| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/16747776 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in BMS 303141 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ALS2CL | ALS2 C-terminal like | 0.72 |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 0.53 |
| BPTF | bromodomain PHD finger transcription factor | 0.46 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | 0.45 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.44 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | 0.44 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.43 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.42 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 0.42 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.41 |
| AMPD1 | adenosine monophosphate deaminase 1 | 0.4 |
| TOR2A | torsin family 2, member A | 0.39 |
| MINDY4 | MINDY lysine 48 deubiquitinase 4 | 0.39 |
| FAM20C | family with sequence similarity 20, member C | 0.39 |
| ABHD4 | abhydrolase domain containing 4 | 0.38 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | 0.37 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.37 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.37 |
| CDC25B | cell division cycle 25B | 0.36 |
| ZNF777 | zinc finger protein 777 | 0.36 |
| TTC39B | tetratricopeptide repeat domain 39B | 0.35 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 0.35 |
| FBXO46 | F-box protein 46 | 0.35 |
| ZIC5 | Zic family member 5 | 0.35 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | 0.35 |
| TFPT | TCF3 (E2A) fusion partner (in childhood Leukemia) | 0.34 |
| ATMIN | ATM interactor | 0.34 |
| PIAS3 | protein inhibitor of activated STAT, 3 | 0.34 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.33 |
| HOXB7 | homeobox B7 | 0.33 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.33 |
| ZBED5 | zinc finger, BED-type containing 5 | 0.33 |
| PGBD1 | piggyBac transposable element derived 1 | 0.32 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | 0.32 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.32 |
| TMPO | thymopoietin | 0.32 |
| RNF166 | ring finger protein 166 | 0.32 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.32 |
| UPP1 | uridine phosphorylase 1 | 0.31 |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) | 0.31 |
| POLE3 | polymerase (DNA directed), epsilon 3, accessory subunit | 0.31 |
| ADAT2 | adenosine deaminase, tRNA-specific 2 | 0.31 |
| IRF2 | interferon regulatory factor 2 | 0.31 |
| FAAP100 | FA core complex associated protein 100 | 0.3 |
| HOXB8 | homeobox B8 | 0.3 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.3 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.3 |
| TPCN1 | two pore segment channel 1 | 0.3 |
| BORA | bora, aurora kinase A activator | 0.3 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | 0.3 |
| TMEM184A | transmembrane protein 184A | 0.3 |
| SKI | SKI proto-oncogene | 0.29 |
| FAM102B | family with sequence similarity 102, member B | 0.29 |
| CCDC170 | coiled-coil domain containing 170 | 0.29 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.29 |
| ZNF184 | zinc finger protein 184 | 0.28 |
| CHMP7 | charged multivesicular body protein 7 | 0.28 |
| MYL9 | myosin, light chain 9, regulatory | 0.28 |
| ZNF460 | zinc finger protein 460 | 0.27 |
| HOXA7 | homeobox A7 | 0.27 |
| SCARA3 | scavenger receptor class A, member 3 | 0.27 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.27 |
| JOSD1 | Josephin domain containing 1 | 0.27 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.27 |
| AP5M1 | adaptor-related protein complex 5, mu 1 subunit | 0.27 |
| PRMT6 | protein arginine methyltransferase 6 | 0.27 |
| RTEL1 | regulator of telomere elongation helicase 1 | 0.27 |
| MEX3C | mex-3 RNA binding family member C | 0.27 |
| TMEM51 | transmembrane protein 51 | 0.27 |
| PLIN2 | perilipin 2 | 0.27 |
| EEF2KMT | eukaryotic elongation factor 2 lysine methyltransferase | 0.26 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.26 |
| IFFO1 | intermediate filament family orphan 1 | 0.26 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.26 |
| TTC7B | tetratricopeptide repeat domain 7B | 0.26 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.26 |
| CCSER2 | coiled-coil serine-rich protein 2 | 0.26 |
| FZD2 | frizzled class receptor 2 | 0.26 |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 0.26 |
| TMEM177 | transmembrane protein 177 | 0.26 |
| PRR14L | proline rich 14-like | 0.25 |
| STX10 | syntaxin 10 | 0.25 |
| MYNN | myoneurin | 0.25 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.25 |
| CASTOR2 | cytosolic arginine sensor for mTORC1 subunit 2 | 0.25 |
| KIAA0556 | KIAA0556 | 0.25 |
| RTL6 | retrotransposon Gag like 6 | 0.25 |
| KIAA1324L | KIAA1324-like | 0.25 |
| GPANK1 | G patch domain and ankyrin repeats 1 | 0.25 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.25 |
| FAM171A2 | family with sequence similarity 171, member A2 | 0.25 |
| OAF | OAF homolog (Drosophila) | 0.25 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.25 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | 0.25 |
| CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta | 0.25 |
| CCDC112 | coiled-coil domain containing 112 | 0.25 |
| RPGRIP1L | RPGRIP1-like | 0.25 |
| ENDOV | endonuclease V | 0.24 |
| FAM89A | family with sequence similarity 89, member A | 0.24 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.49 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.86 |
| SBSN | suprabasin | -0.79 |
| PSEN2 | presenilin 2 | -0.74 |
| TTC30B | tetratricopeptide repeat domain 30B | -0.7 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.66 |
| ADIRF | adipogenesis regulatory factor | -0.6 |
| SASH1 | SAM and SH3 domain containing 1 | -0.53 |
| SYNPO | synaptopodin | -0.52 |
| GDF15 | growth differentiation factor 15 | -0.5 |
| SLC25A46 | solute carrier family 25, member 46 | -0.5 |
| PIP | prolactin-induced protein | -0.48 |
| BBS7 | Bardet-Biedl syndrome 7 | -0.45 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.44 |
| BSDC1 | BSD domain containing 1 | -0.44 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.42 |
| CSNK1A1L | casein kinase 1, alpha 1-like | -0.41 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.39 |
| IRF5 | interferon regulatory factor 5 | -0.38 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.37 |
| MYH15 | myosin, heavy chain 15 | -0.35 |
| TMEM179B | transmembrane protein 179B | -0.35 |
| TNIP2 | TNFAIP3 interacting protein 2 | -0.35 |
| CYB5R2 | cytochrome b5 reductase 2 | -0.35 |
| CCDC115 | coiled-coil domain containing 115 | -0.34 |
| CEP290 | centrosomal protein 290kDa | -0.33 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.33 |
| S100A6 | S100 calcium binding protein A6 | -0.33 |
| RNF34 | ring finger protein 34, E3 ubiquitin protein ligase | -0.33 |
| ACTBL2 | actin, beta-like 2 | -0.32 |
| TSNARE1 | t-SNARE domain containing 1 | -0.32 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | -0.32 |
| UNC93B1 | unc-93 homolog B1 (C. elegans) | -0.32 |
| ING4 | inhibitor of growth family, member 4 | -0.31 |
| CCDC66 | coiled-coil domain containing 66 | -0.31 |
| CRLF1 | cytokine receptor-like factor 1 | -0.31 |
| TMSB10 | thymosin beta 10 | -0.31 |
| HDAC5 | histone deacetylase 5 | -0.3 |
| IMMT | inner membrane protein, mitochondrial | -0.3 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | -0.3 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.3 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.3 |
| HYKK | hydroxylysine kinase | -0.29 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.29 |
| MICB | MHC class I polypeptide-related sequence B | -0.29 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | -0.29 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.28 |
| HBA1 | hemoglobin, alpha 1 | -0.28 |
| RGL3 | ral guanine nucleotide dissociation stimulator-like 3 | -0.28 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.28 |
| ZNF76 | zinc finger protein 76 | -0.27 |
| MCRIP1 | MAPK regulated corepressor interacting protein 1 | -0.27 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.27 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | -0.27 |
| TIGD2 | tigger transposable element derived 2 | -0.26 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.26 |
| VHL | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | -0.26 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.26 |
| CDK18 | cyclin-dependent kinase 18 | -0.26 |
| DPYSL4 | dihydropyrimidinase-like 4 | -0.25 |
| ADCY6 | adenylate cyclase 6 | -0.25 |
| ELAC1 | elaC ribonuclease Z 1 | -0.25 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.25 |
| TCP11L2 | t-complex 11, testis-specific-like 2 | -0.25 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.25 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | -0.25 |
| KCTD1 | potassium channel tetramerization domain containing 1 | -0.25 |
| FAM160B2 | family with sequence similarity 160, member B2 | -0.25 |
| S100A2 | S100 calcium binding protein A2 | -0.25 |
| FAT3 | FAT atypical cadherin 3 | -0.25 |
| PDE4DIP | phosphodiesterase 4D interacting protein | -0.25 |
| RPP21 | ribonuclease P/MRP 21kDa subunit | -0.25 |
| TMEM263 | transmembrane protein 263 | -0.24 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.24 |
| CLASP2 | cytoplasmic linker associated protein 2 | -0.24 |
| AREG | amphiregulin | -0.24 |
| ZBTB45 | zinc finger and BTB domain containing 45 | -0.24 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | -0.24 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.23 |
| TOM1L2 | target of myb1-like 2 (chicken) | -0.23 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.23 |
| LAMC2 | laminin, gamma 2 | -0.23 |
| MANEA | mannosidase, endo-alpha | -0.23 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | -0.23 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.23 |
| PUM1 | pumilio RNA-binding family member 1 | -0.23 |
| SVIP | small VCP/p97-interacting protein | -0.23 |
| LYST | lysosomal trafficking regulator | -0.22 |
| WASHC3 | WASH complex subunit 3 | -0.22 |
| TDG | thymine-DNA glycosylase | -0.22 |
| MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) | -0.22 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | -0.22 |
| PLAUR | plasminogen activator, urokinase receptor | -0.22 |
| PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | -0.22 |
| SESN2 | sestrin 2 | -0.22 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.22 |
| TBC1D13 | TBC1 domain family, member 13 | -0.22 |
| DAPK1 | death-associated protein kinase 1 | -0.22 |
| PRPF40B | PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) | -0.22 |
