BMF Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description Bcl2 modifying factor|The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 90427)
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Genes

343 genes differentially expressed following the BMF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PADI4 peptidyl arginine deiminase, type IV 3.1739
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.94798
AQP9 aquaporin 9 2.94798
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.94798
SCUBE1 signal peptide, CUB domain, EGF-like 1 2.94798
ZPLD1 zona pellucida-like domain containing 1 2.94798
GREM1 gremlin 1, DAN family BMP antagonist 2.94798
CNTNAP4 contactin associated protein-like 4 2.94798
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.94798
PARVG parvin, gamma 2.94798
GJB5 gap junction protein, beta 5, 31.1kDa 2.94798
CD8A CD8a molecule 2.94798
EPHX4 epoxide hydrolase 4 2.94798
BTN1A1 butyrophilin, subfamily 1, member A1 2.94798
RAD51AP2 RAD51 associated protein 2 2.94798
STKLD1 serine/threonine kinase-like domain containing 1 2.94798
LAMB3 laminin, beta 3 2.94798
RDH16 retinol dehydrogenase 16 (all-trans) 2.94798
LOC122526780 uncharacterized LOC122526780 2.94798
IRX5 iroquois homeobox 5 2.94798
C1R complement component 1, r subcomponent 2.94798
SLC46A2 solute carrier family 46, member 2 2.94798
RNASE6 ribonuclease, RNase A family, k6 2.94798
PRR22 proline rich 22 2.94798
FOXR1 forkhead box R1 2.90655
ALG1L2 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2 2.90655
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.90655
ELSPBP1 epididymal sperm binding protein 1 2.90655
PDZD9 PDZ domain containing 9 2.90655
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.90655
IZUMO3 IZUMO family member 3 2.90655
HORMAD1 HORMA domain containing 1 2.90655
CAMP cathelicidin antimicrobial peptide 2.90655
SPINK1 serine peptidase inhibitor, Kazal type 1 2.90655
IL22RA1 interleukin 22 receptor, alpha 1 2.90655
GFAP glial fibrillary acidic protein 2.90655
OLIG3 oligodendrocyte transcription factor 3 2.90655
MEIKIN meiotic kinetochore factor 2.90655
ANKK1 ankyrin repeat and kinase domain containing 1 2.90655
PRSS22 protease, serine, 22 2.90655
C1GALT1C1L C1GALT1-specific chaperone 1 like 2.90655
GPR101 G protein-coupled receptor 101 2.90655
BMP5 bone morphogenetic protein 5 2.90655
MYO1G myosin IG 2.90655
RXRG retinoid X receptor, gamma 2.90655
CELA1 chymotrypsin-like elastase family, member 1 2.90655
PSCA prostate stem cell antigen 2.90655
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.90655
SIGLEC9 sialic acid binding Ig-like lectin 9 2.90655
MSC musculin 2.90655
TUBB1 tubulin, beta 1 class VI 2.90655
GPR25 G protein-coupled receptor 25 2.90655
TRAT1 T cell receptor associated transmembrane adaptor 1 2.90655
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.90655
HAS1 hyaluronan synthase 1 2.90655
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.90655
FGF7 fibroblast growth factor 7 2.90655
TXLNB taxilin beta 2.90655
SPMIP10 sperm microtubule inner protein 10 2.90655
VSIR V-set immunoregulatory receptor 2.90655
GOLGA6L7 golgin A6 family like 7 2.90655
CES4A carboxylesterase 4A 2.90655
TMOD4 tropomodulin 4 (muscle) 2.90655
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.90655
POM121L2 POM121 transmembrane nucleoporin-like 2 2.90655
FRG2C FSHD region gene 2 family, member C 2.90655
PAPOLB poly(A) polymerase beta (testis specific) 2.90655
ASB9 ankyrin repeat and SOCS box containing 9 2.90655
GPR37L1 G protein-coupled receptor 37 like 1 2.90655
ODAD1 outer dynein arm docking complex subunit 1 2.90655
PLAAT4 phospholipase A and acyltransferase 4 2.90655
THSD8 thrombospondin type 1 domain containing 8 2.90655
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.90655
CFAP97D2 CFAP97 domain containing 2 2.90655
LHFPL7 LHFPL tetraspan subfamily member 7 2.90655
CPHXL cytoplasmic polyadenylated homeobox like 2.90655
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.90655
DUSP29 dual specificity phosphatase 29 2.90655
CGB3 chorionic gonadotropin subunit beta 3 2.90655
VEGFD vascular endothelial growth factor D 2.90655
LORICRIN loricrin cornified envelope precursor protein 2.90655
TBX10 T-box 10 2.90655
ACE2 angiotensin I converting enzyme 2 2.90655
PTGDR2 prostaglandin D2 receptor 2 2.90655
LGALS7B lectin, galactoside-binding, soluble, 7B 2.90655
CFAP99 cilia and flagella associated protein 99 2.90655
MTNR1B melatonin receptor 1B 2.90655
ACOT1 acyl-CoA thioesterase 1 2.90655
LBHD1 LBH domain containing 1 2.90655
SYCP2 synaptonemal complex protein 2 2.90655
TMPRSS11F transmembrane protease, serine 11F 2.90655
HRH4 histamine receptor H4 2.90655
FOLR1 folate receptor 1 (adult) 2.90655
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.90655
CCR3 chemokine (C-C motif) receptor 3 2.90655
PXDC1 PX domain containing 1 2.90655
HAL histidine ammonia-lyase 2.90655
FRK fyn-related Src family tyrosine kinase 2.90655
FGFBP1 fibroblast growth factor binding protein 1 2.90655
FAM131C family with sequence similarity 131, member C 2.90655
SAMD12 sterile alpha motif domain containing 12 2.90655
PGA5 pepsinogen 5, group I (pepsinogen A) 2.90655
C6 complement component 6 2.90655
CDKN2A cyclin-dependent kinase inhibitor 2A 2.90655
CDSN corneodesmosin 2.90655
MVP major vault protein 2.90655
FAM81B family with sequence similarity 81, member B 2.90655
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.90655
LRTM2 leucine-rich repeats and transmembrane domains 2 2.90655
DYDC1 DPY30 domain containing 1 2.90655
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.90655
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.90655
CABP7 calcium binding protein 7 2.90655
HGFAC HGF activator 2.90655
GLOD5 glyoxalase domain containing 5 2.90655
KRT17 keratin 17, type I 2.90655
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 2.90655
NOBOX NOBOX oogenesis homeobox 2.90655
PRSS54 protease, serine, 54 2.90655
C8ORF89 chromosome 8 open reading frame 89 2.90655
SCP2D1 SCP2 sterol-binding domain containing 1 2.90655
CALML6 calmodulin-like 6 2.90655
SLC38A8 solute carrier family 38, member 8 2.90655
IER5L immediate early response 5-like 2.90655
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.90655
CERS3 ceramide synthase 3 2.90655
CERKL ceramide kinase-like 2.90655
GPR61 G protein-coupled receptor 61 2.90655
PSKH2 protein serine kinase H2 2.90655
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 2.90655
SIAH3 siah E3 ubiquitin protein ligase family member 3 2.90655
CLEC4G C-type lectin domain family 4, member G 2.90655
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.90655
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.90655
AKNAD1 AKNA domain containing 1 2.90655
HPX hemopexin 2.90655
EGR3 early growth response 3 2.90655
GML glycosylphosphatidylinositol anchored molecule like 2.90655
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.90655
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.90655
RAD54B RAD54 homolog B (S. cerevisiae) 2.90655
COMP cartilage oligomeric matrix protein 2.90655
C11ORF91 chromosome 11 open reading frame 91 2.90655
TPPP3 tubulin polymerization-promoting protein family member 3 2.90655
EFCAB3 EF-hand calcium binding domain 3 2.90655
RGS8 regulator of G-protein signaling 8 2.90655
TWIST1 twist family bHLH transcription factor 1 2.90655
C10ORF105 chromosome 10 open reading frame 105 2.90655
ASCL1 achaete-scute family bHLH transcription factor 1 2.90655
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.90655
FOXG1 forkhead box G1 2.90655
CD163 CD163 molecule 2.90655
ROM1 retinal outer segment membrane protein 1 2.90655
ADAM20 ADAM metallopeptidase domain 20 2.90655
CCNA1 cyclin A1 2.90655
MNX1 motor neuron and pancreas homeobox 1 2.90655
R3HDML R3H domain containing-like 2.90655
GRM6 glutamate receptor, metabotropic 6 2.90655
MEIG1 meiosis/spermiogenesis associated 1 2.90655
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.90655
ZNF835 zinc finger protein 835 2.90655
WFDC11 WAP four-disulfide core domain 11 2.90655
C22ORF31 chromosome 22 open reading frame 31 2.90655
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.90655
LRRC24 leucine rich repeat containing 24 2.90655
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.90655
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.90655
HLA-G major histocompatibility complex, class I, G 2.90655
ST18 suppression of tumorigenicity 18, zinc finger 2.90655
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.90655
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.90655
HPGDS hematopoietic prostaglandin D synthase 2.90655
LMAN1L lectin, mannose-binding, 1 like 2.90655
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.90655
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.90655
PLGLB1 plasminogen-like B1 2.90655
MC5R melanocortin 5 receptor 2.90655
PRR15L proline rich 15-like 2.90655
FRMPD1 FERM and PDZ domain containing 1 2.90655
GRB2 growth factor receptor-bound protein 2 2.83871
BCL6B B-cell CLL/lymphoma 6, member B 2.80552
ZC3H11A zinc finger CCCH-type containing 11A 2.80552
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.80552
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 2.80552
PGM3 phosphoglucomutase 3 2.73375
SETD1A SET domain containing 1A 2.72522
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 2.72522
ZNF221 zinc finger protein 221 2.69789
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 2.69789
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 2.69789
CSNK1E casein kinase 1, epsilon 2.69366
DVL3 dishevelled segment polarity protein 3 2.67869
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.63747
EZR ezrin 2.61821
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 2.61119
SP110 SP110 nuclear body protein 2.54727
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.52571
DLEU7 deleted in lymphocytic leukemia, 7 2.50317
CCDC9 coiled-coil domain containing 9 2.50264
TMEM63A transmembrane protein 63A 2.49928
TMEM268 transmembrane protein 268 2.45185
FABP5 fatty acid binding protein 5 (psoriasis-associated) 2.44718
RASD1 RAS, dexamethasone-induced 1 2.4259
LSM10 LSM10, U7 small nuclear RNA associated 2.42013
BANK1 B-cell scaffold protein with ankyrin repeats 1 2.41073
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.4068
VANGL2 VANGL planar cell polarity protein 2 2.33426
RPL13A ribosomal protein L13a 2.29642
MOB1B MOB kinase activator 1B 2.29176
MTCL1 microtubule crosslinking factor 1 2.27782
TRIM25 tripartite motif containing 25 2.25957
WDR17 WD repeat domain 17 2.25881
DOT1L DOT1-like histone H3K79 methyltransferase 2.23668
IQCH IQ motif containing H 2.21174
RPL27 ribosomal protein L27 2.21049
ARMH3 armadillo like helical domain containing 3 2.20756
NHSL2 NHS-like 2 2.19977
EXD3 exonuclease 3'-5' domain containing 3 2.18096
ATAD3B ATPase family, AAA domain containing 3B 2.1697
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 2.1697
NUBP2 nucleotide binding protein 2 2.13784
ANKRD13A ankyrin repeat domain 13A 2.13784
POMP proteasome maturation protein 2.13784
PREP prolyl endopeptidase 2.12169
FSIP2 fibrous sheath interacting protein 2 2.11772
GDF15 growth differentiation factor 15 2.11772
MIER1 mesoderm induction early response 1, transcriptional regulator 2.08875
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 2.08053
DCPH1 damage control phosphatase 1 2.07174
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 2.06259
CCDC107 coiled-coil domain containing 107 2.06259
TGFB1 transforming growth factor, beta 1 2.05598
TUBG1 tubulin, gamma 1 2.04876
ZNF227 zinc finger protein 227 2.03963
PFKP phosphofructokinase, platelet 2.03963
ARHGAP10 Rho GTPase activating protein 10 2.03932
ZNF766 zinc finger protein 766 2.03611
NUP88 nucleoporin 88kDa 2.03435
TCTN3 tectonic family member 3 2.02827
RCN2 reticulocalbin 2, EF-hand calcium binding domain 2.02827
PELO pelota homolog (Drosophila) 2.02818
SIPA1L3 signal-induced proliferation-associated 1 like 3 2.02566
DNAI4 dynein axonemal intermediate chain 4 2.02449
LAT linker for activation of T cells 2.01164
ZNF526 zinc finger protein 526 2.00253

decreased expression

Symbol Name Standardized Value
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 -2.94798
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -2.94798
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 -2.94798
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -2.90655
MAMDC2 MAM domain containing 2 -2.90655
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -2.90655
SOAT1 sterol O-acyltransferase 1 -2.90655
CHL1 cell adhesion molecule L1-like -2.90655
SLC30A10 solute carrier family 30, member 10 -2.90655
CHD5 chromodomain helicase DNA binding protein 5 -2.90655
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) -2.90655
HNMT histamine N-methyltransferase -2.90655
ETV4 ets variant 4 -2.90655
FAM76A family with sequence similarity 76, member A -2.90655
LAPTM5 lysosomal protein transmembrane 5 -2.80552
SH2D7 SH2 domain containing 7 -2.80552
CA1 carbonic anhydrase I -2.80552
MROH6 maestro heat-like repeat family member 6 -2.80552
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.80552
DUSP13B dual specificity phosphatase 13B -2.80552
MEP1B meprin A, beta -2.80552
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -2.80552
H3C13 H3 clustered histone 13 -2.80552
ALKAL1 ALK and LTK ligand 1 -2.80552
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.80552
PROC protein C (inactivator of coagulation factors Va and VIIIa) -2.80552
ZNF441 zinc finger protein 441 -2.80552
NGEF neuronal guanine nucleotide exchange factor -2.80552
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -2.80552
BARX1 BARX homeobox 1 -2.80552
C1QL2 complement component 1, q subcomponent-like 2 -2.80552
TFEB transcription factor EB -2.80552
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 -2.80552
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.80552
CHRD chordin -2.80552
PCDHB12 protocadherin beta 12 -2.80552
CSNK2A3 casein kinase 2, alpha 3 polypeptide -2.80552
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.80552
KIFC2 kinesin family member C2 -2.80552
ARL13A ADP-ribosylation factor-like 13A -2.80552
ZNF471 zinc finger protein 471 -2.80552
ARL9 ADP-ribosylation factor-like 9 -2.80552
LRRC3 leucine rich repeat containing 3 -2.80552
LRRN4 leucine rich repeat neuronal 4 -2.80552
GTF2A1L general transcription factor IIA, 1-like -2.80552
SYTL3 synaptotagmin-like 3 -2.80552
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.80552
ACAN aggrecan -2.80552
MEIOB meiosis specific with OB domains -2.80552
LRRC26 leucine rich repeat containing 26 -2.80552
CCDC73 coiled-coil domain containing 73 -2.80552
FAM209A family with sequence similarity 209, member A -2.80552
VRK3 vaccinia related kinase 3 -2.7267
EFTUD2 elongation factor Tu GTP binding domain containing 2 -2.7114
RACGAP1 Rac GTPase activating protein 1 -2.69294
ZSCAN22 zinc finger and SCAN domain containing 22 -2.67869
HSPB8 heat shock 22kDa protein 8 -2.67869
ITLN2 intelectin 2 -2.67869
CLPSL1 colipase-like 1 -2.65771
LRRC39 leucine rich repeat containing 39 -2.65771
PLPPR4 phospholipid phosphatase related 4 -2.65771
TMEM234 transmembrane protein 234 -2.65251
GPR157 G protein-coupled receptor 157 -2.65251
SNX10 sorting nexin 10 -2.64928
C9ORF72 chromosome 9 open reading frame 72 -2.45031
MARVELD1 MARVEL domain containing 1 -2.44437
CMBL carboxymethylenebutenolidase homolog (Pseudomonas) -2.41352
MAP2 microtubule-associated protein 2 -2.41352
SEC63 SEC63 homolog (S. cerevisiae) -2.39591
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -2.34381
PDE7A phosphodiesterase 7A -2.34203
ATP13A1 ATPase type 13A1 -2.2888
SKAP1 src kinase associated phosphoprotein 1 -2.26404
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 -2.25882
SLC45A1 solute carrier family 45, member 1 -2.25881
TLK1 tousled-like kinase 1 -2.2285
ZNF239 zinc finger protein 239 -2.21174
APOC1 apolipoprotein C-I -2.20716
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -2.1882
PDE4B phosphodiesterase 4B, cAMP-specific -2.18167
MRFAP1L2 Morf4 family associated protein 1 like 2 -2.1747
CDK15 cyclin-dependent kinase 15 -2.167
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -2.15956
RPL4 ribosomal protein L4 -2.14918
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -2.14032
NOXRED1 NADP-dependent oxidoreductase domain containing 1 -2.13788
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -2.12227
CCDC180 coiled-coil domain containing 180 -2.08875
ZNF706 zinc finger protein 706 -2.07178
ZNF264 zinc finger protein 264 -2.07178
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -2.07149
TPRA1 transmembrane protein, adipocyte asscociated 1 -2.05598
GOLGA5 golgin A5 -2.03932
PRRT2 proline-rich transmembrane protein 2 -2.03133
BIN1 bridging integrator 1 -2.02864
LIPE lipase, hormone-sensitive -2.00393
PRH1 proline-rich protein HaeIII subfamily 1 -2.00393
CRAMP1 cramped chromatin regulator homolog 1 -2.00256