BRD-A11087911_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-A11087911_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ALOX5 arachidonate 5-lipoxygenase
ANKRD10 ankyrin repeat domain 10
ASPN asporin
ATM ATM serine/threonine kinase
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCP110 centriolar coiled coil protein 110kDa
CD9 CD9 molecule
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC7A C-type lectin domain family 7, member A
COL11A1 collagen, type XI, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CSTA cystatin A (stefin A)
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
CYBB cytochrome b-245, beta polypeptide
DACT1 dishevelled-binding antagonist of beta-catenin 1
DCN decorin
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
FZD7 frizzled class receptor 7
GMPR guanosine monophosphate reductase
GSPT2 G1 to S phase transition 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HTRA1 HtrA serine peptidase 1
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LDHB lactate dehydrogenase B
LRRC15 leucine rich repeat containing 15
LY96 lymphocyte antigen 96
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MTSS1 metastasis suppressor 1
NEB nebulin
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
P3H2 prolyl 3-hydroxylase 2
PFKM phosphofructokinase, muscle
PLBD1 phospholipase B domain containing 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
QKI QKI, KH domain containing, RNA binding
RABGAP1L RAB GTPase activating protein 1-like
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPL39L ribosomal protein L39-like
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SULF1 sulfatase 1
TCL1A T-cell leukemia/lymphoma 1A
THBS1 thrombospondin 1
TRIB2 tribbles pseudokinase 2
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZEB2 zinc finger E-box binding homeobox 2
ZFPM2 zinc finger protein, FOG family member 2
ZNF423 zinc finger protein 423
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOB apolipoprotein B
BMP4 bone morphogenetic protein 4
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DCK deoxycytidine kinase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB3 erb-b2 receptor tyrosine kinase 3
F5 coagulation factor V (proaccelerin, labile factor)
FCGBP Fc fragment of IgG binding protein
FMO5 flavin containing monooxygenase 5
FRZB frizzled-related protein
GPX3 glutathione peroxidase 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LHX2 LIM homeobox 2
MAP7 microtubule-associated protein 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F1 nuclear receptor subfamily 2, group F, member 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARP2 poly (ADP-ribose) polymerase 2
PRKCH protein kinase C, eta
PRR7 proline rich 7 (synaptic)
PSPH phosphoserine phosphatase
REG3A regenerating islet-derived 3 alpha
S100P S100 calcium binding protein P
SEPT9 septin 9
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SORBS2 sorbin and SH3 domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TF transferrin
TGFBI transforming growth factor, beta-induced, 68kDa
Funding