| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | breast cancer 2, early onset|Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 675) |
| External Link | https://ncbi.nlm.nih.gov/gene/675 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the BRCA2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.024959 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.0242828 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.0160071 |
| TARP | TCR gamma alternate reading frame protein | 0.0157527 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0143767 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.0142231 |
| C10ORF10 | chromosome 10 open reading frame 10 | 0.0138683 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0138517 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0136202 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0134695 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0124028 |
| ATF3 | activating transcription factor 3 | 0.0122689 |
| XIC | X chromosome inactivation center | 0.0119485 |
| IDO1 | indoleamine 2,3-dioxygenase 1 | 0.011891 |
| CST7 | cystatin F (leukocystatin) | 0.0118503 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.0117958 |
| ASS1 | argininosuccinate synthase 1 | 0.0117612 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0115144 |
| LBH | limb bud and heart development | 0.0114305 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.0112601 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.0112525 |
| KRT15 | keratin 15, type I | 0.0110769 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.011035 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.0110014 |
| RAB38 | RAB38, member RAS oncogene family | 0.010911 |
| C1S | complement component 1, s subcomponent | 0.0108709 |
| STK26 | serine/threonine protein kinase 26 | 0.0108564 |
| VEGFC | vascular endothelial growth factor C | 0.0108539 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0108212 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.0105486 |
| MXRA7 | matrix-remodelling associated 7 | 0.0105375 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A | 0.0105167 |
| ATP5MF | ATP synthase membrane subunit f | 0.0104672 |
| XPO7 | exportin 7 | 0.0103963 |
| LY96 | lymphocyte antigen 96 | 0.0103472 |
| FKBP11 | FK506 binding protein 11, 19 kDa | 0.0103189 |
| LTF | lactotransferrin | 0.0100977 |
| CMAHP | cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene | 0.0100733 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0100445 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00996594 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.0099656 |
| TMEM131L | transmembrane 131 like | 0.00993128 |
| IL7R | interleukin 7 receptor | 0.00983448 |
| CD69 | CD69 molecule | 0.00976596 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00972284 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00967414 |
| BMP2K | BMP2 inducible kinase | 0.00965002 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00952661 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00945269 |
| IL32 | interleukin 32 | 0.00945151 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00941614 |
| MT1G | metallothionein 1G | 0.00936774 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00934747 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.00933713 |
| ZNHIT1 | zinc finger, HIT-type containing 1 | 0.00922853 |
| HIST1H2BK | histone cluster 1, H2bk | 0.00921625 |
| NPY1R | neuropeptide Y receptor Y1 | 0.00920319 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | 0.00914918 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00906982 |
| LYRM4 | LYR motif containing 4 | 0.00901808 |
| BCL2A1 | BCL2-related protein A1 | 0.00898511 |
| DUSP5 | dual specificity phosphatase 5 | 0.0089456 |
| RCAN1 | regulator of calcineurin 1 | 0.00891319 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.00890874 |
| CLIC2 | chloride intracellular channel 2 | 0.0089041 |
| C8ORF4 | chromosome 8 open reading frame 4 | 0.00884882 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.0088467 |
| TGM2 | transglutaminase 2 | 0.00879053 |
| OFD1 | oral-facial-digital syndrome 1 | 0.00877164 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00877074 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.00876492 |
| SSX1 | synovial sarcoma, X breakpoint 1 | 0.00869344 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.00867374 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00866626 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00859049 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00848221 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.00845689 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00844986 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00841546 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | 0.00839574 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 0.00837365 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | 0.00836967 |
| DCLK1 | doublecortin-like kinase 1 | 0.00830504 |
| ARL4A | ADP-ribosylation factor-like 4A | 0.008254 |
| C1QA | complement component 1, q subcomponent, A chain | 0.00824906 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.00823428 |
| CFB | complement factor B | 0.00822892 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00820628 |
| MT1X | metallothionein 1X | 0.00817947 |
| NUP58 | nucleoporin 58 | 0.00817213 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.00816027 |
| STOM | stomatin | 0.00813969 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00806618 |
| LXN | latexin | 0.00805689 |
| GRN | granulin | 0.00805425 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.00800813 |
| ORC5 | origin recognition complex, subunit 5 | 0.00800538 |
| MMP9 | matrix metallopeptidase 9 | 0.00799433 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.00797753 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.00797281 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | 0.00793955 |
| IRS2 | insulin receptor substrate 2 | 0.00793432 |
| MTCL1 | microtubule crosslinking factor 1 | 0.00788029 |
| WDR45 | WD repeat domain 45 | 0.00784864 |
| UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI | 0.00784646 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00779867 |
| FBXO11 | F-box protein 11 | 0.00779328 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.00778677 |
| PENK | proenkephalin | 0.00777051 |
| ACP5 | acid phosphatase 5, tartrate resistant | 0.00775438 |
| MIR22HG | MIR22 host gene | 0.00775108 |
| NPY | neuropeptide Y | 0.00775006 |
| GAL | galanin/GMAP prepropeptide | 0.00774505 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 0.00771466 |
| IFRD1 | interferon-related developmental regulator 1 | 0.00770293 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.00769496 |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.00769299 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | 0.00768983 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00767847 |
| TFF1 | trefoil factor 1 | 0.00767 |
| TSPAN13 | tetraspanin 13 | 0.00764739 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.00764415 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.00762872 |
| TMEM140 | transmembrane protein 140 | 0.00762578 |
| EFNB2 | ephrin-B2 | 0.00762457 |
| ATG14 | autophagy related 14 | 0.00757212 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00757129 |
| COCH | cochlin | 0.00754394 |
| OPN3 | opsin 3 | 0.00751337 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.00750081 |
| PLA1A | phospholipase A1 member A | 0.00748713 |
| BUD31 | BUD31 homolog (S. cerevisiae) | 0.00747049 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 0.0074689 |
| KYNU | kynureninase | 0.00744256 |
| COA3 | cytochrome c oxidase assembly factor 3 | 0.0074392 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.00742095 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.00741255 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00740522 |
| FAM46C | family with sequence similarity 46, member C | 0.00740312 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0073547 |
| KRT17 | keratin 17, type I | 0.00735254 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00734364 |
| C1QB | complement component 1, q subcomponent, B chain | 0.00733955 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00731296 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00729697 |
| GLRX | glutaredoxin (thioltransferase) | 0.00728807 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.0072567 |
| CAPG | capping protein (actin filament), gelsolin-like | 0.00724802 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.00723508 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.00722781 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00721675 |
| AGTR1 | angiotensin II receptor, type 1 | 0.00720472 |
| SELENBP1 | selenium binding protein 1 | 0.0072036 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.00720111 |
| ABHD6 | abhydrolase domain containing 6 | 0.00718758 |
| RABAC1 | Rab acceptor 1 (prenylated) | 0.00717195 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.00717032 |
| CTH | cystathionine gamma-lyase | 0.00713646 |
| NNMT | nicotinamide N-methyltransferase | 0.00713223 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00712433 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | 0.00711945 |
| PFDN4 | prefoldin subunit 4 | 0.00710838 |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 0.00710389 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.00710004 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.00709696 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.00708424 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0070841 |
| AGA | aspartylglucosaminidase | 0.00708337 |
| MT1E | metallothionein 1E | 0.00707172 |
| FGF13 | fibroblast growth factor 13 | 0.00705893 |
| RND3 | Rho family GTPase 3 | 0.00704518 |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 0.00704149 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00704052 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.00701818 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.00701131 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | 0.00699922 |
| RAB13 | RAB13, member RAS oncogene family | 0.00699318 |
| PRF1 | perforin 1 (pore forming protein) | 0.00699189 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0069859 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.00696189 |
| C1ORF54 | chromosome 1 open reading frame 54 | 0.00694004 |
| PON2 | paraoxonase 2 | 0.00693977 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | 0.00693002 |
| RRAS | related RAS viral (r-ras) oncogene homolog | 0.00690258 |
| PI3 | peptidase inhibitor 3, skin-derived | 0.00688977 |
| MT1F | metallothionein 1F | 0.00685618 |
| ACKR1 | atypical chemokine receptor 1 (Duffy blood group) | 0.00683749 |
| ALG6 | ALG6, alpha-1,3-glucosyltransferase | 0.00681816 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.00681613 |
| CD8A | CD8a molecule | 0.00679662 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | 0.00678815 |
| MGST3 | microsomal glutathione S-transferase 3 | 0.00678752 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.00678542 |
| BTN3A2 | butyrophilin, subfamily 3, member A2 | 0.006783 |
| IFI44L | interferon-induced protein 44-like | 0.00677565 |
| RIPOR2 | RHO family interacting cell polarization regulator 2 | 0.00677528 |
| TMEM106B | transmembrane protein 106B | 0.00675237 |
| STC2 | stanniocalcin 2 | 0.00675116 |
| IFI35 | interferon-induced protein 35 | 0.00673811 |
| FCMR | Fc fragment of IgM receptor | 0.00672861 |
| KRT18 | keratin 18, type I | 0.00672542 |
| DDI2 | DNA-damage inducible 1 homolog 2 (S. cerevisiae) | 0.00672247 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.00672069 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.00670461 |
| LCK | LCK proto-oncogene, Src family tyrosine kinase | 0.00670148 |
| GSPT2 | G1 to S phase transition 2 | 0.00670103 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00669759 |
| BTN3A1 | butyrophilin, subfamily 3, member A1 | 0.0066891 |
| XCL1 | chemokine (C motif) ligand 1 | 0.00668818 |
| MRPL40 | mitochondrial ribosomal protein L40 | 0.0066815 |
| GRWD1 | glutamate-rich WD repeat containing 1 | 0.00666915 |
| KRT14 | keratin 14, type I | 0.00666146 |
| ATOX1 | antioxidant 1 copper chaperone | 0.00665467 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00664378 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 | 0.00664191 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.00663014 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.00661015 |
| GATAD1 | GATA zinc finger domain containing 1 | 0.0066099 |
| EPB42 | erythrocyte membrane protein band 4.2 | 0.00659796 |
| ADRB2 | adrenoceptor beta 2, surface | 0.0065775 |
| PKP1 | plakophilin 1 | 0.00657716 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.00657439 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.00657132 |
| HIST1H2AE | histone cluster 1, H2ae | 0.00654987 |
| CCNG2 | cyclin G2 | 0.00653726 |
| ITGAV | integrin, alpha V | 0.00651922 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.00651533 |
| TAPBPL | TAP binding protein-like | 0.00651116 |
| CLU | clusterin | 0.0064928 |
| DIPK1A | divergent protein kinase domain 1A | 0.00649166 |
| CHI3L2 | chitinase 3-like 2 | 0.00647434 |
| CRABP1 | cellular retinoic acid binding protein 1 | 0.00646269 |
| GMPR | guanosine monophosphate reductase | 0.00646047 |
| CHMP4A | charged multivesicular body protein 4A | 0.00643984 |
| CREM | cAMP responsive element modulator | 0.00643657 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.00642075 |
| MAGED1 | melanoma antigen family D1 | 0.00641997 |
| SYNGR3 | synaptogyrin 3 | 0.00640297 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00637485 |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.00635788 |
| SOCS1 | suppressor of cytokine signaling 1 | 0.00634972 |
| IFI30 | interferon, gamma-inducible protein 30 | 0.00633809 |
| KMO | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 0.00632393 |
| RGS2 | regulator of G-protein signaling 2 | 0.00629375 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00629178 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00628725 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.00628137 |
| ATP6V1D | ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D | 0.006272 |
| MTIF2 | mitochondrial translational initiation factor 2 | 0.00626808 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0227534 |
| METRN | meteorin, glial cell differentiation regulator | -0.0150835 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0148036 |
| EIF5A | eukaryotic translation initiation factor 5A | -0.01393 |
| GAS1 | growth arrest-specific 1 | -0.0126732 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0123951 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.0123535 |
| RAB25 | RAB25, member RAS oncogene family | -0.0120393 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.0120268 |
| GPC3 | glypican 3 | -0.0119166 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.0116852 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0116516 |
| PROM1 | prominin 1 | -0.0116119 |
| HOXB6 | homeobox B6 | -0.0114477 |
| PDLIM3 | PDZ and LIM domain 3 | -0.0114165 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.011294 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.0112863 |
| MEIS2 | Meis homeobox 2 | -0.0112478 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.0110253 |
| COL1A2 | collagen, type I, alpha 2 | -0.0106013 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | -0.0105107 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.0104887 |
| MUC16 | mucin 16, cell surface associated | -0.0104744 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.0103744 |
| HELLS | helicase, lymphoid-specific | -0.0103587 |
| MGP | matrix Gla protein | -0.0101849 |
| TFDP1 | transcription factor Dp-1 | -0.0101715 |
| COL3A1 | collagen, type III, alpha 1 | -0.0100988 |
| HIP1 | huntingtin interacting protein 1 | -0.00994973 |
| PEG3 | paternally expressed 3 | -0.00991461 |
| ASRGL1 | asparaginase like 1 | -0.00988904 |
| PTCH1 | patched 1 | -0.00988072 |
| CXADR | coxsackie virus and adenovirus receptor | -0.00986544 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00977419 |
| CD14 | CD14 molecule | -0.00958852 |
| SYNM | synemin, intermediate filament protein | -0.00958396 |
| PAPSS1 | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | -0.00954833 |
| CRIP2 | cysteine-rich protein 2 | -0.00953441 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | -0.00950566 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.00948553 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.00947271 |
| FAM120A | family with sequence similarity 120A | -0.00943427 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.00937356 |
| RNF130 | ring finger protein 130 | -0.00933685 |
| FLNA | filamin A, alpha | -0.0092722 |
| LMNB1 | lamin B1 | -0.00916739 |
| DHFR | dihydrofolate reductase | -0.00907976 |
| POSTN | periostin, osteoblast specific factor | -0.0090367 |
| TLR4 | toll-like receptor 4 | -0.00903178 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | -0.00900228 |
| PLLP | plasmolipin | -0.00895908 |
| VCAN | versican | -0.00895244 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | -0.00893545 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.00892088 |
| GLTP | glycolipid transfer protein | -0.00884914 |
| SEPTIN10 | septin 10 | -0.00883186 |
| GPSM2 | G-protein signaling modulator 2 | -0.00858161 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.00856629 |
| CCND1 | cyclin D1 | -0.00853738 |
| GPM6A | glycoprotein M6A | -0.0084979 |
| ETV5 | ets variant 5 | -0.00848345 |
| SPON1 | spondin 1, extracellular matrix protein | -0.00837951 |
| ACTG2 | actin, gamma 2, smooth muscle, enteric | -0.00836062 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0083563 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | -0.00832885 |
| BGN | biglycan | -0.00825627 |
| DMD | dystrophin | -0.00823255 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | -0.00820952 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -0.00819548 |
| PTGER2 | prostaglandin E receptor 2 (subtype EP2), 53kDa | -0.00819022 |
| C7 | complement component 7 | -0.00815541 |
| CUEDC1 | CUE domain containing 1 | -0.00813972 |
| FBP1 | fructose-1,6-bisphosphatase 1 | -0.00812826 |
| ZNF91 | zinc finger protein 91 | -0.00806655 |
| KLK11 | kallikrein-related peptidase 11 | -0.00804046 |
| LIG1 | ligase I, DNA, ATP-dependent | -0.00803833 |
| CALD1 | caldesmon 1 | -0.00803569 |
| PAX6 | paired box 6 | -0.00799459 |
| FZD6 | frizzled class receptor 6 | -0.00798586 |
| COLEC12 | collectin sub-family member 12 | -0.00798322 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.00798139 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.00796991 |
| FOXC1 | forkhead box C1 | -0.00792787 |
| COL6A1 | collagen, type VI, alpha 1 | -0.00792082 |
| EXPH5 | exophilin 5 | -0.00791437 |
| LYZ | lysozyme | -0.00791222 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00785496 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.0078215 |
| TPPP3 | tubulin polymerization-promoting protein family member 3 | -0.00779774 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.00778972 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00778093 |
| MYRF | myelin regulatory factor | -0.00775022 |
| MDFIC | MyoD family inhibitor domain containing | -0.00773381 |
| SOWAHC | sosondowah ankyrin repeat domain family member C | -0.00770455 |
| HAS2 | hyaluronan synthase 2 | -0.00767419 |
| PITX1 | paired-like homeodomain 1 | -0.00767395 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.00766294 |
| MECOM | MDS1 and EVI1 complex locus | -0.00765805 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.00762664 |
| SCRIB | scribbled planar cell polarity protein | -0.00757946 |
| KLK6 | kallikrein-related peptidase 6 | -0.00755507 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | -0.00755417 |
| SQLE | squalene epoxidase | -0.00755393 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00752072 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00751267 |
| RCAN2 | regulator of calcineurin 2 | -0.00749394 |
| H2AFV | H2A histone family, member V | -0.0074593 |
| PODXL | podocalyxin-like | -0.00743655 |
| HOXC6 | homeobox C6 | -0.00740856 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.00738159 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.00735586 |
| BCHE | butyrylcholinesterase | -0.00734884 |
| WLS | wntless Wnt ligand secretion mediator | -0.0073422 |
| METTL7A | methyltransferase like 7A | -0.00733904 |
| FKBP5 | FK506 binding protein 5 | -0.00733537 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.00733536 |
| ACTA2 | actin, alpha 2, smooth muscle, aorta | -0.00732373 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00732224 |
| MUC4 | mucin 4, cell surface associated | -0.00731245 |
| HBB | hemoglobin, beta | -0.0072772 |
| KIFC1 | kinesin family member C1 | -0.00727167 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | -0.007251 |
| RNH1 | ribonuclease/angiogenin inhibitor 1 | -0.00724555 |
| AFP | alpha-fetoprotein | -0.00723788 |
| THBS2 | thrombospondin 2 | -0.00723249 |
| BEX1 | brain expressed, X-linked 1 | -0.00721018 |
| CCR1 | chemokine (C-C motif) receptor 1 | -0.0071993 |
| KIF20A | kinesin family member 20A | -0.0071859 |
| SDC2 | syndecan 2 | -0.00716922 |
| GLO1 | glyoxalase I | -0.00712184 |
| MPDZ | multiple PDZ domain protein | -0.00710399 |
| STON1 | stonin 1 | -0.00709617 |
| PLN | phospholamban | -0.00709248 |
| TRIP13 | thyroid hormone receptor interactor 13 | -0.00709173 |
| ESR1 | estrogen receptor 1 | -0.00706656 |
| ADD3 | adducin 3 (gamma) | -0.00706515 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.00705858 |
| BRD2 | bromodomain containing 2 | -0.0070527 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | -0.00704267 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.0070119 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0069812 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.00698076 |
| CALCA | calcitonin-related polypeptide alpha | -0.00697293 |
| MYO5C | myosin VC | -0.00696629 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.00695809 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | -0.00694178 |
| COL6A2 | collagen, type VI, alpha 2 | -0.00694133 |
| AURKB | aurora kinase B | -0.00694011 |
| CDC45 | cell division cycle 45 | -0.00693977 |
| NCOA3 | nuclear receptor coactivator 3 | -0.00693673 |
| FAM198B | family with sequence similarity 198, member B | -0.00692253 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.0069095 |
| KLK10 | kallikrein-related peptidase 10 | -0.00689615 |
| DACH1 | dachshund family transcription factor 1 | -0.00689001 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.00688253 |
| STK10 | serine/threonine kinase 10 | -0.00687776 |
| SPIN1 | spindlin 1 | -0.00686571 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.00686507 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.00684929 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00684694 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00684656 |
| ZNF423 | zinc finger protein 423 | -0.00684075 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.00682795 |
| KIF15 | kinesin family member 15 | -0.00682748 |
| MPZL2 | myelin protein zero-like 2 | -0.00682466 |
| CDCA4 | cell division cycle associated 4 | -0.00680195 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.00678051 |
| PRKD3 | protein kinase D3 | -0.00676489 |
| MACROH2A1 | macroH2A.1 histone | -0.00676203 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | -0.00676099 |
| PTK2 | protein tyrosine kinase 2 | -0.00674353 |
| CPSF1 | cleavage and polyadenylation specific factor 1, 160kDa | -0.00667273 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.00666611 |
| PURA | purine-rich element binding protein A | -0.00666425 |
| TMEM204 | transmembrane protein 204 | -0.00664853 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.00662886 |
| TBC1D9B | TBC1 domain family, member 9B (with GRAM domain) | -0.00662686 |
| EMP2 | epithelial membrane protein 2 | -0.00662589 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | -0.00660323 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.00659143 |
| FHL1 | four and a half LIM domains 1 | -0.00659062 |
| CRYBG3 | beta-gamma crystallin domain containing 3 | -0.00657218 |
| KLK8 | kallikrein-related peptidase 8 | -0.00656132 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | -0.00655192 |
| CEP55 | centrosomal protein 55kDa | -0.0065453 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00654324 |
| UPK1B | uroplakin 1B | -0.00654192 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.00654128 |
| UBXN7 | UBX domain protein 7 | -0.00652848 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | -0.00652518 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.00650736 |
| CLDN3 | claudin 3 | -0.00650668 |
| SRPX | sushi-repeat containing protein, X-linked | -0.00650544 |
| CCKBR | cholecystokinin B receptor | -0.00650426 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.00650315 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.00650007 |
| NCALD | neurocalcin delta | -0.00649581 |
| GRHPR | glyoxylate reductase/hydroxypyruvate reductase | -0.00648292 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.00647594 |
| IL17RB | interleukin 17 receptor B | -0.00647193 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -0.006462 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | -0.00646004 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.00644606 |
| LY6D | lymphocyte antigen 6 complex, locus D | -0.00644383 |
| BMP4 | bone morphogenetic protein 4 | -0.0064247 |
| PCYOX1 | prenylcysteine oxidase 1 | -0.00641868 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00640135 |
| ENOPH1 | enolase-phosphatase 1 | -0.0063981 |
| GPX7 | glutathione peroxidase 7 | -0.00637664 |
| ASF1B | anti-silencing function 1B histone chaperone | -0.00637484 |
| ATXN1 | ataxin 1 | -0.0063734 |
| PAK2 | p21 protein (Cdc42/Rac)-activated kinase 2 | -0.0063704 |
| ARRB2 | arrestin, beta 2 | -0.00636914 |
| GRHL2 | grainyhead-like 2 (Drosophila) | -0.00636786 |
| NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor | -0.0063453 |
| RAPSN | receptor-associated protein of the synapse | -0.00632216 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.00630526 |
| CLDN10 | claudin 10 | -0.00630071 |
| SPC25 | SPC25, NDC80 kinetochore complex component | -0.00629618 |
| ADORA2B | adenosine A2b receptor | -0.00628876 |
| KCTD14 | potassium channel tetramerization domain containing 14 | -0.00628866 |
| LOXL1 | lysyl oxidase-like 1 | -0.00628245 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0062771 |
| TOB1 | transducer of ERBB2, 1 | -0.00626503 |
| MSLN | mesothelin | -0.00626325 |
| HOXB2 | homeobox B2 | -0.00622734 |
| ZNF665 | zinc finger protein 665 | -0.00622223 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | -0.00621965 |
| FANCI | Fanconi anemia, complementation group I | -0.0062093 |
| SERINC5 | serine incorporator 5 | -0.00619425 |
| COL9A3 | collagen, type IX, alpha 3 | -0.00616831 |
| RBBP4 | retinoblastoma binding protein 4 | -0.00615982 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.00615544 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | -0.00614378 |
| FILIP1L | filamin A interacting protein 1-like | -0.00612216 |
| CCR2 | chemokine (C-C motif) receptor 2 | -0.00611972 |
| QKI | QKI, KH domain containing, RNA binding | -0.00611601 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.00611242 |
| CYC1 | cytochrome c-1 | -0.0061122 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.00610958 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -0.00610598 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | -0.00609597 |
| EIF6 | eukaryotic translation initiation factor 6 | -0.00604557 |
| HNRNPF | heterogeneous nuclear ribonucleoprotein F | -0.00604158 |
| CARHSP1 | calcium regulated heat stable protein 1, 24kDa | -0.00603571 |
| ZNF551 | zinc finger protein 551 | -0.0060295 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.00602745 |
| ISOC1 | isochorismatase domain containing 1 | -0.00601955 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.00600402 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.00600335 |
