BRD-A10523515_GSK-429286A_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-A10523515_GSK-429286A_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
BASP1 brain abundant, membrane attached signal protein 1
BTBD3 BTB (POZ) domain containing 3
CD24 CD24 molecule
CD70 CD70 molecule
CLPTM1 cleft lip and palate associated transmembrane protein 1
CLU clusterin
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB2 EPH receptor B2
FAM171A1 family with sequence similarity 171, member A1
GOLM1 golgi membrane protein 1
HLA-DRA major histocompatibility complex, class II, DR alpha
IQCG IQ motif containing G
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF5C kinesin family member 5C
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNB1 lamin B1
LY6D lymphocyte antigen 6 complex, locus D
MAMLD1 mastermind-like domain containing 1
MT1E metallothionein 1E
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NPY neuropeptide Y
PCP4 Purkinje cell protein 4
PHYH phytanoyl-CoA 2-hydroxylase
PLAC8 placenta-specific 8
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIDT2 SID1 transmembrane family, member 2
SORD sorbitol dehydrogenase
SOX11 SRY (sex determining region Y)-box 11
SPP1 secreted phosphoprotein 1
TARP TCR gamma alternate reading frame protein
TMEM97 transmembrane protein 97
TNIP1 TNFAIP3 interacting protein 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
AAK1 AP2 associated kinase 1
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASPN asporin
ATF3 activating transcription factor 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CALD1 caldesmon 1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC11A C-type lectin domain family 11, member A
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DCN decorin
DEGS1 delta(4)-desaturase, sphingolipid 1
DSG2 desmoglein 2
ECM1 extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FABP4 fatty acid binding protein 4, adipocyte
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FST follistatin
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
ITM2A integral membrane protein 2A
KRT8 keratin 8, type II
LY96 lymphocyte antigen 96
MGLL monoglyceride lipase
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTUS1 microtubule associated tumor suppressor 1
MYL9 myosin, light chain 9, regulatory
NVL nuclear VCP-like
OSBPL1A oxysterol binding protein-like 1A
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PEG3 paternally expressed 3
PLIN3 perilipin 3
PTGIS prostaglandin I2 (prostacyclin) synthase
RGCC regulator of cell cycle
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLAMF7 SLAM family member 7
SNAI2 snail family zinc finger 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON2 spondin 2, extracellular matrix protein
SRPX sushi-repeat containing protein, X-linked
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TPM2 tropomyosin 2 (beta)
TUBA1A tubulin, alpha 1a
TUBB6 tubulin, beta 6 class V
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)
Funding