BRD-A19633847_PERHEXILINE MALEATE_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-A19633847_PERHEXILINE MALEATE_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
AREG amphiregulin
ASS1 argininosuccinate synthase 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
ELOVL6 ELOVL fatty acid elongase 6
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FADS1 fatty acid desaturase 1
FAM46A family with sequence similarity 46, member A
FN1 fibronectin 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IER3 immediate early response 3
IL32 interleukin 32
INSIG1 insulin induced gene 1
ITGB5 integrin, beta 5
JUN jun proto-oncogene
KLF6 Kruppel-like factor 6
KRT20 keratin 20, type I
KRT23 keratin 23, type I
LDLR low density lipoprotein receptor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
OSBPL10 oxysterol binding protein-like 10
PPOX protoporphyrinogen oxidase
PTPRK protein tyrosine phosphatase, receptor type, K
RAI14 retinoic acid induced 14
RAP1GAP RAP1 GTPase activating protein
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SQSTM1 sequestosome 1
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX3 syntaxin 3
TES testin LIM domain protein
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DSCC1 DNA replication and sister chromatid cohesion 1
E2F8 E2F transcription factor 8
ELOVL2 ELOVL fatty acid elongase 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLK1 polo-like kinase 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RNASEH2A ribonuclease H2, subunit A
RRM2 ribonucleotide reductase M2
SHCBP1 SHC SH2-domain binding protein 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
TACC3 transforming, acidic coiled-coil containing protein 3
TDP1 tyrosyl-DNA phosphodiesterase 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
ZNF586 zinc finger protein 586
ZWINT ZW10 interacting kinetochore protein
Funding