BMY 7378 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/210172
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Genes

199 proteins with high or low expression in BMY 7378 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MPHOSPH9 M-phase phosphoprotein 9 1.34
CYBA cytochrome b-245, alpha polypeptide 1.06
MYH4 myosin, heavy chain 4, skeletal muscle 0.62
CCDC9B coiled-coil domain containing 9B 0.57
MIIP migration and invasion inhibitory protein 0.56
RNF130 ring finger protein 130 0.49
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.49
SYNGAP1 synaptic Ras GTPase activating protein 1 0.47
CCDC115 coiled-coil domain containing 115 0.42
H1-0 H1.0 linker histone 0.41
ZNF282 zinc finger protein 282 0.39
HSPA14 heat shock 70kDa protein 14 0.38
KLC1 kinesin light chain 1 0.38
ATXN7L3B ataxin 7-like 3B 0.37
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) 0.36
PLXNB1 plexin B1 0.35
AKAP6 A kinase (PRKA) anchor protein 6 0.35
H1-2 H1.2 linker histone, cluster member 0.34
STK40 serine/threonine kinase 40 0.34
FAT4 FAT atypical cadherin 4 0.34
TET3 tet methylcytosine dioxygenase 3 0.33
LYRM1 LYR motif containing 1 0.32
CEP63 centrosomal protein 63kDa 0.31
TRIM62 tripartite motif containing 62 0.31
LIPH lipase, member H 0.31
ZC3H6 zinc finger CCCH-type containing 6 0.31
DOLK dolichol kinase 0.3
JAK2 Janus kinase 2 0.3
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 0.3
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.29
ZNF646 zinc finger protein 646 0.29
CD99 CD99 molecule 0.29
TMEM246 transmembrane protein 246 0.28
LOXL2 lysyl oxidase-like 2 0.28
H1-4 H1.4 linker histone, cluster member 0.28
PXMP4 peroxisomal membrane protein 4, 24kDa 0.27
SYPL1 synaptophysin-like 1 0.27
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.26
MTF1 metal-regulatory transcription factor 1 0.26
PRR5 proline rich 5 (renal) 0.26
MIEN1 migration and invasion enhancer 1 0.26
NOTCH3 notch 3 0.26
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.25
TRIM23 tripartite motif containing 23 0.25
RNF139 ring finger protein 139 0.25
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.25
ZNF484 zinc finger protein 484 0.25
PRAME preferentially expressed antigen in melanoma 0.25
KLHL23 kelch-like family member 23 0.25
ENO1 enolase 1, (alpha) 0.25
GPANK1 G patch domain and ankyrin repeats 1 0.24
LIPA lipase A, lysosomal acid, cholesterol esterase 0.24
TMCC3 transmembrane and coiled-coil domain family 3 0.24
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta 0.24
RPL26 ribosomal protein L26 0.24
MIS12 MIS12 kinetochore complex component 0.24
PNPLA2 patatin-like phospholipase domain containing 2 0.24
DALRD3 DALR anticodon binding domain containing 3 0.23
DDIT4 DNA-damage-inducible transcript 4 0.23
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.23
TEAD3 TEA domain family member 3 0.23
TRAPPC3 trafficking protein particle complex 3 0.23
UBQLN2 ubiquilin 2 0.23
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 0.23
CTDNEP1 CTD nuclear envelope phosphatase 1 0.23
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.23
USP27X ubiquitin specific peptidase 27, X-linked 0.23
NDRG2 NDRG family member 2 0.22
SORT1 sortilin 1 0.22
MIGA1 mitoguardin 1 0.22
MDP1 magnesium-dependent phosphatase 1 0.22
KIAA1586 KIAA1586 0.22
SMYD2 SET and MYND domain containing 2 0.22
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.22
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.22
ALG12 ALG12, alpha-1,6-mannosyltransferase 0.22
DDT D-dopachrome tautomerase 0.22
IER3IP1 immediate early response 3 interacting protein 1 0.22
ATMIN ATM interactor 0.22
SMC1B structural maintenance of chromosomes 1B 0.22
OSBPL2 oxysterol binding protein-like 2 0.22
SP140L SP140 nuclear body protein-like 0.21
LMOD1 leiomodin 1 (smooth muscle) 0.21
FAM241A family with sequence similarity 241 member A 0.21
ATP5F1D ATP synthase F1 subunit delta 0.21
MAT1A methionine adenosyltransferase I, alpha 0.21
VSNL1 visinin-like 1 0.21
H1-5 H1.5 linker histone, cluster member 0.21
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.21
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.21
RNF145 ring finger protein 145 0.21
NDRG1 N-myc downstream regulated 1 0.21
LGALS1 lectin, galactoside-binding, soluble, 1 0.21
ZNF594 zinc finger protein 594 0.21
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.21
PUM1 pumilio RNA-binding family member 1 0.21
CEP70 centrosomal protein 70kDa 0.21
FOXO1 forkhead box O1 0.21
GCA grancalcin, EF-hand calcium binding protein 0.21

low expression

Symbol Name Standardized Value
EIF3C eukaryotic translation initiation factor 3, subunit C -1.31
ACTBL2 actin, beta-like 2 -1.17
FAM110C family with sequence similarity 110, member C -0.8
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -0.8
ZBTB4 zinc finger and BTB domain containing 4 -0.77
ADAM22 ADAM metallopeptidase domain 22 -0.77
RAB27B RAB27B, member RAS oncogene family -0.74
KDM5B lysine (K)-specific demethylase 5B -0.72
ARHGAP22 Rho GTPase activating protein 22 -0.65
MDM1 Mdm1 nuclear protein homolog (mouse) -0.62
ZMAT5 zinc finger, matrin-type 5 -0.6
ZNF276 zinc finger protein 276 -0.6
AXIN2 axin 2 -0.58
ALG10B ALG10B, alpha-1,2-glucosyltransferase -0.55
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 -0.52
LNX2 ligand of numb-protein X 2 -0.52
CREG1 cellular repressor of E1A-stimulated genes 1 -0.49
ZSCAN26 zinc finger and SCAN domain containing 26 -0.48
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -0.47
TTLL4 tubulin tyrosine ligase-like family member 4 -0.46
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 -0.44
TMSB10 thymosin beta 10 -0.43
CMC1 C-x(9)-C motif containing 1 -0.43
NOVA1 neuro-oncological ventral antigen 1 -0.43
METTL25 methyltransferase like 25 -0.4
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.4
AASS aminoadipate-semialdehyde synthase -0.39
ZFP36 ZFP36 ring finger protein -0.39
DAP death-associated protein -0.39
NCAPH2 non-SMC condensin II complex, subunit H2 -0.38
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -0.38
FGD1 FYVE, RhoGEF and PH domain containing 1 -0.37
ZFP30 ZFP30 zinc finger protein -0.37
SUGCT succinyl-CoA:glutarate-CoA transferase -0.37
ATM ATM serine/threonine kinase -0.37
TUBAL3 tubulin, alpha-like 3 -0.36
ATL1 atlastin GTPase 1 -0.36
ZNF469 zinc finger protein 469 -0.36
TREX1 three prime repair exonuclease 1 -0.36
HIST3H2BB histone cluster 3, H2bb -0.36
NDOR1 NADPH dependent diflavin oxidoreductase 1 -0.36
NLGN2 neuroligin 2 -0.36
MCPH1 microcephalin 1 -0.35
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.35
C1ORF52 chromosome 1 open reading frame 52 -0.35
SLC35A5 solute carrier family 35, member A5 -0.35
SETD9 SET domain containing 9 -0.35
ITGA7 integrin, alpha 7 -0.34
PECR peroxisomal trans-2-enoyl-CoA reductase -0.34
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.34
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.34
CFAP58 cilia and flagella associated protein 58 -0.33
UNC93B1 unc-93 homolog B1 (C. elegans) -0.33
HSPA1L heat shock 70kDa protein 1-like -0.33
SON SON DNA binding protein -0.33
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -0.33
SPIN4 spindlin family, member 4 -0.33
NADSYN1 NAD synthetase 1 -0.33
TMPPE transmembrane protein with metallophosphoesterase domain -0.33
RHBDD2 rhomboid domain containing 2 -0.33
FAM13A family with sequence similarity 13, member A -0.33
COL14A1 collagen, type XIV, alpha 1 -0.33
PGK2 phosphoglycerate kinase 2 -0.32
KMT2B lysine (K)-specific methyltransferase 2B -0.32
PEX6 peroxisomal biogenesis factor 6 -0.32
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 -0.32
MID1IP1 MID1 interacting protein 1 -0.32
SPATA2L spermatogenesis associated 2-like -0.32
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.32
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -0.31
TRIM9 tripartite motif containing 9 -0.31
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -0.31
ARMC7 armadillo repeat containing 7 -0.31
TBX3 T-box 3 -0.31
MYZAP myocardial zonula adherens protein -0.31
PPP1R26 protein phosphatase 1, regulatory subunit 26 -0.31
RNF220 ring finger protein 220 -0.31
CRIP2 cysteine-rich protein 2 -0.31
SMO smoothened, frizzled class receptor -0.31
SPPL2A signal peptide peptidase like 2A -0.31
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.31
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit -0.31
AZIN1 antizyme inhibitor 1 -0.31
DEDD death effector domain containing -0.31
TNK2 tyrosine kinase, non-receptor, 2 -0.31
PIP4P2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 -0.3
WASHC4 WASH complex subunit 4 -0.3
SYBU syntabulin (syntaxin-interacting) -0.3
DEPDC5 DEP domain containing 5 -0.3
CUEDC1 CUE domain containing 1 -0.3
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) -0.3
PDLIM3 PDZ and LIM domain 3 -0.3
GSTA1 glutathione S-transferase alpha 1 -0.29
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.29
MTG1 mitochondrial ribosome-associated GTPase 1 -0.29
CARD8 caspase recruitment domain family, member 8 -0.29
RERE arginine-glutamic acid dipeptide (RE) repeats -0.29
TMEM161A transmembrane protein 161A -0.29
DEGS1 delta(4)-desaturase, sphingolipid 1 -0.29
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like -0.29