -0.007283
TXLNA taxilin alpha -0.0072527
MYRF myelin regulatory factor -0.00723701
CEMIP cell migration inducing protein, hyaluronan binding -0.00707677
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -0.00706745
TFRC transferrin receptor -0.00698496
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.00695962
TCL1A T-cell leukemia/lymphoma 1A -0.00695234
PAX5 paired box 5 -0.00689328
THBS2 thrombospondin 2 -0.00689284
MAP7 microtubule-associated protein 7 -0.00686462
VEGFA vascular endothelial growth factor A -0.00685529
MXRA5 matrix-remodelling associated 5 -0.00679057
CD52 CD52 molecule -0.00678036
SDC2 syndecan 2 -0.00673516
CBX6 chromobox homolog 6 -0.00670161
ANGPTL4 angiopoietin-like 4 -0.0066947
POSTN periostin, osteoblast specific factor -0.00663347
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -0.0066232
LGALS2 lectin, galactoside-binding, soluble, 2 -0.00662101
GLA galactosidase, alpha -0.00654099
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00651175
FADS3 fatty acid desaturase 3 -0.0064843
TFPI2 tissue factor pathway inhibitor 2 -0.0063556
VTCN1 V-set domain containing T cell activation inhibitor 1 -0.00633458
ERBB3 erb-b2 receptor tyrosine kinase 3 -0.00632574
CCDC86 coiled-coil domain containing 86 -0.00631288
IGFBP5 insulin-like growth factor binding protein 5 -0.00630557
DEPTOR DEP domain containing MTOR-interacting protein -0.00630033
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -0.00627044
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00624111
CCL2 chemokine (C-C motif) ligand 2 -0.00623917
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.00623164
SULF1 sulfatase 1 -0.00621905
PLIN2 perilipin 2 -0.00621559
HK2 hexokinase 2 -0.00617466
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00617052
RNH1 ribonuclease/angiogenin inhibitor 1 -0.00616118
SLC12A8 solute carrier family 12, member 8 -0.00614553
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) -0.00614172
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.00613568
CXCL8 chemokine (C-X-C motif) ligand 8 -0.00612387
NVL nuclear VCP-like -0.0061213
SNX13 sorting nexin 13 -0.00609455
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -0.00606091
EXT1 exostosin glycosyltransferase 1 -0.0060552
CIAO3 cytosolic iron-sulfur assembly component 3 -0.00602059
VNN1 vanin 1 -0.00598757
SC5D sterol-C5-desaturase -0.005918
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -0.00590101
VPREB3 pre-B lymphocyte 3 -0.00588279
OSBPL10 oxysterol binding protein-like 10 -0.00587026
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 -0.00586948
CD1B CD1b molecule -0.0058532
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.005852
CRLF1 cytokine receptor-like factor 1 -0.00584545
FBP1 fructose-1,6-bisphosphatase 1 -0.00583525
IPO13 importin 13 -0.00582532
STC1 stanniocalcin 1 -0.0058009
GBP2 guanylate binding protein 2, interferon-inducible -0.005752
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.00573998
CD79B CD79b molecule, immunoglobulin-associated beta -0.00572
INHBA inhibin, beta A -0.00568695
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.00567576
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -0.00563188
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 -0.00562074
H2AFV H2A histone family, member V -0.00558031
ACKR3 atypical chemokine receptor 3 -0.00557714
TM7SF2 transmembrane 7 superfamily member 2 -0.00557258
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -0.00553859
LOXL1 lysyl oxidase-like 1 -0.00553839
WASF1 WAS protein family, member 1 -0.00553585
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -0.00552785
NPEPL1 aminopeptidase-like 1 -0.00552768
CTSA cathepsin A -0.00552649
CTBP2 C-terminal binding protein 2 -0.00550421
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -0.00550264
PTGER3 prostaglandin E receptor 3 (subtype EP3) -0.00549295
PFKP phosphofructokinase, platelet -0.00549232
COMP cartilage oligomeric matrix protein -0.00549029
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.00537659
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.00535966
DKFZP586I1420 uncharacterized protein DKFZp586I1420 -0.00535408
SYNE3 spectrin repeat containing, nuclear envelope family member 3 -0.00534692
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00533982
ZDHHC6 zinc finger, DHHC-type containing 6 -0.00532385
PHIP pleckstrin homology domain interacting protein -0.00532371
TRIM13 tripartite motif containing 13 -0.00528277
PGRMC2 progesterone receptor membrane component 2 -0.00526156
PROM1 prominin 1 -0.00520233
GLUL glutamate-ammonia ligase -0.00520053
MED13 mediator complex subunit 13 -0.00518711
NPM3 nucleophosmin/nucleoplasmin 3 -0.00516105
C4BPB complement component 4 binding protein, beta -0.00515352
DUOX2 dual oxidase 2 -0.00511658
F5 coagulation factor V (proaccelerin, labile factor) -0.00510992
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -0.00510582
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 -0.00508581
CTSZ cathepsin Z -0.00507358
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0050607
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.00505958
CD1E CD1e molecule -0.00505866
L1CAM L1 cell adhesion molecule -0.00505051
RTN4 reticulon 4 -0.00504765
LITAF lipopolysaccharide-induced TNF factor -0.00502096
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -0.00501433
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -0.00500349
CDH16 cadherin 16, KSP-cadherin -0.00495873
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -0.00495185
BEX1 brain expressed, X-linked 1 -0.00494141
REG1A regenerating islet-derived 1 alpha -0.00493949
ANGPT1 angiopoietin 1 -0.00493594
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -0.00492
HSPA1A heat shock 70kDa protein 1A -0.0048992
ZDHHC17 zinc finger, DHHC-type containing 17 -0.0048791
SPINK1 serine peptidase inhibitor, Kazal type 1 -0.00486258
UXT ubiquitously-expressed, prefoldin-like chaperone -0.0048555
ATP2A3 ATPase, Ca++ transporting, ubiquitous -0.00483468
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.004822
LYN LYN proto-oncogene, Src family tyrosine kinase -0.00481984
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.00481463
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.00480245
DHDDS dehydrodolichyl diphosphate synthase -0.00480141
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) -0.00478533
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -0.00477887
TSEN34 TSEN34 tRNA splicing endonuclease subunit -0.004777
LXN latexin -0.00477524
INSIG1 insulin induced gene 1 -0.00476494
LGALS4 lectin, galactoside-binding, soluble, 4 -0.00476053
ANXA10 annexin A10 -0.00476022
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -0.00475589
EML3 echinoderm microtubule associated protein like 3 -0.00475429
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.00475128
LOX lysyl oxidase -0.00474963
HHEX hematopoietically expressed homeobox -0.00474652
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.00473836
HSPA6 heat shock 70kDa protein 6 (HSP70B') -0.00473719
NFE2L3 nuclear factor, erythroid 2-like 3 -0.00473704
SIX2 SIX homeobox 2 -0.00472869
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.00472546
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -0.00472104
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.00472053
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.00467234
TPD52L1 tumor protein D52-like 1 -0.00465761
KLHDC2 kelch domain containing 2 -0.00463292
F3 coagulation factor III (thromboplastin, tissue factor) -0.00462583
ZHX2 zinc fingers and homeoboxes 2 -0.00462569
VCAM1 vascular cell adhesion molecule 1 -0.00462424
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -0.00462298
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 -0.00461125
KCTD14 potassium channel tetramerization domain containing 14 -0.00461087
HOMER2 homer scaffolding protein 2 -0.00459876
EIF5A eukaryotic translation initiation factor 5A -0.00459306
ORC1 origin recognition complex, subunit 1 -0.00459256
BTK Bruton agammaglobulinemia tyrosine kinase -0.00458493
SLC38A2 solute carrier family 38, member 2 -0.00458159
HOXC10 homeobox C10 -0.00457637
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -0.00457122
DERL1 derlin 1 -0.00455836
HPCAL1 hippocalcin-like 1 -0.00455786
CCN3 cellular communication network factor 3 -0.00454995
SOD2 superoxide dismutase 2, mitochondrial -0.0045498
FBN2 fibrillin 2 -0.0045461
TLN1 talin 1 -0.00454394
DSCC1 DNA replication and sister chromatid cohesion 1 -0.00454128
MMP2 matrix metallopeptidase 2 -0.00453353
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.00450793
HOXD1 homeobox D1 -0.00450172
ATP13A3 ATPase type 13A3 -0.00449277
ETFB electron-transfer-flavoprotein, beta polypeptide -0.00447517
KLHDC3 kelch domain containing 3 -0.00447468
FXYD2 FXYD domain containing ion transport regulator 2 -0.00447227
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.00446936
DPP4 dipeptidyl-peptidase 4 -0.00445933
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.00444665
GPNMB glycoprotein (transmembrane) nmb -0.00444437
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -0.00443961
OAT ornithine aminotransferase -0.00443586
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -0.00443273
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.00442481
SFRP4 secreted frizzled-related protein 4 -0.00442281
TRIB3 tribbles pseudokinase 3 -0.00441683
NDRG1 N-myc downstream regulated 1 -0.00441628
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 -0.00440861
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.00440769
LY6E lymphocyte antigen 6 complex, locus E -0.00439235
PIP prolactin-induced protein -0.00437343
STC2 stanniocalcin 2 -0.00436823
PTK7 protein tyrosine kinase 7 (inactive) -0.0043664
MXRA8 matrix-remodelling associated 8 -0.00436406
SEPTIN2 septin 2 -0.00435431
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.00435105
GPC1 glypican 1 -0.00434582
CERS2 ceramide synthase 2 -0.00433095
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 -0.00432745
BARX1 BARX homeobox 1 -0.00432624
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -0.00432265
TNPO2 transportin 2 -0.00431066
SPP1 secreted phosphoprotein 1 -0.00430401
FRS2 fibroblast growth factor receptor substrate 2 -0.00428787
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -0.00428615
APLP2 amyloid beta (A4) precursor-like protein 2 -0.00427032
PHACTR2 phosphatase and actin regulator 2 -0.00426377
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) -0.00426365
HOXC6 homeobox C6 -0.00426208
CALB2 calbindin 2 -0.00425616
FKBP4 FK506 binding protein 4, 59kDa -0.00425439
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -0.00424939
EVI2A ecotropic viral integration site 2A -0.00424608
TMC6 transmembrane channel-like 6 -0.00424059
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 -0.00423269
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 -0.00423054
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 -0.00422798
USP3 ubiquitin specific peptidase 3 -0.00422531
SCARB1 scavenger receptor class B, member 1 -0.0042233
OFD1 oral-facial-digital syndrome 1 -0.00422242
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0042146
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 -0.00420769
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase -0.00420079
CHPF chondroitin polymerizing factor -0.00419166
TMEM165 transmembrane protein 165 -0.00418664
LEPROTL1 leptin receptor overlapping transcript-like 1 -0.00417452
BHMT betaine--homocysteine S-methyltransferase -0.00417112
RTN3 reticulon 3 -0.00417016
LGALS8 lectin, galactoside-binding, soluble, 8 -0.00416719