BRD-A10977446_CARVEDILOL_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-A10977446_CARVEDILOL_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANOS1 anosmin 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CAMP cathelicidin antimicrobial peptide
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CKB creatine kinase, brain
CLDN8 claudin 8
CLIC3 chloride intracellular channel 3
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DIO1 deiodinase, iodothyronine, type I
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
EZR ezrin
FAM69A family with sequence similarity 69, member A
FCHO1 FCH domain only 1
FGFR2 fibroblast growth factor receptor 2
FLT1 fms-related tyrosine kinase 1
FOLR1 folate receptor 1 (adult)
FRZB frizzled-related protein
FZD1 frizzled class receptor 1
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GSTA1 glutathione S-transferase alpha 1
HBP1 HMG-box transcription factor 1
HIRA histone cell cycle regulator
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
IPO13 importin 13
KDR kinase insert domain receptor
KRT19 keratin 19, type I
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
MBOAT7 membrane bound O-acyltransferase domain containing 7
MME membrane metallo-endopeptidase
NEB nebulin
NXN nucleoredoxin
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM3 PDZ and LIM domain 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PON3 paraoxonase 3
RAB21 RAB21, member RAS oncogene family
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SRGN serglycin
SYNGR1 synaptogyrin 1
TACSTD2 tumor-associated calcium signal transducer 2
TBXA2R thromboxane A2 receptor
TESK1 testis-specific kinase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPMT thiopurine S-methyltransferase
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BST2 bone marrow stromal cell antigen 2
C6ORF48 chromosome 6 open reading frame 48
CCL19 chemokine (C-C motif) ligand 19
CD59 CD59 molecule, complement regulatory protein
CDKN2A cyclin-dependent kinase inhibitor 2A
CST3 cystatin C
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DICER1 dicer 1, ribonuclease type III
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM171A1 family with sequence similarity 171, member A1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAS1 growth arrest-specific 1
GCH1 GTP cyclohydrolase 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8A golgin A8 family, member A
HOXB7 homeobox B7
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
KLC1 kinesin light chain 1
LAMC2 laminin, gamma 2
NFIB nuclear factor I/B
NGRN neugrin, neurite outgrowth associated
NKTR natural killer cell triggering receptor
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
PCDH9 protocadherin 9
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PROM1 prominin 1
PTER phosphotriesterase related
RPS27L ribosomal protein S27-like
S100A2 S100 calcium binding protein A2
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SRSF7 serine/arginine-rich splicing factor 7
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM260 transmembrane protein 260
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TSTA3 tissue specific transplantation antigen P35B
TXNDC9 thioredoxin domain containing 9
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
Funding