BMPR1B Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description bone morphogenetic protein receptor, type IB|This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 658)
External Link http://www.ncbi.nlm.nih.gov/gene/658
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Genes

100 interacting proteins for BMPR1B from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
AMHR2 anti-Mullerian hormone receptor, type II
APP amyloid beta (A4) precursor protein
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL13B ADP-ribosylation factor-like 13B
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BAMBI BMP and activin membrane-bound inhibitor
BCR breakpoint cluster region
BMP15 bone morphogenetic protein 15
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
CDK14 cyclin-dependent kinase 14
CDK4 cyclin-dependent kinase 4
CHN1 chimerin 1
DCAF12 DDB1 and CUL4 associated factor 12
DCAF6 DDB1 and CUL4 associated factor 6
DCAF7 DDB1 and CUL4 associated factor 7
FANCL Fanconi anemia, complementation group L
FBXO24 F-box protein 24
FBXO3 F-box protein 3
FBXO44 F-box protein 44
FBXW5 F-box and WD repeat domain containing 5
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
GDF5 growth differentiation factor 5
GDF6 growth differentiation factor 6
GDF9 growth differentiation factor 9
HRAS Harvey rat sarcoma viral oncogene homolog
IGSF1 immunoglobulin superfamily, member 1
ILKAP integrin-linked kinase-associated serine/threonine phosphatase
IRF7 interferon regulatory factor 7
KLHL1 kelch-like family member 1
LZTR1 leucine-zipper-like transcription regulator 1
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K7CL MAP3K7 C-terminal like
MKNK2 MAP kinase interacting serine/threonine kinase 2
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit
NKIRAS1 NFKB inhibitor interacting Ras-like 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OXSR1 oxidative stress responsive 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PEG10 paternally expressed 10
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
RAB25 RAB25, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAN RAN, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RASD2 RASD family, member 2
RASL12 RAS-like, family 12
RHEBL1 Ras homolog enriched in brain like 1
RHOBTB1 Rho-related BTB domain containing 1
RHOD ras homolog family member D
RHOJ ras homolog family member J
RPS27A ribosomal protein S27a
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SASH3 SAM and SH3 domain containing 3
SH3KBP1 SH3-domain kinase binding protein 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD5 SMAD family member 5
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNX6 sorting nexin 6
SOCS6 suppressor of cytokine signaling 6
SQSTM1 sequestosome 1
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
STAMBP STAM binding protein
STK35 serine/threonine kinase 35
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TGFBR1 transforming growth factor, beta receptor 1
TNNT1 troponin T type 1 (skeletal, slow)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TSC22D1 TSC22 domain family, member 1
TTC17 tetratricopeptide repeat domain 17
TTC27 tetratricopeptide repeat domain 27
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBC ubiquitin C
UBE2Z ubiquitin-conjugating enzyme E2Z
UBXN1 UBX domain protein 1
UHMK1 U2AF homology motif (UHM) kinase 1
USP15 ubiquitin specific peptidase 15
USP45 ubiquitin specific peptidase 45
VEPH1 ventricular zone expressed PH domain-containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase