BRCA2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description breast cancer 2, early onset|Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 675)
External Link http://www.ncbi.nlm.nih.gov/gene/675
Similar Terms
Downloads & Tools

Genes

86 interacting proteins for BRCA2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AURKB aurora kinase B
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BARD1 BRCA1 associated RING domain 1
BCCIP BRCA2 and CDKN1A interacting protein
BRCA1 breast cancer 1, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C11ORF30 chromosome 11 open reading frame 30
CCNA2 cyclin A2
CCNE1 cyclin E1
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CFAP52 cilia and flagella associated protein 52
CHD3 chromodomain helicase DNA binding protein 3
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
DMC1 DNA meiotic recombinase 1
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FANCG Fanconi anemia, complementation group G
FLNA filamin A, alpha
FYN FYN proto-oncogene, Src family tyrosine kinase
GRB2 growth factor receptor-bound protein 2
H2AFX H2A histone family, member X
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HMG20B high mobility group 20B
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
KAT2B K(lysine) acetyltransferase 2B
KDM1A lysine (K)-specific demethylase 1A
KIF4A kinesin family member 4A
LMNA lamin A/C
MAGED1 melanoma antigen family D1
MBD3 methyl-CpG binding domain protein 3
MCPH1 microcephalin 1
MGMT O-6-methylguanine-DNA methyltransferase
MND1 meiotic nuclear divisions 1 homolog (S. cerevisiae)
MORF4L1 mortality factor 4 like 1
MTA2 metastasis associated 1 family, member 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
PALB2 partner and localizer of BRCA2
PCNA proliferating cell nuclear antigen
PDS5B PDS5 cohesin associated factor B
PLK1 polo-like kinase 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLH polymerase (DNA directed), eta
PSMC3IP PSMC3 interacting protein
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
RAD21 RAD21 homolog (S. pombe)
RAD23A RAD23 homolog A (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAD51D RAD51 paralog D
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
RBBP8 retinoblastoma binding protein 8
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMC3 structural maintenance of chromosomes 3
SP1 Sp1 transcription factor
STAT5A signal transducer and activator of transcription 5A
SYCP3 synaptonemal complex protein 3
TACC1 transforming, acidic coiled-coil containing protein 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TEX15 testis expressed 15
TP53 tumor protein p53
UBC ubiquitin C
USP11 ubiquitin specific peptidase 11
XPO1 exportin 1
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3