BMS-5 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/56965901
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Genes

199 proteins with high or low expression in BMS-5 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
HMCN1 hemicentin 1 1.45
DEPDC7 DEP domain containing 7 1.06
SLC41A3 solute carrier family 41, member 3 0.87
C7 complement component 7 0.83
SOX4 SRY (sex determining region Y)-box 4 0.75
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.7
PLIN2 perilipin 2 0.67
TMUB1 transmembrane and ubiquitin-like domain containing 1 0.61
COL6A3 collagen, type VI, alpha 3 0.61
NEK2 NIMA-related kinase 2 0.55
MT2A metallothionein 2A 0.54
ADM adrenomedullin 0.48
FOXC1 forkhead box C1 0.44
DNAH6 dynein, axonemal, heavy chain 6 0.44
ATG4D autophagy related 4D, cysteine peptidase 0.44
CILP2 cartilage intermediate layer protein 2 0.43
MT1X metallothionein 1X 0.43
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 0.43
C19ORF54 chromosome 19 open reading frame 54 0.42
KMT2B lysine (K)-specific methyltransferase 2B 0.42
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.42
ABHD5 abhydrolase domain containing 5 0.42
TXNDC15 thioredoxin domain containing 15 0.41
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.4
SYCP1 synaptonemal complex protein 1 0.4
ARHGAP42 Rho GTPase activating protein 42 0.4
GDF15 growth differentiation factor 15 0.4
PDLIM3 PDZ and LIM domain 3 0.39
PRELID3B PRELI domain containing 3B 0.38
C16ORF72 chromosome 16 open reading frame 72 0.38
MYOM2 myomesin 2 0.37
EMB embigin 0.37
ROGDI rogdi homolog (Drosophila) 0.37
LYRM1 LYR motif containing 1 0.37
MORC4 MORC family CW-type zinc finger 4 0.37
MT1F metallothionein 1F 0.36
LMX1B LIM homeobox transcription factor 1, beta 0.36
FNIP1 folliculin interacting protein 1 0.36
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.35
PGPEP1 pyroglutamyl-peptidase I 0.35
FAM219B family with sequence similarity 219, member B 0.35
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.35
GRTP1 growth hormone regulated TBC protein 1 0.34
PRELID1 PRELI domain containing 1 0.34
NEO1 neogenin 1 0.34
JOSD1 Josephin domain containing 1 0.34
GTF2IRD1 GTF2I repeat domain containing 1 0.33
CNTNAP1 contactin associated protein 1 0.32
C1ORF43 chromosome 1 open reading frame 43 0.32
FAM241A family with sequence similarity 241 member A 0.32
ATP9A ATPase, class II, type 9A 0.32
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 0.32
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.31
HMBOX1 homeobox containing 1 0.31
PRRX2 paired related homeobox 2 0.31
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.31
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 0.31
LACC1 laccase (multicopper oxidoreductase) domain containing 1 0.3
ZMAT3 zinc finger, matrin-type 3 0.3
FZD7 frizzled class receptor 7 0.3
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.3
GRK5 G protein-coupled receptor kinase 5 0.3
ZNF724 zinc finger protein 724 0.3
TP53 tumor protein p53 0.3
ARL4D ADP-ribosylation factor-like 4D 0.29
ABHD17A abhydrolase domain containing 17A 0.29
R3HDM4 R3H domain containing 4 0.29
MEST mesoderm specific transcript 0.29
MRPL18 mitochondrial ribosomal protein L18 0.29
ZNF814 zinc finger protein 814 0.29
SRD5A3 steroid 5 alpha-reductase 3 0.29
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.28
PHYH phytanoyl-CoA 2-hydroxylase 0.28
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.28
MT1E metallothionein 1E 0.28
ZNF319 zinc finger protein 319 0.28
SMOX spermine oxidase 0.28
TGFBR3 transforming growth factor, beta receptor III 0.28
ABLIM3 actin binding LIM protein family, member 3 0.27
HBA1 hemoglobin, alpha 1 0.27
NT5E 5'-nucleotidase, ecto (CD73) 0.27
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.27
NHSL1 NHS-like 1 0.27
APOOL apolipoprotein O-like 0.27
FBXL8 F-box and leucine-rich repeat protein 8 0.27
KCTD20 potassium channel tetramerization domain containing 20 0.27
MED22 mediator complex subunit 22 0.27
NR1H2 nuclear receptor subfamily 1, group H, member 2 0.27
SIDT2 SID1 transmembrane family, member 2 0.27
FMNL3 formin-like 3 0.27
MSX1 msh homeobox 1 0.26
RPGR retinitis pigmentosa GTPase regulator 0.26
COQ3 coenzyme Q3 methyltransferase 0.26
CEMIP cell migration inducing protein, hyaluronan binding 0.26
DEAF1 DEAF1 transcription factor 0.26
AMOTL1 angiomotin like 1 0.26
FOXRED2 FAD-dependent oxidoreductase domain containing 2 0.26
ABRACL ABRA C-terminal like 0.25
TENT5A terminal nucleotidyltransferase 5A 0.25

low expression

Symbol Name Standardized Value
KLHL23 kelch-like family member 23 -1.94
NDFIP2 Nedd4 family interacting protein 2 -1.18
SEC14L1 SEC14-like 1 (S. cerevisiae) -1.05
DNAH12 dynein, axonemal, heavy chain 12 -1.05
TBC1D32 TBC1 domain family, member 32 -0.83
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.71
B9D1 B9 protein domain 1 -0.69
TMX2 thioredoxin-related transmembrane protein 2 -0.68
MSMO1 methylsterol monooxygenase 1 -0.59
METTL22 methyltransferase like 22 -0.57
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.56
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 -0.56
CPD carboxypeptidase D -0.51
EFCAB14 EF-hand calcium binding domain 14 -0.51
MFSD14B major facilitator superfamily domain containing 14B -0.49
TACSTD2 tumor-associated calcium signal transducer 2 -0.48
ALG3 ALG3, alpha-1,3- mannosyltransferase -0.47
DXO decapping exoribonuclease -0.46
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 -0.46
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.46
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) -0.45
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.45
PCSK9 proprotein convertase subtilisin/kexin type 9 -0.43
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 -0.43
ZNRD1 zinc ribbon domain containing 1 -0.43
SLC39A3 solute carrier family 39 (zinc transporter), member 3 -0.41
CCDC57 coiled-coil domain containing 57 -0.41
STK16 serine/threonine kinase 16 -0.4
SERINC1 serine incorporator 1 -0.4
GREB1 growth regulation by estrogen in breast cancer 1 -0.4
JUN jun proto-oncogene -0.38
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.38
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 -0.37
SLC10A4 solute carrier family 10, member 4 -0.37
SLC30A3 solute carrier family 30 (zinc transporter), member 3 -0.37
CCDC158 coiled-coil domain containing 158 -0.37
TMEM63A transmembrane protein 63A -0.36
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.36
RNF126 ring finger protein 126 -0.35
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -0.35
SQLE squalene epoxidase -0.35
POMK protein-O-mannose kinase -0.35
DSTYK dual serine/threonine and tyrosine protein kinase -0.35
ZDHHC8 zinc finger, DHHC-type containing 8 -0.35
CRTC1 CREB regulated transcription coactivator 1 -0.34
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) -0.34
ENO1 enolase 1, (alpha) -0.34
PAM peptidylglycine alpha-amidating monooxygenase -0.34
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -0.33
MYH2 myosin, heavy chain 2, skeletal muscle, adult -0.33
VIM vimentin -0.33
PAQR7 progestin and adipoQ receptor family member VII -0.33
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -0.33
RGS20 regulator of G-protein signaling 20 -0.33
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.33
CLDN3 claudin 3 -0.32
ZNF729 zinc finger protein 729 -0.32
STC2 stanniocalcin 2 -0.32
TMEM9 transmembrane protein 9 -0.31
MVK mevalonate kinase -0.31
KPNA5 karyopherin alpha 5 (importin alpha 6) -0.31
FAR1 fatty acyl CoA reductase 1 -0.31
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.31
F8 coagulation factor VIII, procoagulant component -0.31
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.3
FADS1 fatty acid desaturase 1 -0.3
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.3
AXL AXL receptor tyrosine kinase -0.3
KIZ kizuna centrosomal protein -0.3
BPTF bromodomain PHD finger transcription factor -0.3
ATP5IF1 ATP synthase inhibitory factor subunit 1 -0.29
F3 coagulation factor III (thromboplastin, tissue factor) -0.29
LMAN2 lectin, mannose-binding 2 -0.29
SC5D sterol-C5-desaturase -0.29
CPE carboxypeptidase E -0.29
TICAM1 toll-like receptor adaptor molecule 1 -0.29
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.29
GINM1 glycoprotein integral membrane 1 -0.29
LRP1 low density lipoprotein receptor-related protein 1 -0.29
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.29
TMEM67 transmembrane protein 67 -0.28
TET2 tet methylcytosine dioxygenase 2 -0.28
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -0.28
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -0.28
ZC3H10 zinc finger CCCH-type containing 10 -0.27
LRRC28 leucine rich repeat containing 28 -0.27
DNPEP aspartyl aminopeptidase -0.27
FBF1 Fas (TNFRSF6) binding factor 1 -0.27
ZNF320 zinc finger protein 320 -0.27
AXIN2 axin 2 -0.27
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -0.27
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted -0.27
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 -0.27
NRBF2 nuclear receptor binding factor 2 -0.26
SFN stratifin -0.26
TRHDE thyrotropin-releasing hormone degrading enzyme -0.26
LDLR low density lipoprotein receptor -0.26
ACTL8 actin-like 8 -0.26
ANAPC11 anaphase promoting complex subunit 11 -0.26
TPK1 thiamin pyrophosphokinase 1 -0.26