| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/9969021 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in BML-277 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GLUL | glutamate-ammonia ligase | 1.87 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 1.68 |
| RITA1 | RBPJ interacting and tubulin associated 1 | 1.06 |
| PLA2G12A | phospholipase A2, group XIIA | 0.88 |
| BPTF | bromodomain PHD finger transcription factor | 0.78 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.78 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | 0.76 |
| CRELD1 | cysteine-rich with EGF-like domains 1 | 0.73 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.7 |
| SESN2 | sestrin 2 | 0.69 |
| BBS10 | Bardet-Biedl syndrome 10 | 0.68 |
| HOXB9 | homeobox B9 | 0.67 |
| GOLGA4 | golgin A4 | 0.66 |
| NES | nestin | 0.66 |
| ANKLE1 | ankyrin repeat and LEM domain containing 1 | 0.65 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | 0.64 |
| EWSR1 | EWS RNA-binding protein 1 | 0.63 |
| LETMD1 | LETM1 domain containing 1 | 0.62 |
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.62 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.62 |
| CEP128 | centrosomal protein 128kDa | 0.62 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.62 |
| TMX3 | thioredoxin-related transmembrane protein 3 | 0.61 |
| ZNF428 | zinc finger protein 428 | 0.61 |
| CCDC85B | coiled-coil domain containing 85B | 0.6 |
| CENPH | centromere protein H | 0.59 |
| TUT1 | terminal uridylyl transferase 1, U6 snRNA-specific | 0.58 |
| SPIN2B | spindlin family, member 2B | 0.57 |
| FAM219B | family with sequence similarity 219, member B | 0.54 |
| TRIB1 | tribbles pseudokinase 1 | 0.54 |
| MOB3A | MOB kinase activator 3A | 0.54 |
| TSPAN31 | tetraspanin 31 | 0.54 |
| VWDE | von Willebrand factor D and EGF domains | 0.53 |
| MEGF9 | multiple EGF-like-domains 9 | 0.53 |
| CHPF2 | chondroitin polymerizing factor 2 | 0.53 |
| NUDT7 | nudix (nucleoside diphosphate linked moiety X)-type motif 7 | 0.53 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.53 |
| TMEM39B | transmembrane protein 39B | 0.51 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | 0.51 |
| C15ORF61 | chromosome 15 open reading frame 61 | 0.5 |
| IFRD1 | interferon-related developmental regulator 1 | 0.5 |
| APLP1 | amyloid beta (A4) precursor-like protein 1 | 0.5 |
| CLK3 | CDC-like kinase 3 | 0.49 |
| NRBP2 | nuclear receptor binding protein 2 | 0.49 |
| SPEG | SPEG complex locus | 0.49 |
| KIAA1586 | KIAA1586 | 0.49 |
| BAIAP2 | BAI1-associated protein 2 | 0.49 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.49 |
| TSPAN5 | tetraspanin 5 | 0.49 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | 0.49 |
| RPS6KB2 | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | 0.48 |
| CLK1 | CDC-like kinase 1 | 0.48 |
| RPL36A | ribosomal protein L36a | 0.47 |
| NPNT | nephronectin | 0.46 |
| NKTR | natural killer cell triggering receptor | 0.46 |
| FICD | FIC domain containing | 0.46 |
| RANBP6 | RAN binding protein 6 | 0.45 |
| KIAA1191 | KIAA1191 | 0.45 |
| FJX1 | four jointed box 1 (Drosophila) | 0.45 |
| DUOX1 | dual oxidase 1 | 0.45 |
| ACTBL2 | actin, beta-like 2 | 0.44 |
| DENND5A | DENN/MADD domain containing 5A | 0.44 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | 0.44 |
| RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | 0.43 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 0.43 |
| POLH | polymerase (DNA directed), eta | 0.43 |
| CPA4 | carboxypeptidase A4 | 0.43 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.42 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | 0.42 |
| RPAIN | RPA interacting protein | 0.42 |
| VCAN | versican | 0.42 |
| CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2) | 0.42 |
| SH3YL1 | SH3 and SYLF domain containing 1 | 0.42 |
| MPZL2 | myelin protein zero-like 2 | 0.41 |
| SLC38A2 | solute carrier family 38, member 2 | 0.41 |
| WNT10B | wingless-type MMTV integration site family, member 10B | 0.41 |
| ACYP1 | acylphosphatase 1, erythrocyte (common) type | 0.41 |
| NAA40 | N(alpha)-acetyltransferase 40, NatD catalytic subunit | 0.41 |
| NEMP1 | nuclear envelope integral membrane protein 1 | 0.41 |
| TRIM14 | tripartite motif containing 14 | 0.41 |
| SPPL2A | signal peptide peptidase like 2A | 0.41 |
| FUNDC1 | FUN14 domain containing 1 | 0.4 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.4 |
| CLK2 | CDC-like kinase 2 | 0.4 |
| STK19 | serine/threonine kinase 19 | 0.39 |
| RAB25 | RAB25, member RAS oncogene family | 0.39 |
| NFATC2IP | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein | 0.39 |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.39 |
| GLS | glutaminase | 0.39 |
| AUNIP | aurora kinase A and ninein interacting protein | 0.39 |
| TRAK2 | trafficking protein, kinesin binding 2 | 0.39 |
| TMEM223 | transmembrane protein 223 | 0.39 |
| DROSHA | drosha, ribonuclease type III | 0.39 |
| TMEM222 | transmembrane protein 222 | 0.39 |
| ACTR1B | ARP1 actin-related protein 1 homolog B, centractin beta (yeast) | 0.38 |
| CCDC66 | coiled-coil domain containing 66 | 0.38 |
| MSH5 | mutS homolog 5 | 0.38 |
| LRRC40 | leucine rich repeat containing 40 | 0.38 |
| FBXW9 | F-box and WD repeat domain containing 9 | 0.38 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | 0.38 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | -1.34 |
| UBXN2B | UBX domain protein 2B | -1.09 |
| KLHL23 | kelch-like family member 23 | -1.04 |
| ANKRD20A4 | ankyrin repeat domain 20 family, member A4 | -0.98 |
| LUC7L | LUC7-like (S. cerevisiae) | -0.91 |
| ZBED6 | zinc finger, BED-type containing 6 | -0.91 |
| KIAA1109 | KIAA1109 | -0.9 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.84 |
| DNAJA4 | DnaJ (Hsp40) homolog, subfamily A, member 4 | -0.82 |
| NBN | nibrin | -0.78 |
| BAIAP3 | BAI1-associated protein 3 | -0.77 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | -0.76 |
| ABHD4 | abhydrolase domain containing 4 | -0.75 |
| TBC1D32 | TBC1 domain family, member 32 | -0.75 |
| PRR3 | proline rich 3 | -0.72 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.72 |
| JAK1 | Janus kinase 1 | -0.69 |
| MAX | MYC associated factor X | -0.67 |
| ZNF865 | zinc finger protein 865 | -0.67 |
| HMBOX1 | homeobox containing 1 | -0.67 |
| R3HDM2 | R3H domain containing 2 | -0.66 |
| ERICH1 | glutamate-rich 1 | -0.65 |
| RPRD1A | regulation of nuclear pre-mRNA domain containing 1A | -0.65 |
| KLHL42 | kelch-like family member 42 | -0.64 |
| LRRK1 | leucine-rich repeat kinase 1 | -0.64 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.64 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | -0.63 |
| SLC16A6 | solute carrier family 16, member 6 | -0.63 |
| SENP7 | SUMO1/sentrin specific peptidase 7 | -0.62 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.62 |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase | -0.61 |
| PRRX2 | paired related homeobox 2 | -0.61 |
| FAM193B | family with sequence similarity 193, member B | -0.61 |
| FAM160B2 | family with sequence similarity 160, member B2 | -0.6 |
| SHFL | shiftless antiviral inhibitor of ribosomal frameshifting | -0.6 |
| PLEKHA7 | pleckstrin homology domain containing, family A member 7 | -0.6 |
| TMEM175 | transmembrane protein 175 | -0.6 |
| BCORL1 | BCL6 corepressor-like 1 | -0.6 |
| ACAD11 | acyl-CoA dehydrogenase family, member 11 | -0.6 |
| VASN | vasorin | -0.59 |
| SRR | serine racemase | -0.59 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -0.58 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.58 |
| MRE11 | MRE11 homolog, double strand break repair nuclease | -0.57 |
| TCTN1 | tectonic family member 1 | -0.57 |
| ZNF444 | zinc finger protein 444 | -0.57 |
| PCYOX1L | prenylcysteine oxidase 1 like | -0.57 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.57 |
| ANKRD10 | ankyrin repeat domain 10 | -0.56 |
| SUCO | SUN domain containing ossification factor | -0.56 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.55 |
| DAP | death-associated protein | -0.55 |
| STXBP4 | syntaxin binding protein 4 | -0.55 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.54 |
| MROH6 | maestro heat-like repeat family member 6 | -0.54 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.54 |
| TTC8 | tetratricopeptide repeat domain 8 | -0.54 |
| KIAA1107 | KIAA1107 | -0.53 |
| CEP72 | centrosomal protein 72kDa | -0.53 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.53 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.52 |
| EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | -0.52 |
| GNB1L | guanine nucleotide binding protein (G protein), beta polypeptide 1-like | -0.52 |
| RIBC2 | RIB43A domain with coiled-coils 2 | -0.52 |
| TCTEX1D2 | Tctex1 domain containing 2 | -0.52 |
| WDYHV1 | WDYHV motif containing 1 | -0.51 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.51 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | -0.51 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.51 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.5 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | -0.5 |
| HELLS | helicase, lymphoid-specific | -0.5 |
| ZNF567 | zinc finger protein 567 | -0.5 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | -0.5 |
| SLX4IP | SLX4 interacting protein | -0.5 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.49 |
| C1ORF43 | chromosome 1 open reading frame 43 | -0.49 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | -0.49 |
| BOK | BCL2-related ovarian killer | -0.49 |
| NOS1 | nitric oxide synthase 1 (neuronal) | -0.49 |
| CCDC112 | coiled-coil domain containing 112 | -0.49 |
| TMEM134 | transmembrane protein 134 | -0.49 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.48 |
| LMBR1 | limb development membrane protein 1 | -0.48 |
| BBS7 | Bardet-Biedl syndrome 7 | -0.48 |
| TYK2 | tyrosine kinase 2 | -0.48 |
| MTFR2 | mitochondrial fission regulator 2 | -0.48 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | -0.48 |
| COL6A6 | collagen, type VI, alpha 6 | -0.48 |
| MAGEB1 | melanoma antigen family B1 | -0.48 |
| WRNIP1 | Werner helicase interacting protein 1 | -0.47 |
| CPNE5 | copine V | -0.47 |
| TTC13 | tetratricopeptide repeat domain 13 | -0.47 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.47 |
| PTOV1 | prostate tumor overexpressed 1 | -0.47 |
| RAB37 | RAB37, member RAS oncogene family | -0.47 |
| IARS | isoleucyl-tRNA synthetase | -0.46 |
| EGR1 | early growth response 1 | -0.46 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.46 |
