BRD-A10420615_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-A10420615_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CEMIP cell migration inducing protein, hyaluronan binding
CLC Charcot-Leyden crystal galectin
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FNDC3B fibronectin type III domain containing 3B
FZD7 frizzled class receptor 7
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA13 heat shock protein 70kDa family, member 13
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
JCHAIN joining chain of multimeric IgA and IgM
KRT23 keratin 23, type I
LIMCH1 LIM and calponin homology domains 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MBNL2 muscleblind-like splicing regulator 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCB2 nucleobindin 2
PHGDH phosphoglycerate dehydrogenase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC35B1 solute carrier family 35, member B1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRPR signal recognition particle receptor (docking protein)
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
UFM1 ubiquitin-fold modifier 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CD24 CD24 molecule
CD34 CD34 molecule
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CXADR coxsackie virus and adenovirus receptor
DLK1 delta-like 1 homolog (Drosophila)
FHL1 four and a half LIM domains 1
GJA1 gap junction protein, alpha 1, 43kDa
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HOMER1 homer scaffolding protein 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KLK11 kallikrein-related peptidase 11
LOC100505650 uncharacterized LOC100505650
MMP12 matrix metallopeptidase 12
MXRA7 matrix-remodelling associated 7
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
S100A10 S100 calcium binding protein A10
TFPI2 tissue factor pathway inhibitor 2
WFDC2 WAP four-disulfide core domain 2
ZNF586 zinc finger protein 586
Funding