BMI1_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/BMI1_DN.V1_UP
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Genes

291 genes differentially expressed following the BMI1_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAM12 ADAM metallopeptidase domain 12
ADGRE5 adhesion G protein-coupled receptor E5
ADRB2 adrenoceptor beta 2, surface
AGRN agrin
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
ASPH aspartate beta-hydroxylase
ATF6 activating transcription factor 6
ATP13A2 ATPase type 13A2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BDKRB2 bradykinin receptor B2
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BST1 bone marrow stromal cell antigen 1
C2CD2L C2CD2-like
C3AR1 complement component 3a receptor 1
C8ORF4 chromosome 8 open reading frame 4
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD82 CD82 molecule
CDCP1 CUB domain containing protein 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CLDN1 claudin 1
CLSPN claspin
COL13A1 collagen, type XIII, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL7A1 collagen, type VII, alpha 1
CPA4 carboxypeptidase A4
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSPG4 chondroitin sulfate proteoglycan 4
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CTNS cystinosin, lysosomal cystine transporter
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDN1 endothelin 1
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
FADS3 fatty acid desaturase 3
FAM57A family with sequence similarity 57, member A
FAP fibroblast activation protein, alpha
FES FES proto-oncogene, tyrosine kinase
FGF21 fibroblast growth factor 21
FGFR1 fibroblast growth factor receptor 1
FJX1 four jointed box 1 (Drosophila)
FKRP fukutin related protein
FLNB filamin B, beta
FOXP3 forkhead box P3
FURIN furin (paired basic amino acid cleaving enzyme)
FZD5 frizzled class receptor 5
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAL galanin/GMAP prepropeptide
GDF5 growth differentiation factor 5
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
HAPLN1 hyaluronan and proteoglycan link protein 1
HAS2 hyaluronan synthase 2
HBEGF heparin-binding EGF-like growth factor
HOXB1 homeobox B1
IGKC immunoglobulin kappa constant
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INHBE inhibin, beta E
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB6 integrin, beta 6
ITGB8 integrin, beta 8
JAG1 jagged 1
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KMT2A lysine (K)-specific methyltransferase 2A
KRT17 keratin 17, type I
LAMB3 laminin, beta 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LHFPL2 lipoma HMGIC fusion partner-like 2
LIF leukemia inhibitory factor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP5 low density lipoprotein receptor-related protein 5
LRRC15 leucine rich repeat containing 15
LSAMP limbic system-associated membrane protein
LTBP4 latent transforming growth factor beta binding protein 4
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
NOV nephroblastoma overexpressed
NRP2 neuropilin 2
NT5E 5'-nucleotidase, ecto (CD73)
P3H3 prolyl 3-hydroxylase 3
PANX1 pannexin 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PDCD1LG2 programmed cell death 1 ligand 2
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLAT plasminogen activator, tissue
PLXNA2 plexin A2
PMEPA1 prostate transmembrane protein, androgen induced 1
PODXL podocalyxin-like
POMT2 protein-O-mannosyltransferase 2
PROP1 PROP paired-like homeobox 1
PSG5 pregnancy specific beta-1-glycoprotein 5
PTHLH parathyroid hormone-like hormone
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SIRPA signal-regulatory protein alpha
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SRPX2 sushi-repeat containing protein, X-linked 2
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TAGLN transgelin
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TEK TEK tyrosine kinase, endothelial
TGFB2 transforming growth factor, beta 2
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM51 transmembrane protein 51
TMEM62 transmembrane protein 62
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIO trio Rho guanine nucleotide exchange factor
VANGL1 VANGL planar cell polarity protein 1
VEGFC vascular endothelial growth factor C
VLDLR very low density lipoprotein receptor
VNN1 vanin 1

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ALX4 ALX homeobox 4
API5 apoptosis inhibitor 5
ARHGAP12 Rho GTPase activating protein 12
ARHGAP15 Rho GTPase activating protein 15
BLVRB biliverdin reductase B
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BST2 bone marrow stromal cell antigen 2
C17ORF59 chromosome 17 open reading frame 59
C1ORF54 chromosome 1 open reading frame 54
C2ORF27A chromosome 2 open reading frame 27A
CA2 carbonic anhydrase II
CAB39 calcium binding protein 39
CCKAR cholecystokinin A receptor
CDH22 cadherin 22, type 2
CES1 carboxylesterase 1
CHL1 cell adhesion molecule L1-like
CHMP2B charged multivesicular body protein 2B
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLDN16 claudin 16
CLIP3 CAP-GLY domain containing linker protein 3
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COL9A3 collagen, type IX, alpha 3
CREM cAMP responsive element modulator
CTAG1A cancer/testis antigen 1A
CTNNBIP1 catenin, beta interacting protein 1
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
DCTN6 dynactin 6
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOK5 docking protein 5
DPYD dihydropyrimidine dehydrogenase
DYNLT3 dynein, light chain, Tctex-type 3
ECH1 enoyl CoA hydratase 1, peroxisomal
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF4B eukaryotic translation initiation factor 4B
EPHA4 EPH receptor A4
ESRP1 epithelial splicing regulatory protein 1
ETFB electron-transfer-flavoprotein, beta polypeptide
ETV1 ets variant 1
FAM76A family with sequence similarity 76, member A
FLJ42627 uncharacterized LOC645644
FOS FBJ murine osteosarcoma viral oncogene homolog
GAS2 growth arrest-specific 2
GAS7 growth arrest-specific 7
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPR162 G protein-coupled receptor 162
GPR88 G protein-coupled receptor 88
GPX3 glutathione peroxidase 3
GTF2A1L general transcription factor IIA, 1-like
GTF2I general transcription factor IIi
HIST1H3G histone cluster 1, H3g
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HOXB13 homeobox B13
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
ISOC1 isochorismatase domain containing 1
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF15 Kruppel-like factor 15
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LECT1 leukocyte cell derived chemotaxin 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR2 lysophosphatidic acid receptor 2
MAOB monoamine oxidase B
METTL7A methyltransferase like 7A
MGC2889 uncharacterized protein MGC2889
MSRB2 methionine sulfoxide reductase B2
MSX2 msh homeobox 2
MVP major vault protein
MYH13 myosin, heavy chain 13, skeletal muscle
NDRG2 NDRG family member 2
NENF neudesin neurotrophic factor
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
PADI2 peptidyl arginine deiminase, type II
PCDH8 protocadherin 8
PCP4 Purkinje cell protein 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDE4B phosphodiesterase 4B, cAMP-specific
PDE5A phosphodiesterase 5A, cGMP-specific
PEG3 paternally expressed 3
PID1 phosphotyrosine interaction domain containing 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAC4 placenta-specific 4
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
PLS1 plastin 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRDX2 peroxiredoxin 2
PRPF6 pre-mRNA processing factor 6
PRPH peripherin
RPL18AP16 ribosomal protein L18a pseudogene 16
RPS20P14 ribosomal protein S20 pseudogene 14
RXRG retinoid X receptor, gamma
S100A4 S100 calcium binding protein A4
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SEPP1 selenoprotein P, plasma, 1
SFXN1 sideroflexin 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIM1 single-minded family bHLH transcription factor 1
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SNAI1 snail family zinc finger 1
SNX4 sorting nexin 4
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SOX2 SRY (sex determining region Y)-box 2
SSBP2 single-stranded DNA binding protein 2
SSPN sarcospan
STON1 stonin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TCEAL2 transcription elongation factor A (SII)-like 2
TEX14 testis expressed 14
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF2 trefoil factor 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNNT1 troponin T type 1 (skeletal, slow)
TNP1 transition protein 1 (during histone to protamine replacement)
TP63 tumor protein p63
TRAF3IP2 TRAF3 interacting protein 2
TRAPPC6A trafficking protein particle complex 6A
TRIM2 tripartite motif containing 2
TRPS1 trichorhinophalangeal syndrome I
TSPAN1 tetraspanin 1
TSPO translocator protein (18kDa)
TTC33 tetratricopeptide repeat domain 33
VAV3 vav 3 guanine nucleotide exchange factor
WDR25 WD repeat domain 25
WFDC2 WAP four-disulfide core domain 2
WNT16 wingless-type MMTV integration site family, member 16
ZNF423 zinc finger protein 423