BRD-A19500257_geldanamycin_MDAMB231_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-A19500257_geldanamycin_MDAMB231_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV3-19 immunoglobulin lambda variable 3-19
LTBP1 latent transforming growth factor beta binding protein 1
LYPD1 LY6/PLAUR domain containing 1
MBP myelin basic protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
RRAD Ras-related associated with diabetes
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCTN1 tectonic family member 1
TIMP3 TIMP metallopeptidase inhibitor 3
TRA2A transformer 2 alpha homolog (Drosophila)
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ARL4C ADP-ribosylation factor-like 4C
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
C3ORF14 chromosome 3 open reading frame 14
C5ORF30 chromosome 5 open reading frame 30
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CCND2 cyclin D2
CDKN2A cyclin-dependent kinase inhibitor 2A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CST1 cystatin SN
E2F2 E2F transcription factor 2
ELMO1 engulfment and cell motility 1
FHL1 four and a half LIM domains 1
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPM6A glycoprotein M6A
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXA10 homeobox A10
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KRT19 keratin 19, type I
LDHB lactate dehydrogenase B
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTF lactotransferrin
MYB v-myb avian myeloblastosis viral oncogene homolog
NDNF neuron-derived neurotrophic factor
NLRP2 NLR family, pyrin domain containing 2
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
NTS neurotensin
OXCT1 3-oxoacid CoA transferase 1
PALLD palladin, cytoskeletal associated protein
PDLIM5 PDZ and LIM domain 5
PEX11A peroxisomal biogenesis factor 11 alpha
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
RAP2A RAP2A, member of RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SERINC5 serine incorporator 5
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SRSF6 serine/arginine-rich splicing factor 6
SYBU syntabulin (syntaxin-interacting)
TES testin LIM domain protein
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TPD52L1 tumor protein D52-like 1
TSPAN7 tetraspanin 7
TSPAN8 tetraspanin 8
TTC39A tetratricopeptide repeat domain 39A
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18
Funding