BRD-A10523515_GSK-429286A_HEPG2_24_h_0.12_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-A10523515_GSK-429286A_HEPG2_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
C21ORF91 chromosome 21 open reading frame 91
CADM1 cell adhesion molecule 1
CCDC86 coiled-coil domain containing 86
CDC42 cell division cycle 42
CES1 carboxylesterase 1
CHI3L2 chitinase 3-like 2
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
DDR1 discoidin domain receptor tyrosine kinase 1
DNM1L dynamin 1-like
ELN elastin
EPHB2 EPH receptor B2
FOXC1 forkhead box C1
GNAS GNAS complex locus
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL6R interleukin 6 receptor
ITM2A integral membrane protein 2A
KLHL21 kelch-like family member 21
KRT19 keratin 19, type I
LPPR1 lipid phosphate phosphatase-related protein type 1
MAGED1 melanoma antigen family D1
MBTPS1 membrane-bound transcription factor peptidase, site 1
PFKL phosphofructokinase, liver
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCH protein kinase C, eta
PTN pleiotrophin
SCRG1 stimulator of chondrogenesis 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SORBS2 sorbin and SH3 domain containing 2
SRPX sushi-repeat containing protein, X-linked
TMEM97 transmembrane protein 97
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
ARG1 arginase 1
ARHGAP29 Rho GTPase activating protein 29
ASPH aspartate beta-hydroxylase
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL6A3 collagen, type VI, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS2 dehydrogenase/reductase (SDR family) member 2
ECT2 epithelial cell transforming 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENAH enabled homolog (Drosophila)
FAP fibroblast activation protein, alpha
FBN1 fibrillin 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FILIP1L filamin A interacting protein 1-like
FLG filaggrin
H2AFY H2A histone family, member Y
HEPH hephaestin
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB6 homeobox B6
HOXC6 homeobox C6
HPCAL1 hippocalcin-like 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT1 keratin 1, type II
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTSS1 metastasis suppressor 1
NT5E 5'-nucleotidase, ecto (CD73)
PAPD7 PAP associated domain containing 7
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PELI1 pellino E3 ubiquitin protein ligase 1
PLS3 plastin 3
RBPMS RNA binding protein with multiple splicing
RCAN2 regulator of calcineurin 2
RGS4 regulator of G-protein signaling 4
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SRRM2 serine/arginine repetitive matrix 2
SULF1 sulfatase 1
TAGLN transgelin
TCF4 transcription factor 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFRC transferrin receptor
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TMEM47 transmembrane protein 47
TMPRSS3 transmembrane protease, serine 3
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TWIST1 twist family bHLH transcription factor 1
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
WDR7 WD repeat domain 7
WNT5A wingless-type MMTV integration site family, member 5A
Funding