| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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367 genes differentially expressed following the BRD-A19500257_geldanamycin_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
| ABHD4 | abhydrolase domain containing 4 |
| ACKR3 | atypical chemokine receptor 3 |
| ACP1 | acid phosphatase 1, soluble |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 |
| ADI1 | acireductone dioxygenase 1 |
| ADM | adrenomedullin |
| AFF1 | AF4/FMR2 family, member 1 |
| AKAP9 | A kinase (PRKA) anchor protein 9 |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| APOD | apolipoprotein D |
| ARHGAP29 | Rho GTPase activating protein 29 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 |
| ARMCX1 | armadillo repeat containing, X-linked 1 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B |
| BBX | bobby sox homolog (Drosophila) |
| BCAM | basal cell adhesion molecule (Lutheran blood group) |
| BLNK | B-cell linker |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| BPIFA1 | BPI fold containing family A, member 1 |
| BRD8 | bromodomain containing 8 |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| C6ORF48 | chromosome 6 open reading frame 48 |
| CAB39 | calcium binding protein 39 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 |
| CALU | calumenin |
| CCDC28A | coiled-coil domain containing 28A |
| CCNG1 | cyclin G1 |
| CCNG2 | cyclin G2 |
| CD163 | CD163 molecule |
| CD24 | CD24 molecule |
| CD46 | CD46 molecule, complement regulatory protein |
| CD59 | CD59 molecule, complement regulatory protein |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) |
| CDK19 | cyclin-dependent kinase 19 |
| CES1 | carboxylesterase 1 |
| COBL | cordon-bleu WH2 repeat protein |
| COL4A5 | collagen, type IV, alpha 5 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 |
| CRYZ | crystallin, zeta (quinone reductase) |
| CSRP2 | cysteine and glycine-rich protein 2 |
| CTGF | connective tissue growth factor |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 |
| DAZAP2 | DAZ associated protein 2 |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 |
| DIAPH2 | diaphanous-related formin 2 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 |
| EFCAB14 | EF-hand calcium binding domain 14 |
| EGF | epidermal growth factor |
| EGFL6 | EGF-like-domain, multiple 6 |
| EIF4B | eukaryotic translation initiation factor 4B |
| ENO2 | enolase 2 (gamma, neuronal) |
| EPAS1 | endothelial PAS domain protein 1 |
| EPCAM | epithelial cell adhesion molecule |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| EXOSC4 | exosome component 4 |
| FAM13A | family with sequence similarity 13, member A |
| FAM63A | family with sequence similarity 63, member A |
| FBN2 | fibrillin 2 |
| FOXJ3 | forkhead box J3 |
| FOXO4 | forkhead box O4 |
| FTH1 | ferritin, heavy polypeptide 1 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 |
| GATA2 | GATA binding protein 2 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 |
| GLRX | glutaredoxin (thioltransferase) |
| GLUL | glutamate-ammonia ligase |
| GOLGB1 | golgin B1 |
| GPC4 | glypican 4 |
| GPNMB | glycoprotein (transmembrane) nmb |
| GPX3 | glutathione peroxidase 3 |
| H3F3B | H3 histone, family 3B (H3.3B) |
| HBP1 | HMG-box transcription factor 1 |
| HIST1H2AC | histone cluster 1, H2ac |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) |
| HSBP1 | heat shock factor binding protein 1 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 |
| HSPA1A | heat shock 70kDa protein 1A |
| HSPA2 | heat shock 70kDa protein 2 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') |
| HSPH1 | heat shock 105kDa/110kDa protein 1 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
| IGFBP3 | insulin-like growth factor binding protein 3 |
| INSIG2 | insulin induced gene 2 |
| INSR | insulin receptor |
| IRS2 | insulin receptor substrate 2 |
| JUP | junction plakoglobin |
| KDM3A | lysine (K)-specific demethylase 3A |
| KDM5B | lysine (K)-specific demethylase 5B |
| KLHDC10 | kelch domain containing 10 |
| KLHL24 | kelch-like family member 24 |
| LDHB | lactate dehydrogenase B |
| LETMD1 | LETM1 domain containing 1 |
| LITAF | lipopolysaccharide-induced TNF factor |
| LOC100272216 | uncharacterized LOC100272216 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 |
| MAOA | monoamine oxidase A |
| MARCH8 | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase |
| METTL7A | methyltransferase like 7A |
| MFAP5 | microfibrillar associated protein 5 |
| MID1 | midline 1 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
| MOAP1 | modulator of apoptosis 1 |
| MOB1A | MOB kinase activator 1A |
| MXI1 | MAX interactor 1, dimerization protein |
| MYLIP | myosin regulatory light chain interacting protein |
| NAV2 | neuron navigator 2 |
| NDRG1 | N-myc downstream regulated 1 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase |
| NEU1 | sialidase 1 (lysosomal sialidase) |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive |
| NOTCH2NL | notch 2 N-terminal like |
| NPTX2 | neuronal pentraxin II |
| NUCB2 | nucleobindin 2 |
| OBSL1 | obscurin-like 1 |
| OGDHL | oxoglutarate dehydrogenase-like |
| OSBPL9 | oxysterol binding protein-like 9 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PEG10 | paternally expressed 10 |
| PERP | PERP, TP53 apoptosis effector |
| PFKM | phosphofructokinase, muscle |
| PFN2 | profilin 2 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| PRAME | preferentially expressed antigen in melanoma |
| PROM1 | prominin 1 |
| PRSS8 | protease, serine, 8 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
| QPRT | quinolinate phosphoribosyltransferase |
| RAB17 | RAB17, member RAS oncogene family |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 |
| RBM47 | RNA binding motif protein 47 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) |
| RPL31 | ribosomal protein L31 |
| RPS27L | ribosomal protein S27-like |
| S100A4 | S100 calcium binding protein A4 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SC5D | sterol-C5-desaturase |
| SCGB1A1 | secretoglobin, family 1A, member 1 (uteroglobin) |
| SECISBP2L | SECIS binding protein 2-like |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) |
| SEPP1 | selenoprotein P, plasma, 1 |
| SERINC1 | serine incorporator 1 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa |
| SFRP1 | secreted frizzled-related protein 1 |
| SOCS2 | suppressor of cytokine signaling 2 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
| STC1 | stanniocalcin 1 |
| STOM | stomatin |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
| SULT1A2 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| THSD7A | thrombospondin, type I, domain containing 7A |
| TMEM45A | transmembrane protein 45A |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 |
| TRIM2 | tripartite motif containing 2 |
| TXNIP | thioredoxin interacting protein |
| UBXN7 | UBX domain protein 7 |
| VTCN1 | V-set domain containing T cell activation inhibitor 1 |
| WFDC2 | WAP four-disulfide core domain 2 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 |
| WSB1 | WD repeat and SOCS box containing 1 |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZBTB38 | zinc finger and BTB domain containing 38 |
| ZMAT3 | zinc finger, matrin-type 3 |
| ZNF292 | zinc finger protein 292 |
| Symbol | Name |
|---|---|
| ABCE1 | ATP-binding cassette, sub-family E (OABP), member 1 |
| ABLIM1 | actin binding LIM protein 1 |
| ACTN1 | actinin, alpha 1 |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| AK4 | adenylate kinase 4 |
| ALOX5 | arachidonate 5-lipoxygenase |
| ANXA5 | annexin A5 |
| APOC1 | apolipoprotein C-I |
| AREG | amphiregulin |
| ASF1B | anti-silencing function 1B histone chaperone |
| ATAD2 | ATPase family, AAA domain containing 2 |
| AURKB | aurora kinase B |
| BHLHE41 | basic helix-loop-helix family, member e41 |
| BOP1 | block of proliferation 1 |
| BRCA1 | breast cancer 1, early onset |
| BYSL | bystin-like |
| C14ORF169 | chromosome 14 open reading frame 169 |
| C1ORF116 | chromosome 1 open reading frame 116 |
| C20ORF27 | chromosome 20 open reading frame 27 |
| CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
| CCDC85B | coiled-coil domain containing 85B |
| CCND1 | cyclin D1 |
| CCNE2 | cyclin E2 |
| CD36 | CD36 molecule (thrombospondin receptor) |
| CDC25A | cell division cycle 25A |
| CDC45 | cell division cycle 45 |
| CDC6 | cell division cycle 6 |
| CDC7 | cell division cycle 7 |
| CDCA4 | cell division cycle associated 4 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) |
| CDK4 | cyclin-dependent kinase 4 |
| CECR5 | cat eye syndrome chromosome region, candidate 5 |
| CENPU | centromere protein U |
| CHEK1 | checkpoint kinase 1 |
| CKLF | chemokine-like factor |
| CLTB | clathrin, light chain B |
| COTL1 | coactosin-like F-actin binding protein 1 |
| CSTA | cystatin A (stefin A) |
| CXCL14 | chemokine (C-X-C motif) ligand 14 |
| DCTPP1 | dCTP pyrophosphatase 1 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 |
| DESI1 | desumoylating isopeptidase 1 |
| DHFR | dihydrofolate reductase |
| DLC1 | DLC1 Rho GTPase activating protein |
| DNM1L | dynamin 1-like |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
| DONSON | downstream neighbor of SON |
| DPH2 | DPH2 homolog (S. cerevisiae) |
| DSCC1 | DNA replication and sister chromatid cohesion 1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DUT | deoxyuridine triphosphatase |
| EGR3 | early growth response 3 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 |
| EREG | epiregulin |
| ETV1 | ets variant 1 |
| EXOSC2 | exosome component 2 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| F12 | coagulation factor XII (Hageman factor) |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) |
| FAM216A | family with sequence similarity 216, member A |
| FAM57A | family with sequence similarity 57, member A |
| FANCG | Fanconi anemia, complementation group G |
| FEN1 | flap structure-specific endonuclease 1 |
| G0S2 | G0/G1 switch 2 |
| GALE | UDP-galactose-4-epimerase |
| GART | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
| GBP1 | guanylate binding protein 1, interferon-inducible |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GLRX2 | glutaredoxin 2 |
| GPM6A | glycoprotein M6A |
| H2AFX | H2A histone family, member X |
| HBEGF | heparin-binding EGF-like growth factor |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 |
| HN1 | hematological and neurological expressed 1 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B |
| HOMER2 | homer scaffolding protein 2 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
| IGKC | immunoglobulin kappa constant |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa |
| IPO4 | importin 4 |
| IRF8 | interferon regulatory factor 8 |
| ITM2A | integral membrane protein 2A |
| JAG1 | jagged 1 |
| JCHAIN | joining chain of multimeric IgA and IgM |
| KANK1 | KN motif and ankyrin repeat domains 1 |
| KLF4 | Kruppel-like factor 4 (gut) |
| KLF6 | Kruppel-like factor 6 |
| KRT16 | keratin 16, type I |
| LAGE3 | L antigen family, member 3 |
| LHFP | lipoma HMGIC fusion partner |
| LOXL1 | lysyl oxidase-like 1 |
| LSM7 | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| LYZ | lysozyme |
| MALL | mal, T-cell differentiation protein-like |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM2 | minichromosome maintenance complex component 2 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM5 | minichromosome maintenance complex component 5 |
| MCM6 | minichromosome maintenance complex component 6 |
| MCM7 | minichromosome maintenance complex component 7 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 |
| MREG | melanoregulin |
| MRPL12 | mitochondrial ribosomal protein L12 |
| MRPL15 | mitochondrial ribosomal protein L15 |
| MRTO4 | mRNA turnover 4 homolog (S. cerevisiae) |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 |
| NOP16 | NOP16 nucleolar protein |
| NPM3 | nucleophosmin/nucleoplasmin 3 |
| NRIP1 | nuclear receptor interacting protein 1 |
| NXT1 | nuclear transport factor 2-like export factor 1 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| PCNA | proliferating cell nuclear antigen |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase |
| PEA15 | phosphoprotein enriched in astrocytes 15 |
| PFAS | phosphoribosylformylglycinamidine synthase |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PLAT | plasminogen activator, tissue |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 |
| PNP | purine nucleoside phosphorylase |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| POLR2E | polymerase (RNA) II (DNA directed) polypeptide E, 25kDa |
| PPA1 | pyrophosphatase (inorganic) 1 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) |
| PRKCI | protein kinase C, iota |
| PRPF19 | pre-mRNA processing factor 19 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| PTPRE | protein tyrosine phosphatase, receptor type, E |
| PUS1 | pseudouridylate synthase 1 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa |
| PYCR1 | pyrroline-5-carboxylate reductase 1 |
| RANBP1 | RAN binding protein 1 |
| RBBP8 | retinoblastoma binding protein 8 |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RFTN1 | raftlin, lipid raft linker 1 |
| RMI1 | RecQ mediated genome instability 1 |
| RNASEH2A | ribonuclease H2, subunit A |
| RPIA | ribose 5-phosphate isomerase A |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) |
| RUNX1 | runt-related transcription factor 1 |
| S100A7 | S100 calcium binding protein A7 |
| SCML1 | sex comb on midleg-like 1 (Drosophila) |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 |
| SNAI2 | snail family zinc finger 2 |
| SOX9 | SRY (sex determining region Y)-box 9 |
| SRM | spermidine synthase |
| TAGLN | transgelin |
| TCFL5 | transcription factor-like 5 (basic helix-loop-helix) |
| TEAD4 | TEA domain family member 4 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase |
| TIPIN | TIMELESS interacting protein |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TMEM109 | transmembrane protein 109 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit |
| TUBA4A | tubulin, alpha 4a |
| TUBB2A | tubulin, beta 2A class IIa |
| TUBG1 | tubulin, gamma 1 |
| ZWINT | ZW10 interacting kinetochore protein |
