| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/50922691 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in BMS-911543 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZSCAN32 | zinc finger and SCAN domain containing 32 | 2.68 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | 2.13 |
| WDR60 | WD repeat domain 60 | 1.32 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 1.31 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.19 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | 1.15 |
| COL17A1 | collagen, type XVII, alpha 1 | 1.07 |
| NPHP3 | nephronophthisis 3 (adolescent) | 0.92 |
| KSR2 | kinase suppressor of ras 2 | 0.83 |
| C7 | complement component 7 | 0.78 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.76 |
| C9ORF40 | chromosome 9 open reading frame 40 | 0.71 |
| PICK1 | protein interacting with PRKCA 1 | 0.68 |
| TAZ | tafazzin | 0.68 |
| SLC16A6 | solute carrier family 16, member 6 | 0.62 |
| SMIM19 | small integral membrane protein 19 | 0.57 |
| LNX2 | ligand of numb-protein X 2 | 0.56 |
| FAM221A | family with sequence similarity 221, member A | 0.54 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.53 |
| FGGY | FGGY carbohydrate kinase domain containing | 0.52 |
| KIAA1958 | KIAA1958 | 0.52 |
| UPP1 | uridine phosphorylase 1 | 0.52 |
| CNTRL | centriolin | 0.51 |
| UEVLD | UEV and lactate/malate dehyrogenase domains | 0.5 |
| E2F2 | E2F transcription factor 2 | 0.5 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | 0.49 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.47 |
| PEG10 | paternally expressed 10 | 0.47 |
| TPM4 | tropomyosin 4 | 0.46 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.46 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.46 |
| TMEM200A | transmembrane protein 200A | 0.45 |
| ABHD4 | abhydrolase domain containing 4 | 0.44 |
| OBSL1 | obscurin-like 1 | 0.44 |
| CFAP54 | cilia and flagella associated 54 | 0.44 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | 0.44 |
| TMEM179B | transmembrane protein 179B | 0.43 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.41 |
| ATF6B | activating transcription factor 6 beta | 0.41 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.41 |
| FABP6 | fatty acid binding protein 6, ileal | 0.41 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 0.41 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.41 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.4 |
| BAK1 | BCL2-antagonist/killer 1 | 0.4 |
| MEGF8 | multiple EGF-like-domains 8 | 0.4 |
| SRD5A3 | steroid 5 alpha-reductase 3 | 0.4 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 0.4 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.4 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.4 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.4 |
| PCTP | phosphatidylcholine transfer protein | 0.39 |
| MROH6 | maestro heat-like repeat family member 6 | 0.39 |
| IGF1R | insulin-like growth factor 1 receptor | 0.39 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.39 |
| MAP2 | microtubule-associated protein 2 | 0.39 |
| ZNF532 | zinc finger protein 532 | 0.39 |
| COQ4 | coenzyme Q4 | 0.38 |
| ATXN1L | ataxin 1-like | 0.37 |
| FUNDC1 | FUN14 domain containing 1 | 0.37 |
| NIBAN1 | niban apoptosis regulator 1 | 0.37 |
| LYSMD2 | LysM, putative peptidoglycan-binding, domain containing 2 | 0.37 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | 0.37 |
| ODC1 | ornithine decarboxylase 1 | 0.37 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | 0.37 |
| SDSL | serine dehydratase-like | 0.37 |
| DNAH6 | dynein, axonemal, heavy chain 6 | 0.37 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.36 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.36 |
| EVA1C | eva-1 homolog C (C. elegans) | 0.36 |
| CREBZF | CREB/ATF bZIP transcription factor | 0.36 |
| MT2A | metallothionein 2A | 0.36 |
| SLC12A8 | solute carrier family 12, member 8 | 0.35 |
| OTX1 | orthodenticle homeobox 1 | 0.35 |
| ZNF446 | zinc finger protein 446 | 0.35 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.35 |
| CCDC77 | coiled-coil domain containing 77 | 0.35 |
| SQSTM1 | sequestosome 1 | 0.35 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | 0.34 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | 0.34 |
| FAM53B | family with sequence similarity 53, member B | 0.34 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.34 |
| ACVR2A | activin A receptor, type IIA | 0.34 |
| RGN | regucalcin | 0.34 |
| TMEM39B | transmembrane protein 39B | 0.34 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.34 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | 0.33 |
| C6ORF47 | chromosome 6 open reading frame 47 | 0.33 |
| ZNF100 | zinc finger protein 100 | 0.33 |
| SHROOM1 | shroom family member 1 | 0.33 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | 0.33 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | 0.33 |
| DUSP6 | dual specificity phosphatase 6 | 0.32 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.32 |
| PRG4 | proteoglycan 4 | 0.32 |
| UCHL5 | ubiquitin carboxyl-terminal hydrolase L5 | 0.32 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.32 |
| SLC22A18 | solute carrier family 22, member 18 | 0.32 |
| SARDH | sarcosine dehydrogenase | 0.32 |
| M1AP | meiosis 1 associated protein | 0.32 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | -5.81 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.96 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | -0.68 |
| COL6A3 | collagen, type VI, alpha 3 | -0.67 |
| SLC38A2 | solute carrier family 38, member 2 | -0.65 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | -0.64 |
| SGSM1 | small G protein signaling modulator 1 | -0.58 |
| CPA4 | carboxypeptidase A4 | -0.56 |
| ZKSCAN3 | zinc finger with KRAB and SCAN domains 3 | -0.56 |
| PAQR7 | progestin and adipoQ receptor family member VII | -0.52 |
| PLPP3 | phospholipid phosphatase 3 | -0.51 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.48 |
| JAK3 | Janus kinase 3 | -0.48 |
| SOCS7 | suppressor of cytokine signaling 7 | -0.46 |
| CCDC91 | coiled-coil domain containing 91 | -0.43 |
| DEPDC1 | DEP domain containing 1 | -0.41 |
| SYTL3 | synaptotagmin-like 3 | -0.41 |
| MICA | MHC class I polypeptide-related sequence A | -0.4 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | -0.39 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.38 |
| GPATCH2L | G patch domain containing 2-like | -0.38 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.38 |
| FBXO17 | F-box protein 17 | -0.37 |
| UBTD1 | ubiquitin domain containing 1 | -0.37 |
| TMEM177 | transmembrane protein 177 | -0.37 |
| GTDC1 | glycosyltransferase-like domain containing 1 | -0.37 |
| HMCN1 | hemicentin 1 | -0.36 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.36 |
| LDLR | low density lipoprotein receptor | -0.36 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.36 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.36 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.36 |
| TTC9 | tetratricopeptide repeat domain 9 | -0.35 |
| CCN1 | cellular communication network factor 1 | -0.35 |
| MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) | -0.34 |
| HEMK1 | HemK methyltransferase family member 1 | -0.34 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.34 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -0.33 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | -0.32 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | -0.32 |
| ERVK3-1 | endogenous retrovirus group K3, member 1 | -0.32 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.32 |
| SIVA1 | SIVA1, apoptosis-inducing factor | -0.31 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.31 |
| CMC4 | C-x(9)-C motif containing 4 | -0.3 |
| PTRHD1 | peptidyl-tRNA hydrolase domain containing 1 | -0.3 |
| BCAR1 | breast cancer anti-estrogen resistance 1 | -0.3 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.29 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.29 |
| RXYLT1 | ribitol xylosyltransferase 1 | -0.29 |
| RBAK | RB-associated KRAB zinc finger | -0.29 |
| SPRTN | SprT-like N-terminal domain | -0.29 |
| ZFP36 | ZFP36 ring finger protein | -0.29 |
| PRDM15 | PR domain containing 15 | -0.29 |
| BEND7 | BEN domain containing 7 | -0.28 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.28 |
| VSIR | V-set immunoregulatory receptor | -0.28 |
| PDCD7 | programmed cell death 7 | -0.28 |
| FBXO31 | F-box protein 31 | -0.28 |
| PGK2 | phosphoglycerate kinase 2 | -0.28 |
| ZNF57 | zinc finger protein 57 | -0.28 |
| TBC1D14 | TBC1 domain family, member 14 | -0.28 |
| PAH | phenylalanine hydroxylase | -0.28 |
| PRXL2C | peroxiredoxin like 2C | -0.28 |
| XTBD1 | XRN2 binding domain containing 1 | -0.28 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.28 |
| ENO1 | enolase 1, (alpha) | -0.27 |
| TMEM242 | transmembrane protein 242 | -0.27 |
| HACE1 | HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | -0.27 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -0.27 |
| FEM1C | fem-1 homolog c (C. elegans) | -0.27 |
| TEX15 | testis expressed 15 | -0.26 |
| VCAN | versican | -0.26 |
| SULF2 | sulfatase 2 | -0.26 |
| GLS | glutaminase | -0.26 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.26 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.26 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.26 |
| SET | SET nuclear proto-oncogene | -0.26 |
| CEP55 | centrosomal protein 55kDa | -0.26 |
| ATP9A | ATPase, class II, type 9A | -0.26 |
| TET1 | tet methylcytosine dioxygenase 1 | -0.26 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.26 |
| SMAD3 | SMAD family member 3 | -0.25 |
| TCHP | trichoplein, keratin filament binding | -0.25 |
| PVR | poliovirus receptor | -0.25 |
| PKM | pyruvate kinase, muscle | -0.25 |
| LYPLA2 | lysophospholipase II | -0.25 |
| THUMPD2 | THUMP domain containing 2 | -0.25 |
| CINP | cyclin-dependent kinase 2 interacting protein | -0.25 |
| DPH7 | diphthamide biosynthesis 7 | -0.24 |
| FAM89A | family with sequence similarity 89, member A | -0.24 |
| DUSP5 | dual specificity phosphatase 5 | -0.24 |
| AXL | AXL receptor tyrosine kinase | -0.24 |
| FOXM1 | forkhead box M1 | -0.24 |
| PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | -0.24 |
| RAB28 | RAB28, member RAS oncogene family | -0.24 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | -0.23 |
| ANTXR1 | anthrax toxin receptor 1 | -0.23 |
| DNM1 | dynamin 1 | -0.23 |
