BRAF Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description B-Raf proto-oncogene, serine/threonine kinase|This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 673)
External Link http://www.ncbi.nlm.nih.gov/gene/673
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Genes

412 interacting proteins for BRAF from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ABLIM1 actin binding LIM protein 1
ACOX3 acyl-CoA oxidase 3, pristanoyl
ACTB actin, beta
ACTN4 actinin, alpha 4
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
ADAM28 ADAM metallopeptidase domain 28
ADCK1 aarF domain containing kinase 1
ADCK3 aarF domain containing kinase 3
ADK adenosine kinase
AFF4 AF4/FMR2 family, member 4
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AHRR aryl-hydrocarbon receptor repressor
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT1S1 AKT1 substrate 1 (proline-rich)
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDOA aldolase A, fructose-bisphosphate
ALPK3 alpha-kinase 3
AMPD2 adenosine monophosphate deaminase 2
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA2 annexin A2
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATAD3B ATPase family, AAA domain containing 3B
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
AURKA aurora kinase A
AURKB aurora kinase B
AZI2 5-azacytidine induced 2
BAD BCL2-associated agonist of cell death
BAIAP2 BAI1-associated protein 2
BCAR1 breast cancer anti-estrogen resistance 1
BCR breakpoint cluster region
BMP2K BMP2 inducible kinase
BMPR1A bone morphogenetic protein receptor, type IA
BRAP BRCA1 associated protein
BRD3 bromodomain containing 3
BRD4 bromodomain containing 4
BTK Bruton agammaglobulinemia tyrosine kinase
C1QBP complement component 1, q subcomponent binding protein
C2CD5 C2 calcium-dependent domain containing 5
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC6 coiled-coil domain containing 6
CCDC88A coiled-coil domain containing 88A
CCNH cyclin H
CDC25C cell division cycle 25C
CDC37 cell division cycle 37
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK1 cyclin-dependent kinase 1
CDK12 cyclin-dependent kinase 12
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
CDK18 cyclin-dependent kinase 18
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDK7 cyclin-dependent kinase 7
CDK9 cyclin-dependent kinase 9
CEP170 centrosomal protein 170kDa
CEP170B centrosomal protein 170B
CEP250 centrosomal protein 250kDa
CGN cingulin
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CLK1 CDC-like kinase 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRTC1 CREB regulated transcription coactivator 1
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK1G3 casein kinase 1, gamma 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DCAF7 DDB1 and CUL4 associated factor 7
DCK deoxycytidine kinase
DCTPP1 dCTP pyrophosphatase 1
DDR1 discoidin domain receptor tyrosine kinase 1
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND1A DENN/MADD domain containing 1A
DENND4A DENN/MADD domain containing 4A
DENND4C DENN/MADD domain containing 4C
DMTN dematin actin binding protein
DOCK11 dedicator of cytokinesis 11
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDC3 enhancer of mRNA decapping 3
EGFR epidermal growth factor receptor
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
EIF3J eukaryotic translation initiation factor 3, subunit J
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA2 EPH receptor A2
EPHA7 EPH receptor A7
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB4 EPH receptor B4
EXO1 exonuclease 1
FAM53C family with sequence similarity 53, member C
FER fer (fps/fes related) tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FOXO3 forkhead box O3
FRK fyn-related Src family tyrosine kinase
FRS2 fibroblast growth factor receptor substrate 2
FRYL FRY-like
FYN FYN proto-oncogene, Src family tyrosine kinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAK cyclin G associated kinase
GAPVD1 GTPase activating protein and VPS9 domains 1
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GIGYF1 GRB10 interacting GYF protein 1
GIGYF2 GRB10 interacting GYF protein 2
GRAMD1A GRAM domain containing 1A
GRIP1 glutamate receptor interacting protein 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
HCK HCK proto-oncogene, Src family tyrosine kinase
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIPK1 homeodomain interacting protein kinase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HRNR hornerin
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
INPP5F inositol polyphosphate-5-phosphatase F
INPPL1 inositol polyphosphate phosphatase-like 1
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KIAA0195 KIAA0195
KIAA0355 KIAA0355
KIAA0930 KIAA0930
KIAA1671 KIAA1671
KIF1B kinesin family member 1B
KIF1C kinesin family member 1C
KIF23 kinesin family member 23
KIF5B kinesin family member 5B
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLC1 kinesin light chain 1
KLC2 kinesin light chain 2
KLC3 kinesin light chain 3
KLC4 kinesin light chain 4
KRAS Kirsten rat sarcoma viral oncogene homolog
KSR1 kinase suppressor of ras 1
KSR2 kinase suppressor of ras 2
LARP1 La ribonucleoprotein domain family, member 1
LIMA1 LIM domain and actin binding 1
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LMO7 LIM domain 7
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
LSR lipolysis stimulated lipoprotein receptor
LUZP1 leucine zipper protein 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MAST2 microtubule associated serine/threonine kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MELK maternal embryonic leucine zipper kinase
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRAS muscle RAS oncogene homolog
MTMR12 myotubularin related protein 12
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NADK NAD kinase
NAV1 neuron navigator 1
NCK2 NCK adaptor protein 2
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEK11 NIMA-related kinase 11
NEK9 NIMA-related kinase 9
NELFA negative elongation factor complex member A
NELFB negative elongation factor complex member B
NF1 neurofibromin 1
NLK nemo-like kinase
NQO2 NAD(P)H dehydrogenase, quinone 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OIP5 Opa interacting protein 5
OSBPL3 oxysterol binding protein-like 3
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD3 par-3 family cell polarity regulator
PARP8 poly (ADP-ribose) polymerase family, member 8
PDE4A phosphodiesterase 4A, cAMP-specific
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PDZD11 PDZ domain containing 11
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHKB phosphorylase kinase, beta
PHLDB2 pleckstrin homology-like domain, family B, member 2
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PKN1 protein kinase N1
PKN3 protein kinase N3
PKP2 plakophilin 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLK4 polo-like kinase 4
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKD2 protein kinase D2
PRKD3 protein kinase D3
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
PUM1 pumilio RNA-binding family member 1
R3HDM1 R3H domain containing 1
R3HDM2 R3H domain containing 2
RAB11B RAB11B, member RAS oncogene family
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RAP2A RAP2A, member of RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASAL2 RAS protein activator like 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
REEP1 receptor accessory protein 1
REEP4 receptor accessory protein 4
RERG RAS-like, estrogen-regulated, growth inhibitor
RHEB Ras homolog enriched in brain
RICTOR RPTOR independent companion of MTOR, complex 2
RIPK2 receptor-interacting serine-threonine kinase 2
RIT1 Ras-like without CAAX 1
RIT2 Ras-like without CAAX 2
RNF149 ring finger protein 149
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
RRAS related RAS viral (r-ras) oncogene homolog
RTKN rhotekin
SACK1A scaffolding CK1 anchoring protein A
SACK1B scaffolding CK1 anchoring protein B
SAMD4A sterile alpha motif domain containing 4A
SAMD4B sterile alpha motif domain containing 4B
SEC16A SEC16 homolog A (S. cerevisiae)
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SH3PXD2A SH3 and PX domains 2A
SH3RF1 SH3 domain containing ring finger 1
SH3RF3 SH3 domain containing ring finger 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHKBP1 SH3KBP1 binding protein 1
SHROOM2 shroom family member 2
SHROOM3 shroom family member 3
SIK2 salt-inducible kinase 2
SIK3 SIK family kinase 3
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLK STE20-like kinase
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SPEG SPEG complex locus
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SRRM2 serine/arginine repetitive matrix 2
SSB Sjogren syndrome antigen B (autoantigen La)
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STK16 serine/threonine kinase 16
STK3 serine/threonine kinase 3
SYK spleen tyrosine kinase
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TANK TRAF family member-associated NFKB activator
TAOK1 TAO kinase 1
TAOK3 TAO kinase 3
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TBC1D22B TBC1 domain family, member 22B
TBC1D4 TBC1 domain family, member 4
TBC1D5 TBC1 domain family, member 5
TBK1 TANK-binding kinase 1
TBKBP1 TBK1 binding protein 1
TEC tec protein tyrosine kinase
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TESK2 testis-specific kinase 2
TGFBR1 transforming growth factor, beta receptor 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNIK TRAF2 and NCK interacting kinase
TNK1 tyrosine kinase, non-receptor, 1
TNK2 tyrosine kinase, non-receptor, 2
TP53BP2 tumor protein p53 binding protein 2
TPD52L1 tumor protein D52-like 1
TRAF3 TNF receptor-associated factor 3
TRIM32 tripartite motif containing 32
TRIP11 thyroid hormone receptor interactor 11
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TTC28 tetratricopeptide repeat domain 28
TTK TTK protein kinase
TTN titin
TUBA1B tubulin, alpha 1b
TYK2 tyrosine kinase 2
UBC ubiquitin C
UHRF1BP1L UHRF1 binding protein 1-like
ULK3 unc-51 like kinase 3
USP54 ubiquitin specific peptidase 54
USP8 ubiquitin specific peptidase 8
VAMP8 vesicle-associated membrane protein 8
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WDR62 WD repeat domain 62
WEE1 WEE1 G2 checkpoint kinase
WNK1 WNK lysine deficient protein kinase 1
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2