BRD-A13122391_16-HYDROXYTRIPTOLIDE_RKO_6.0_h_0.0799999982119_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-A13122391_16-HYDROXYTRIPTOLIDE_RKO_6.0_h_0.0799999982119_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADK adenosine kinase
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPTL2 angiopoietin-like 2
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
BEX4 brain expressed, X-linked 4
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CCP110 centriolar coiled coil protein 110kDa
CD200 CD200 molecule
CD24 CD24 molecule
CDC20 cell division cycle 20
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CECR1 cat eye syndrome chromosome region, candidate 1
CERS2 ceramide synthase 2
CERS6 ceramide synthase 6
CLDN3 claudin 3
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COLEC12 collectin sub-family member 12
CREM cAMP responsive element modulator
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYTIP cytohesin 1 interacting protein
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECM1 extracellular matrix protein 1
EDNRA endothelin receptor type A
EMP1 epithelial membrane protein 1
EPYC epiphycan
EXPH5 exophilin 5
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAR2 fatty acyl CoA reductase 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FRZB frizzled-related protein
GJA1 gap junction protein, alpha 1, 43kDa
GNAS GNAS complex locus
GPM6A glycoprotein M6A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN5 high mobility group nucleosome binding domain 5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INHBA inhibin, beta A
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LXN latexin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED2 melanoma antigen family D2
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
MN1 meningioma (disrupted in balanced translocation) 1
MSMB microseminoprotein, beta-
MSN moesin
MXRA5 matrix-remodelling associated 5
NDN necdin, melanoma antigen (MAGE) family member
NEBL nebulette
NGRN neugrin, neurite outgrowth associated
NMU neuromedin U
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELENBP1 selenium binding protein 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SSPN sarcospan
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMSB15A thymosin beta 15a
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WLS wntless Wnt ligand secretion mediator
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BCLAF1 BCL2-associated transcription factor 1
BHLHE40 basic helix-loop-helix family, member e40
CCL19 chemokine (C-C motif) ligand 19
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
COPS7A COP9 signalosome subunit 7A
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GEM GTP binding protein overexpressed in skeletal muscle
GLIPR1 GLI pathogenesis-related 1
GRWD1 glutamate-rich WD repeat containing 1
HMOX1 heme oxygenase 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV1-40 immunoglobulin lambda variable 1-40
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KEAP1 kelch-like ECH-associated protein 1
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LMO4 LIM domain only 4
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NBPF10 neuroblastoma breakpoint family, member 10
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOTCH2 notch 2
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PAM peptidylglycine alpha-amidating monooxygenase
PLSCR3 phospholipid scramblase 3
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPAP2B phosphatidic acid phosphatase type 2B
PRR7 proline rich 7 (synaptic)
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RPL36 ribosomal protein L36
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A6 S100 calcium binding protein A6
SCAND1 SCAN domain containing 1
SERTAD2 SERTA domain containing 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPEN spen family transcriptional repressor
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP1 topoisomerase (DNA) I
TRIB1 tribbles pseudokinase 1
UGCG UDP-glucose ceramide glucosyltransferase
WEE1 WEE1 G2 checkpoint kinase
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
Funding