| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/24785538 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in BMS 754807 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZG16B | zymogen granule protein 16B | 1.92 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 1.66 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 1.54 |
| TP53 | tumor protein p53 | 1.53 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 1.52 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.46 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 1.23 |
| GDF15 | growth differentiation factor 15 | 1.1 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 1.1 |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | 1.06 |
| HSH2D | hematopoietic SH2 domain containing | 1.05 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 1.04 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 1.02 |
| ZFAT | zinc finger and AT hook domain containing | 0.96 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.95 |
| SETDB1 | SET domain, bifurcated 1 | 0.95 |
| SYTL2 | synaptotagmin-like 2 | 0.89 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 0.89 |
| CTHRC1 | collagen triple helix repeat containing 1 | 0.88 |
| NDRG1 | N-myc downstream regulated 1 | 0.88 |
| ARG2 | arginase 2 | 0.87 |
| ZBTB4 | zinc finger and BTB domain containing 4 | 0.85 |
| PLK4 | polo-like kinase 4 | 0.85 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.85 |
| FAM122B | family with sequence similarity 122B | 0.84 |
| CUL7 | cullin 7 | 0.84 |
| AXIN2 | axin 2 | 0.83 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | 0.79 |
| PGPEP1 | pyroglutamyl-peptidase I | 0.78 |
| SYTL1 | synaptotagmin-like 1 | 0.76 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | 0.74 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.73 |
| DHDDS | dehydrodolichyl diphosphate synthase | 0.73 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.73 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.73 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.72 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.72 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.71 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.71 |
| LIPH | lipase, member H | 0.71 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.7 |
| TMEM59 | transmembrane protein 59 | 0.7 |
| S100A14 | S100 calcium binding protein A14 | 0.69 |
| PLD3 | phospholipase D family, member 3 | 0.67 |
| MAOB | monoamine oxidase B | 0.66 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.65 |
| AREG | amphiregulin | 0.65 |
| SLC38A7 | solute carrier family 38, member 7 | 0.65 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | 0.65 |
| FAS | Fas cell surface death receptor | 0.64 |
| FGB | fibrinogen beta chain | 0.63 |
| ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein-like 2 | 0.63 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 0.62 |
| H1-0 | H1.0 linker histone | 0.62 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 0.61 |
| SIRT7 | sirtuin 7 | 0.6 |
| ZNF76 | zinc finger protein 76 | 0.6 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.6 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | 0.59 |
| MPZL2 | myelin protein zero-like 2 | 0.59 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.59 |
| ISOC2 | isochorismatase domain containing 2 | 0.58 |
| RBP1 | retinol binding protein 1, cellular | 0.58 |
| PDE7A | phosphodiesterase 7A | 0.57 |
| DHRS1 | dehydrogenase/reductase (SDR family) member 1 | 0.57 |
| CLDN3 | claudin 3 | 0.57 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.56 |
| GNPTG | N-acetylglucosamine-1-phosphate transferase, gamma subunit | 0.56 |
| TIPE1 | TNF alpha induced protein 8 like 1 | 0.55 |
| CARD19 | caspase recruitment domain family member 19 | 0.55 |
| PLCD1 | phospholipase C, delta 1 | 0.55 |
| KLHDC2 | kelch domain containing 2 | 0.54 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.54 |
| TDG | thymine-DNA glycosylase | 0.54 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 0.54 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.54 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.54 |
| KLK6 | kallikrein-related peptidase 6 | 0.53 |
| ACVR1B | activin A receptor, type IB | 0.52 |
| LSM1 | LSM1, U6 small nuclear RNA associated | 0.52 |
| MYO10 | myosin X | 0.51 |
| GRN | granulin | 0.51 |
| RNF13 | ring finger protein 13 | 0.51 |
| LAMA3 | laminin, alpha 3 | 0.51 |
| CCND1 | cyclin D1 | 0.51 |
| LYRM1 | LYR motif containing 1 | 0.51 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.51 |
| COQ8A | coenzyme Q8A | 0.5 |
| MAGI1 | membrane associated guanylate kinase, WW and PDZ domain containing 1 | 0.5 |
| H6PD | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) | 0.5 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.5 |
| L1CAM | L1 cell adhesion molecule | 0.49 |
| JUN | jun proto-oncogene | 0.49 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 0.49 |
| KSR2 | kinase suppressor of ras 2 | 0.49 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 0.49 |
| CBY1 | chibby homolog 1 (Drosophila) | 0.48 |
| JRKL | JRK-like | 0.48 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DUOX1 | dual oxidase 1 | -1.47 |
| RND3 | Rho family GTPase 3 | -1.44 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -1.02 |
| FRMD6 | FERM domain containing 6 | -1.01 |
| RAP1GAP | RAP1 GTPase activating protein | -0.99 |
| CEP72 | centrosomal protein 72kDa | -0.98 |
| ALKBH7 | alkB, alkylation repair homolog 7 (E. coli) | -0.96 |
| MARVELD3 | MARVEL domain containing 3 | -0.95 |
| GLI2 | GLI family zinc finger 2 | -0.95 |
| ZNF367 | zinc finger protein 367 | -0.9 |
| CDCA7 | cell division cycle associated 7 | -0.88 |
| PEF1 | penta-EF-hand domain containing 1 | -0.88 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.87 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.86 |
| ZMYND19 | zinc finger, MYND-type containing 19 | -0.85 |
| BAHD1 | bromo adjacent homology domain containing 1 | -0.85 |
| DGKE | diacylglycerol kinase, epsilon 64kDa | -0.83 |
| SQSTM1 | sequestosome 1 | -0.83 |
| CCNA1 | cyclin A1 | -0.82 |
| CENPM | centromere protein M | -0.82 |
| TPM2 | tropomyosin 2 (beta) | -0.82 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.82 |
| MCM10 | minichromosome maintenance complex component 10 | -0.8 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.8 |
| CDC6 | cell division cycle 6 | -0.8 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -0.79 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.78 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.77 |
| BMP8A | bone morphogenetic protein 8a | -0.77 |
| TTPA | tocopherol (alpha) transfer protein | -0.76 |
| CBLC | Cbl proto-oncogene C, E3 ubiquitin protein ligase | -0.73 |
| ZNF267 | zinc finger protein 267 | -0.73 |
| SNX24 | sorting nexin 24 | -0.73 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | -0.73 |
| ABAT | 4-aminobutyrate aminotransferase | -0.73 |
| ARHGAP19 | Rho GTPase activating protein 19 | -0.72 |
| DCAF15 | DDB1 and CUL4 associated factor 15 | -0.72 |
| HELLS | helicase, lymphoid-specific | -0.7 |
| EXO1 | exonuclease 1 | -0.7 |
| NECTIN1 | nectin cell adhesion molecule 1 | -0.7 |
| FBXO44 | F-box protein 44 | -0.7 |
| BCL9 | B-cell CLL/lymphoma 9 | -0.7 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.7 |
| C15ORF41 | chromosome 15 open reading frame 41 | -0.69 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.69 |
| SHPRH | SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase | -0.69 |
| EFNB2 | ephrin-B2 | -0.68 |
| PCLAF | PCNA clamp associated factor | -0.68 |
| MCL1 | myeloid cell leukemia 1 | -0.68 |
| OBI1 | ORC ubiquitin ligase 1 | -0.67 |
| E2F2 | E2F transcription factor 2 | -0.67 |
| AEN | apoptosis enhancing nuclease | -0.67 |
| RRM2 | ribonucleotide reductase M2 | -0.67 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.66 |
| LIMK1 | LIM domain kinase 1 | -0.66 |
| CENPJ | centromere protein J | -0.66 |
| AFAP1 | actin filament associated protein 1 | -0.65 |
| ATAD2B | ATPase family, AAA domain containing 2B | -0.65 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.65 |
| RGS3 | regulator of G-protein signaling 3 | -0.65 |
| SYTL3 | synaptotagmin-like 3 | -0.64 |
| RAD51AP1 | RAD51 associated protein 1 | -0.64 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.64 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.64 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.63 |
| CAMK4 | calcium/calmodulin-dependent protein kinase IV | -0.62 |
| GGA2 | golgi-associated, gamma adaptin ear containing, ARF binding protein 2 | -0.62 |
| HOXA9 | homeobox A9 | -0.61 |
| FGFR4 | fibroblast growth factor receptor 4 | -0.61 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | -0.61 |
| DIAPH3 | diaphanous-related formin 3 | -0.6 |
| KIF1B | kinesin family member 1B | -0.6 |
| PRELID1 | PRELI domain containing 1 | -0.6 |
| USP37 | ubiquitin specific peptidase 37 | -0.6 |
| AIF1L | allograft inflammatory factor 1-like | -0.6 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.59 |
| SKA2 | spindle and kinetochore associated complex subunit 2 | -0.59 |
| TRERF1 | transcriptional regulating factor 1 | -0.59 |
| UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | -0.59 |
| CERK | ceramide kinase | -0.58 |
| KNL1 | kinetochore scaffold 1 | -0.58 |
| GLT8D1 | glycosyltransferase 8 domain containing 1 | -0.58 |
| MT1F | metallothionein 1F | -0.58 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.58 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.58 |
| MICB | MHC class I polypeptide-related sequence B | -0.57 |
| TK1 | thymidine kinase 1, soluble | -0.57 |
| PBK | PDZ binding kinase | -0.57 |
| FBXO5 | F-box protein 5 | -0.57 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.57 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | -0.57 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -0.57 |
| PTTG1 | pituitary tumor-transforming 1 | -0.57 |
| ZNF277 | zinc finger protein 277 | -0.57 |
| COPRS | coordinator of PRMT5, differentiation stimulator | -0.57 |
| DONSON | downstream neighbor of SON | -0.56 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.56 |
| ARHGEF17 | Rho guanine nucleotide exchange factor (GEF) 17 | -0.56 |
| E2F7 | E2F transcription factor 7 | -0.56 |
