BRD-A19500257_geldanamycin_BT20_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-A19500257_geldanamycin_BT20_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BAG3 BCL2-associated athanogene 3
CCL5 chemokine (C-C motif) ligand 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COL1A1 collagen, type I, alpha 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOLR1 folate receptor 1 (adult)
GREB1 growth regulation by estrogen in breast cancer 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LPL lipoprotein lipase
LUM lumican
MSX1 msh homeobox 1
MTDH metadherin
PDPN podoplanin
PDZD2 PDZ domain containing 2
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
STC2 stanniocalcin 2
STK39 serine threonine kinase 39
TYMP thymidine phosphorylase
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
APOLD1 apolipoprotein L domain containing 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
CPB1 carboxypeptidase B1 (tissue)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYR61 cysteine-rich, angiogenic inducer, 61
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPM6B glycoprotein M6B
HES1 hes family bHLH transcription factor 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
JAG1 jagged 1
LOXL2 lysyl oxidase-like 2
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCP4 Purkinje cell protein 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNC tenascin C
Funding