| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | breast cancer 1, early onset|This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009] (NCBI Entrez Gene Database, 672) |
| External Link | https://ncbi.nlm.nih.gov/gene/672 |
| Similar Terms | |
| Downloads & Tools |
498 genes differentially expressed following the BRCA1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.0185608 |
| MT1G | metallothionein 1G | 0.0120097 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 0.0115674 |
| MAGEA3 | melanoma antigen family A3 | 0.0114362 |
| MT1E | metallothionein 1E | 0.0113356 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.0112378 |
| H1-2 | H1.2 linker histone, cluster member | 0.0108406 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.0108227 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0104155 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.0102032 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | 0.0101179 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.0100617 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00977658 |
| HSPB1 | heat shock 27kDa protein 1 | 0.00949282 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | 0.00942258 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | 0.00937309 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.0089586 |
| ADIRF | adipogenesis regulatory factor | 0.00883902 |
| MT1F | metallothionein 1F | 0.00882656 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00837888 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00803556 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.00802813 |
| LY96 | lymphocyte antigen 96 | 0.00796407 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.00780293 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00769379 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.00767066 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.0076281 |
| HOXC6 | homeobox C6 | 0.00756519 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | 0.00747317 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00738281 |
| CD44 | CD44 molecule (Indian blood group) | 0.00735889 |
| MT1H | metallothionein 1H | 0.00735208 |
| LOXL2 | lysyl oxidase-like 2 | 0.00732864 |
| NPY1R | neuropeptide Y receptor Y1 | 0.0072698 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.00724711 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00724457 |
| MT1X | metallothionein 1X | 0.00721008 |
| PLA1A | phospholipase A1 member A | 0.00699895 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00698605 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | 0.00697526 |
| METTL7A | methyltransferase like 7A | 0.0069089 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.00688593 |
| GMPR | guanosine monophosphate reductase | 0.00685164 |
| SECTM1 | secreted and transmembrane 1 | 0.00683818 |
| CA2 | carbonic anhydrase II | 0.00679753 |
| ARMT1 | acidic residue methyltransferase 1 | 0.00677344 |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta | 0.00667641 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.00666129 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | 0.00664165 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | 0.00662976 |
| E2F2 | E2F transcription factor 2 | 0.00659392 |
| RPS27L | ribosomal protein S27-like | 0.00657868 |
| SNAP29 | synaptosomal-associated protein, 29kDa | 0.00657115 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | 0.00657011 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00656533 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.00655617 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.00654838 |
| SNAP23 | synaptosomal-associated protein, 23kDa | 0.00654313 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00653261 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00652351 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00649457 |
| HHEX | hematopoietically expressed homeobox | 0.006487 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00646287 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00644354 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00638719 |
| NNMT | nicotinamide N-methyltransferase | 0.00637812 |
| GPX1 | glutathione peroxidase 1 | 0.00629315 |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.00627696 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00627345 |
| SPP1 | secreted phosphoprotein 1 | 0.00626856 |
| FZD6 | frizzled class receptor 6 | 0.00626615 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00618108 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.00614701 |
| COL15A1 | collagen, type XV, alpha 1 | 0.00611001 |
| SST | somatostatin | 0.00609862 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.00602607 |
| GCH1 | GTP cyclohydrolase 1 | 0.00599472 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0059696 |
| LDOC1 | leucine zipper, down-regulated in cancer 1 | 0.00595184 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00591933 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.00591269 |
| HBZ | hemoglobin, zeta | 0.00589736 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.00583446 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.00582704 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.00577113 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00576908 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | 0.00573047 |
| HOXB2 | homeobox B2 | 0.00569872 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.0056722 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.00565102 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.00564717 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.00559987 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.0055938 |
| MAGEA12 | melanoma antigen family A12 | 0.00557164 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00557159 |
| MT1M | metallothionein 1M | 0.00556662 |
| MT2A | metallothionein 2A | 0.00556015 |
| MAP3K7CL | MAP3K7 C-terminal like | 0.00554169 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.00553535 |
| ERGIC2 | ERGIC and golgi 2 | 0.00551701 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | 0.00547955 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00545755 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00541274 |
| REG1A | regenerating islet-derived 1 alpha | 0.00539407 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.00536298 |
| DCLK1 | doublecortin-like kinase 1 | 0.0053401 |
| ASS1 | argininosuccinate synthase 1 | 0.00532677 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.0053205 |
| KLK5 | kallikrein-related peptidase 5 | 0.00531837 |
| RWDD1 | RWD domain containing 1 | 0.00531722 |
| KRT8 | keratin 8, type II | 0.00529169 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.00528835 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.00526954 |
| KAT2B | K(lysine) acetyltransferase 2B | 0.00525595 |
| PDGFRL | platelet-derived growth factor receptor-like | 0.00523853 |
| COL10A1 | collagen, type X, alpha 1 | 0.00522883 |
| MX2 | MX dynamin-like GTPase 2 | 0.00522276 |
| MMP11 | matrix metallopeptidase 11 | 0.00522247 |
| MEOX1 | mesenchyme homeobox 1 | 0.00517717 |
| NUP58 | nucleoporin 58 | 0.00516307 |
| TXLNA | taxilin alpha | 0.00515966 |
| PTGER3 | prostaglandin E receptor 3 (subtype EP3) | 0.00514045 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.00513743 |
| STK39 | serine threonine kinase 39 | 0.00512073 |
| SOCS1 | suppressor of cytokine signaling 1 | 0.00510982 |
| DDX42 | DEAD (Asp-Glu-Ala-Asp) box helicase 42 | 0.00510514 |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | 0.00508964 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 0.00507878 |
| HLA-DMB | major histocompatibility complex, class II, DM beta | 0.00506481 |
| TCL1A | T-cell leukemia/lymphoma 1A | 0.00505201 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | 0.00504535 |
| MAGEA1 | melanoma antigen family A1 | 0.00502823 |
| ACKR3 | atypical chemokine receptor 3 | 0.0050093 |
| RGS4 | regulator of G-protein signaling 4 | 0.00500847 |
| CD200 | CD200 molecule | 0.00500492 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.00499718 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.00498333 |
| POU2AF1 | POU class 2 associating factor 1 | 0.00497557 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | 0.00495956 |
| TCF12 | transcription factor 12 | 0.00495937 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00493319 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.00493143 |
| APOB | apolipoprotein B | 0.00492577 |
| STAG3 | stromal antigen 3 | 0.00492158 |
| VAMP5 | vesicle-associated membrane protein 5 | 0.00492154 |
| PDE10A | phosphodiesterase 10A | 0.00489809 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.00489298 |
| CLIC2 | chloride intracellular channel 2 | 0.00488728 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0048781 |
| RIPOR2 | RHO family interacting cell polarization regulator 2 | 0.00486629 |
| ATP6V1B1 | ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 | 0.00484959 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00484912 |
| MAGEB2 | melanoma antigen family B2 | 0.00484555 |
| BEX1 | brain expressed, X-linked 1 | 0.00483642 |
| ESR1 | estrogen receptor 1 | 0.00483019 |
| HIST1H2BK | histone cluster 1, H2bk | 0.0048187 |
| SNAPC5 | small nuclear RNA activating complex, polypeptide 5, 19kDa | 0.0048091 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.00480622 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.00479847 |
| ERBIN | erbb2 interacting protein | 0.00478247 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.00476908 |
| RAP1GAP | RAP1 GTPase activating protein | 0.0047656 |
| TM4SF4 | transmembrane 4 L six family member 4 | 0.00476197 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00475918 |
| LY6E | lymphocyte antigen 6 complex, locus E | 0.00473232 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | 0.0047275 |
| AMMECR1 | Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.00471856 |
| EMP3 | epithelial membrane protein 3 | 0.00471358 |
| R3HDM4 | R3H domain containing 4 | 0.0047102 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00470119 |
| CDC34 | cell division cycle 34 | 0.00469056 |
| AADAC | arylacetamide deacetylase | 0.00467431 |
| CA12 | carbonic anhydrase XII | 0.0046646 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.00464812 |
| TMEM126B | transmembrane protein 126B | 0.00464351 |
| MFAP5 | microfibrillar associated protein 5 | 0.00463994 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00463679 |
| UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI | 0.00462665 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00462117 |
| PGF | placental growth factor | 0.00461917 |
| HOXB7 | homeobox B7 | 0.00461169 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | 0.00460798 |
| EVA1B | eva-1 homolog B (C. elegans) | 0.0046055 |
| CST6 | cystatin E/M | 0.0045987 |
| IL6 | interleukin 6 | 0.0045987 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.00458689 |
| ADCY9 | adenylate cyclase 9 | 0.00458246 |
| DDT | D-dopachrome tautomerase | 0.00457802 |
| NUP43 | nucleoporin 43kDa | 0.00457272 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.00456238 |
| NSFL1C | NSFL1 (p97) cofactor (p47) | 0.00454982 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | 0.0045441 |
| EDRF1 | erythroid differentiation regulatory factor 1 | 0.00453806 |
| TMEM106B | transmembrane protein 106B | 0.00451947 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.00451705 |
| OFD1 | oral-facial-digital syndrome 1 | 0.00448803 |
| PLXNC1 | plexin C1 | 0.00448053 |
| KLK7 | kallikrein-related peptidase 7 | 0.00446803 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.00446777 |
| TWF1 | twinfilin actin binding protein 1 | 0.00445576 |
| HCRT | hypocretin (orexin) neuropeptide precursor | 0.00445126 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | 0.00444873 |
| HOXB6 | homeobox B6 | 0.00444718 |
| SNX13 | sorting nexin 13 | 0.00444682 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0044465 |
| RAB38 | RAB38, member RAS oncogene family | 0.00444522 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00443505 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.00443282 |
| EZR | ezrin | 0.00442966 |
| S100A14 | S100 calcium binding protein A14 | 0.00442412 |
| DAAM2 | dishevelled associated activator of morphogenesis 2 | 0.00442387 |
| SNX10 | sorting nexin 10 | 0.00440335 |
| TGDS | TDP-glucose 4,6-dehydratase | 0.00440208 |
| C1D | C1D nuclear receptor corepressor | 0.00440185 |
| SLBP | stem-loop binding protein | 0.00439753 |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.00438965 |
| CCNL2 | cyclin L2 | 0.00438653 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.00438451 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.00438304 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.00438127 |
| EVI2A | ecotropic viral integration site 2A | 0.00437835 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.00437395 |
| METTL5 | methyltransferase like 5 | 0.00437309 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00437092 |
| WTAP | Wilms tumor 1 associated protein | 0.00437063 |
| COMMD4 | COMM domain containing 4 | 0.00436901 |
| PTK2 | protein tyrosine kinase 2 | 0.00436526 |
| HIC2 | hypermethylated in cancer 2 | 0.00436014 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00435582 |
| MRPL18 | mitochondrial ribosomal protein L18 | 0.00433771 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.00433506 |
| DRAM1 | DNA-damage regulated autophagy modulator 1 | 0.00433462 |
| FGB | fibrinogen beta chain | 0.00433371 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.00433178 |
| SPON2 | spondin 2, extracellular matrix protein | 0.00432564 |
| LUM | lumican | 0.00432322 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 0.0043211 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0043132 |
| YIPF6 | Yip1 domain family, member 6 | 0.0043129 |
| KRT18 | keratin 18, type I | 0.00431169 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.00430922 |
| PCLAF | PCNA clamp associated factor | 0.00429275 |
| GSTO1 | glutathione S-transferase omega 1 | 0.0042896 |
| DOCK9 | dedicator of cytokinesis 9 | 0.00427556 |
| LRRC17 | leucine rich repeat containing 17 | 0.00425492 |
| KLK8 | kallikrein-related peptidase 8 | 0.0042506 |
| MRPL49 | mitochondrial ribosomal protein L49 | 0.00424288 |
| HELLS | helicase, lymphoid-specific | 0.00423928 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LTF | lactotransferrin | -0.0149182 |
| FABP7 | fatty acid binding protein 7, brain | -0.0131559 |
| TARP | TCR gamma alternate reading frame protein | -0.0111002 |
| MAP7 | microtubule-associated protein 7 | -0.00926381 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -0.0090877 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | -0.00887384 |
| ZIC1 | Zic family member 1 | -0.00882414 |
| GPM6B | glycoprotein M6B | -0.00837747 |
| CTSZ | cathepsin Z | -0.00831182 |
| TNNC1 | troponin C type 1 (slow) | -0.00811172 |
| COQ8A | coenzyme Q8A | -0.0079906 |
| S100A7 | S100 calcium binding protein A7 | -0.00779606 |
| SEPP1 | selenoprotein P, plasma, 1 | -0.00769064 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00762729 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | -0.00753978 |
| PADI2 | peptidyl arginine deiminase, type II | -0.00743668 |
| GPM6A | glycoprotein M6A | -0.00740275 |
| S100A8 | S100 calcium binding protein A8 | -0.00739025 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.00737075 |
| NEBL | nebulette | -0.00735371 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.0073193 |
| AUTS2 | autism susceptibility candidate 2 | -0.00725651 |
| FERMT1 | fermitin family member 1 | -0.0071596 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -0.00704568 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | -0.00701079 |
| TLR4 | toll-like receptor 4 | -0.00698726 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.00697822 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -0.00694055 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0068981 |
| TTN | titin | -0.00689536 |
| NDRG4 | NDRG family member 4 | -0.0068831 |
| CES1 | carboxylesterase 1 | -0.0068488 |
| DIXDC1 | DIX domain containing 1 | -0.00679773 |
| NES | nestin | -0.00676872 |
| PCYOX1 | prenylcysteine oxidase 1 | -0.00674377 |
| FMO2 | flavin containing monooxygenase 2 (non-functional) | -0.00668885 |
| FAR2 | fatty acyl CoA reductase 2 | -0.00665474 |
| SVIL | supervillin | -0.0066002 |
| TUBB4B | tubulin, beta 4B class IVb | -0.00651594 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.00646158 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.00645518 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.0064454 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00641194 |
| HIP1 | huntingtin interacting protein 1 | -0.00637555 |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial | -0.0063338 |
| CORO1A | coronin, actin binding protein, 1A | -0.0063175 |
| ABHD6 | abhydrolase domain containing 6 | -0.00631591 |
| PTN | pleiotrophin | -0.00629519 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.00629307 |
| NELL1 | NEL-like 1 (chicken) | -0.00627133 |
| COG7 | component of oligomeric golgi complex 7 | -0.00626615 |
| DACH1 | dachshund family transcription factor 1 | -0.00624841 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00622541 |
| EGR2 | early growth response 2 | -0.00622273 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | -0.0062125 |
| LAPTM5 | lysosomal protein transmembrane 5 | -0.00620675 |
| ACP6 | acid phosphatase 6, lysophosphatidic | -0.00614736 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | -0.00612595 |
| MPDZ | multiple PDZ domain protein | -0.00607618 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | -0.00602858 |
| CST7 | cystatin F (leukocystatin) | -0.00601632 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.00598469 |
| PRPF4 | pre-mRNA processing factor 4 | -0.0059372 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.00593228 |
| TPM4 | tropomyosin 4 | -0.00593034 |
| TNNC2 | troponin C type 2 (fast) | -0.00592951 |
| CTSG | cathepsin G | -0.00592276 |
| HACD1 | 3-hydroxyacyl-CoA dehydratase 1 | -0.00590094 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0058916 |
| CHGB | chromogranin B | -0.00589101 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.00587914 |
| IRF6 | interferon regulatory factor 6 | -0.00585568 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -0.00584764 |
| PODXL | podocalyxin-like | -0.00584038 |
| MGP | matrix Gla protein | -0.00579652 |
| LTA4H | leukotriene A4 hydrolase | -0.00578747 |
| ZNF274 | zinc finger protein 274 | -0.00577608 |
| SCAMP1 | secretory carrier membrane protein 1 | -0.00576369 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.00572212 |
| JAG1 | jagged 1 | -0.00571198 |
| SATB2 | SATB homeobox 2 | -0.00570256 |
| ANXA6 | annexin A6 | -0.00567486 |
| B4GALT6 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | -0.00565138 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0056357 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.00559649 |
| NRCAM | neuronal cell adhesion molecule | -0.00558966 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -0.00557526 |
| FAIM | Fas apoptotic inhibitory molecule | -0.00557326 |
| ZNF331 | zinc finger protein 331 | -0.00557108 |
| SH3BGR | SH3 domain binding glutamate-rich protein | -0.00555307 |
| SLN | sarcolipin | -0.00554746 |
| ANGPT1 | angiopoietin 1 | -0.00554225 |
| FHOD3 | formin homology 2 domain containing 3 | -0.00553903 |
| FAM107A | family with sequence similarity 107, member A | -0.00552723 |
| GDI2 | GDP dissociation inhibitor 2 | -0.00551532 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00551094 |
| FOXC1 | forkhead box C1 | -0.00550499 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.00550203 |
| YME1L1 | YME1-like 1 ATPase | -0.00549808 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.00548198 |
| PLAUR | plasminogen activator, urokinase receptor | -0.00547452 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.00546343 |
| MAP1B | microtubule-associated protein 1B | -0.00546342 |
| NDRG2 | NDRG family member 2 | -0.00544192 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | -0.00542598 |
| TUBB2A | tubulin, beta 2A class IIa | -0.00539505 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | -0.00539064 |
| DLD | dihydrolipoamide dehydrogenase | -0.00536825 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00534895 |
| CYP27A1 | cytochrome P450, family 27, subfamily A, polypeptide 1 | -0.00533942 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00533139 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.00532929 |
| LMAN1 | lectin, mannose-binding, 1 | -0.00531799 |
| CNR1 | cannabinoid receptor 1 (brain) | -0.00531424 |
| FBXW2 | F-box and WD repeat domain containing 2 | -0.00528343 |
| NIP7 | NIP7, nucleolar pre-rRNA processing protein | -0.00526995 |
| KLHL41 | kelch-like family member 41 | -0.00526068 |
| CKM | creatine kinase, muscle | -0.00525728 |
| MPO | myeloperoxidase | -0.0052557 |
| SEPTIN9 | septin 9 | -0.00524453 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.00524254 |
| TUBB3 | tubulin, beta 3 class III | -0.00522841 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00522006 |
| VLDLR | very low density lipoprotein receptor | -0.00520993 |
| EXOC5 | exocyst complex component 5 | -0.00518342 |
| ACAA2 | acetyl-CoA acyltransferase 2 | -0.00518014 |
| KIF5C | kinesin family member 5C | -0.00515624 |
| NELL2 | NEL-like 2 (chicken) | -0.00514466 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.00513814 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.00513096 |
| NDRG1 | N-myc downstream regulated 1 | -0.00508559 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.00505518 |
| STUB1 | STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase | -0.00503346 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.00501966 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.0050101 |
| PRKCA | protein kinase C, alpha | -0.0049792 |
| ADORA2B | adenosine A2b receptor | -0.00496651 |
| S100A9 | S100 calcium binding protein A9 | -0.00496292 |
| PRKACA | protein kinase, cAMP-dependent, catalytic, alpha | -0.00495962 |
| OLFM4 | olfactomedin 4 | -0.00495292 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.00493834 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.00490509 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.00490015 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00489173 |
| SET | SET nuclear proto-oncogene | -0.00489053 |
| IL2RG | interleukin 2 receptor, gamma | -0.00487168 |
| ABHD2 | abhydrolase domain containing 2 | -0.00486054 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | -0.00485057 |
| NCOR2 | nuclear receptor corepressor 2 | -0.00484207 |
| SIRT3 | sirtuin 3 | -0.00484077 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | -0.00481823 |
| SIK1 | salt-inducible kinase 1 | -0.00481591 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.00481548 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00480992 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.00480204 |
| FNBP1 | formin binding protein 1 | -0.00479881 |
| SPRY2 | sprouty homolog 2 (Drosophila) | -0.00479767 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.00479638 |
| NEFH | neurofilament, heavy polypeptide | -0.00479216 |
| SPOCK2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | -0.00478453 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.00477711 |
| POPDC3 | popeye domain containing 3 | -0.0047701 |
| PPID | peptidylprolyl isomerase D | -0.00476587 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.00476081 |
| COCH | cochlin | -0.00475493 |
| PAPSS1 | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | -0.00475071 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.00473731 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.00472475 |
| TACC1 | transforming, acidic coiled-coil containing protein 1 | -0.00472248 |
| INAVA | innate immunity activator | -0.00472232 |
| PRKCQ | protein kinase C, theta | -0.00470466 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.0046877 |
| RCAN2 | regulator of calcineurin 2 | -0.00468646 |
| COPA | coatomer protein complex, subunit alpha | -0.00468496 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.00468133 |
| CAPRIN1 | cell cycle associated protein 1 | -0.0046697 |
| HNMT | histamine N-methyltransferase | -0.00466942 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00466793 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.00466323 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00465262 |
| GPR35 | G protein-coupled receptor 35 | -0.0046125 |
| STAC | SH3 and cysteine rich domain | -0.00460679 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.00460629 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.0046031 |
| MEF2C | myocyte enhancer factor 2C | -0.00460014 |
| PDLIM3 | PDZ and LIM domain 3 | -0.00459907 |
| ABITRAM | actin binding transcription modulator | -0.00458906 |
| CSTA | cystatin A (stefin A) | -0.00458641 |
| PNMA2 | paraneoplastic Ma antigen 2 | -0.00457728 |
| PROM1 | prominin 1 | -0.00456314 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.00455372 |
| PRTN3 | proteinase 3 | -0.00454927 |
| MB | myoglobin | -0.00453678 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.00452814 |
| SPRR3 | small proline-rich protein 3 | -0.004518 |
| MCOLN1 | mucolipin 1 | -0.00450377 |
| SNX7 | sorting nexin 7 | -0.00449912 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | -0.00449559 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor | -0.00449376 |
| TRIP13 | thyroid hormone receptor interactor 13 | -0.00449183 |
| ZNF266 | zinc finger protein 266 | -0.00447158 |
| DUSP2 | dual specificity phosphatase 2 | -0.00446891 |
| GFAP | glial fibrillary acidic protein | -0.00446613 |
| AOC1 | amine oxidase, copper containing 1 | -0.00446018 |
| DZIP1 | DAZ interacting zinc finger protein 1 | -0.00445636 |
| PER3 | period circadian clock 3 | -0.00445256 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | -0.00445225 |
| PITRM1 | pitrilysin metallopeptidase 1 | -0.00444514 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00443532 |
| CD177 | CD177 molecule | -0.00442633 |
| PON3 | paraoxonase 3 | -0.00441955 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.00441306 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00441128 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.00440291 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | -0.00439289 |
| TPX2 | TPX2, microtubule-associated | -0.00438609 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | -0.00438228 |
| LEFTY1 | left-right determination factor 1 | -0.00438086 |
| CYB561 | cytochrome b561 | -0.00437324 |
| SRPRA | SRP receptor subunit alpha | -0.00436392 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.00436304 |
| KIF21B | kinesin family member 21B | -0.00436068 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | -0.00435649 |
| SETBP1 | SET binding protein 1 | -0.00435246 |
| CHEK1 | checkpoint kinase 1 | -0.004334 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | -0.00433112 |
| PER2 | period circadian clock 2 | -0.00432867 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | -0.00432377 |
| SASH3 | SAM and SH3 domain containing 3 | -0.00432053 |
| PRPF8 | pre-mRNA processing factor 8 | -0.00431768 |
| TIMP4 | TIMP metallopeptidase inhibitor 4 | -0.00431185 |
| OLFML2A | olfactomedin-like 2A | -0.00430885 |
| SGPP1 | sphingosine-1-phosphate phosphatase 1 | -0.00430478 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.00429129 |
| BRINP3 | bone morphogenetic protein/retinoic acid inducible neural-specific 3 | -0.00428646 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.00428355 |
| CDO1 | cysteine dioxygenase type 1 | -0.00428213 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.00428205 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.00426916 |
| KIAA0125 | KIAA0125 | -0.00426555 |
| SUN2 | Sad1 and UNC84 domain containing 2 | -0.00425653 |
| ZMYND11 | zinc finger, MYND-type containing 11 | -0.00425495 |
| CALB1 | calbindin 1, 28kDa | -0.00424904 |
| MSL1 | male-specific lethal 1 homolog (Drosophila) | -0.00424502 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | -0.00423683 |
| TUBB2B | tubulin, beta 2B class IIb | -0.00423387 |
| SERINC3 | serine incorporator 3 | -0.00423208 |
| GYS1 | glycogen synthase 1 (muscle) | -0.00422909 |
| ELN | elastin | -0.00422892 |
| TPM3 | tropomyosin 3 | -0.00422431 |
