BRCA1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description breast cancer 1, early onset|This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009] (NCBI Entrez Gene Database, 672)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/MORF_BRCA1
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Genes

264 co-expressed genes for BRCA1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ADAM20 ADAM metallopeptidase domain 20
ADCY3 adenylate cyclase 3
AFF2 AF4/FMR2 family, member 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
AOC4P amine oxidase, copper containing 4, pseudogene
AQP7 aquaporin 7
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP11A Rho GTPase activating protein 11A
ARL3 ADP-ribosylation factor-like 3
ATF2 activating transcription factor 2
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
ATXN3 ataxin 3
BARX2 BARX homeobox 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMP10 bone morphogenetic protein 10
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
BRCA1 breast cancer 1, early onset
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BRWD1 bromodomain and WD repeat domain containing 1
C1ORF216 chromosome 1 open reading frame 216
CADM4 cell adhesion molecule 4
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCNF cyclin F
CDC73 cell division cycle 73
CDK8 cyclin-dependent kinase 8
CDYL chromodomain protein, Y-like
CELA2B chymotrypsin-like elastase family, member 2B
CEP162 centrosomal protein 162kDa
CETN3 centrin, EF-hand protein, 3
CFH complement factor H
CHD9 chromodomain helicase DNA binding protein 9
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COL19A1 collagen, type XIX, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPB2 carboxypeptidase B2 (plasma)
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CRHR1 corticotropin releasing hormone receptor 1
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTRL chymotrypsin-like
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DKK4 dickkopf WNT signaling pathway inhibitor 4
DNA2 DNA replication helicase/nuclease 2
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DPT dermatopontin
DTNA dystrobrevin, alpha
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EN2 engrailed homeobox 2
EP400 E1A binding protein p400
EPHB2 EPH receptor B2
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERCC4 excision repair cross-complementation group 4
ESR1 estrogen receptor 1
EXTL3 exostosin-like glycosyltransferase 3
FAM153B family with sequence similarity 153, member B
FANCI Fanconi anemia, complementation group I
FGF18 fibroblast growth factor 18
FIG4 FIG4 phosphoinositide 5-phosphatase
FNTB farnesyltransferase, CAAX box, beta
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FPR2 formyl peptide receptor 2
FRYL FRY-like
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GJB5 gap junction protein, beta 5, 31.1kDa
GLE1 GLE1 RNA export mediator
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNPAT glyceronephosphate O-acyltransferase
GPATCH8 G patch domain containing 8
GPR15 G protein-coupled receptor 15
GPR18 G protein-coupled receptor 18
GPR19 G protein-coupled receptor 19
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIP2 glutamate receptor interacting protein 2
GSS glutathione synthetase
GTSE1 G-2 and S-phase expressed 1
HABP4 hyaluronan binding protein 4
HIC2 hypermethylated in cancer 2
HIST1H3E histone cluster 1, H3e
HNF1A HNF1 homeobox A
HOXA11 homeobox A11
HOXD4 homeobox D4
HSPA13 heat shock protein 70kDa family, member 13
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IGKV7-3 immunoglobulin kappa variable 7-3 (pseudogene)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL11RA interleukin 11 receptor, alpha
IL13 interleukin 13
IL16 interleukin 16
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
INSIG2 insulin induced gene 2
IPO9 importin 9
IRS2 insulin receptor substrate 2
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
IVL involucrin
JADE3 jade family PHD finger 3
JRK Jrk homolog (mouse)
KAZN kazrin, periplakin interacting protein
KIAA0586 KIAA0586
KLHDC10 kelch domain containing 10
KLHL18 kelch-like family member 18
KLRC4 killer cell lectin-like receptor subfamily C, member 4
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
KRT2 keratin 2, type II
KRT33A keratin 33A, type I
KRT86 keratin 86, type II
LEPROTL1 leptin receptor overlapping transcript-like 1
LOR loricrin
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LRRC48 leucine rich repeat containing 48
LTBP4 latent transforming growth factor beta binding protein 4
LY9 lymphocyte antigen 9
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA9 melanoma antigen family A9
MAP2 microtubule-associated protein 2
MC5R melanocortin 5 receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFN1 mitofusin 1
MGA MGA, MAX dimerization protein
MKI67 marker of proliferation Ki-67
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MSH3 mutS homolog 3
MSL3 male-specific lethal 3 homolog (Drosophila)
NCKIPSD NCK interacting protein with SH3 domain
NEK2 NIMA-related kinase 2
NF1 neurofibromin 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFX1 nuclear transcription factor, X-box binding 1
NKRF NFKB repressing factor
NMT1 N-myristoyltransferase 1
NMT2 N-myristoyltransferase 2
NOS2 nitric oxide synthase 2, inducible
NPFF neuropeptide FF-amide peptide precursor
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRP2 neuropilin 2
NRTN neurturin
NTNG2 netrin G2
NXPE3 neurexophilin and PC-esterase domain family, member 3
OR2B6 olfactory receptor, family 2, subfamily B, member 6
P2RY10 purinergic receptor P2Y, G-protein coupled, 10
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PAX7 paired box 7
PAX9 paired box 9
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDE4D phosphodiesterase 4D, cAMP-specific
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PGM3 phosphoglucomutase 3
PHF10 PHD finger protein 10
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIAS2 protein inhibitor of activated STAT, 2
PIGF phosphatidylinositol glycan anchor biosynthesis, class F
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POFUT2 protein O-fucosyltransferase 2
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POU6F1 POU class 6 homeobox 1
POU6F2 POU class 6 homeobox 2
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP5C protein phosphatase 5, catalytic subunit
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSG1 pregnancy specific beta-1-glycoprotein 1
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PVR poliovirus receptor
RAD51D RAD51 paralog D
RAP1A RAP1A, member of RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RBMXL1 RNA binding motif protein, X-linked-like 1
RECQL RecQ helicase-like
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RREB1 ras responsive element binding protein 1
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
RXRG retinoid X receptor, gamma
S100A5 S100 calcium binding protein A5
SCAMP1 secretory carrier membrane protein 1
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC22A6 solute carrier family 22 (organic anion transporter), member 6
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMYD5 SMYD family member 5
SNX4 sorting nexin 4
SPA17 sperm autoantigenic protein 17
SPAG11B sperm associated antigen 11B
SPAST spastin
SPRED2 sprouty-related, EVH1 domain containing 2
STAC SH3 and cysteine rich domain
STAG1 stromal antigen 1
STARD5 StAR-related lipid transfer (START) domain containing 5
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SULT4A1 sulfotransferase family 4A, member 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SURF2 surfeit 2
SYNJ2 synaptojanin 2
SYT5 synaptotagmin V
T T, brachyury homolog (mouse)
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D22A TBC1 domain family, member 22A
TBX19 T-box 19
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM11 transmembrane protein 11
TMEM184B transmembrane protein 184B
TPP2 tripeptidyl peptidase II
TRIM24 tripartite motif containing 24
TSPAN2 tetraspanin 2
TSSK2 testis-specific serine kinase 2
TTI1 TELO2 interacting protein 1
TTLL4 tubulin tyrosine ligase-like family member 4
TTLL5 tubulin tyrosine ligase-like family member 5
UBE4B ubiquitination factor E4B
UPK1A uroplakin 1A
USP20 ubiquitin specific peptidase 20
WBP4 WW domain binding protein 4
YAF2 YY1 associated factor 2
ZBTB14 zinc finger and BTB domain containing 14
ZBTB22 zinc finger and BTB domain containing 22
ZBTB33 zinc finger and BTB domain containing 33
ZBTB40 zinc finger and BTB domain containing 40
ZNF133 zinc finger protein 133
ZNF134 zinc finger protein 134
ZNF157 zinc finger protein 157
ZNF200 zinc finger protein 200
ZNF202 zinc finger protein 202
ZNF266 zinc finger protein 266
ZNF33B zinc finger protein 33B
ZNF500 zinc finger protein 500
ZP2 zona pellucida glycoprotein 2 (sperm receptor)
ZSCAN26 zinc finger and SCAN domain containing 26