BPH-1 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description Human benign prostate hyperplasia; prostate epithelial cells from a 68-year-old man with benign prostate hyperplasia; cells were immortalized with SV-40 large T-antigen; cells were described to express cytokeratins 8, 18, and 19 (but not 14) and to metabolize prostatic androgens. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001323)
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Genes

296 genes with high or low expression in BPH-1 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
DUOX2 dual oxidase 2 3.58361
RSAD2 radical S-adenosyl methionine domain containing 2 3.38539
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 3.21485
SAMD9 sterile alpha motif domain containing 9 3.0817
SPATA5L1 spermatogenesis associated 5-like 1 2.96667
XAF1 XIAP associated factor 1 2.79494
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.75412
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.60339
N4BP1 NEDD4 binding protein 1 2.55038
SP110 SP110 nuclear body protein 2.48496
TRIM31 tripartite motif containing 31 2.45881
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 2.39435
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.3884
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.38344
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 2.31646
CRYBB3 crystallin, beta B3 2.28921
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.28308
OASL 2'-5'-oligoadenylate synthetase-like 2.25675
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 2.25174
PLSCR1 phospholipid scramblase 1 2.21634
SAA4 serum amyloid A4, constitutive 2.18071
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.17512
GBP1 guanylate binding protein 1, interferon-inducible 2.17129
HLA-F major histocompatibility complex, class I, F 2.16682
TRIM5 tripartite motif containing 5 2.08019
RNF126 ring finger protein 126 2.0746
IFNGR1 interferon gamma receptor 1 2.0451
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 2.02892
TGM1 transglutaminase 1 2.01829
CFB complement factor B 2.00474
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 1.9699
SAMHD1 SAM domain and HD domain 1 1.96833
APOL1 apolipoprotein L, 1 1.96226
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 1.95545
IVL involucrin 1.95206
RNF114 ring finger protein 114 1.95078
ASCC3 activating signal cointegrator 1 complex subunit 3 1.9408
USP18 ubiquitin specific peptidase 18 1.92489
ISG15 ISG15 ubiquitin-like modifier 1.91394
WTAP Wilms tumor 1 associated protein 1.89458
CSNK1G1 casein kinase 1, gamma 1 1.88839
IL1A interleukin 1, alpha 1.88686
TRIM14 tripartite motif containing 14 1.88074
CXCL11 chemokine (C-X-C motif) ligand 11 1.87718
IRF7 interferon regulatory factor 7 1.83621
APOL2 apolipoprotein L, 2 1.8338
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.79875
CLCA4 chloride channel accessory 4 1.79034
SDC4 syndecan 4 1.78711
IFI35 interferon-induced protein 35 1.78009
LAMP3 lysosomal-associated membrane protein 3 1.75476
DRAM1 DNA-damage regulated autophagy modulator 1 1.75388
TMEM40 transmembrane protein 40 1.75287
MPZL2 myelin protein zero-like 2 1.74158
IL36G interleukin 36, gamma 1.73731
ULBP2 UL16 binding protein 2 1.73007
TOR1B torsin family 1, member B (torsin B) 1.71948
IRF9 interferon regulatory factor 9 1.71885
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.71048
HLA-G major histocompatibility complex, class I, G 1.70865
ADRB2 adrenoceptor beta 2, surface 1.70121
TRIM22 tripartite motif containing 22 1.68003
DHRS9 dehydrogenase/reductase (SDR family) member 9 1.66961
ATF3 activating transcription factor 3 1.65699
CCNC cyclin C 1.64916
ACE2 angiotensin I converting enzyme 2 1.64862
RFC5 replication factor C (activator 1) 5, 36.5kDa 1.64798
MX1 MX dynamin-like GTPase 1 1.64603
SAA1 serum amyloid A1 1.64359
PEX3 peroxisomal biogenesis factor 3 1.63858
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 1.63582
CXCL10 chemokine (C-X-C motif) ligand 10 1.62822
CPM carboxypeptidase M 1.62214
IFIH1 interferon induced with helicase C domain 1 1.62172
LAP3 leucine aminopeptidase 3 1.61396
PDE8A phosphodiesterase 8A 1.61274
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 1.61205
PGLYRP4 peptidoglycan recognition protein 4 1.61126
MXD1 MAX dimerization protein 1 1.61116
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13 1.61107
CASP8AP2 caspase 8 associated protein 2 1.60679
MAP2K1 mitogen-activated protein kinase kinase 1 1.60414
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.60261
ZNF180 zinc finger protein 180 1.59748
HBEGF heparin-binding EGF-like growth factor 1.59584
IFI44 interferon-induced protein 44 1.58756
F3 coagulation factor III (thromboplastin, tissue factor) 1.5866
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.57571
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 1.57435
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.57036
CHMP5 charged multivesicular body protein 5 1.56683
IQCB1 IQ motif containing B1 1.55504
DUOX1 dual oxidase 1 1.55383
SPRR3 small proline-rich protein 3 1.54712
LGALS13 lectin, galactoside-binding, soluble, 13 1.54388
GPN3 GPN-loop GTPase 3 1.51315
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 1.50594
PCNA proliferating cell nuclear antigen 1.50584
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 1.50457
BLCAP bladder cancer associated protein 1.50277
IRF1 interferon regulatory factor 1 1.49985
HRASLS2 HRAS-like suppressor 2 1.4974
BLZF1 basic leucine zipper nuclear factor 1 1.49058
RPE ribulose-5-phosphate-3-epimerase 1.48982
IFI6 interferon, alpha-inducible protein 6 1.48643
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa 1.47817
PEX7 peroxisomal biogenesis factor 7 1.47388
TRIM21 tripartite motif containing 21 1.46742
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.46205
NAE1 NEDD8 activating enzyme E1 subunit 1 1.46107
IDO1 indoleamine 2,3-dioxygenase 1 1.45799
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 1.45792
KLK10 kallikrein-related peptidase 10 1.45753
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 1.44599
APAF1 apoptotic peptidase activating factor 1 1.44513
TOR1A torsin family 1, member A (torsin A) 1.44329
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.43492
KLK7 kallikrein-related peptidase 7 1.43272
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.43126
TDRD7 tudor domain containing 7 1.42683
PARP12 poly (ADP-ribose) polymerase family, member 12 1.418
RTP4 receptor (chemosensory) transporter protein 4 1.41781
SAR1A secretion associated, Ras related GTPase 1A 1.41646

low expression

Symbol Name Standardized Value
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -3.53725
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -3.10632
COMMD3 COMM domain containing 3 -3.09265
PER1 period circadian clock 1 -3.07236
SETD4 SET domain containing 4 -2.85196
STX10 syntaxin 10 -2.82712
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.70348
RHOF ras homolog family member F (in filopodia) -2.63452
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E -2.61579
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) -2.60116
SFSWAP splicing factor, suppressor of white-apricot family -2.58621
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 -2.56146
CS citrate synthase -2.54931
WDR37 WD repeat domain 37 -2.4242
PAN2 PAN2 poly(A) specific ribonuclease subunit -2.42157
SEPHS1 selenophosphate synthetase 1 -2.26521
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.25742
CLEC4E C-type lectin domain family 4, member E -2.24023
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 -2.19552
AMT aminomethyltransferase -2.18666
HIGD2A HIG1 hypoxia inducible domain family, member 2A -2.17157
GDI2 GDP dissociation inhibitor 2 -2.15332
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.13558
SLIT1 slit homolog 1 (Drosophila) -2.13366
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -2.11902
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa -2.08372
AREG amphiregulin -2.0801
ESYT1 extended synaptotagmin-like protein 1 -2.07794
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) -2.05827
SIRT6 sirtuin 6 -2.03353
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) -2.03143
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -2.01418
CREM cAMP responsive element modulator -2.00592
RASIP1 Ras interacting protein 1 -2.00005
PLCH1 phospholipase C, eta 1 -1.99349
UBE4B ubiquitination factor E4B -1.97829
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -1.97354
JADE1 jade family PHD finger 1 -1.9731
LHX1 LIM homeobox 1 -1.97286
RAPSN receptor-associated protein of the synapse -1.96878
NRD1 nardilysin (N-arginine dibasic convertase) -1.96399
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -1.96315
ZNF702P zinc finger protein 702, pseudogene -1.95846
PDE4B phosphodiesterase 4B, cAMP-specific -1.94908
CRY2 cryptochrome circadian clock 2 -1.94351
ARNT aryl hydrocarbon receptor nuclear translocator -1.92373
RAB33A RAB33A, member RAS oncogene family -1.92363
FOXO4 forkhead box O4 -1.90538
ZNHIT1 zinc finger, HIT-type containing 1 -1.89866
ASIC1 acid sensing (proton gated) ion channel 1 -1.89835
MTPAP mitochondrial poly(A) polymerase -1.89476
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -1.88889
COX6C cytochrome c oxidase subunit VIc -1.88772
SCD stearoyl-CoA desaturase (delta-9-desaturase) -1.85651
SERF2 small EDRK-rich factor 2 -1.85543
LRRC23 leucine rich repeat containing 23 -1.855
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) -1.85127
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -1.83247
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -1.83221
ANAPC5 anaphase promoting complex subunit 5 -1.82909
NEUROD2 neuronal differentiation 2 -1.81357
PFDN5 prefoldin subunit 5 -1.80809
OPRM1 opioid receptor, mu 1 -1.80491
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -1.80198
OCM oncomodulin -1.79913
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -1.79223
BMI1 BMI1 proto-oncogene, polycomb ring finger -1.78532
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) -1.78271
STAB2 stabilin 2 -1.77406
BANP BTG3 associated nuclear protein -1.77163
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -1.76753
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -1.7627
CD79A CD79a molecule, immunoglobulin-associated alpha -1.75128
SREBF2 sterol regulatory element binding transcription factor 2 -1.74453
GPR85 G protein-coupled receptor 85 -1.74252
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -1.74109
IQCC IQ motif containing C -1.73543
DOCK4 dedicator of cytokinesis 4 -1.728
WAC WW domain containing adaptor with coiled-coil -1.72148
ALPK1 alpha-kinase 1 -1.71711
PITRM1 pitrilysin metallopeptidase 1 -1.71364
ZNF468 zinc finger protein 468 -1.70396
TMEM57 transmembrane protein 57 -1.70234
UBTD1 ubiquitin domain containing 1 -1.70207
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 -1.70105
ARSA arylsulfatase A -1.69573
ZHX3 zinc fingers and homeoboxes 3 -1.69243
CLCN4 chloride channel, voltage-sensitive 4 -1.68662
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -1.67482
UQCRC1 ubiquinol-cytochrome c reductase core protein I -1.66817
CAMTA1 calmodulin binding transcription activator 1 -1.66641
MICU1 mitochondrial calcium uptake 1 -1.6649
GNPAT glyceronephosphate O-acyltransferase -1.65377
SNX27 sorting nexin family member 27 -1.64922
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -1.64781
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -1.63981
NRG2 neuregulin 2 -1.63485
LUC7L LUC7-like (S. cerevisiae) -1.6343
EIF3L eukaryotic translation initiation factor 3, subunit L -1.63223
TNRC6B trinucleotide repeat containing 6B -1.63104
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 -1.62826
AKT2 v-akt murine thymoma viral oncogene homolog 2 -1.62652
CLCN3 chloride channel, voltage-sensitive 3 -1.62212
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -1.61655
SBNO1 strawberry notch homolog 1 (Drosophila) -1.61519
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -1.61194
MCRS1 microspherule protein 1 -1.60304
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -1.60072
MRPS34 mitochondrial ribosomal protein S34 -1.59944
TGFB3 transforming growth factor, beta 3 -1.59891
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 -1.59321
TREM2 triggering receptor expressed on myeloid cells 2 -1.58541
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -1.58491
SETD8 SET domain containing (lysine methyltransferase) 8 -1.57724
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 -1.57348
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) -1.57295
IQSEC2 IQ motif and Sec7 domain 2 -1.57193
USP53 ubiquitin specific peptidase 53 -1.56837
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase -1.56364
DPH5 diphthamide biosynthesis 5 -1.56257
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -1.56104
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) -1.56002
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) -1.55866
NOL12 nucleolar protein 12 -1.55684
MLEC malectin -1.55535
VKORC1 vitamin K epoxide reductase complex, subunit 1 -1.5501
DCTN1 dynactin 1 -1.54799
NEUROG2 neurogenin 2 -1.54354
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 -1.54319
NDUFA4 NDUFA4, mitochondrial complex associated -1.54294
SEC31A SEC31 homolog A (S. cerevisiae) -1.53837
SORBS1 sorbin and SH3 domain containing 1 -1.53479
PNMT phenylethanolamine N-methyltransferase -1.52926
NIPSNAP1 nipsnap homolog 1 (C. elegans) -1.52236
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 -1.51542
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -1.51473
ANGPT2 angiopoietin 2 -1.51285
TARBP2 TAR (HIV-1) RNA binding protein 2 -1.51263
HIST1H2AI histone cluster 1, H2ai -1.50893
PFDN6 prefoldin subunit 6 -1.50461
SEC61G Sec61 gamma subunit -1.50012
JRK Jrk homolog (mouse) -1.49798
TMEM110 transmembrane protein 110 -1.48845
GTF3A general transcription factor IIIA -1.48688
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -1.48505
WDR48 WD repeat domain 48 -1.48203
NTHL1 nth endonuclease III-like 1 (E. coli) -1.47898
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -1.47207
RBM17 RNA binding motif protein 17 -1.47088
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -1.46247
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 -1.46194
PCGF1 polycomb group ring finger 1 -1.4615
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -1.45863
MRPL33 mitochondrial ribosomal protein L33 -1.45508
ZNF669 zinc finger protein 669 -1.45449
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -1.44117
RBPJ recombination signal binding protein for immunoglobulin kappa J region -1.4411
PITX3 paired-like homeodomain 3 -1.44064
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -1.44035
CALCR calcitonin receptor -1.43939
HTT huntingtin -1.43771
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -1.43487
ZNF695 zinc finger protein 695 -1.43407
ABHD6 abhydrolase domain containing 6 -1.42938
KLHL25 kelch-like family member 25 -1.42722
GNG7 guanine nucleotide binding protein (G protein), gamma 7 -1.42694
MIP major intrinsic protein of lens fiber -1.42494
NABP2 nucleic acid binding protein 2 -1.42369
GRWD1 glutamate-rich WD repeat containing 1 -1.42259
OLFML2B olfactomedin-like 2B -1.42026
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -1.41758
ZRSR1 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1 -1.41623
RPRM reprimo, TP53 dependent G2 arrest mediator candidate -1.41582