BRAF Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description B-Raf proto-oncogene, serine/threonine kinase|This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 673)
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Genes

100 substrates of the kinase BRAF from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
RGPD8 RANBP2-like and GRIP domain containing 8
CABLES1 Cdk5 and Abl enzyme substrate 1
LIMA1 LIM domain and actin binding 1
PKP3 plakophilin 3
RAB13 RAB13, member RAS oncogene family
ENAH enabled homolog (Drosophila)
HNF4A hepatocyte nuclear factor 4, alpha
GZF1 GDNF-inducible zinc finger protein 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
ATG14 autophagy related 14
ARHGAP32 Rho GTPase activating protein 32
EIF5B eukaryotic translation initiation factor 5B
SPP1 secreted phosphoprotein 1
TJP1 tight junction protein 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ATF4 activating transcription factor 4
BIRC5 baculoviral IAP repeat containing 5
EIF5 eukaryotic translation initiation factor 5
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
SCAF8 SR-related CTD-associated factor 8
CAT catalase
MYOM1 myomesin 1
SNX29 sorting nexin 29
ZNF639 zinc finger protein 639
RAB30 RAB30, member RAS oncogene family
TBC1D31 TBC1 domain family, member 31
STX12 syntaxin 12
RAD18 RAD18 E3 ubiquitin protein ligase
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYH9 myosin, heavy chain 9, non-muscle
SATB1 SATB homeobox 1
CAPN2 calpain 2, (m/II) large subunit
RAB35 RAB35, member RAS oncogene family
SCAMP4 secretory carrier membrane protein 4
SAMD9L sterile alpha motif domain containing 9-like
L1CAM L1 cell adhesion molecule
RANBP2 RAN binding protein 2
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
STK26 serine/threonine protein kinase 26
MTSS1 metastasis suppressor 1
DLC1 DLC1 Rho GTPase activating protein
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
CD3EAP CD3e molecule, epsilon associated protein
FAM73B family with sequence similarity 73, member B
LTV1 LTV1 ribosome biogenesis factor
NOM1 nucleolar protein with MIF4G domain 1
TAGLN transgelin
DOCK10 dedicator of cytokinesis 10
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
REST RE1-silencing transcription factor
STK11 serine/threonine kinase 11
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
SCAF11 SR-related CTD-associated factor 11
FBXO38 F-box protein 38
SACK1F scaffolding CK1 anchoring protein F
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
DRD1 dopamine receptor D1
WWC2 WW and C2 domain containing 2
NCAPH2 non-SMC condensin II complex, subunit H2
BCLAF1 BCL2-associated transcription factor 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
SLK STE20-like kinase
TPD52L2 tumor protein D52-like 2
HSPA4L heat shock 70kDa protein 4-like
RIF1 replication timing regulatory factor 1
XIRP2 xin actin binding repeat containing 2
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
ARFGEF3 ARFGEF family member 3
BAG3 BCL2-associated athanogene 3
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
LUZP1 leucine zipper protein 1
THSD1 thrombospondin, type I, domain containing 1
ZC3H15 zinc finger CCCH-type containing 15
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
NEMF nuclear export mediator factor
SPEN spen family transcriptional repressor
DBF4 DBF4 zinc finger
RGPD3 RANBP2-like and GRIP domain containing 3
KANSL1 KAT8 regulatory NSL complex subunit 1
CTTN cortactin
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
TBC1D2B TBC1 domain family, member 2B
STARD13 StAR-related lipid transfer (START) domain containing 13
NOP56 NOP56 ribonucleoprotein
USP34 ubiquitin specific peptidase 34
CTNND1 catenin (cadherin-associated protein), delta 1
ZC3H8 zinc finger CCCH-type containing 8
SYNRG synergin, gamma
RGPD5 RANBP2-like and GRIP domain containing 5
ADRA1D adrenoceptor alpha 1D
PPP6R1 protein phosphatase 6, regulatory subunit 1
RGPD4 RANBP2-like and GRIP domain containing 4