BRD-A18328003_GDC-0980_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-A18328003_GDC-0980_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ACVR1 activin A receptor, type I
AMIGO2 adhesion molecule with Ig-like domain 2
ANG angiogenin, ribonuclease, RNase A family, 5
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
AREG amphiregulin
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
ATM ATM serine/threonine kinase
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CALCOCO1 calcium binding and coiled-coil domain 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
COL10A1 collagen, type X, alpha 1
CREBL2 cAMP responsive element binding protein-like 2
CRIP1 cysteine-rich protein 1 (intestinal)
CST1 cystatin SN
CXCR4 chemokine (C-X-C motif) receptor 4
CYTH1 cytohesin 1
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOCK9 dedicator of cytokinesis 9
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM63A family with sequence similarity 63, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAA glucosidase, alpha; acid
GAS6 growth arrest-specific 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IRS1 insulin receptor substrate 1
ITGAV integrin, alpha V
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDM3A lysine (K)-specific demethylase 3A
KRT8 keratin 8, type II
KYNU kynureninase
LETMD1 LETM1 domain containing 1
LOC100272216 uncharacterized LOC100272216
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MAGEA3 melanoma antigen family A3
MAGED2 melanoma antigen family D2
MAP1B microtubule-associated protein 1B
METRN meteorin, glial cell differentiation regulator
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MT1F metallothionein 1F
MTMR11 myotubularin related protein 11
MXRA5 matrix-remodelling associated 5
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NMRK1 nicotinamide riboside kinase 1
NPDC1 neural proliferation, differentiation and control, 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORAI3 ORAI calcium release-activated calcium modulator 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP2 poly(rC) binding protein 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLLP plasmolipin
PPL periplakin
PTK2B protein tyrosine kinase 2 beta
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBKS ribokinase
RNASE4 ribonuclease, RNase A family, 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SSPN sarcospan
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VCAN versican
VEGFC vascular endothelial growth factor C
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16
ZMYND8 zinc finger, MYND-type containing 8
ZNF277 zinc finger protein 277
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEPDC1 DEP domain containing 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
ENO1 enolase 1, (alpha)
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GYG1 glycogenin 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IL13RA2 interleukin 13 receptor, alpha 2
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
LBR lamin B receptor
LMNB1 lamin B1
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAK16 MAK16 homolog (S. cerevisiae)
MAMLD1 mastermind-like domain containing 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYBPC1 myosin binding protein C, slow type
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NEK2 NIMA-related kinase 2
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
PBK PDZ binding kinase
PCDH9 protocadherin 9
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRC1 protein regulator of cytokinesis 1
PSAT1 phosphoserine aminotransferase 1
RAE1 ribonucleic acid export 1
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SDF2L1 stromal cell-derived factor 2-like 1
SEH1L SEH1-like (S. cerevisiae)
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNAP25 synaptosomal-associated protein, 25kDa
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNX10 sorting nexin 10
SPC25 SPC25, NDC80 kinetochore complex component
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
TACC3 transforming, acidic coiled-coil containing protein 3
TFAM transcription factor A, mitochondrial
TIPIN TIMELESS interacting protein
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
VRK1 vaccinia related kinase 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZWINT ZW10 interacting kinetochore protein
Funding