| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/BRCA1_DN.V1_UP |
| Similar Terms | |
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278 genes differentially expressed following the BRCA1_DN.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| AIM2 | absent in melanoma 2 |
| ANGPT4 | angiopoietin 4 |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) |
| APOH | apolipoprotein H (beta-2-glycoprotein I) |
| ARHGAP15 | Rho GTPase activating protein 15 |
| ASMT | acetylserotonin O-methyltransferase |
| B3GALT2 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 |
| BTG4 | B-cell translocation gene 4 |
| CCKBR | cholecystokinin B receptor |
| CCL27 | chemokine (C-C motif) ligand 27 |
| CD160 | CD160 molecule |
| CD34 | CD34 molecule |
| CD3D | CD3d molecule, delta (CD3-TCR complex) |
| CDH13 | cadherin 13 |
| CDH22 | cadherin 22, type 2 |
| CDKL5 | cyclin-dependent kinase-like 5 |
| CDX1 | caudal type homeobox 1 |
| CFAP69 | cilia and flagella associated protein 69 |
| CHAT | choline O-acetyltransferase |
| CHD5 | chromodomain helicase DNA binding protein 5 |
| CHRNA6 | cholinergic receptor, nicotinic, alpha 6 (neuronal) |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase |
| CLDN14 | claudin 14 |
| CLDN6 | claudin 6 |
| CLEC7A | C-type lectin domain family 7, member A |
| CMKLR1 | chemerin chemokine-like receptor 1 |
| CNTN6 | contactin 6 |
| CRYGD | crystallin, gamma D |
| CTLA4 | cytotoxic T-lymphocyte-associated protein 4 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 |
| CYP2U1 | cytochrome P450, family 2, subfamily U, polypeptide 1 |
| DAGLA | diacylglycerol lipase, alpha |
| DAZL | deleted in azoospermia-like |
| DDX25 | DEAD (Asp-Glu-Ala-Asp) box helicase 25 |
| DENND1C | DENN/MADD domain containing 1C |
| DNAAF1 | dynein, axonemal, assembly factor 1 |
| ETNK2 | ethanolamine kinase 2 |
| EXTL1 | exostosin-like glycosyltransferase 1 |
| FAM46C | family with sequence similarity 46, member C |
| FCGBP | Fc fragment of IgG binding protein |
| FCGR2C | Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) |
| FLJ20712 | uncharacterized FLJ20712 |
| GABRB1 | gamma-aminobutyric acid (GABA) A receptor, beta 1 |
| GAGE3 | G antigen 3 |
| GJA5 | gap junction protein, alpha 5, 40kDa |
| GML | glycosylphosphatidylinositol anchored molecule like |
| GPR6 | G protein-coupled receptor 6 |
| GRID2 | glutamate receptor, ionotropic, delta 2 |
| HAAO | 3-hydroxyanthranilate 3,4-dioxygenase |
| HIST1H2BJ | histone cluster 1, H2bj |
| HIST1H3E | histone cluster 1, H3e |
| HMGA2 | high mobility group AT-hook 2 |
| HOXB7 | homeobox B7 |
| IFNA14 | interferon, alpha 14 |
| IGLL3P | immunoglobulin lambda-like polypeptide 3, pseudogene |
| IL17A | interleukin 17A |
| IL1RL2 | interleukin 1 receptor-like 2 |
| IL5 | interleukin 5 |
| INE1 | inactivation escape 1 (non-protein coding) |
| IPW | imprinted in Prader-Willi syndrome (non-protein coding) |
| IQCA1 | IQ motif containing with AAA domain 1 |
| ISYNA1 | inositol-3-phosphate synthase 1 |
| KCNA2 | potassium channel, voltage gated shaker related subfamily A, member 2 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 |
| KCNH7 | potassium channel, voltage gated eag related subfamily H, member 7 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 |
| KLHL35 | kelch-like family member 35 |
| KLK8 | kallikrein-related peptidase 8 |
| KRT18P51 | keratin 18 pseudogene 51 |
| LDB2 | LIM domain binding 2 |
| LGALS9 | lectin, galactoside-binding, soluble, 9 |
| LHX6 | LIM homeobox 6 |
| LILRP2 | leukocyte immunoglobulin-like receptor pseudogene 2 |
| LINC00260 | long intergenic non-protein coding RNA 260 |
| LOC79999 | uncharacterized LOC79999 |
| LRMP | lymphoid-restricted membrane protein |
| LRRTM2 | leucine rich repeat transmembrane neuronal 2 |
| LRTM1 | leucine-rich repeats and transmembrane domains 1 |
| LTC4S | leukotriene C4 synthase |
| MAP2 | microtubule-associated protein 2 |
| MTMR8 | myotubularin related protein 8 |
| MYBPC1 | myosin binding protein C, slow type |
| N4BP2L2-IT2 | N4BPL2 intronic transcript 2 |
| NEUROD4 | neuronal differentiation 4 |
| NEUROD6 | neuronal differentiation 6 |
| NKX2-2 | NK2 homeobox 2 |
| NLGN4Y | neuroligin 4, Y-linked |
| NPHS2 | nephrosis 2, idiopathic, steroid-resistant (podocin) |
| OSR2 | odd-skipped related transciption factor 2 |
| P3H3 | prolyl 3-hydroxylase 3 |
| PAEP | progestagen-associated endometrial protein |
| PHOX2B | paired-like homeobox 2b |
| PIP | prolactin-induced protein |
| POU2F3 | POU class 2 homeobox 3 |
| PRAMEF12 | PRAME family member 12 |
| PRKACG | protein kinase, cAMP-dependent, catalytic, gamma |
| PRSS21 | protease, serine, 21 (testisin) |
| PTPRS | protein tyrosine phosphatase, receptor type, S |
| RAG2 | recombination activating gene 2 |
| RCN3 | reticulocalbin 3, EF-hand calcium binding domain |
| RHOH | ras homolog family member H |
| RLN1 | relaxin 1 |
| RNF122 | ring finger protein 122 |
| ROPN1B | rhophilin associated tail protein 1B |
| RPP25 | ribonuclease P/MRP 25kDa subunit |
| RPS2P45 | ribosomal protein S2 pseudogene 45 |
| SGCA | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) |
| SHANK1 | SH3 and multiple ankyrin repeat domains 1 |
| SIX1 | SIX homeobox 1 |
| SLC16A4 | solute carrier family 16, member 4 |
| SLC16A6 | solute carrier family 16, member 6 |
| SLC43A1 | solute carrier family 43 (amino acid system L transporter), member 1 |
| SLCO1A2 | solute carrier organic anion transporter family, member 1A2 |
| SLURP1 | secreted LY6/PLAUR domain containing 1 |
| SMA4 | glucuronidase, beta pseudogene |
| SP4 | Sp4 transcription factor |
| SPO11 | SPO11 meiotic protein covalently bound to DSB |
| STAR | steroidogenic acute regulatory protein |
| TACR3 | tachykinin receptor 3 |
| THBS2 | thrombospondin 2 |
| THPO | thrombopoietin |
| TIMP4 | TIMP metallopeptidase inhibitor 4 |
| TLX3 | T-cell leukemia homeobox 3 |
| TNC | tenascin C |
| TP53TG5 | TP53 target 5 |
| TRGV7 | T cell receptor gamma variable 7 (pseudogene) |
| TRPA1 | transient receptor potential cation channel, subfamily A, member 1 |
| TRPM8 | transient receptor potential cation channel, subfamily M, member 8 |
| TRPV6 | transient receptor potential cation channel, subfamily V, member 6 |
| TSSK2 | testis-specific serine kinase 2 |
| TTLL7 | tubulin tyrosine ligase-like family member 7 |
| UPK1B | uroplakin 1B |
| USP9Y | ubiquitin specific peptidase 9, Y-linked |
| VAV1 | vav 1 guanine nucleotide exchange factor |
| WDR25 | WD repeat domain 25 |
| ZNF423 | zinc finger protein 423 |
| ZNF529 | zinc finger protein 529 |
| ZNF682 | zinc finger protein 682 |
| ZNF780B | zinc finger protein 780B |
| Symbol | Name |
|---|---|
| AIM1L | absent in melanoma 1-like |
| AMBN | ameloblastin (enamel matrix protein) |
| APOA4 | apolipoprotein A-IV |
| ARF1P1 | ADP-ribosylation factor 1 pseudogene 1 |
| ASPA | aspartoacylase |
| ATP4A | ATPase, H+/K+ exchanging, alpha polypeptide |
| AURKC | aurora kinase C |
| BMPR1B | bone morphogenetic protein receptor, type IB |
| BRCA1 | breast cancer 1, early onset |
| C14ORF93 | chromosome 14 open reading frame 93 |
| C1ORF116 | chromosome 1 open reading frame 116 |
| C1ORF159 | chromosome 1 open reading frame 159 |
| CA14 | carbonic anhydrase XIV |
| CARD10 | caspase recruitment domain family, member 10 |
| CCDC106 | coiled-coil domain containing 106 |
| CCDC132 | coiled-coil domain containing 132 |
| CD79A | CD79a molecule, immunoglobulin-associated alpha |
| CD80 | CD80 molecule |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 |
| CDK11A | cyclin-dependent kinase 11A |
| CES1P1 | carboxylesterase 1 pseudogene 1 |
| CHD2 | chromodomain helicase DNA binding protein 2 |
| CLCA3P | chloride channel accessory 3, pseudogene |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 |
| COLQ | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase |
| CTDSP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 |
| CTSW | cathepsin W |
| CYSLTR1 | cysteinyl leukotriene receptor 1 |
| CYSLTR2 | cysteinyl leukotriene receptor 2 |
| CYTH3 | cytohesin 3 |
| DLK2 | delta-like 2 homolog (Drosophila) |
| DPY19L1P1 | DPY19L1 pseudogene 1 |
| DPYSL3 | dihydropyrimidinase-like 3 |
| E2F2 | E2F transcription factor 2 |
| EFNA5 | ephrin-A5 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 |
| ERO1LB | ERO1-like beta (S. cerevisiae) |
| EXD3 | exonuclease 3'-5' domain containing 3 |
| EXOC6B | exocyst complex component 6B |
| FAM57A | family with sequence similarity 57, member A |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide |
| FGF22 | fibroblast growth factor 22 |
| FGF9 | fibroblast growth factor 9 |
| FOXJ1 | forkhead box J1 |
| GABRB3 | gamma-aminobutyric acid (GABA) A receptor, beta 3 |
| GATAD2A | GATA zinc finger domain containing 2A |
| GDF5 | growth differentiation factor 5 |
| GM2A | GM2 ganglioside activator |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 |
| GNRH2 | gonadotropin-releasing hormone 2 |
| GPR157 | G protein-coupled receptor 157 |
| GPR19 | G protein-coupled receptor 19 |
| GPR35 | G protein-coupled receptor 35 |
| GPT | glutamic-pyruvate transaminase (alanine aminotransferase) |
| GREB1L | growth regulation by estrogen in breast cancer-like |
| GRIP1 | glutamate receptor interacting protein 1 |
| GSDMD | gasdermin D |
| HAND1 | heart and neural crest derivatives expressed 1 |
| HAO2 | hydroxyacid oxidase 2 (long chain) |
| HHAT | hedgehog acyltransferase |
| HIST1H4B | histone cluster 1, H4b |
| HIST1H4E | histone cluster 1, H4e |
| HMGB3P30 | high mobility group box 3 pseudogene 30 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa |
| ICAM4 | intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) |
| ICMT | isoprenylcysteine carboxyl methyltransferase |
| IFI35 | interferon-induced protein 35 |
| IL19 | interleukin 19 |
| INPP5J | inositol polyphosphate-5-phosphatase J |
| INSR | insulin receptor |
| ITGB1BP2 | integrin beta 1 binding protein (melusin) 2 |
| ITIH3 | inter-alpha-trypsin inhibitor heavy chain 3 |
| KANSL3 | KAT8 regulatory NSL complex subunit 3 |
| KCNQ2 | potassium channel, voltage gated KQT-like subfamily Q, member 2 |
| KLHL11 | kelch-like family member 11 |
| KLK15 | kallikrein-related peptidase 15 |
| LRRC17 | leucine rich repeat containing 17 |
| LYL1 | lymphoblastic leukemia associated hematopoiesis regulator 1 |
| LYVE1 | lymphatic vessel endothelial hyaluronan receptor 1 |
| MC4R | melanocortin 4 receptor |
| MEOX2 | mesenchyme homeobox 2 |
| MS4A5 | membrane-spanning 4-domains, subfamily A, member 5 |
| MSH5 | mutS homolog 5 |
| MX2 | MX dynamin-like GTPase 2 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 |
| NPFFR1 | neuropeptide FF receptor 1 |
| NRGN | neurogranin (protein kinase C substrate, RC3) |
| NYX | nyctalopin |
| OLFML2B | olfactomedin-like 2B |
| OR7A10 | olfactory receptor, family 7, subfamily A, member 10 |
| PCDHB1 | protocadherin beta 1 |
| PCDHGB6 | protocadherin gamma subfamily B, 6 |
| PDLIM3 | PDZ and LIM domain 3 |
| PLBD1 | phospholipase B domain containing 1 |
| PLEKHO1 | pleckstrin homology domain containing, family O member 1 |
| PMCH | pro-melanin-concentrating hormone |
| PNMA3 | paraneoplastic Ma antigen 3 |
| PPM1E | protein phosphatase, Mg2+/Mn2+ dependent, 1E |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A |
| PROX1 | prospero homeobox 1 |
| PRSS2 | protease, serine, 2 (trypsin 2) |
| PTCD2 | pentatricopeptide repeat domain 2 |
| PTH2R | parathyroid hormone 2 receptor |
| RAB40C | RAB40C, member RAS oncogene family |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 |
| RBP4 | retinol binding protein 4, plasma |
| RSAD2 | radical S-adenosyl methionine domain containing 2 |
| RUNX1-IT1 | RUNX1 intronic transcript 1 |
| SCARF1 | scavenger receptor class F, member 1 |
| SCN10A | sodium channel, voltage gated, type X alpha subunit |
| SCNN1D | sodium channel, non voltage gated 1 delta subunit |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
| SLC5A1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
| SLC5A2 | solute carrier family 5 (sodium/glucose cotransporter), member 2 |
| SMO | smoothened, frizzled class receptor |
| SMPX | small muscle protein, X-linked |
| SNAI1 | snail family zinc finger 1 |
| SNHG20 | small nucleolar RNA host gene 20 |
| SPATA31A1 | SPATA31 subfamily A, member 1 |
| SPG21 | spastic paraplegia 21 (autosomal recessive, Mast syndrome) |
| SPHK2 | sphingosine kinase 2 |
| STX10 | syntaxin 10 |
| SUSD5 | sushi domain containing 5 |
| TCF7L1 | transcription factor 7-like 1 (T-cell specific, HMG-box) |
| TMEM143 | transmembrane protein 143 |
| TMPRSS11D | transmembrane protease, serine 11D |
| TRAF3 | TNF receptor-associated factor 3 |
| VAMP3 | vesicle-associated membrane protein 3 |
| WDR60 | WD repeat domain 60 |
| WFDC1 | WAP four-disulfide core domain 1 |
| XCL1 | chemokine (C motif) ligand 1 |
| ZBTB44 | zinc finger and BTB domain containing 44 |
| ZMYND10 | zinc finger, MYND-type containing 10 |
| ZNF124 | zinc finger protein 124 |
| ZNF253 | zinc finger protein 253 |
| ZNF32 | zinc finger protein 32 |
| ZNF668 | zinc finger protein 668 |
| ZRSR1 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1 |
