BMS-536924 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/135440466
Similar Terms
Downloads & Tools

Genes

199 proteins with high or low expression in BMS-536924 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.9
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.64
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.13
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.09
TACSTD2 tumor-associated calcium signal transducer 2 1.83
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.78
METTL7A methyltransferase like 7A 1.74
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 1.66
OASL 2'-5'-oligoadenylate synthetase-like 1.6
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.59
TP53 tumor protein p53 1.58
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.56
PIP prolactin-induced protein 1.53
ATF3 activating transcription factor 3 1.52
FGFBP1 fibroblast growth factor binding protein 1 1.44
OPTN optineurin 1.38
COQ8A coenzyme Q8A 1.33
FBXL8 F-box and leucine-rich repeat protein 8 1.32
TBX3 T-box 3 1.3
SULF2 sulfatase 2 1.29
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 1.28
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 1.27
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.26
PDLIM3 PDZ and LIM domain 3 1.24
TP53I3 tumor protein p53 inducible protein 3 1.24
ITM2B integral membrane protein 2B 1.24
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.19
MISP3 MISP family member 3 1.18
SLC49A4 solute carrier family 49 member 4 1.16
CLDN3 claudin 3 1.16
ARG2 arginase 2 1.15
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.14
MAN1A1 mannosidase, alpha, class 1A, member 1 1.13
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 1.13
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 1.12
TRIM2 tripartite motif containing 2 1.12
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.11
GRN granulin 1.09
SYTL1 synaptotagmin-like 1 1.08
FN1 fibronectin 1 1.07
RTN2 reticulon 2 1.07
MEGF8 multiple EGF-like-domains 8 1.06
CLK1 CDC-like kinase 1 1.06
MLXIPL MLX interacting protein-like 1.03
FDXR ferredoxin reductase 1.02
RFX5 regulatory factor X, 5 (influences HLA class II expression) 1.01
ZNF888 zinc finger protein 888 1.0
PLCD1 phospholipase C, delta 1 1.0
TJP3 tight junction protein 3 1.0
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 0.98
PNPLA2 patatin-like phospholipase domain containing 2 0.98
GDF15 growth differentiation factor 15 0.97
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 0.97
PLD3 phospholipase D family, member 3 0.96
ELOVL6 ELOVL fatty acid elongase 6 0.95
LRP10 low density lipoprotein receptor-related protein 10 0.94
PTPRF protein tyrosine phosphatase, receptor type, F 0.93
DDB2 damage-specific DNA binding protein 2, 48kDa 0.92
F2R coagulation factor II (thrombin) receptor 0.91
FAS Fas cell surface death receptor 0.91
KIAA1107 KIAA1107 0.91
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 0.9
IGFBP3 insulin-like growth factor binding protein 3 0.9
GRB7 growth factor receptor-bound protein 7 0.89
HIST2H2AA3 histone cluster 2, H2aa3 0.89
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.89
SIDT2 SID1 transmembrane family, member 2 0.88
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 0.88
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 0.87
DHRS1 dehydrogenase/reductase (SDR family) member 1 0.86
PAQR7 progestin and adipoQ receptor family member VII 0.86
CST3 cystatin C 0.86
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D 0.86
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 0.86
RBL2 retinoblastoma-like 2 0.86
MARCKS myristoylated alanine-rich protein kinase C substrate 0.86
CLSTN3 calsyntenin 3 0.85
ABAT 4-aminobutyrate aminotransferase 0.85
ACSF2 acyl-CoA synthetase family member 2 0.85
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.85
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.84
CDA cytidine deaminase 0.84
TMEM87B transmembrane protein 87B 0.84
ZER1 zyg-11 related, cell cycle regulator 0.84
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.84
PTPRD protein tyrosine phosphatase, receptor type, D 0.84
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.84
MPZL2 myelin protein zero-like 2 0.82
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 0.82
RIOX1 ribosomal oxygenase 1 0.82
NIPSNAP3A nipsnap homolog 3A (C. elegans) 0.82
TMEM173 transmembrane protein 173 0.82
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 0.82
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 0.82
F5 coagulation factor V (proaccelerin, labile factor) 0.81
PRMT2 protein arginine methyltransferase 2 0.81
FBXL20 F-box and leucine-rich repeat protein 20 0.81
PHLDA3 pleckstrin homology-like domain, family A, member 3 0.81
CLK4 CDC-like kinase 4 0.81

low expression

Symbol Name Standardized Value
GREB1 growth regulation by estrogen in breast cancer 1 -3.27
AUNIP aurora kinase A and ninein interacting protein -2.58
TRIB3 tribbles pseudokinase 3 -2.26
EGR1 early growth response 1 -2.16
RRM2 ribonucleotide reductase M2 -2.16
TNS4 tensin 4 -2.13
ZNF555 zinc finger protein 555 -2.12
ARHGAP44 Rho GTPase activating protein 44 -2.04
CCNF cyclin F -2.01
PCLAF PCNA clamp associated factor -2.0
CCNA2 cyclin A2 -1.88
F3 coagulation factor III (thromboplastin, tissue factor) -1.77
CDC6 cell division cycle 6 -1.75
CCNA1 cyclin A1 -1.74
SYTL3 synaptotagmin-like 3 -1.7
UBE2C ubiquitin-conjugating enzyme E2C -1.68
CDC20 cell division cycle 20 -1.65
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -1.61
ODC1 ornithine decarboxylase 1 -1.56
PLK1 polo-like kinase 1 -1.56
CLSPN claspin -1.56
MRFAP1 Morf4 family associated protein 1 -1.53
IFFO1 intermediate filament family orphan 1 -1.49
CCNB1 cyclin B1 -1.49
EXO1 exonuclease 1 -1.48
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -1.45
DNAH6 dynein, axonemal, heavy chain 6 -1.43
PTTG1 pituitary tumor-transforming 1 -1.43
MCM10 minichromosome maintenance complex component 10 -1.41
ANLN anillin, actin binding protein -1.41
GMNN geminin, DNA replication inhibitor -1.39
CDC7 cell division cycle 7 -1.38
CDCA5 cell division cycle associated 5 -1.38
KIF18A kinesin family member 18A -1.37
CDKN3 cyclin-dependent kinase inhibitor 3 -1.37
TK1 thymidine kinase 1, soluble -1.36
KIF22 kinesin family member 22 -1.36
NRP1 neuropilin 1 -1.31
WDR76 WD repeat domain 76 -1.3
FBXO5 F-box protein 5 -1.3
TPX2 TPX2, microtubule-associated -1.28
MELK maternal embryonic leucine zipper kinase -1.28
UBE2S ubiquitin-conjugating enzyme E2S -1.28
SH3RF1 SH3 domain containing ring finger 1 -1.27
CCNB2 cyclin B2 -1.26
TOX2 TOX high mobility group box family member 2 -1.26
MYNN myoneurin -1.24
AURKA aurora kinase A -1.24
KIF2C kinesin family member 2C -1.23
SASS6 spindle assembly 6 homolog (C. elegans) -1.22
SPRY4 sprouty homolog 4 (Drosophila) -1.22
SACK1D scaffolding CK1 anchoring protein D -1.2
ARHGAP11A Rho GTPase activating protein 11A -1.2
EIF1AD eukaryotic translation initiation factor 1A domain containing -1.19
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -1.18
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -1.18
LRR1 leucine rich repeat protein 1 -1.17
MLPH melanophilin -1.17
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -1.16
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.16
PIMREG PICALM interacting mitotic regulator -1.15
KIF20B kinesin family member 20B -1.15
BAIAP2 BAI1-associated protein 2 -1.15
DIAPH3 diaphanous-related formin 3 -1.14
DNA2 DNA replication helicase/nuclease 2 -1.14
ARHGAP19 Rho GTPase activating protein 19 -1.14
TOP2A topoisomerase (DNA) II alpha 170kDa -1.14
ORC6 origin recognition complex, subunit 6 -1.13
NES nestin -1.12
TTK TTK protein kinase -1.12
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -1.12
PRR11 proline rich 11 -1.12
GSE1 Gse1 coiled-coil protein -1.11
ANKRD39 ankyrin repeat domain 39 -1.11
KNL1 kinetochore scaffold 1 -1.11
SLBP stem-loop binding protein -1.11
KIF11 kinesin family member 11 -1.11
RAD54L RAD54-like (S. cerevisiae) -1.1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.1
UBE2T ubiquitin-conjugating enzyme E2T -1.09
VIM vimentin -1.08
RAD54B RAD54 homolog B (S. cerevisiae) -1.08
AMD1 adenosylmethionine decarboxylase 1 -1.08
TROAP trophinin associated protein -1.08
GTSE1 G-2 and S-phase expressed 1 -1.08
ZNF428 zinc finger protein 428 -1.07
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -1.07
AKAP6 A kinase (PRKA) anchor protein 6 -1.07
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -1.06
OBI1 ORC ubiquitin ligase 1 -1.06
KIF18B kinesin family member 18B -1.05
HMMR hyaluronan-mediated motility receptor (RHAMM) -1.05
FLII flightless I homolog (Drosophila) -1.05
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -1.05
BCAR3 breast cancer anti-estrogen resistance 3 -1.04
TYRO3 TYRO3 protein tyrosine kinase -1.04
CDCA8 cell division cycle associated 8 -1.04
ALOXE3 arachidonate lipoxygenase 3 -1.03
PBK PDZ binding kinase -1.03
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 -1.03