BRD-A19500257_geldanamycin_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

284 genes differentially expressed following the BRD-A19500257_geldanamycin_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
AFF1 AF4/FMR2 family, member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKAP8 A kinase (PRKA) anchor protein 8
ANGPT1 angiopoietin 1
ANOS1 anosmin 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ATF7IP activating transcription factor 7 interacting protein
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BBX bobby sox homolog (Drosophila)
BHLHE41 basic helix-loop-helix family, member e41
BRD4 bromodomain containing 4
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CALCA calcitonin-related polypeptide alpha
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN6 calpain 6
CAST calpastatin
CAT catalase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG1 cyclin G1
CDK19 cyclin-dependent kinase 19
CES1 carboxylesterase 1
CGA glycoprotein hormones, alpha polypeptide
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLDN8 claudin 8
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COL2A1 collagen, type II, alpha 1
CRABP1 cellular retinoic acid binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5R2 cytochrome b5 reductase 2
DAPK1 death-associated protein kinase 1
DFNA5 deafness, autosomal dominant 5
DHDDS dehydrodolichyl diphosphate synthase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPP4 dipeptidyl-peptidase 4
DUSP14 dual specificity phosphatase 14
ECHDC2 enoyl CoA hydratase domain containing 2
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
EIF4B eukaryotic translation initiation factor 4B
EPS8L2 EPS8-like 2
FAM117A family with sequence similarity 117, member A
FAM134B family with sequence similarity 134, member B
FAM46A family with sequence similarity 46, member A
FBLN1 fibulin 1
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
FXR1 fragile X mental retardation, autosomal homolog 1
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GLG1 golgi glycoprotein 1
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGL immunoglobulin lambda locus
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
IQCG IQ motif containing G
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA0125 KIAA0125
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
KLK5 kallikrein-related peptidase 5
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LBH limb bud and heart development
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
LY75 lymphocyte antigen 75
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MAPK13 mitogen-activated protein kinase 13
MIA melanoma inhibitory activity
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MXI1 MAX interactor 1, dimerization protein
MYB v-myb avian myeloblastosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
OPTN optineurin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAGE4 P antigen family, member 4 (prostate associated)
PDZK1 PDZ domain containing 1
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PENK proenkephalin
PLBD1 phospholipase B domain containing 1
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PRUNE prune exopolyphosphatase
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB9A RAB9A, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RBM47 RNA binding motif protein 47
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNPEP arginyl aminopeptidase (aminopeptidase B)
RPL22 ribosomal protein L22
S100A10 S100 calcium binding protein A10
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCPEP1 serine carboxypeptidase 1
SECISBP2L SECIS binding protein 2-like
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRSF5 serine/arginine-rich splicing factor 5
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK26 serine/threonine protein kinase 26
TBL1X transducin (beta)-like 1X-linked
TCF4 transcription factor 4
TF transferrin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNC1 troponin C type 1 (slow)
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TTC39A tetratricopeptide repeat domain 39A
TWF1 twinfilin actin binding protein 1
UBE2H ubiquitin-conjugating enzyme E2H
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANXA1 annexin A1
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ASRGL1 asparaginase like 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
AXL AXL receptor tyrosine kinase
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
C7 complement component 7
CCDC109B coiled-coil domain containing 109B
CCDC85B coiled-coil domain containing 85B
CCNE2 cyclin E2
CD47 CD47 molecule
CDCA4 cell division cycle associated 4
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CFH complement factor H
CHMP6 charged multivesicular body protein 6
CLTB clathrin, light chain B
CRIP2 cysteine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYR61 cysteine-rich, angiogenic inducer, 61
DCXR dicarbonyl/L-xylulose reductase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX2 distal-less homeobox 2
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ELOVL1 ELOVL fatty acid elongase 1
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
ETV1 ets variant 1
EXOSC4 exosome component 4
FGF2 fibroblast growth factor 2 (basic)
FKBP14 FK506 binding protein 14, 22 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
HAL histidine ammonia-lyase
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFITM2 interferon induced transmembrane protein 2
IGFBP5 insulin-like growth factor binding protein 5
IGKC immunoglobulin kappa constant
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JUN jun proto-oncogene
KYNU kynureninase
LMCD1 LIM and cysteine-rich domains 1
LOC100505650 uncharacterized LOC100505650
MAL mal, T-cell differentiation protein
MCL1 myeloid cell leukemia 1
MCM5 minichromosome maintenance complex component 5
METRN meteorin, glial cell differentiation regulator
MMD monocyte to macrophage differentiation-associated
MSLN mesothelin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NT5E 5'-nucleotidase, ecto (CD73)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKCA protein kinase C, alpha
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRD protein tyrosine phosphatase, receptor type, D
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS1 regulator of G-protein signaling 1
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SDF2L1 stromal cell-derived factor 2-like 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TK1 thymidine kinase 1, soluble
TMEM160 transmembrane protein 160
TMEM223 transmembrane protein 223
TNC tenascin C
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TUBB6 tubulin, beta 6 class V
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
WNT5A wingless-type MMTV integration site family, member 5A
WSB2 WD repeat and SOCS box containing 2
Funding