BRD-A17065207_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-A17065207_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACBD3 acyl-CoA binding domain containing 3
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARL1 ADP-ribosylation factor-like 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
CANX calnexin
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L2 chitinase 3-like 2
CLIC4 chloride intracellular channel 4
CLINT1 clathrin interactor 1
COPB2 coatomer protein complex, subunit beta 2 (beta prime)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EPRS glutamyl-prolyl-tRNA synthetase
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GLRX glutaredoxin (thioltransferase)
GOLT1B golgi transport 1B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LRRC59 leucine rich repeat containing 59
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MINA MYC induced nuclear antigen
MLEC malectin
MPO myeloperoxidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUCB2 nucleobindin 2
OAT ornithine aminotransferase
OSER1 oxidative stress responsive serine-rich 1
PDGFRL platelet-derived growth factor receptor-like
PDIA3 protein disulfide isomerase family A, member 3
PDIA6 protein disulfide isomerase family A, member 6
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRNP prion protein
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC23A Sec23 homolog A (S. cerevisiae)
SEC24D SEC24 family member D
SEC31A SEC31 homolog A (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERINC3 serine incorporator 3
SERP1 stress-associated endoplasmic reticulum protein 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC35B1 solute carrier family 35, member B1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRPRB signal recognition particle receptor, B subunit
SSR1 signal sequence receptor, alpha
SUCO SUN domain containing ossification factor
TFF1 trefoil factor 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
CAMK1 calcium/calmodulin-dependent protein kinase I
FZD5 frizzled class receptor 5
GPNMB glycoprotein (transmembrane) nmb
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
KRT17 keratin 17, type I
MECOM MDS1 and EVI1 complex locus
NTS neurotensin
PCDH7 protocadherin 7
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
SCGB2A1 secretoglobin, family 2A, member 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
TGFB1 transforming growth factor, beta 1
TMEM2 transmembrane protein 2
TOX3 TOX high mobility group box family member 3
TUBA4A tubulin, alpha 4a
UPK1B uroplakin 1B