BMPR1B Gene Set

Dataset KEA Substrates of Kinases
Category physical interactions
Type kinase
Description bone morphogenetic protein receptor, type IB|This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 658)
External Link http://www.ncbi.nlm.nih.gov/gene/658
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Genes

11 substrates of the kinase BMPR1B from the curated KEA Substrates of Kinases dataset.

Symbol Name
BMPR1A bone morphogenetic protein receptor, type IA
CDK14 cyclin-dependent kinase 14
CDK4 cyclin-dependent kinase 4
OXSR1 oxidative stress responsive 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
STAMBP STAM binding protein
STK35 serine/threonine kinase 35
TGFBR1 transforming growth factor, beta receptor 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase