BRCA1_DN.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
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278 genes differentially expressed following the BRCA1_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
AIM2 absent in melanoma 2
ANGPT4 angiopoietin 4
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APOH apolipoprotein H (beta-2-glycoprotein I)
ARHGAP15 Rho GTPase activating protein 15
ASMT acetylserotonin O-methyltransferase
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
BTG4 B-cell translocation gene 4
CCKBR cholecystokinin B receptor
CCL27 chemokine (C-C motif) ligand 27
CD160 CD160 molecule
CD34 CD34 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CDH13 cadherin 13
CDH22 cadherin 22, type 2
CDKL5 cyclin-dependent kinase-like 5
CDX1 caudal type homeobox 1
CFAP69 cilia and flagella associated protein 69
CHAT choline O-acetyltransferase
CHD5 chromodomain helicase DNA binding protein 5
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN14 claudin 14
CLDN6 claudin 6
CLEC7A C-type lectin domain family 7, member A
CMKLR1 chemerin chemokine-like receptor 1
CNTN6 contactin 6
CRYGD crystallin, gamma D
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA3 catenin (cadherin-associated protein), alpha 3
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DAZL deleted in azoospermia-like
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25
DENND1C DENN/MADD domain containing 1C
DNAAF1 dynein, axonemal, assembly factor 1
ETNK2 ethanolamine kinase 2
EXTL1 exostosin-like glycosyltransferase 1
FAM46C family with sequence similarity 46, member C
FCGBP Fc fragment of IgG binding protein
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FLJ20712 uncharacterized FLJ20712
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GAGE3 G antigen 3
GJA5 gap junction protein, alpha 5, 40kDa
GML glycosylphosphatidylinositol anchored molecule like
GPR6 G protein-coupled receptor 6
GRID2 glutamate receptor, ionotropic, delta 2
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H2BJ histone cluster 1, H2bj
HIST1H3E histone cluster 1, H3e
HMGA2 high mobility group AT-hook 2
HOXB7 homeobox B7
IFNA14 interferon, alpha 14
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL17A interleukin 17A
IL1RL2 interleukin 1 receptor-like 2
IL5 interleukin 5
INE1 inactivation escape 1 (non-protein coding)
IPW imprinted in Prader-Willi syndrome (non-protein coding)
IQCA1 IQ motif containing with AAA domain 1
ISYNA1 inositol-3-phosphate synthase 1
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2
KCNH7 potassium channel, voltage gated eag related subfamily H, member 7
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLHL35 kelch-like family member 35
KLK8 kallikrein-related peptidase 8
KRT18P51 keratin 18 pseudogene 51
LDB2 LIM domain binding 2
LGALS9 lectin, galactoside-binding, soluble, 9
LHX6 LIM homeobox 6
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2
LINC00260 long intergenic non-protein coding RNA 260
LOC79999 uncharacterized LOC79999
LRMP lymphoid-restricted membrane protein
LRRTM2 leucine rich repeat transmembrane neuronal 2
LRTM1 leucine-rich repeats and transmembrane domains 1
LTC4S leukotriene C4 synthase
MAP2 microtubule-associated protein 2
MTMR8 myotubularin related protein 8
MYBPC1 myosin binding protein C, slow type
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NEUROD4 neuronal differentiation 4
NEUROD6 neuronal differentiation 6
NKX2-2 NK2 homeobox 2
NLGN4Y neuroligin 4, Y-linked
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
OSR2 odd-skipped related transciption factor 2
P3H3 prolyl 3-hydroxylase 3
PAEP progestagen-associated endometrial protein
PHOX2B paired-like homeobox 2b
PIP prolactin-induced protein
POU2F3 POU class 2 homeobox 3
PRAMEF12 PRAME family member 12
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRSS21 protease, serine, 21 (testisin)
PTPRS protein tyrosine phosphatase, receptor type, S
RAG2 recombination activating gene 2
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RHOH ras homolog family member H
RLN1 relaxin 1
RNF122 ring finger protein 122
ROPN1B rhophilin associated tail protein 1B
RPP25 ribonuclease P/MRP 25kDa subunit
RPS2P45 ribosomal protein S2 pseudogene 45
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
SHANK1 SH3 and multiple ankyrin repeat domains 1
SIX1 SIX homeobox 1
SLC16A4 solute carrier family 16, member 4
SLC16A6 solute carrier family 16, member 6
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLURP1 secreted LY6/PLAUR domain containing 1
SMA4 glucuronidase, beta pseudogene
SP4 Sp4 transcription factor
SPO11 SPO11 meiotic protein covalently bound to DSB
STAR steroidogenic acute regulatory protein
TACR3 tachykinin receptor 3
THBS2 thrombospondin 2
THPO thrombopoietin
TIMP4 TIMP metallopeptidase inhibitor 4
TLX3 T-cell leukemia homeobox 3
TNC tenascin C
TP53TG5 TP53 target 5
TRGV7 T cell receptor gamma variable 7 (pseudogene)
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSSK2 testis-specific serine kinase 2
TTLL7 tubulin tyrosine ligase-like family member 7
UPK1B uroplakin 1B
USP9Y ubiquitin specific peptidase 9, Y-linked
VAV1 vav 1 guanine nucleotide exchange factor
WDR25 WD repeat domain 25
ZNF423 zinc finger protein 423
ZNF529 zinc finger protein 529
ZNF682 zinc finger protein 682
ZNF780B zinc finger protein 780B

decreased expression

Symbol Name
AIM1L absent in melanoma 1-like
AMBN ameloblastin (enamel matrix protein)
APOA4 apolipoprotein A-IV
ARF1P1 ADP-ribosylation factor 1 pseudogene 1
ASPA aspartoacylase
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide
AURKC aurora kinase C
BMPR1B bone morphogenetic protein receptor, type IB
BRCA1 breast cancer 1, early onset
C14ORF93 chromosome 14 open reading frame 93
C1ORF116 chromosome 1 open reading frame 116
C1ORF159 chromosome 1 open reading frame 159
CA14 carbonic anhydrase XIV
CARD10 caspase recruitment domain family, member 10
CCDC106 coiled-coil domain containing 106
CCDC132 coiled-coil domain containing 132
CD79A CD79a molecule, immunoglobulin-associated alpha
CD80 CD80 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDK11A cyclin-dependent kinase 11A
CES1P1 carboxylesterase 1 pseudogene 1
CHD2 chromodomain helicase DNA binding protein 2
CLCA3P chloride channel accessory 3, pseudogene
CNIH4 cornichon family AMPA receptor auxiliary protein 4
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CTSW cathepsin W
CYSLTR1 cysteinyl leukotriene receptor 1
CYSLTR2 cysteinyl leukotriene receptor 2
CYTH3 cytohesin 3
DLK2 delta-like 2 homolog (Drosophila)
DPY19L1P1 DPY19L1 pseudogene 1
DPYSL3 dihydropyrimidinase-like 3
E2F2 E2F transcription factor 2
EFNA5 ephrin-A5
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERO1LB ERO1-like beta (S. cerevisiae)
EXD3 exonuclease 3'-5' domain containing 3
EXOC6B exocyst complex component 6B
FAM57A family with sequence similarity 57, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF22 fibroblast growth factor 22
FGF9 fibroblast growth factor 9
FOXJ1 forkhead box J1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GATAD2A GATA zinc finger domain containing 2A
GDF5 growth differentiation factor 5
GM2A GM2 ganglioside activator
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNRH2 gonadotropin-releasing hormone 2
GPR157 G protein-coupled receptor 157
GPR19 G protein-coupled receptor 19
GPR35 G protein-coupled receptor 35
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GREB1L growth regulation by estrogen in breast cancer-like
GRIP1 glutamate receptor interacting protein 1
GSDMD gasdermin D
HAND1 heart and neural crest derivatives expressed 1
HAO2 hydroxyacid oxidase 2 (long chain)
HHAT hedgehog acyltransferase
HIST1H4B histone cluster 1, H4b
HIST1H4E histone cluster 1, H4e
HMGB3P30 high mobility group box 3 pseudogene 30
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICMT isoprenylcysteine carboxyl methyltransferase
IFI35 interferon-induced protein 35
IL19 interleukin 19
INPP5J inositol polyphosphate-5-phosphatase J
INSR insulin receptor
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
KANSL3 KAT8 regulatory NSL complex subunit 3
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KLHL11 kelch-like family member 11
KLK15 kallikrein-related peptidase 15
LRRC17 leucine rich repeat containing 17
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MC4R melanocortin 4 receptor
MEOX2 mesenchyme homeobox 2
MS4A5 membrane-spanning 4-domains, subfamily A, member 5
MSH5 mutS homolog 5
MX2 MX dynamin-like GTPase 2
NDOR1 NADPH dependent diflavin oxidoreductase 1
NPFFR1 neuropeptide FF receptor 1
NRGN neurogranin (protein kinase C substrate, RC3)
NYX nyctalopin
OLFML2B olfactomedin-like 2B
OR7A10 olfactory receptor, family 7, subfamily A, member 10
PCDHB1 protocadherin beta 1
PCDHGB6 protocadherin gamma subfamily B, 6
PDLIM3 PDZ and LIM domain 3
PLBD1 phospholipase B domain containing 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMCH pro-melanin-concentrating hormone
PNMA3 paraneoplastic Ma antigen 3
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PROX1 prospero homeobox 1
PRSS2 protease, serine, 2 (trypsin 2)
PTCD2 pentatricopeptide repeat domain 2
PTH2R parathyroid hormone 2 receptor
RAB40C RAB40C, member RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RBP4 retinol binding protein 4, plasma
RSAD2 radical S-adenosyl methionine domain containing 2
RUNX1-IT1 RUNX1 intronic transcript 1
SCARF1 scavenger receptor class F, member 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SCNN1D sodium channel, non voltage gated 1 delta subunit
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMO smoothened, frizzled class receptor
SMPX small muscle protein, X-linked
SNAI1 snail family zinc finger 1
SNHG20 small nucleolar RNA host gene 20
SPATA31A1 SPATA31 subfamily A, member 1
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPHK2 sphingosine kinase 2
STX10 syntaxin 10
SUSD5 sushi domain containing 5
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TMEM143 transmembrane protein 143
TMPRSS11D transmembrane protease, serine 11D
TRAF3 TNF receptor-associated factor 3
VAMP3 vesicle-associated membrane protein 3
WDR60 WD repeat domain 60
WFDC1 WAP four-disulfide core domain 1
XCL1 chemokine (C motif) ligand 1
ZBTB44 zinc finger and BTB domain containing 44
ZMYND10 zinc finger, MYND-type containing 10
ZNF124 zinc finger protein 124
ZNF253 zinc finger protein 253
ZNF32 zinc finger protein 32
ZNF668 zinc finger protein 668
ZRSR1 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1