Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
Category | transcriptomics |
Type | small molecule perturbation |
Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
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179 genes differentially expressed following the BRD-A18411371_2-[(chloroacetyl)(3-chlorophenyl)amino]-N-cyclohexyl-2-(4-methoxyphenyl)acetamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
Symbol | Name |
---|---|
1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
A2M | alpha-2-macroglobulin |
ARG2 | arginase 2 |
ATF3 | activating transcription factor 3 |
BHLHE41 | basic helix-loop-helix family, member e41 |
BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
BTG3 | BTG family, member 3 |
C5AR1 | complement component 5a receptor 1 |
CCNL1 | cyclin L1 |
CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) |
CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) |
CTBS | chitobiase, di-N-acetyl- |
CTSZ | cathepsin Z |
CTTN | cortactin |
CXCL13 | chemokine (C-X-C motif) ligand 13 |
CXCL8 | chemokine (C-X-C motif) ligand 8 |
DDIT3 | DNA-damage-inducible transcript 3 |
DDIT4 | DNA-damage-inducible transcript 4 |
DUSP1 | dual specificity phosphatase 1 |
EGR1 | early growth response 1 |
EGR2 | early growth response 2 |
EGR3 | early growth response 3 |
ENO2 | enolase 2 (gamma, neuronal) |
EPHA3 | EPH receptor A3 |
FASN | fatty acid synthase |
FOS | FBJ murine osteosarcoma viral oncogene homolog |
FOSB | FBJ murine osteosarcoma viral oncogene homolog B |
GAGE3 | G antigen 3 |
GPNMB | glycoprotein (transmembrane) nmb |
HCAR3 | hydroxycarboxylic acid receptor 3 |
HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 |
HK2 | hexokinase 2 |
HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
HMOX1 | heme oxygenase 1 |
HSPA1A | heat shock 70kDa protein 1A |
HSPA6 | heat shock 70kDa protein 6 (HSP70B') |
IFI27 | interferon, alpha-inducible protein 27 |
IL1R1 | interleukin 1 receptor, type I |
INSIG1 | insulin induced gene 1 |
JUN | jun proto-oncogene |
JUND | jun D proto-oncogene |
KDM3A | lysine (K)-specific demethylase 3A |
KDM6B | lysine (K)-specific demethylase 6B |
KIAA0226L | KIAA0226-like |
KLF4 | Kruppel-like factor 4 (gut) |
KLF6 | Kruppel-like factor 6 |
KLHL24 | kelch-like family member 24 |
LDLR | low density lipoprotein receptor |
MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
MAGEA3 | melanoma antigen family A3 |
MAGEA6 | melanoma antigen family A6 |
MME | membrane metallo-endopeptidase |
MMP9 | matrix metallopeptidase 9 |
MXI1 | MAX interactor 1, dimerization protein |
NDRG1 | N-myc downstream regulated 1 |
NDUFA4L2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 |
NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
NEBL | nebulette |
NEFH | neurofilament, heavy polypeptide |
NFIL3 | nuclear factor, interleukin 3 regulated |
NPC1 | Niemann-Pick disease, type C1 |
NR4A1 | nuclear receptor subfamily 4, group A, member 1 |
NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
NUPR1 | nuclear protein, transcriptional regulator, 1 |
P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I |
P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II |
PECR | peroxisomal trans-2-enoyl-CoA reductase |
PELI1 | pellino E3 ubiquitin protein ligase 1 |
PER1 | period circadian clock 1 |
PGK1 | phosphoglycerate kinase 1 |
PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
PIGA | phosphatidylinositol glycan anchor biosynthesis, class A |
PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 |
PPP1R15A | protein phosphatase 1, regulatory subunit 15A |
PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
RB1CC1 | RB1-inducible coiled-coil 1 |
RGCC | regulator of cell cycle |
RGS1 | regulator of G-protein signaling 1 |
RHOB | ras homolog family member B |
RIOK3 | RIO kinase 3 |
SCD | stearoyl-CoA desaturase (delta-9-desaturase) |
SCGB1D2 | secretoglobin, family 1D, member 2 |
SDC2 | syndecan 2 |
SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 |
SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 |
SNAI2 | snail family zinc finger 2 |
TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) |
TFRC | transferrin receptor |
TMEM45A | transmembrane protein 45A |
TSC22D3 | TSC22 domain family, member 3 |
TUSC3 | tumor suppressor candidate 3 |
UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) |
VEGFA | vascular endothelial growth factor A |
WSB1 | WD repeat and SOCS box containing 1 |
ZC2HC1A | zinc finger, C2HC-type containing 1A |
ZFP36 | ZFP36 ring finger protein |
ZNF589 | zinc finger protein 589 |
Symbol | Name |
---|---|
ACSL5 | acyl-CoA synthetase long-chain family member 5 |
ADO | 2-aminoethanethiol (cysteamine) dioxygenase |
AIM1 | absent in melanoma 1 |
ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 |
BAMBI | BMP and activin membrane-bound inhibitor |
BEX1 | brain expressed, X-linked 1 |
CA12 | carbonic anhydrase XII |
CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 |
CAST | calpastatin |
CCL2 | chemokine (C-C motif) ligand 2 |
CCL5 | chemokine (C-C motif) ligand 5 |
CDC25A | cell division cycle 25A |
CDH2 | cadherin 2, type 1, N-cadherin (neuronal) |
CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
CLU | clusterin |
CRIP1 | cysteine-rich protein 1 (intestinal) |
DEFA5 | defensin, alpha 5, Paneth cell-specific |
DEFB1 | defensin, beta 1 |
DUSP22 | dual specificity phosphatase 22 |
ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) |
ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
ERLIN2 | ER lipid raft associated 2 |
FABP4 | fatty acid binding protein 4, adipocyte |
FKBP11 | FK506 binding protein 11, 19 kDa |
FLT3 | fms-related tyrosine kinase 3 |
GABRP | gamma-aminobutyric acid (GABA) A receptor, pi |
GADD45B | growth arrest and DNA-damage-inducible, beta |
GATA2 | GATA binding protein 2 |
H2AFX | H2A histone family, member X |
HLA-B | major histocompatibility complex, class I, B |
HLA-C | major histocompatibility complex, class I, C |
HMGA2 | high mobility group AT-hook 2 |
HOPX | HOP homeobox |
HOXA5 | homeobox A5 |
ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
IL6ST | interleukin 6 signal transducer |
KANK1 | KN motif and ankyrin repeat domains 1 |
KANK2 | KN motif and ankyrin repeat domains 2 |
KRT7 | keratin 7, type II |
LMO2 | LIM domain only 2 (rhombotin-like 1) |
MARCKS | myristoylated alanine-rich protein kinase C substrate |
MBNL2 | muscleblind-like splicing regulator 2 |
MED13 | mediator complex subunit 13 |
MGAT2 | mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase |
MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 |
NKG7 | natural killer cell granule protein 7 |
NPY | neuropeptide Y |
NRIP1 | nuclear receptor interacting protein 1 |
NTS | neurotensin |
OXTR | oxytocin receptor |
PDHB | pyruvate dehydrogenase (lipoamide) beta |
PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta |
PIP4K2B | phosphatidylinositol-5-phosphate 4-kinase, type II, beta |
PLAC8 | placenta-specific 8 |
POLG2 | polymerase (DNA directed), gamma 2, accessory subunit |
PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma |
PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme |
PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit |
RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 |
RBP1 | retinol binding protein 1, cellular |
RBPMS | RNA binding protein with multiple splicing |
RPA3 | replication protein A3, 14kDa |
RRP1B | ribosomal RNA processing 1B |
SACS | sacsin molecular chaperone |
SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 |
SFRP1 | secreted frizzled-related protein 1 |
SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
SMAD7 | SMAD family member 7 |
SOX11 | SRY (sex determining region Y)-box 11 |
TFPI2 | tissue factor pathway inhibitor 2 |
TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) |
TLE4 | transducin-like enhancer of split 4 |
TSKU | tsukushi, small leucine rich proteoglycan |
TXNDC9 | thioredoxin domain containing 9 |
UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
UPK1B | uroplakin 1B |
VCAN | versican |