BPH-1 Gene Set

Dataset COSMIC Cell Line Gene Mutation Profiles
Category genomics
Type cell line
Description Human benign prostate hyperplasia; prostate epithelial cells from a 68-year-old man with benign prostate hyperplasia; cells were immortalized with SV-40 large T-antigen; cells were described to express cytokeratins 8, 18, and 19 (but not 14) and to metabolize prostatic androgens. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001323)
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Genes

203 genes mutated in the BPH-1 cell line from the COSMIC Cell Line Gene Mutation Profiles dataset.

Symbol Name
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADAP1 ArfGAP with dual PH domains 1
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
ADGRV1 adhesion G protein-coupled receptor V1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKR7L aldo-keto reductase family 7-like (gene/pseudogene)
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALOX15B arachidonate 15-lipoxygenase, type B
AMDHD2 amidohydrolase domain containing 2
AMY1C amylase, alpha 1C (salivary)
ANK2 ankyrin 2, neuronal
ANKRD11 ankyrin repeat domain 11
AQP1 aquaporin 1 (Colton blood group)
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARFGEF3 ARFGEF family member 3
ARHGAP23 Rho GTPase activating protein 23
ARHGAP4 Rho GTPase activating protein 4
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ASTN1 astrotactin 1
AVPR1A arginine vasopressin receptor 1A
B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
BZW1 basic leucine zipper and W2 domains 1
CD226 CD226 molecule
CDH20 cadherin 20, type 2
CDH4 cadherin 4, type 1, R-cadherin (retinal)
CEP170B centrosomal protein 170B
CNTNAP3B contactin associated protein-like 3B
CNTNAP4 contactin associated protein-like 4
COL4A1 collagen, type IV, alpha 1
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung)
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CSMD2 CUB and Sushi multiple domains 2
CUL9 cullin 9
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDHD2 DDHD domain containing 2
DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37
DMBT1 deleted in malignant brain tumors 1
DMBX1 diencephalon/mesencephalon homeobox 1
DNAH1 dynein, axonemal, heavy chain 1
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30
DRC7 dynein regulatory complex subunit 7
ELANE elastase, neutrophil expressed
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETNK2 ethanolamine kinase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EVC Ellis van Creveld protein
FBXO38 F-box protein 38
FBXW10 F-box and WD repeat domain containing 10
FIP1L1 factor interacting with PAPOLA and CPSF1
FPGS folylpolyglutamate synthase
FRRS1 ferric-chelate reductase 1
FRY furry homolog (Drosophila)
FYCO1 FYVE and coiled-coil domain containing 1
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6
GSG1 germ cell associated 1
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
H1FX H1 histone family, member X
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
HLA-C major histocompatibility complex, class I, C
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA1L heat shock 70kDa protein 1-like
HSPG2 heparan sulfate proteoglycan 2
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IER5 immediate early response 5
IGSF3 immunoglobulin superfamily, member 3
IPO4 importin 4
JAG1 jagged 1
KANSL1 KAT8 regulatory NSL complex subunit 1
KDM1B lysine (K)-specific demethylase 1B
KIAA1671 KIAA1671
KIF1B kinesin family member 1B
KMT2A lysine (K)-specific methyltransferase 2A
KRTAP4-6 keratin associated protein 4-6
KRTAP5-11 keratin associated protein 5-11
KRTAP6-1 keratin associated protein 6-1
LAMA1 laminin, alpha 1
LGALS9 lectin, galactoside-binding, soluble, 9
LRP1B low density lipoprotein receptor-related protein 1B
MACF1 microtubule-actin crosslinking factor 1
MAOA monoamine oxidase A
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MAP7D1 MAP7 domain containing 1
MED12L mediator complex subunit 12-like
MLYCD malonyl-CoA decarboxylase
MPL MPL proto-oncogene, thrombopoietin receptor
MRPL13 mitochondrial ribosomal protein L13
MRPL54 mitochondrial ribosomal protein L54
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMP microseminoprotein, prostate associated
MTMR10 myotubularin related protein 10
MTMR12 myotubularin related protein 12
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH7B myosin, heavy chain 7B, cardiac muscle, beta
MYO18B myosin XVIIIB
MYOM2 myomesin 2
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NEK1 NIMA-related kinase 1
NLRP7 NLR family, pyrin domain containing 7
NPC1 Niemann-Pick disease, type C1
NPSR1 neuropeptide S receptor 1
NUPL1 nucleoporin like 1
NVL nuclear VCP-like
OAZ2 ornithine decarboxylase antizyme 2
ODF2 outer dense fiber of sperm tails 2
OR2T33 olfactory receptor, family 2, subfamily T, member 33
PCDHB14 protocadherin beta 14
PCNT pericentrin
PCNXL3 pecanex-like 3 (Drosophila)
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM2 PDZ and LIM domain 2 (mystique)
PHRF1 PHD and ring finger domains 1
PKD1L1 polycystic kidney disease 1 like 1
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1
PLA2G4E phospholipase A2, group IVE
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PNMAL2 paraneoplastic Ma antigen family-like 2
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
POU5F1B POU class 5 homeobox 1B
PRAME preferentially expressed antigen in melanoma
PRICKLE4 prickle homolog 4 (Drosophila)
PRMT6 protein arginine methyltransferase 6
PRR14L proline rich 14-like
PRSS36 protease, serine, 36
PSKH1 protein serine kinase H1
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RARS2 arginyl-tRNA synthetase 2, mitochondrial
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RAX retina and anterior neural fold homeobox
RBP3 retinol binding protein 3, interstitial
RFX7 regulatory factor X, 7
RGS3 regulator of G-protein signaling 3
RIC1 RAB6A GEF complex partner 1
RPLP0 ribosomal protein, large, P0
RPS24 ribosomal protein S24
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCN1A sodium channel, voltage gated, type I alpha subunit
SCRIB scribbled planar cell polarity protein
SFRP5 secreted frizzled-related protein 5
SGK494 uncharacterized serine/threonine-protein kinase SgK494
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SHROOM3 shroom family member 3
SI sucrase-isomaltase (alpha-glucosidase)
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLAMF9 SLAM family member 9
SLC16A4 solute carrier family 16, member 4
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SNX19 sorting nexin 19
SORCS1 sortilin-related VPS10 domain containing receptor 1
SORT1 sortilin 1
SP110 SP110 nuclear body protein
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
STAG3 stromal antigen 3
SURF1 surfeit 1
SYNE1 spectrin repeat containing, nuclear envelope 1
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TDRD6 tudor domain containing 6
TENM2 teneurin transmembrane protein 2
TERT telomerase reverse transcriptase
TG thyroglobulin
THAP3 THAP domain containing, apoptosis associated protein 3
TLR9 toll-like receptor 9
TMC2 transmembrane channel-like 2
TMEM178A transmembrane protein 178A
TMPRSS5 transmembrane protease, serine 5
TNC tenascin C
TNNI3K TNNI3 interacting kinase
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREML2 triggering receptor expressed on myeloid cells-like 2
TRIM21 tripartite motif containing 21
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TTC3 tetratricopeptide repeat domain 3
TTN titin
UBASH3A ubiquitin associated and SH3 domain containing A
VWA2 von Willebrand factor A domain containing 2
WNT2B wingless-type MMTV integration site family, member 2B
YBX1 Y box binding protein 1
ZBED9 zinc finger, BED-type containing 9
ZC3H18 zinc finger CCCH-type containing 18
ZFHX3 zinc finger homeobox 3
ZFPM2 zinc finger protein, FOG family member 2
ZFYVE16 zinc finger, FYVE domain containing 16
ZMYM6 zinc finger, MYM-type 6
ZNF2 zinc finger protein 2
ZNF225 zinc finger protein 225
ZNF287 zinc finger protein 287
ZNF527 zinc finger protein 527
ZNF77 zinc finger protein 77
ZNF778 zinc finger protein 778
ZSCAN21 zinc finger and SCAN domain containing 21
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1